Clinical trials: Bladder Infection
Pelvic Toxicity, Radiation Toxicity
Gut Microbiome in Gynecological Cancer Patients With Pelvic Toxicity: Controls Versus Ozone Treatment. (MicrOzoGineTox)
Patients treated for gynecological tumors with radiotherapy (RT) and/or chemotherapy (CT) frequently develop pelvic toxicity (TPIRQT), a condition that can become persistent, progressive, and refractory to standard treatments.
- Conditions
- Pelvic Toxicity, Radiation Toxicity, Chemotherapy Toxicity, Gynecological Tumors
- Trial name
- MicrOGineTox (NCT07259681)
- Where
- 2 sites in Spain
- Volunteers
- 38 people
- Sponsor
- Bernardino Clavo, MD, PhD
Interstitial Cystitis, Bladder Pain Syndrome
Supervised Exercise as a Therapeutic Strategy for Interstitial Cystitis/Bladder Pain Syndrome
In this study, the efficacy of exercise to improve interstitial cystitis/bladder pain syndrome symptoms and quality of life will be investigated.
- Trial name
- IC/BPS (NCT05699551)
- Testing
- Exercise regimen
- Sponsor
- Wake Forest University Health Sciences
Interstitial Cystitis
Safety Study of LiRIS in Interstitial Cystitis (IC) Patients
The purpose of this study is primarily to evaluate the safety and tolerability of two dose levels of an investigational drug-delivery system (LiRIS) in patients who have moderate to severe symptoms of interstitial cystitis.
- Trial name
- NCT01150565
- Testing
- LiRIS low dose and LiRIS high dose
- Where
- 3 sites in Canada
- Volunteers
- 18 people
- Sponsor
- Allergan
Hemorrhagic Cystitis
Tolerability and Efficacy of INSTYLAN in Subjects With Moderate to Severe Hemorrhagic Cystitis
The purpose of this study is to assess the efficacy and tolerability of INSTYLAN (Sodium Hyaluronate 80mg/50ml) in Patients with early or late symptoms of moderate to severe hemorrhagic cystitis caused by pelvic radiation therapy…
- Trial name
- NCT04696666
- Testing
- INSTYLAN (Sodium Hyaluronate 80mg/50ml)
- Where
- 10 sites in France
- Volunteers
- 30 people
- Sponsor
- LIDDE Therapeutics
Interstitial Cystitis
Platelet Activating Factor Stability in Urine
The investigator's hypothesis is that smoking induces inflammation in the bladder wall. This may predispose to the development of Interstitial cystitis(IC) / bladder pain syndrome(BPS).
- Trial name
- NCT03103477
- Testing
- Urine stability
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- St. Louis University
Bladder Pain Syndrome, Interstitial Cystitis
Diagnosis of Bladder Pain Syndrome / Interstitial Cystitis
To identify new, simple and reliable biomarkers for bladder pain syndrome/interstitial cystitis (BPS/IC) for diagnosis of this disease.
- Conditions
- Bladder Pain Syndrome, Interstitial Cystitis, Overactive Bladder
- Trial name
- NCT03023241
- Testing
- biopsy
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- Cantonal Hospital, Frauenfeld
Cystitis, Radio Induced
Radiation Induced Cystitis Treated With Hyperbaric Oxygen - A Randomized Controlled Trial
The primary objective of this study is to assess the relief of symptoms after Hyperbaric Oxygen Therapy (HBOT) in patients with late radiation cystitis by having Expanded Prostate cancer Index Composite (EPIC)symptom estimation…
- Trial name
- RICH-ART (NCT01659723)
- Testing
- Hyperbaric Oxygen
- Where
- 5 sites in Denmark, Finland and 2 more
- Volunteers
- 75 people
- Sponsor
- Göteborg University
Painful Bladder Syndrome (PBS)
Botulinum A Toxin in the Treatment of Patients With Painful Bladder Syndrome
Previous clinical observations showed that Botulinum A toxin (BoNT/A) has also an antinociceptive effect and can control the neuropathic pain.
- Trial name
- NCT01157507
- Testing
- Intravesical injection of Botulinum A Toxin, Bladder overdistension
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University Of Perugia
Interstitial Cystitis
The Effects of Mindfulness-based Stress Reduction in Interstitial Cystitis Patients
This is a prospective cohort study to investigate differences in the bladder environment (i.e. urinary microbiome) amongst women with interstitial cystitis (IC) before and after undergoing mindfulness-based stress reduction…
- Trial name
- NCT03722992
- Testing
- MBSR
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- TriHealth Inc.
