Clinical trials: Birth Defects
Patent Ductus Arteriosus After Premature Birth
Hemodynamically Important Patent Ductus Arteriosus in Newborns Under 32 Weeks
To define the characteristics of hemodynamically significant PDA by echocardiography, to investigate the systemic effects of the ductus with cerebral and renal Doppler flow studies, and to determine the oxygen consumption in the…
- Trial name
- NCT05686343
- Testing
- Echocardiography, Doppler ultrasonography, Near-infrared spectroscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ankara University
Influenza, Human, Pregnancy
Flucelvax (TIVc or QIVc) Pregnancy Registry
The study is a population based prospective cohort study designed to collect data on pregnancy outcomes and events of interest among women immunized with the TIVc or QIVc vaccine during pregnancy.
- Conditions
- Influenza, Human, Pregnancy, Birth Defect
- Trial name
- NCT03438487
- Testing
- Flucelvax Trivalent Influenza Vaccine, Flucelvax Quadrivalent Influenza Vaccine
- Where
- United States
- Volunteers
- 692 people, healthy volunteers welcome
- Sponsor
- Seqirus
Birth Defect, Newborn; Fit
The Pilot Study of High-throughput Sequencing in Neonatal Birth Defects
In China, birth defects can reach as high as 5.6%, about 900,000 new cases of birth defects are added each year, making it the second cause of death for infants, with a total death rate of 19.1%.
- Conditions
- Birth Defect, Newborn; Fit, Genetic Diseases, Multiple Malformation
- Trial name
- NCT03984266
- Testing
- NGS panel
- Where
- China
- Volunteers
- 3,423 people
- Sponsor
- Children's Hospital of Chongqing Medical University
Influenza, Human, Pregnancy
Afluria Pregnancy Registry
The study is a population based prospective cohort study designed to collect data on pregnancy outcomes and events of interest among women immunized with Afluria during pregnancy.
- Conditions
- Influenza, Human, Pregnancy, Birth Defect
- Trial name
- NCT03442582
- Testing
- Afluria Influenza Vaccine
- Where
- United States
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Seqirus
Birth Defects, Pregnancy
Uterine Fibroid Pregnancy Registry
The Uterine Fibroid Pregnancy Registry is a USA and European-based registry designed to monitor pregnancies in women with uterine fibroids in order to 1.
- Conditions
- Birth Defects, Pregnancy, Uterine Fibroids
- Trial name
- NCT00232713
- Volunteers
- 2,360 people
- Sponsor
- Syneos Health
Birth Defects, Pregnancy Complications
The Ribavirin Pregnancy Registry
Ribavirin should be avoided during pregnancy and during the 6 months before pregnancy in both the female and the male sexual partner.
- Conditions
- Birth Defects, Pregnancy Complications, Hepatitis C
- Trial name
- RPR (NCT00114712)
- Where
- United States
- Volunteers
- 477 people
- Sponsor
- Syneos Health
Genetics, Genetic Disease
Personalized Genomic Research
Background: Congenital malformations, sometimes called birth defects, occur because of a difference in early human development. There are many different types of congenital malformations, and some of these can be caused by…
- Conditions
- Genetics, Genetic Disease, Genetic Linkage, Birth Defects
- Trial name
- NCT01294345
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Aneuploidy, Birth Defect
Use of Videos to Improve Patient Knowledge on Prenatal Genetics
This is a randomized controlled trial of a low income and low health literacy population of pregnant women from a diverse racial and ethnic background to assess the effectiveness of a pre-visit educational video on prenatal…
- Trial name
- VPE (NCT03816423)
- Testing
- video
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Hepatitis B Infection, Congenital Malformation
Tenofovir Disoproxil Fumarate in Combination of Hepatitis B Vaccine for Preventing Hepatitis B Vertical Transmission
Immunoprophylaxis with two hepatitis B vaccinations following the hepatitis B immune globulin (HBIg) and hepatitis B vaccine at birth is largely effective in protecting infants from hepatitis B virus (HBV) infection.
- Conditions
- Hepatitis B Infection, Congenital Malformation, Birth Defect, Viremia
- Trial name
- NCT03476083
- Testing
- Tenofovir Disoproxil Fumarate (TDF) 300 mg oral daily.
- Where
- 7 sites in China
- Volunteers
- 280 people
- Sponsor
- New Discovery LLC
Spontaneous Abortion, Fetal Death
Environmental Factors and Embryonic Development Project
The Environmental Factors and Embryonic Development Project was set up to investigate environmental exposures and behavioral factors responsible for embryonic dysplasia and gestational complications in pregnant women.
