Clinical trials: Biofilms
Oral Disease
The Effect of Probiotics on Oral Health
This will be a double-blind, randomized, placebo-controlled two-arm parallel groups study of the effect of oral probiotics containing Streptococcus salivarius K12 on oral biofilm, salivation rate, and secretory immunoglobulin A…
- Trial name
- NCT05039320
- Testing
- Bactoblis
- Where
- Russia
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Ventilation, Mechanical, Ventilation-Associated Pneumonia
Surveillance of Neonatal Endotracheal Tube Colonisation
Babies in neonatal intensive care units (NICUs) sometimes need help breathing using a breathing tube (endotracheal tube, or ETT) connected to a breathing machine (ventilator).
- Trial name
- NETT (NCT07664449)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Dental Hygiene, Probiotics, Periodontitis
Probiotic Nanofiber Floss and Subgingival Pathogen Suppression
This randomized, double-blind, crossover clinical trial evaluated the effect of a probiotic-containing nanofiber dental floss on subgingival red complex periopathogens and gingival health in periodontally healthy individuals.
- Conditions
- Dental Hygiene, Probiotics, Periodontitis, Prevention of Dental Caries, Gingivitis and Periodontal Diseases
- Trial name
- NCT07149493
- Testing
- Probiotic nanofiber floss
- Where
- Czechia
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Gingival Hyperpigmentation, Oral Pigmentation
Comparison of Er-YAG Laser, Air Polishing, and Surgical Excision for Gingival Hyperpigmentation
This randomized controlled clinical trial aimed to compare the effectiveness of different treatment approaches for physiologic gingival hyperpigmentation.
- Trial name
- APGH (NCT07672587)
- Testing
- Er:YAG Laser Therapy, Air Polishing with Erythritol Powder, Air Polishing with Sodium Bicarbonate Powder
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Tooth Stain
Guided Biofilm Therapy Versus Conventional Polishing for Tooth Re-Staining
This study compared Guided Biofilm Therapy with conventional polishing in adults with visible extrinsic tooth staining. Each participant received Guided Biofilm Therapy on one side of the mouth and conventional polishing on the…
- Trial name
- NCT07799558
- Testing
- Guided Biofilm Therapy, Conventional Polishing
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Gingivitis
Effectiveness of Black Tea Mouthwash on Plaque Formation
The study was conducted to measure the effectiveness of Black Tea in reducing the deposits on teeth. It also compares the effect between use of black tea mouthwash and green tea mouthwash to that of chlorhexidine in reducing…
- Trial name
- Blacktea (NCT02545244)
- Testing
- Black Tea, Green Tea, 0.12% Chlorhexidine Mouthwash.
- Where
- India
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sri Hasanamba Dental College and Hospital
Dental Caries
The Effect of Aerosol Formed From Tobacco Heating Systems on the Microbiome of Supragingival Dental Biofilm
Dental caries is a multifactorial disease primarily caused by supragingival dental biofilm. Its progression is influenced by many environmental factors, which include smoking.
- Trial name
- NCT06314100
- Testing
- Tobacco heating systems, cigarette smoking, non smoking
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Rijeka
Dental Plaque
Efficacy of Plaque Removal of a Novel Brushing Device
The purpose of this research study is to compare how a novel, automated mouthpiece-based toothbrushing device removes dental plaque compared to a manual toothbrush.
- Trial name
- NCT05038293
- Testing
- Automated mouthpiece-based toothbrush, Manual toothbrush
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Washington
Biofilm, Dental Plaque
Comparison of Biofilm Characteristics Between an in Situ Biofilm Model of Supragingival Plaque and Natural Teeth
The purpose of this study is to determine in situ the bacterial viability, thickness and bacterial diversity of a biofilm formed on different substrates in comparison to a naturally tooth-formed oral biofilm.
- Trial name
- NCT02769260
- Testing
- Toothbrushing
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Biofilms, Oils, Essential
Antiplaque Effect of Essential Oils With and Without Alcochol on an in Situ Model of Oral Biofilm Growth
The accumulation and maturation of oral biofilm in the gingival margin is widely recognised to be the primary aetiological factor in the development of chronic gingivitis.
