Clinical trials: Birth
Maternal Depressive Disorder Complicating Childbirth, Preterm Birth
Mother's Recorded Voice for Preterm Infants
The early birth of a premature baby can be a devastating and unplanned situation for parents. Often, their baby cannot be readily held; they can be very sick and fragile.
- Conditions
- Maternal Depressive Disorder Complicating Childbirth, Preterm Birth, Maternal Anxiety Disorder Complicating Childbirth
- Trial name
- NCT04559620
- Testing
- Maternal voice
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- AdventHealth
Labor Onset and Length Abnormalities, Induced; Birth
Comparison of Misoprostol Ripening Efficacy With Dilapan
The purpose of this study is to find out if Dilapan works as well as Misoprostol for preparing the mouth of the uterus (cervix) for inducing labor in women who need to undergo this procedure.
- Trial name
- COMRED (NCT03670836)
- Testing
- Dilapan, Misoprostol
- Where
- 2 sites in United States
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- Columbia University
Infant, Newborn, Infant, Low Birth Weight
Laparotomy vs. Drainage for Infants With Necrotizing Enterocolitis
This study will compare the effectiveness of two surgical procedures -laparotomy versus drainage - commonly used to treat necrotizing enterocolitis (NEC) or isolated intestinal perforations (IP) in extremely low birth weight…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- NEST (NCT01029353)
- Testing
- Laparotomy, Drainage
- Where
- 22 sites in United States
- Volunteers
- 529 people
- Sponsor
- NICHD Neonatal Research Network
Postnatal Growth Disorder
Impact of Electrolyte Intake (Sodium, Phosphorus) on the Growth of Premature Newborns
Extrauterine growth restriction (EUGR) is a common complication in the medical management of premature newborns. The long-term consequences of EUGR are weight and height restriction, metabolic disorders, and neurodevelopmental…
- Trial name
- ELECTROGRO (NCT06506981)
- Where
- France
- Volunteers
- 684 people
- Sponsor
- Central Hospital, Nancy, France
Premature
dTDI During a SBT to Predict Extubation Failure in Preterm Infants
Weaning from mechanical ventilation is a critical issue and the diaphragmatic disfunction has been demonstrated to play an important role in extubation failure.
- Trial name
- NCT05865977
- Testing
- diaphragmatic tissue Doppler imaging，dTDI
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Wang Jianhui
Induced; Birth, Pregnancy
Comparison of Patient Satisfaction With Home Induction and In-patient Induction.
Induced labour is a medical intervention designed to initiate or accelerate the childbirth process when clinically indicated. Induced labour concerns 25.8% of pregnant women in France, according to the latest National Perinatal…
- Trial name
- NCT06272591
- Testing
- Preliminary search in the patient's file, A posteriori research in the patient's file, First questionnaire : choice of induction method reason for choice
- Where
- France
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Premature, Olive Oil
Enteral Feeding of Premature Babies and Olive Oil Supplementation
It is a two-arm prospective interventional study. 40 babies in both groups will be enrolment in the study. In the intervention group, babies will take 1 ml/kg/day of the study product (ULTRA PREMIUM) after full enteral feeding.
- Conditions
- Premature, Olive Oil, Enteral Feeding
- Trial name
- NCT06072625
- Testing
- Extra virgin organic olive oil (ULTRA PREMIUM)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bursa City Hospital
Premature Infants, Necrotizing Enterocolitis
PREMAPROB. Probiotics to Prevent Necrotizing Enterocolitis
The main objective of this study is to assess the impact of two different doses of a mixture of probiotics from two strains isolated in human milk on the incidence of severe necrotizing enterocolitis (NEC) and death among preterm…
- Trial name
- NCT06501404
- Testing
- High dose group, Low dose group
- Where
- Spain
- Volunteers
- 583 people, healthy volunteers welcome
- Sponsor
- José Antonio Hurtado Suazo
Psychological Distress
Preventing Premature Family Maladjustment: an e-Health Interdisciplinary Research
The consequences of preterm birth extend beyond the clinical conditions of the newborn, profoundly impacting the functioning and well-being of families.
