Clinical trials: Biotherapy, open to volunteers
Ulcerative Colitis, Inflammatory Bowel Diseases
Comparison of Ustekinumab, Infliximab and Combination Therapy in Moderately to Severely Active Ulcerative Colitis
The goal of this clinical trial is to learn if combined therapy with infliximab and ustekinumab works better than using these drugs alone in adult patients with ulcerative colitis.
- Trial name
- COMBO-UC (NCT06453317)
- Testing
- Infliximab, Ustekinumab
- Where
- Poland
- Volunteers
- 172 people
- Sponsor
- Medical University of Lodz
Systemic Lupus Erythematous (SLE)
LUpus Eritematoso Sistemico NETwork and Registry
The LUNET Registry is intended to serve as a comprehensive primary data source, capturing real-world longitudinal clinical information, and the heterogeneity of patient presentations that are often underrepresented in traditional…
- Trial name
- LUNET (NCT07175610)
- Where
- 16 sites in Italy
- Volunteers
- 1,500 people
- Sponsor
- Società Italiana di Allergologia, Asma e Immunologia Clinica
Anterior Cruciate Ligament Injuries
Biologic Therapy to Prevent Osteoarthritis After ACL Injury
Anterior cruciate ligament (ACL) injuries are extremely common. On average, 50% of individuals suffering an ACL injury will develop radiographic osteoarthritis (OA) 10 to 20 years after injury.
- Trial name
- NCT03968913
- Testing
- Anakinra injection, sterile saline injection
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Chronic Inflammatory Disease
Impact of the Therapeutic Education Program "living with a Chronic Inflammatory Disease Under Biotherapy" on Patient Compliance and Quality of Life
Patient therapeutic education programs have been shown to be effective in many specialties, allowing "Improving biological and psychological parameters, allowing patients to improve their health knowledge, therapeutic adherence…
- Trial name
- IMPEBIO (NCT06620770)
- Testing
- questionnaires
- Where
- France
- Volunteers
- 126 people
- Sponsor
- Groupe Hospitalier de Bretagne Sud
Breast Cancer, Breast Carcinoma
TIL Gean Therapy Combined With Immunotherapy for Advanced or Metastatic Refractory Breast Cancer
This Phase I/II study evaluates the safety and efficacy of autologous tumor-infiltrating lymphocytes (TIL) therapy combined with Pembrolizumab (Keytruda) immunotherapy in patients with advanced or metastatic refractory breast…
- Conditions
- Breast Cancer, Breast Carcinoma, Breast Cancer Metastatic, Breast Cancer Triple Negative
- Trial name
- BAH249 (NCT06532812)
- Testing
- Tumor Infiltrating Lymphocytes (TIL), Cyclophosphamid, Fludarabine
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Essen Biotech
Takayasu Arteritis
Biologic Treatment Withdrawal in Takayasu Arteritis Patients in Sustained Remission
Takayasu arteritis is a chronic large-vessel vasculitis affecting the aorta and its major branches. Biologic therapies such as tumor necrosis factor inhibitors and tocilizumab are commonly used in patients with refractory or…
- Trial name
- NCT07491913
- Testing
- Tociliuzumab, Infliximab, Adalimumab
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Marmara University
Crohn Disease
Safety of Mesentery-embedding Surgery in Patients With Ileocolic Crohn's Disease on Biotherapy
60% of patients with Crohn's disease will undergo surgery during their lifetime and without recurrence prevention treatment, 80% of patients will have an endoscopic recurrence within 1 year of surgery.
- Trial name
- RIC-2 (NCT06856044)
- Testing
- ileocolic resection with extended mesenteric resection
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Lymphoma, T Cell, Peripheral, T-cell Lymphoma
Azacitidine and Abatacept in Relapsed or Refractory T-Cell Lymphoma
Background: T-cell lymphoma is a blood cancer that affects immune system cells. People tend to survive less than 1 year if this disease does not respond to treatment (is refractory) or comes back after treatment (relapses).
- Conditions
- Lymphoma, T Cell, Peripheral, T-cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, Anaplastic Large Cell Lymphoma
- Trial name
- NCT07388563
- Testing
- azacitidine, abatacept
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
Crohn's Disease (CD)
Biologics and Paediatric Enteral Nutrition in Crohn's Disease Study
Crohn's disease (CD) is a chronic, incurable condition associated with gut inflammation. Two important treatments currently used to manage CD are special drug injections (biologics) or a liquid-only diet using specialised…
- Trial name
- BIOPIC-Kids (NCT07522528)
- Testing
- enteral nutrition
- Where
- 6 sites in United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Recurrent Implantation Failure, Endometrial Receptivity Disorders
Experimental Study on the Use of Intrauterine Infusion of Autologous Platelet-rich Plasma (PRGF-IUI) in Patients With Recurrent Implantation Failure and/or Refractory Thin Endometrium
Endometrial receptivity is a key determinant of success in assisted reproductive technology (ART). A significant proportion of patients experience repeated implantation failure despite euploid embryos and adequate laboratory…
- Conditions
- Recurrent Implantation Failure, Endometrial Receptivity Disorders, Embryo Implantation, Platelet-Rich Plasma
- Trial name
- PMA_PREPAIRE (NCT07455773)
- Testing
- Intrauterine Platelet-Rich Plasma (PRP) Infusion, Hormone Replacement Therapy (HRT)
- Volunteers
- 80 people
- Sponsor
- Azienda Sanitaria Locale di Asti
Asthma, Allergic
Biologics and Sublingual Immunotherapy
Most current studies involve using a biological drug to increase the safety of allergen immunotherapy (AIT) especially in the treatment of food allergies, to avoid the risk of anaphylaxis.