- Conditions
- Biofilms, Oils, Essential, Periodontitis
- Trial name
- NCT02946801
- Testing
- Essential oils, Essential oils without alcohol, Sterile water
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Dental Plaque, Gum Bleed
Effect of Professional Prophylaxis on Clinical Parameters and Patient Comfort: Randomized Slipt-Mouth Clinical Trial
The goal of this clinical trial is to evaluate whether the Guided Biofilm Therapy (GBT) protocol can improve or maintain oral health and whether it provides more comfort to patients compared to a conventional protocol.
- Trial name
- NCT06936306
- Testing
- GBT, Master, scalling
- Where
- Portugal
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Lisbon
Gingivitis, Dental Plaque
Clear Aligner Cleaning: Brushing, Chlorhexidine, and BlueM Effects on Oral Microbial Ecology and Periodontal Indices
This randomized crossover study will assess how three aligner-cleaning methods affect early supragingival oral microbial ecology and periodontal health in adults using clear aligners.
- Trial name
- NCT07307716
- Testing
- Mechanical toothbrushing (fluoride toothpaste), Chlorhexidine mouthwash (0.2%), Oxygen-based cleanser
- Where
- Saudi Arabia
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Oral Leukoplakia
Candida Associated Cytokines in Oral Leukoplakia
This study aims to determine the correlation between candida and pro- inflammatory cytokines response in Oral Leukoplakia(OL) with antifungal therapy.
- Trial name
- NCT04712929
- Testing
- Fluconazole
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Peridontal Disease, Periodontal Inflammation
Analysis of the Impact of Contemporary Subgingival Debridement Techniques on Immunological Biomarkers in Gingival Crevicular Fluid
AIM: This prospective clinical study aimed to evaluate the efficacy of two distinct non-surgical periodontal therapy modalities in patients diagnosed with Stage 1 and Stage 2 periodontitis.
- Conditions
- Peridontal Disease, Periodontal Inflammation, Periodontitis, Adult
- Trial name
- NCT07243145
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Selcen Ozcan Bulut
Diabetes
Investigating Ultrasound Debridement in Wound Care
The initial step of wound management, debridement, is thought to be critical in promoting wound healing. Of the numerous debridement modalities, ultrasound seems to hold promising results in accelerate healing in our own clinical…
- Trial name
- NCT03516422
- Testing
- ULTRASOUND DEBRIDEMENT, STANDARD CARE GROUP
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Surface Finish
Influence of Different Zirconia Surface Treatments on Biofilm Formation
The aim is to test the influence of surface finish on biofilm formation on the transmucosal part of zirconia implants in an in vivo study.
- Trial name
- Biofilm2020 (NCT04181099)
- Testing
- Implant neck surface
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Basel
Dental Plaque, Gingivitis
Effect of an Enzyme-containing Lozenge on Dental Biofilm in Healthy Individuals.
The purpose of the study is to assess the effect of an enzyme containing lozenge on dental plaque accumulation in healthy adults.
- Conditions
- Dental Plaque, Gingivitis, Microbial Colonization
- Trial name
- NCT05070507
- Testing
- Enzyme containing lozenge
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Novozymes A/S
Dental Caries, Dental Plaque
Effect of Xylitol- Versus Erythritol-Sweetened Mints on Plaque ATP-Bioluminescence Readings
This study will assess the effectiveness of erythritol and xylitol in suppressing biofilm activity, using both within-subject and between-group comparisons.
- Trial name
- NCT07902323
- Testing
- Xylitol, Erythritol
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Dental Biofilm pH
In Vivo Study of Sucrose and Liquid Oral Pediatric Medicines of Long-term Effect on Dental Biofilm pH
The aims of this study were to determine the sucrose and liquid oral pediatric medicines of long-term effect on dental biofilm pH to evaluate the cariogenic potential in vivo.
- Trial name
- SPMedicines (NCT01819350)
- Testing
- G1, G2 and G3, G4 and G5
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
Mouthwashes, Chlorhexidine
Effects of Two Daily CHX Mouthrinses on Plaque, Gingivitis and Staining
Τhe aim of this randomized clinical trial was to investigate the efficacy of two daily mouth rinses containing CHX and different combinations of H2O2 and CPC, when used adjunctive to mechanical oral hygiene, and compare them with…
- Conditions
- Mouthwashes, Chlorhexidine, Dental Plaque, Gingival and Periodontal Disease
- Trial name
- NCT07351370
- Testing
- chlorhexidine/ cetylpyridinium chloride/ hydrogen peroxide mouthwash, Chlorhexidine/ cetylpyridinium chloride
- Where
- Greece
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Dental School