Clinical trials: Biopsy
Lung Cancer
EPIONE Guided Lung Evaluation
Interventional clinical study to obtain performance and safety data of the EPIONE® device when used for percutaneous procedures in the lung.
- Trial name
- EGLE (NCT05651867)
- Testing
- EPIONE device
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Quantum Surgical
Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis
Endohepatology-Based Reclassification of Treatment Indication in High-Risk MASLD
This prospective observational study evaluates whether endohepatology changes treatment indications in adults at high risk of metabolic dysfunction-associated steatotic liver disease.
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis, Liver Fibrosis, Portal Hypertension
- Trial name
- ENDO-MASH (NCT07877272)
- Testing
- Non-invasive MASLD and portal hypertension assessment, Single-session endohepatology assessment
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University Hospital Muenster
Clinically Significant Prostate Cancer
Plasma exoRNA-Based Liquid Biopsy to Diagnose Clinically Significant Prostate Cancer
The aim of the present study is to investigate a plasma exosome RNA signature to diagnose clinically significant prostate cancer.
- Trial name
- NCT07492927
- Where
- 10 sites in United States, China
- Volunteers
- 1,700 people
- Sponsor
- Xijing Hospital
Giant Cell Arteritis
Temporal Artery Biopsy vs ULtrasound in Diagnosis of GCA (TABUL)
Giant Cell Arteritis (GCA) causes inflammation and narrowing of blood vessels and can cause blindness in one third of patients. It is important that a prompt, accurate diagnosis of GCA is made and treatment given as steroids for…
- Trial name
- TABUL (NCT00974883)
- Testing
- Ultrasound of temporal and axillary arteries, Temporal artery biopsy
- Where
- 27 sites in Germany, Ireland and 3 more
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Lung Cancer
Pre-operative Chemotherapy Versus Concurrent Chemoradiotherapy in N2 Positive IIIA Non Small Cell Lung Cancer (NSCLC)
It is suggested that a bimodal or trimodal approach combining neoadjuvant chemotherapy with or without radiotherapy followed by surgery provides a potentially superior method of enhancing resectability and improving locoregional…
- Trial name
- NCT00452803
- Testing
- chemotherapy, Concurrent chemoradiation therapy
- Where
- South Korea
- Volunteers
- 102 people
- Sponsor
- National Cancer Center, Korea
Breast Fibroadenoma, Atypical Ductal Hyperplasia
Comparing Vacuum-Assisted Percutaneous Excision to Open Surgical Excision for Borderline or High-Risk Breast Lesions
This randomized controlled trial compares vacuum-assisted percutaneous excision to open standard surgical excision in women who have high-risk or borderline, non-malignant breast lesions with respect to efficacy, safety, cosmesis…
- Conditions
- Breast Fibroadenoma, Atypical Ductal Hyperplasia, Atypical Lobular Hyperplasia, Lobular Carcinoma in Situ
- Trial name
- VAPEX (NCT03868475)
- Testing
- Vacuum-assisted percutaneous excision, Open surgical excision
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Prostate Cancer
Evaluation of Tumor Control Based on Serial Multiparametric MRI and Post-Treatment Biopsies For Patients Treated With Dose Intensification to the Dominant Intra-Prostatic Lesion (DIL) Using Ultra-Hypofractionated, MR-Guided Radiotherapy
The purpose of this study is to assess the impact of this MR-guided radiotherapy on tumor control of the dominant intraprostatic lesion among patients with intermediate risk prostate cancer.
- Trial name
- NCT06542757
- Testing
- 1.5 T Elekta Unity MR-Linac system, Hydrogel rectal spacer (SpaceOAR)
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- NYU Langone Health
Kidney Failure
1-deamino 8-d-arginine Vasopressin (DDAVP) in Percutaneous Ultrasound-guided Renal Biopsy
The investigators evaluated the effect of pre-biopsy treatment with 1-deamino-8-D-arginine (DDAVP) on the incidence of post-biopsy bleeding complications.
- Trial name
- NCT00748072
- Testing
- DDAVP, saline solution
- Where
- Italy
- Volunteers
- 162 people
- Sponsor
- University of Bari
Heart Failure, Diastolic, Heart Failure, Systolic
Network Medicine Approaches to Classify Heart Failure With PReserved Ejection Fraction by Signatures of DNA Methylation and Point-of-carE Risk calculaTors (PRESMET)
Heart failure (HF) is a syndrome, resulting from structural or functional impairment of ventricular filling or ejection of blood.
- Conditions
- Heart Failure, Diastolic, Heart Failure, Systolic, Pulmonary Hypertension, Atrial Fibrillation
- Trial name
- PRESMET (NCT05475028)
- Testing
- RRBS
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Campania Luigi Vanvitelli
Asthma
Longitudinal Assessment of Adults With Severe Asthma
Cross-sectional study to characterize cohorts of subjects with asthma and healthy controls in terms of clinical features, physiological measurements and non-invasive measurement of biomarkers and develop phenotype handprints for…
- Trial name
- NCT01976767
- Volunteers
- 725 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Lung Diseases, Interstitial
Diagnostic Yield and Safety of Transbronchial Lung Biopsy Using Cryoprobes Versus Conventional Forceps. A Multicenter Study
The purpose of this study is to evaluate the diagnostic yield and safety of transbronchial lung biopsies (TBLB) with cryoprobe versus conventional forceps in patients with diffuse lung disease.
- Trial name
- NCT02464592
- Testing
- Transbronchial lung biopsy.
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Myocarditis, Heart Failure
ARrhythmias in MYocarditis
Myocarditis promotes the occurrence of serious cardiac arrhythmias and conduction disorders which may lead to sudden cardiac death, the need for catheter ablation of arrhythmia or implantation of a cardioverter-defibrillator or…
- Conditions
- Myocarditis, Heart Failure, Endomyocardial Biopsy, Arrythmia
- Trial name
- ARMY (NCT03801681)
- Testing
- ECG holter monitoring
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Lung Diseases, Interstitial
Definition of the Status of the Human Lung Stem Cell Niches ex Vivo in Tissue Biopsies Performed in Patients With Emphysema and Interstitial Fibrosis
To characterize stem cell compartments in their niches in different clinical situations (non-diseased compared to emphysematous and fibrotic pulmonary tissue) and to assess their proliferative and developmental properties in…
- Trial name
- NCT02705144
- Testing
- analysis of the number of stem cell niches
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Cancer of Pancreas
Echo-endoscopy Biopsy Impact on the Circulating Tumor Cell Level
The aim of this work is to evaluate the impact of endoscopic procedures on the circulating tumoral cells level in order to evaluate the potential effects of an endoscopic procedure in the management of pancreatic tumors.
- Trial name
- EUS-CTC (NCT04677244)
- Testing
- Blood sample in portal vein
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Institut Paoli-Calmettes
Total Pancreatectomy, Pancreaticoduodenectomy
Hepatic Histology and Metabolism Following Total Pancreatectomy and Pancreaticoduodenectomy
The objective of the study is to investigate the development of NAFLD following total pancreatectomy and pancreaticoduodenectomy and to explore the histological and metabolic changes following the procedures.
- Conditions
- Total Pancreatectomy, Pancreaticoduodenectomy, Pancreatic Diabetes, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT03864744
- Where
- Denmark
- Volunteers
- 33 people
- Sponsor
- Steno Diabetes Center Copenhagen
Molecular Residual Disease, Cancer
Unified Network for Integrated Fluid Collection at Yale
UNIFY is a Yale-wide liquid biopsy master repository that prospectively collects Streck-tube blood, dried blood spots (and optional archival tissue) from Yale Cancer Center patients across all tumor types for current and future…
- Trial name
- UNIFY (NCT07689864)
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- Yale University
Lung Cancer, Thoracic Cancer
Validate the Safety and Feasibility of the CT-guided Interventional Robot in Percutaneous Lung Cryablation Procedures
This study aims to investigate whether the interventional robot can be well and safely used for percutaneous lung cryoablation in patients with lung cancer.
- Trial name
- NCT06581107
- Testing
- CT-fluoroscopy guided master-slave intervetional robot-assisted lung Cryoablation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Cancer, Head and Neck Squamous Cell Carcinoma
Real-time Detection of ctDNA and/or HPV DNA in High-risk Locally-advanced Head and Neck Squamous Cell Carcinoma
This research study will include patients with high risk locally advanced head and neck squamous cell carcinoma (LA-HNSCC) of the oral cavity, oropharynx, hypopharynx or larynx and patients that are starting on standard…
- Conditions
- Cancer, Head and Neck Squamous Cell Carcinoma, Head and Neck Cancer
- Trial name
- NCT04599309
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- University Health Network, Toronto
End-Stage Renal Disease
Belatacept in Renal Transplantation With Intermediate Risk Maryland Aggregate Pathology Index (MAPI) Scores
This will be a pilot study to investigate the use of belatacept (BMS) therapy in kidney transplant patients who have a MAPI score of greater than or equal to 8.
- Trial name
- NCT01496417
- Testing
- Belatacept
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Maryland
Contrast Enhanced Mammography-guided Biopsy
Clinical Evaluation of CEM-guided Biopsy
CEM-guided biopsy is an optional accessory of Senographe Pristina intended to provide accurate location of lesions in the breast in three dimensions, using information obtained from Contrast Enhanced Mammography (CEM) images.
- Trial name
- NCT05250674
- Testing
- CEM-guided biopsy
- Where
- Spain
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
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