Clinical trials: Bipolar Disorder Depression
Schizophrenia, Schizoaffective Disorder
Virtual Reality Job Interview Training in Severe Mental Illness
This is a randomized controlled trial to evaluate the community-based effectiveness of virtual reality job interview training (VR-JIT). Northwestern University is partnering with Thresholds Inc.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Depressive Disorder
- Trial name
- NCT03049813
- Testing
- Virtual Reality Job Interview Training, Supported Employment (Services as Usual)
- Where
- 4 sites in United States
- Volunteers
- 168 people
- Sponsor
- University of Michigan
Schizophrenia, Major Depressive Disorder
PHARMO Institute Seroquel Safety Study
The purpose of this observational study is to study specific outcomes of interest in users of quetiapine compared with all other atypical antipsychotics and specifically olanzapine and risperidone.
- Conditions
- Schizophrenia, Major Depressive Disorder, Bipolar Disorder, Generalized Anxiety Disorder
- Trial name
- PHARMO II (NCT01342120)
- Volunteers
- 18,325 people
- Sponsor
- AstraZeneca
Mood Disorder, Bipolar Disorder
Examination of Brain Serotonin Receptors in Patients With Mood Disorders
The purpose of this study is to evaluate the function of certain brain chemicals and receptors in patients with mood disorders. This study will also examine how the stress hormone cortisol affects brain function.
- Conditions
- Mood Disorder, Bipolar Disorder, Depression
- Trial name
- NCT00026832
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder, Catatonia
Clonidine to Prevent Delirium After Electroconvulsive Therapy.
Electroconvulsive therapy (ECT) is a highly effective treatment for some psychiatric disorders like major depressive or bipolar disorder, but may lead to agitation and delirium after the procedure in up to 65% of patients.
- Conditions
- Major Depressive Disorder, Catatonia, Bipolar Disorder, Delirium Postseizure
- Trial name
- ECaTa (NCT04828226)
- Testing
- Clonidine
- Where
- Switzerland
- Volunteers
- 130 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Bipolar Depression
An Open Label Trial of TMS Therapy for Bipolar Depression
Transcranial Magnetic Stimulation (TMS) is an increasingly accepted neurostimulation- based treatment for major depressive disorder.
- Trial name
- NCT02640950
- Testing
- NeuroStar TMS
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Sheppard Pratt Health System
Bipolar Disorder, Depression, Bipolar
Lamotrigine for Symptoms of Geriatric Bipolar Depression
This is a 12-week, open label trial of lamotrigine for older adults (age 60 and older) with type I or type II Bipolar depression.
- Trial name
- Geri-BD SAD (NCT00621842)
- Testing
- Lamotrigine regular tablet formulation, Lamotrigine novel formulation
- Where
- 5 sites in United States
- Volunteers
- 57 people
- Sponsor
- University Hospitals Cleveland Medical Center
Schizophrenia, Schizoaffective Disorder
Observational Study to Evaluate Bipolar Disorder Symptoms in Patients Presented With Schizophrenia or Depression
This study is aimed to evaluate the bipolar disorder symptoms in patients presented with schizophrenia, schizoaffective disorder or recurrent depression.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Recurrent Depression
- Trial name
- NCT01028196
- Where
- 3 sites in Russia
- Volunteers
- 750 people
- Sponsor
- AstraZeneca
Schizophrenia Disorders, Bipolar Disorders
MonPsy&Moi: A Digital Platform for Collecting Patient-Reported Experience and Outcome Measures in Psychiatry
Mental health disorders, with a 30% annual prevalence rate, are a leading cause of disability and reduced life expectancy. Despite their impact, patient-reported experience measures (PREMs) and outcome measures (PROMs) are…
- Conditions
- Schizophrenia Disorders, Bipolar Disorders, Major Depression
- Trial name
- Mon Psy & Moi (NCT06818227)
- Where
- France
- Volunteers
- 23,660 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Bipolar Disorder, Depression
A Trial of SAMe for Treatment-Resistant Bipolar Depression
S-adenosyl-L-methionine (SAMe) is a dietary supplement with antidepressant properties. SAMe's mechanism of action remains unclear, but it appears to be distinct from that of conventional antidepressants.
- Conditions
- Bipolar Disorder, Depression, Bipolar Depression
- Trial name
- NCT00762268
- Testing
- SAMe
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Mclean Hospital
Bipolar Depression
Behavioural Activation for Bipolar Depression: A Case Series
Bipolar Disorders affect around 2% of the population. Most people with Bipolar experience depression; these periods can cause difficulties with relationships, work and daily life.
- Trial name
- BA-BD (NCT03658824)
- Testing
- Behavioural Activation (BA)
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Exeter
Depressive Disorder
Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive Therapy
Ketamine has been used successfully as the sole medication for anesthesia in the setting of electroconvulsive therapy (ECT), and has more recently been studied as an adjunct agent in combination with propofol (the most commonly…
- Trial name
- NCT02579642
- Testing
- Ketamine
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- University of Alberta
Bipolar Disorder
A Glutamate Transporter GLT1, in the Treatment of Bipolar Disorder
This study examines if Ceftriaxone, an antibiotic, will improve symptoms of depression in Bipolar Disorder. Purpose: This study will examine whether the drug ceftriaxone can help patients with bipolar depression during short-term…
- Trial name
- NCT00512616
- Testing
- Ceftriaxone
- Where
- United States
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar Disorder, Depression, Bipolar
Efficacy of Olanzapine Monotherapy for Treatment Bipolar Ⅰ Depression
Olanzapine may have some antidepressant properties and olanzapine monotherapy has been shown efficacy in bipolar depressive episodes in retrospective studies.
- Trial name
- NCT01303601
- Testing
- olanzapine, Starch
- Where
- China
- Volunteers
- 68 people
- Sponsor
- China Medical University, China
Bipolar II Disorder, Most Recent Episode Major Depressive
Lamotrigine Alone Compared to Lamotrigine Plus Antidepressant for the Treatment of Bipolar II Depression
Depression is a medical condition characterized by feeling sad even when good things happen, having low energy and motivation, and sometimes even experiencing suicidal thoughts.
- Trial name
- NCT00475137
- Testing
- Lamotrigine
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Bipolar Disorder I or II
Validation of Multidimensional Assessment of THYmic States (MATHYS): A Study in a Population of Bipolar Patients Treated With Olanzapine
A non randomized study to validate the MATHYS Scale in a population of in and outpatients greater than or equal to 18 years of age, suffering from Bipolar Disorder I or II, and treated with olanzapine.
- Trial name
- NCT00259272
- Testing
- olanzapine
- Where
- 16 sites in France
- Volunteers
- 141 people
- Sponsor
- Eli Lilly and Company
Depressive Disorder, Bipolar Disorder
Mechanisms of Transcutaneous Auricular Vagus Nerve Stimulation in Depression
Invasive vagus nerve stimulation (VNS) is an approved treatment of treatment-resistant depression (TRD) in Europe and in USA. Because of the associated possible surgical complications as well as side effects, invasive VNS is…
- Trial name
- AddVNS (NCT07022171)
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- Germany
- Volunteers
- 86 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Bipolar Disorder, Mania
Taurine as an Anti-Manic Agent: A Double-Blind, Placebo-Controlled Study
The purpose of this study is to determine whether the amino acid taurine has effects on mood stability in bipolar disorder.
- Conditions
- Bipolar Disorder, Mania, Bipolar Depression
- Trial name
- NCT00217165
- Testing
- taurine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mclean Hospital
Bipolar II Disorder
Phase 2 Clinical Trial of GH001 in Bipolar II Disorder
This study is a multicenter, open-label, single-arm Phase 2 clinical trial. Approximately 15 participants with clinically diagnosed bipolar disorder (BD) type II and experiencing a current episode of depression will be included…
- Trial name
- NCT05839509
- Testing
- GH001
- Where
- 7 sites in Germany, Netherlands and 1 more
- Volunteers
- 6 people
- Sponsor
- GH Research Ireland Limited
Unipolar Depression, Bipolar Depression
RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)
The purpose of this research is to understand how changes in RNA editing relate to treatment response in unipolar and bipolar depression.
- Trial name
- NCT07266545
- Testing
- Vortioxetine, Cariprazine (Augmentation Phase)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Mayo Clinic
Depression - Major Depressive Disorder, Depression Bipolar
Longitudinal Study on the Sustainability of Transcranial Magnetic Stimulation Protocols - Biomarkers
Despite advances in the effective treatment of major depressive disorder using repetitive transcranial magnetic stimulation (rTMS), the processes that determine a patient's response trajectory remain poorly understood.
- Conditions
- Depression - Major Depressive Disorder, Depression Bipolar, Depression Unipolar
- Trial name
- LONGISTIM-BIO (NCT07684911)
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospital Center Guillaume Régnier