- Trial name
- BSIPL (NCT06027073)
- Testing
- omalizumab
- Volunteers
- 150 people
- Sponsor
- Medical University of Silesia
Effect of Drug
Efficacy of Biological Therapy in Pediatric Inflammatory Bowel Disease
Compare efficacy of different biologicals in induction of remission including clinical, laboratory and histopathological remission.
- Trial name
- NCT06742606
- Testing
- Group 1 of patients will receive Adalimumab while Group 1 will receive ustekinumab
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Cancer, Radiotherapy Side Effect
Attribution of Toxicities Due to Radiotherapy and Immuno-Biological Therapies
Every year, new molecular agents enter the market with more and more patients receiving these treatments, especially in the metastatic setting.
- Trial name
- AtTRIBut (NCT04115267)
- Testing
- Radiotherapy
- Where
- Canada
- Volunteers
- 3,600 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Axial Spondyloarthritis (Ankylosing Spondylitis)
Mediterranean Diet and Disease Activity in Axial Spondyloarthritis Receiving Biologic Therapy
This study aims to evaluate the effect of the Mediterranean diet on disease activity, quality of life, inflammation, pain, and treatment response in patients with axial spondyloarthritis (ankylosing spondylitis) who are receiving…
- Trial name
- NCT07170384
- Testing
- Mediterranean Diet, Healthy Eating Advice
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Sinem Kübra Beke
Stomach Cancer, Stomach Cancer Recurrent
TIL Therapy Combined With Pembrolizumab for Advanced or Metastatic Refractory Stomach and Esophageal Cancer
This Phase I/II study evaluates the safety and efficacy of autologous tumor-infiltrating lymphocytes (TIL) therapy combined with Pembrolizumab (Keytruda) immunotherapy in patients with advanced or metastatic refractory stomach…
- Conditions
- Stomach Cancer, Stomach Cancer Recurrent, Stomach Cancer, Adenocarcinoma, Esophageal Cancer
- Trial name
- BAH250 (NCT06532799)
- Testing
- Tumor Infiltrating Lymphocytes (TIL), Cyclophosphamid, Fludarabine
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Essen Biotech
Colorectal Cancer, Colon Cancer
Biological Tumor Infiltrating Lymphocytes Therapy With Immunotherapy for Colon and Rectum Cancer
This Phase I/II study evaluates the safety and efficacy of autologous tumor-infiltrating lymphocytes (TIL) therapy combined with Pembrolizumab (Keytruda) and Aldesleukin (interleukin-2, IL-2) immunotherapy in patients with…
- Conditions
- Colorectal Cancer, Colon Cancer, Rectum Cancer
- Trial name
- BAH248 (NCT06530303)
- Testing
- Tumor Infiltrating Lymphocytes (TIL), Cyclophosphamide, Fludarabine
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Essen Biotech
Subclinical Psoriatic Arthritis
A Real-World Study of Biologic Therapy for Subclinical Psoriatic Arthritis
Psoriatic arthritis (PsA) is one of the most common comorbidities in patients with psoriasis (PsO). Current research suggests that the progression from PsO to PsA can be divided into five stages of the disease: PsO, preclinical…
- Trial name
- NCT06686082
- Testing
- Biologics
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chao Ji
Asthma (Diagnosis)
Sustained Asthma Remission and Reduced Relapse Using a Comprehensive Management Strategy (SARRE-COMS)
The goal of this pilot clinical trial is to learn whether it is feasible to conduct a future larger trial of a comprehensive management strategy for adults with severe asthma who are starting biologic therapy.
- Trial name
- SARRE-COMS (NCT07816718)
- Testing
- Comprehensive Biomarker-Guided Management Strategy, Standard of Care
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Hana Serajeddini
Ulcerative Colitis (UC)
Predictive Efficacy of Fecal Calprotectin Assay by Magnetic Particle Chemiluminescence for Mucosal Healing in Moderate-to-Severe Ulcerative Colitis Patients Undergoing Initial Biologic Therapy（PRECAL）
This is a national prospective, multicenter, observational study. A total of 200 eligible patients will be enrolled from 10 hospitals across the country.
- Trial name
- PRECAL (NCT07721441)
- Testing
- fecal calprotectin test
- Where
- 10 sites in China
- Volunteers
- 200 people
- Sponsor
- Tang-Du Hospital
Psoriatic Arthritis (PsA), Liver Fibrosis
Comparison of Liver Health in Psoriatic Arthritis Patients Using Anti-TNF or Anti-IL17 Treatments
Psoriatic arthritis (PsA) is an inflammatory joint disease that can also affect the liver. Some medications used to treat PsA, such as biological agents (TNF-alpha inhibitors and IL-17 inhibitors), may influence liver health over…
- Conditions
- Psoriatic Arthritis (PsA), Liver Fibrosis, Liver Diseases
- Trial name
- FIB-4 PsA (NCT06918886)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bezmialem Vakif University