Melanoma, Non-small Cell Lung Cancer
TiTAN-1: Safety, Proliferation and Persistence of GEN-011 Autologous Cell Therapy
TiTAN-1 is a first-in-human study of GEN-011, an experimental treatment being evaluated in adult patients with advanced cancer. GEN-011 is a T cell therapy made specific to each patient, using the patient's own circulating immune…
- Conditions
- Melanoma, Non-small Cell Lung Cancer, Squamous Cell Carcinoma of Head and Neck, Urothelial Carcinoma
- Trial name
- NCT04596033
- Testing
- GEN-011, IL-2, Fludarabine
- Where
- 8 sites in United States
- Volunteers
- 49 people
- Sponsor
- Genocea Biosciences, Inc.
Transplantation Infection
Cidofovir Versus Best Supportive Care for Hemorrhagic Cystitis
The goal of this clinical research study is to learn if adding cidofovir to the standard of care can improve symptoms of hemorrhagic cystitis caused by the BK virus as compared to standard of care alone.
- Trial name
- NCT01295645
- Testing
- Cidofovir, No Cidofovir
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- M.D. Anderson Cancer Center
Cystitis, Interstitial
DMSO Efficacy in IC/PBS Patients During and After Treatment
The purpose of this study is to examine the efficacy of dimethylsulphoxide (DMSO) cocktail in patients with interstitial cystitis during the treatment period (12 weeks) and after it (at 6 weeks, 3, 6 and 12 month).
- Trial name
- NCT01074567
- Testing
- DMSO cocktail
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Urinary Tract Infections
The Urinary Microbiome and Its Relationship to the Urinary and Serum Metabolome in Healthy Peri- and Postmenopausal Women
The presented project aims to characterize the microbiome of healthy peri- and postmenopausal women and its correlation with the metabolome of urine and serum.
- Trial name
- NCT06573827
- Testing
- Blood and urine sample evaluation
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital Ostrava
Prostate Cancer
Multicentre International STudy for the Prevention With Ialuril® of Radio-induced Cystitis (MISTIC)
The study is randomized and it will be conducted in the field of routine clinical practice. A total of 100 consecutive patients planned to receive radiotherapy for prostate cancer will be enrolled.
- Trial name
- MISTIC (NCT03493997)
- Testing
- Radiotherapy+IAluril®+Ialuril Soft Gels®, Radiotherapy only
- Where
- 7 sites in Italy, Slovakia and 2 more
- Volunteers
- 100 people
- Sponsor
- Study Group for Urogenital Diseases, Italy
Interstitial Cystitis
Genetic and Histopathologic Characteristics of Interstitial Cystitis
Genetic and Histopathologic Characteristics of Interstitial Cystitis
- Trial name
- NCT03523559
- Testing
- bladder tissue of Interstitial Cystitis and normal bladder tissue
- Where
- South Korea
- Volunteers
- 14 people
- Sponsor
- Samsung Medical Center
Interstitial Cystitis/Painful Bladder Syndrome, Myofascial Pelvic Pain
Interstitial Cystitis: Examination of the Central Autonomic Network
This proposal aims to move the science of chronic pelvic pain (CPP) from simple associations towards an investigation of cause and effect relationships.
- Trial name
- ICECAN (NCT03008382)
- Testing
- Metoprolol Tartrate Oral Tablet, No intervention- observational sub-study
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Bladder Pain Syndrome
Comparison of the Treatment of Refractory Bladder Pain Syndrome With DMSO and DMSO With Botulinum Toxin A
The purpose of this research study is to evaluate the efficacy of intravesical botulinum A toxin and DMSO in women with bladder pain syndrome who have not responded to first-line treatments.
- Trial name
- NCT03103594
- Testing
- DMSO, Botox
- Volunteers
- 2 people
- Sponsor
- University of Pennsylvania
Interstitial Cystitis, Chronic Interstitial Cystitis
Investigation of PEMF Therapy for Female Patients With IC/BPS
The purpose of this study is to gather information about the safety and effectiveness of the non-pharmacological (non-drug), non-invasive treatment known as low-frequency pulsed electromagnetic field (PEMF) therapy.
- Conditions
- Interstitial Cystitis, Chronic Interstitial Cystitis, Bladder Pain Syndrome
- Trial name
- NCT05149573
- Testing
- Pulsed Electromagnetic Field (PEMF) Device
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Wake Forest University Health Sciences
Bladder Disease
Different Injection Site Maps & Intravesical Botulinum Toxin
Botulinum toxin injection into the bladder is used in current practice in urological diseases such as overactive bladder or interstitial cystitis. As far as is known, botulinum toxin injection sites have not been clearly defined.
- Trial name
- NCT06185218
- Testing
- Intravesical Botulinum Toxin
- Volunteers
- 60 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Urinary Tract Infections
Probiotics as a Prophylactic Aid in Women With Recurrent Urinary Tract Infections (UTI's)
To investigate if administration of probiotics, either orally or vaginally, Can reduce the number of episodes of acute bacterial cystitis and/or Has tolerable adverse effect profile Improves general QoL in these women Improves…
- Trial name
- NCT00781625
- Testing
- UREX-cap-5
- Where
- 2 sites in Norway
- Volunteers
- 120 people
- Sponsor
- University Hospital, Akershus