- Trial name
- e-ParWelB (NCT06495762)
- Testing
- e-health assesment
- Where
- 6 sites in Italy
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
VLBW - Very Low Birth Weight Infant
Feeding Study in VLBW Premature Infants
A multi-center, single-blind, randomized, controlled, parallel-designed, prospective trial to compare growth between preterm infants fed one of three study human milk fortifiers added to human milk
- Trial name
- NCT05744193
- Testing
- Exempt Infant Formula
- Where
- 6 sites in United States
- Volunteers
- 22 people
- Sponsor
- Mead Johnson Nutrition
Birth Asphyxia With Neurologic Involvement
Cardiac and Cerebral Hemodynamics With Umbilical Cord Milking Compared With Early Cord Clamping
3 clinical sites enrolling in the primary MINVI trial (NCT03631940) will collect Near Infrared Spectroscopy (NIRS) data in the first 10 minutes of life on a subset of 200 non-vigorous term and near-term infants enrolled in the…
- Trial name
- MINVINIRS (NCT03621956)
- Testing
- Umbilical Cord Milking, Early Cord Clamping
- Where
- 3 sites in United States, Canada
- Volunteers
- 34 people
- Sponsor
- Sharp HealthCare
Preterm Birth, Respiratory Distress Syndrome
Surfactant Nebulization for the Early Aeration of the Preterm Lung
Respiratory distress syndrome is the most common cause of respiratory failure in preterm infants. Treatment consists of respiratory support and exogenous surfactant administration.
- Conditions
- Preterm Birth, Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal
- Trial name
- SUNSET (NCT04315636)
- Testing
- Surfactant nebulisation
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- University of Zurich
Metabolic Syndrome, Pregnant Women
Progression of Metabolic Syndrome Components During Pregnancy
The goal of this cohort study is to investigate the underlying risk factors to develop metabolic syndrome (MetS) during pregnancy, and the associations of MetS and its indicators with birth outcomes in southwest Ethiopia.
- Conditions
- Metabolic Syndrome, Pregnant Women, Birth Outcomes, Dietary Habits
- Trial name
- MetS_Preg (NCT05935904)
- Testing
- Exposure, Non exposure
- Where
- Ethiopia
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- University Ghent
Prematurity, Respiratory Distress Syndrome
Comparing Different Delivery Systems of Continuous Positive Airway Pressure in Neonates
The goal of this clinical trial is to compare late preterm newborn lung physiology when supported with different continuous positive airway pressure (CPAP) devices.
- Trial name
- NCT06038565
- Testing
- RAM cannula ventilator CPAP, Occlusive interface bubble CPAP
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Premature Birth of Newborn
The Effect of Perinatal Stress on the Development of Preterm Infants
In this project, the investigators will study a cohort of preterm infants, together with their parents, during NICU hospitalization and follow their developmental trajectory until the age of two.
- Trial name
- RESILIENCE (NCT02623400)
- Where
- Belgium
- Volunteers
- 174 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Bronchopulmonary Dysplasia
A Clinical Safety Study of AT-100 (rhSP-D) in Preterm Neonates at High Risk for Bronchopulmonary Dysplasia (BPD)
The purpose of this study is to determine if an investigational drug, AT-100, can reduce the occurrence of Bronchopulmonary Dysplasia (BPD) in babies born premature, as compared to babies born premature who receive an air-sham…
- Trial name
- NCT04662151
- Testing
- AT-100
- Where
- 19 sites in United States, Spain
- Volunteers
- 37 people
- Sponsor
- Airway Therapeutics, Inc.
Weight Gain, Anemia, Iron Deficiency
Egg Intervention During Pregnancy in Indonesia
The study consists of two arms: 1) intervention group using eggs as supplementary food given from 2nd trimester of pregnancy to birth, and 2) observational group of pregnant mothers.
- Conditions
- Weight Gain, Anemia, Iron Deficiency, Birth Weight, Birth Length
- Trial name
- PRECODE (NCT04694235)
- Testing
- Egg intervention
- Where
- Indonesia
- Volunteers
- 702 people, healthy volunteers welcome
- Sponsor
- SEAMEO Regional Centre for Food and Nutrition
Preterm Birth, Oxygen Toxicity
Fetal Haemoglobin and Cerebral and Peripheral Oxygenation.
The aim of this study is to investigate the relationship between cerebral and peripheral oxygenation and oxygen extraction, as measured by NIRS (near-infrared spectroscopy ), and the FHbF (fraction of fetal hemoglobin) and…
- Conditions
- Preterm Birth, Oxygen Toxicity, Fetal Hemoglobin
- Trial name
- HbFIN (NCT04802629)
- Testing
- Near-infrared spectroscopy
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Premature Infant
Suction and Swalloing Exercises for Premature Babies
Underdeveloped oral structures of preterm infants cause feeding problems. Therefore, the development of sucking reflexes of premature babies should be supported.
- Trial name
- NCT06371443
- Testing
- Sucking and swallowing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Pre-Term, Breast Milk Expression
Preemie Milk Analyser Validation Study
This study aims to test and validate the Preemie Ecosystem- a new device and associated software package for measuring the nutrient (fat, protein and carbohydrate) content of the breast milk of the mothers of premature babies.
- Conditions
- Pre-Term, Breast Milk Expression, Nutrition Disorder, Infant
- Trial name
- NCT06486194
- Testing
- Targeted breast milk fortification using preemie device, Standard Breast milk fortification
- Where
- United Kingdom
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust