Clinical trials: Birth
Sepsis, PROM, Preterm (Pregnancy)
Selective Antibiotics When Symptoms Develop Versus Universal Antibiotics for Preterm Neonates
Preterm infants are born at less than 37 weeks of pregnancy. Sometimes a break or tear in the fluid filled bag that surrounds and protects the infant during pregnancy leads to an untimely birth.
- Conditions
- Sepsis, PROM, Preterm (Pregnancy), Early-Onset Neonatal Sepsis, Preterm Premature Rupture of Membrane
- Trial name
- SAUNA (NCT06377397)
- Testing
- Antibiotics
- Where
- 9 sites in India
- Volunteers
- 1,500 people
- Sponsor
- Indian Council of Medical Research
HIV Infections
Viral Load Triggered ART Care in Lesotho
This cluster randomized clinical trial at 18 nurse-led rural health centers in Lesotho will test an automated differentiated service delivery model using viral load results, other clinical characteristics and participants'…
- Trial name
- VITAL (NCT04527874)
- Testing
- VITAL model
- Where
- 18 sites in Lesotho
- Volunteers
- 5,809 people
- Sponsor
- Swiss Tropical & Public Health Institute
Prostatitis
CBD-based Therapy to Attenuate Non-bacterial Prostatitis Symptoms
Efficacy and safety of the medical device rectal CANNEFF® SUP suppositories containing two active ingredients cannabidiol (CBD) and hyaluronic acid (HA) in alleviating non-bacterial prostatitis symptoms and improving quality of…
- Trial name
- Urol-CBD (NCT06968910)
- Testing
- CANNEFF® SUP rectal suppositories
- Where
- Czechia
- Volunteers
- 35 people
- Sponsor
- Palacky University
Postpartum
Home-based Delivery of the Contraceptive Implant in Postpartum Guatemalan Women
Abstract Background: Postpartum contraception is important to prevent unintended and closely spaced pregnancies following childbirth.
- Trial name
- NCT04005391
- Testing
- Offer of Participant's Choice of Contraception Method
- Where
- 2 sites in United States, Guatemala
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Opioid Overdose, Opioid-use Disorder
User Acceptability of a Device-Based Opioid Overdose Intervention
This pilot study evaluates the needs of opioid users for a device-based intervention for opioid overdoses. The results of this one-time short questionnaire will inform development of a novel naloxone delivery device.
- Conditions
- Opioid Overdose, Opioid-use Disorder, Substance Use Disorders
- Trial name
- NCT04530591
- Testing
- Survey, Interview
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- University of Pennsylvania
Pre-Term, Respiratory Distress Syndrome, Newborn
NeO2Matic-Pilot Trial
The main goal of this trial is to test if: automated adjustment of supplemental oxygen to preterm infants in noninvasive respiratory support based on feedback from a measurement of blood-oxygen saturation results in more stable…
- Conditions
- Pre-Term, Respiratory Distress Syndrome, Newborn, Retinopathy of Prematurity, Bronchopulmonary Dysplasia
- Trial name
- NEO2MATIC (NCT05629910)
- Testing
- O2Matic
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Human Papillomavirus Type 16, Cervical Intraepithelial Neoplasia Grade II
HPV DNA Vaccine Via Electroporation for HPV16 Positive Cervical Neoplasia
The primary goal of this phase I open label study is to determine the safety and tolerability of pNGVL4aCRTE6E7L2 DNA vaccine, as administered by intramuscular (IM) injection with TriGrid™ electroporation to both HIV- or HIV+…
- Conditions
- Human Papillomavirus Type 16, Cervical Intraepithelial Neoplasia Grade II, Cervical Intraepithelial Neoplasia, Grade III
- Trial name
- NCT04131413
- Testing
- pNGVL4aCRTE6E7L2
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
HIV/AIDS
The Deliver Health Study
The investigators hypothesize that routing algorithm based ART delivery will be acceptable, efficient and improve health outcomes, specifically through meeting client needs, retaining HIV-positive persons in care, and achieving…
- Trial name
- NCT04027153
- Testing
- Fee based delivery
- Where
- South Africa
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pneumonia
A Study to Determine the Correct Dose of Amikacin Which is Delivered Directly to the Lungs of Ventilated Patients as an Aerosol Via an Investigational Device Called the Pulmonary Delivery Device System (PDDS)
This study is part of a research program too see if amikacin delivered as an aerosol directly to the lungs in combination with IV antibiotic therapy can help intubated patients with gram-negative pneumonia get better faster than…
- Trial name
- NCT01004445
- Testing
- Amikacin (BAY41-6551)
- Where
- 20 sites in United States, France and 1 more
- Volunteers
- 69 people
- Sponsor
- Bayer
Labor Pain and to Reduce Pain, Birth Beliefs
THE EFFECT OF LISTENING TO SURAH ABESE (VERSES 19-20) DURING CHILDBIRTH ON VAGINAL BIRTH SELF-EFFICACY, BIRTH BELIEFS, AND PAIN PERCEPTION
We are planning this study to determine the effect of listening to verses 19-20 of Surah Abasa during labor on vaginal birth self-efficacy, birth beliefs, and pain perception.