- Conditions
- Spontaneous Abortion, Fetal Death, Stillbirth, Birth Defects
- Trial name
- EFED (NCT04182503)
- Testing
- No intervention
- Where
- 19 sites in China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Birth Defects, Cleft Palate
Svangerskap, Arv, Og Miljo (Pregnancy, Heredity and Environment)
This proposal describes a population-based case-control study of all Norwegian infants born with cleft lip or palate over a five-year period. The study will be jointly supported by the U.S.
- Conditions
- Birth Defects, Cleft Palate, Cleft Lip
- Trial name
- NCT00340977
- Where
- 2 sites in Norway
- Volunteers
- 4,091 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Congenital Abnormalities, Birth Defects
Clinical and Genetic Studies of VACTERL Association
This study will explore the medical problems in patients with VACTERL association and identify gene changes that might be responsible for them.
- Conditions
- Congenital Abnormalities, Birth Defects, Congenital Defects
- Trial name
- NCT00766571
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Prematurity, Immune Defect
Different Doses of Vitamin D and T Regulatory Cells in Preterm Infants
This study evaluate the effect of two different doses of vitamin D on T-regulatory cells in preterm infants. Half of the subjects receives 400 IU vitamin D and the other half receives 800 IU vitamin D.
- Trial name
- NCT03793309
- Testing
- Vitamin D
- Volunteers
- 40 people
- Sponsor
- Cairo University
Birth Defects, Pregnancy Complications
Betaseron Pregnancy Registry
This is a prospective, observational, registration and follow-up study of women exposed to Betaseron® at the time of conception (i.e., any time from the first day of the last menstrual period) and/or during pregnancy.
- Conditions
- Birth Defects, Pregnancy Complications, Multiple Sclerosis
- Trial name
- NCT00317564
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Syneos Health
Pregnancy, Birth Defects
Influence of Genetics on Vitamin Metabolism in Pregnant Women
This study will examine how the body metabolizes micronutrients, such vitamins, during pregnancy and how genetic make-up influences their metabolism.
- Trial name
- NCT00340366
- Where
- Ireland
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Birth Defects, Pregnancy Complications
UCB Antiepileptic Drugs (AED) Pregnancy Registry (Formerly the Keppra® Pregnancy Registry)
This is a prospective, observational, exposure-registration and follow-up study of women and their offspring exposed to Keppra® (levetiracetam) and Keppra XR® at the time of conception (i.e., any time from the first day of the…
- Conditions
- Birth Defects, Pregnancy Complications, Epilepsy, Seizures
- Trial name
- NCT00345475
- Where
- United States
- Volunteers
- 516 people
- Sponsor
- UCB Pharma
Birth Defects, Type 2 Diabetes
Exenatide Pregnancy Registry - Type 2 Diabetes in Pregnancy
This is an observational, prospective cohort study describing pregnancy outcomes in women with pre-existing (prior to pregnancy) type 2 diabetes who have been exposed to any formulation of exenatide during pregnancy.
- Conditions
- Birth Defects, Type 2 Diabetes, Preterm Birth
- Trial name
- Exenatide (NCT00579150)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- AstraZeneca
Environmental Exposures, Other Pregnancy With Abortive Outcome
The China-Anhui Birth Cohort Study (C-ABCS)
The China-Anhui Birth Cohort Study (C-ABCS) was set up to examine the delayed, cumulative and interactive effects of maternal environmental exposures on birth outcomes and children's development.
- Conditions
- Environmental Exposures, Other Pregnancy With Abortive Outcome, Birth Defects, Children Development
- Trial name
- NCT02391610
- Testing
- No intervention
- Volunteers
- 16,766 people, healthy volunteers welcome
- Sponsor
- Fangbiao Tao
Birth Defect, Spontaneous Abortions
Nplate® Pregnancy Exposure Registry
US study to estimate the prevalence at birth of major birth defects (ie, those that cause significant functional or cosmetic impairment, require surgery, or are life-limiting) in children born to mothers who have received Nplate®…
- Conditions
- Birth Defect, Spontaneous Abortions, Low Birth Weight
- Trial name
- NPER (NCT02090088)
- Testing
- Not applicable- observational study
- Volunteers
- 4 people
- Sponsor
- Amgen
Congenital Heart Disease, Prematurity
Prediction of Feeding Problems in Prostaglandin-dependent Prematurely Born Infants With Congenital Heart Disease
Prematurely born infants with ductal-dependent congenital heart disease (CHD) are at increased risk to develop necrotizing enterocolitis (NEC).
- Conditions
- Congenital Heart Disease, Prematurity, Necrotizing Enterocolitis
- Trial name
- NCT01126372
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Utah