- Conditions
- Labor Pain and to Reduce Pain, Birth Beliefs, Childbirth Self Efficacy
- Trial name
- NCT07865637
- Testing
- LISTENING TO VERSES 19-20 OF SURAH ABESE
- Volunteers
- 110 people
- Sponsor
- Ondokuz Mayıs University
Breastfeeding Initiation, Midwifery Support
EVALUATION OF TWO MIDWIFE-SUPPORTED BREASTFEEDING POSITIONS DURING THE FIRST BREASTFEEDING FOLLOWING VAGINAL BIRTH
This study is being conducted by Dr. Benay OĞUZ. This form has been prepared to inform you about the conditions and procedures of the study.
- Conditions
- Breastfeeding Initiation, Midwifery Support, Breastfeeding Support
- Trial name
- NCT07864753
- Testing
- Midwife-Supported Modified Football Hold Group, Midwife-Supported Cradle Hold Group
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Premature Birth
Vaginal Compared With Intramuscular Progesterone for Prevention of Preterm Birth in High Risk Pregnant Women
This study is for compare the efficacy of two different regimens(vaginal vs intramuscular) of progesterone therapy in prevention of preterm birth in high risk pregnant women.
- Trial name
- NCT02304237
- Testing
- Vaginal progesterone, Intramuscular progesterone
- Volunteers
- 360 people
- Sponsor
- Ewha Womans University Mokdong Hospital
PreTerm Birth
Linear Growth and Neurobehavioural Outcome in PT Neonates (<34 Wks) at 37 and 40 Wks of CGA
This study will evaluate the association of linear growth on neurobehavioural outcome in preterm neonates at 37 and 40 weeks of (CGA) corrected gestational age.
- Trial name
- NCT02970994
- Volunteers
- 70 people
- Sponsor
- Lady Hardinge Medical College
Aortic Stenosis
ACURATE Neo™ Aortic Bioprosthesis for Implantation Using the ACURATE TA™ LP Transapical Delivery System in Patients With Severe Aortic Stenosis
Trial of ACURATE neo(TM) Aortic Bioprosthesis for Implantation using the ACURATE TA(TM) LP Transapical Delivery System in Patients with Severe Aortic Stenosis for evaluating the Safety and performance of the study device
- Trial name
- TALP-FIM (NCT02986737)
- Testing
- ACURATE neo™ and ACURATE TA™ LP
- Where
- 2 sites in Germany
- Volunteers
- 15 people
- Sponsor
- Symetis SA
Local Anesthesia, Catheterization
Catheter-over-needle: Inpatient Study
When anesthesiologists perform a regional nerve block, they will often put a catheter - a flexible plastic tube - in the patient to allow for continuous delivery of local anesthetic.
- Trial name
- NCT01522053
- Testing
- Catheter-over-needle, Catheter-through-needle
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- University of Alberta
Respiratory Distress Syndrome, Prematurity
Influence of Flow Rate Change on CO2 Levels During High Flow Nasal Ventilation (HFNV) in Preterm Infants.
Background Preterm infants often need respiratory support. HFNV is a non-invasive method with benefits over CPAP, such as reduced nasal trauma and improved feeding. Aim Study the impact of low (2 LPM) vs.
- Conditions
- Respiratory Distress Syndrome, Prematurity, Non Invasive Ventilation
- Trial name
- NCT06622902
- Testing
- change flow from 6 to 2 LPM. Follow TcCO2 for 3 hours, change flow from 2 to 6 LPM. Follow TcCO2 for 3h
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- Rambam Health Care Campus
Respiratory Syncytial Virus (RSV)
Phase Ib/IIa Clinical Trial of SIBP-A16 Injection in Premature Infants and Full-term Infants
This trial employs a randomized, double-blind, placebo/positive control, and dose-finding design to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary efficacy of SIBP-A16…
- Trial name
- NCT07363837
- Testing
- SIBP-A16 injection, Nirsevimab, SIBP-A16 buffer solution
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute Of Biological Products
Cardiovascular Diseases, Hypertension
Community-led Strategy to Reduce Cardiovascular Disease Risk Among Conflict-affected Populations
The goal of this study is to test a village health worker (VHW) based care model to reduce cardiovascular risk among adults in areas of eastern Myanmar affected by armed conflict.
- Conditions
- Cardiovascular Diseases, Hypertension, Diabetes
- Trial name
- NCT06819839
- Testing
- Village Health Worker (VHW) Care Model
- Where
- Burma
- Volunteers
- 213 people
- Sponsor
- Community Partners International
Parkinson's Disease
A Safety, Tolerability, and Pharmacokinetic Study of ND0612 Delivered as a Continuous Subcutaneous in Parkinson's Disease Patients
An open-label randomized study to evaluate the Safety, Tolerability, and PK of Low and High single doses of ND0612 (i.e. LD/CD ratio 60/7.5 mg/mL and 60/14 mg/mL), as well as the combination with oral Entacapone (concomitant…
- Trial name
- NCT02096601
- Testing
- LD/CD SC solution, Entacapone
- Where
- 2 sites in Israel
- Volunteers
- 16 people
- Sponsor
- NeuroDerm Ltd.
Pneumonia, Hypoxemia
Solar Powered Oxygen Delivery
Globally, approximately 2.1 million children die of pneumonia each year. Most deaths occur in resource-poor settings in Africa and Asia. Oxygen (O2) therapy is essential to support life in these patients.
- Trial name
- NCT02100865
- Testing
- Solar powered oxygen, Oxygen from cylinders
- Where
- Uganda
- Volunteers
- 130 people
- Sponsor
- University of Alberta