Clinical trials: Bioavailability
Post-menopausal Women, Post-menopausal Status
Dairy Choline Bioavailability
The goal of this clinical trial is to find out if dairy is a good source of choline compared to eggs. The main questions it aims to answer are: How the body uses choline; and, What effect WPPC has on choline metabolism.
- Trial name
- NCT06902480
- Testing
- WPPC, Whole egg powder
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Healthy
Bioavailability Study of Sirolimus Tablets 2 mg Under Fed Condition
This study is to assess the Sirolimus Tablets 2 mg of Dr. Reddy's Laboratories Limited, India and Rapamune® (Sirolimus) tablets 2 mg of Wyeth Laboratories, Philadelphia in healthy, adult,human subjects under Fed conditions.
- Trial name
- NCT02296762
- Testing
- Sirolimus
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Dr. Reddy's Laboratories Limited
Malaria
Study Assessing Pharmacokinetics and Bioavailability of Three Novel Triazine Compounds
Open-label, randomized, microdose study
- Trial name
- NCT03436160
- Testing
- WR826647, WR909388, WR909390
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Primary Gout, Hyperuricemia
Study on the Bioavailability of Three Different Prescription Processes of SHR4640 Tablets in Healthy Volunteers
The primary objective of the study is to evaluate the relative bioavailability of three different prescription processes of SHR4640 tablets in healthy volunteers.
- Trial name
- NCT04586803
- Testing
- SHR4640
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Healthy
Assessment of Safety, Pharmacokinetics and the Effect of BIBR 1048 MS on Coagulation Parameters in Healthy Volunteer Subjects
To assess safety, pharmacokinetics and the effect of BIBR 1048 MS on coagulation parameters in healthy volunteer subjects.
- Trial name
- NCT02170740
- Testing
- BIBR 1048 MS - low dose, BIBR 1048 MS - high dose, BIBR 1048 MS + Pantoprazole
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy
Ursodiol Tablets 500 mg Under Fasting Conditions
The objective of this study was to evaluate the comparative bioavailability between Ursodiol 500 mg Tablets (test) and Urso Forte™ 500 mg Tablets (reference) after a single-dose in healthy subjects under fasting conditions.
- Trial name
- NCT00909610
- Testing
- Ursodiol, Urso Forte™
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Iron-deficiency
Iron Bioavailability of High Surface Area Ferric Phosphate
The primary objective of this study is to compare iron absorption of high surface area ferric phosphate with that of ferrous sulfate and bulk ferric phosphate in a rice-based meal in non-pregnant women.
- Trial name
- HiFe (NCT03660462)
- Testing
- FeSO4 fortified rice test meal, FePO4 fortified rice test meal, HiFePO4 1 fortified rice test meal
- Where
- Thailand
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Pain
Methadone Pharmacokinetics and Cardiac Effects in Newborns
The Primary objectives of this proposal are to determine the population kinetics for methadone and its enantiomers in preterm newborns and infants at 29 weeks to 48 weeks post menstrual age (PMA) who are 1 week old and older and…
- Trial name
- NCT00715988
- Testing
- Methadone HCl Inject 10 mg/ml (will require dilution), Methadone
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- University of Utah
Healthy Volunteers
Bioavailability of Phytonutrients From Novel Preparations of Broccoli
The primary objective of this study is to determine the effects of different methods of broccoli preparation on levels of urinary glucosinolate metabolites.
- Trial name
- NCT03773497
- Testing
- Common Snack Combination, Cheesy Broccoli Snack, Cheesy Broccoli with Daikon Radish Snack
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- USDA Beltsville Human Nutrition Research Center
Glucosamine, Liposomal Encapsulation
Human Absorption Study of Liposomal Glucosamine Supplements
The objective of this study is to evaluate the effects of liposomal encapsulation using different ratios of gum arabic and lecithin on the bioavailability of a liquid glucosamine supplement in humans.
- Trial name
- NCT07843342
- Testing
- High-Emulsified Liposomal Glucosamine Liquid, Low-Emulsified Liposomal Glucosamine Liquid, Glucosamine Liquid without Liposomal
- Where
- Taiwan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Infection
To Demonstrate the Relative Bioavailability of Azithromycin 600 mg Tablets Under Fed Conditions
To demonstrate the bioequivalence of Azithromycin 600 mg Tablets Under Fed Conditions.
- Trial name
- NCT00865670
- Testing
- Azithromycin Monohydrate 600 mg Tablets, Zithromax (azithromycin dihydrate) 600 mg Tablets
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Sandoz
Bioequivalence
Effects of Altered Formulation on the Bioequivalence of Tacrolimus in Healthy Female and Male Volunteeers
Amorphous solid dispersion (ASD) formulations are increasingly used by the pharmaceutical industry to develop poorly water-soluble drugs into effective oral dosage forms.
- Trial name
- ASDBioequiv (NCT02341274)
- Testing
- Tacrolimus
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Indiana University
Insomnia
Open-Label Study of Bioavailability of E2006 Tablet Versus Capsule Formulations
This is a single-center, open-label, randomized crossover study being conducted in three cohorts of healthy adult subjects. Approximately 36 subjects will be randomized to one of three cohorts (approximately 12 subjects per…
- Trial name
- NCT01673880
- Testing
- E2006
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Pain
Comparative Bioavailability Between Two Tramadol Formulations: Study of the Better Controlled Release of a New 200 mg Once A Day (OAD) Formulation Versus Zytram® 200 mg
The main purpose of this study is to compare the pharmacokinetic profile to establish the better controlled liberation of the test product (Tramadol HCL OAD tablets of 200 mg, Labopharm) and its bioavailability in relation with…
- Trial name
- NCT00911742
- Testing
- Tramadol Contramid OAD, Zytram
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Labopharm Inc.
Epilepsy
A Conversion Study of Immediate Release (IR) and Modified Release (MR) Forms of Topiramate (TPM)
This multi-center, two-treatment study compares the pharmacokinetic profiles of Immediate Release (IR) and Modified Release (MR) formulations of Topiramate (TPM) in patients with epilepsy.
- Trial name
- NCT01114854
- Testing
- Topiramate IR, Topiramate ER
- Where
- 9 sites in United States
- Volunteers
- 69 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Healthy
Finasteride 5 mg Tablets Under Fasting Conditions
The objective of this study is to compare the relative bioavailability of finasteride 5 mg tablets (manufactured and distributed by TEVA Pharmaceuticals USA) with that of PROSCAR® 5 mg tablets (Merck) in healthy, adult…
- Trial name
- NCT00835666
- Testing
- Finasteride 5 mg tablets, PROSCAR®
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Healthy
Relative Drug Exposures Of Two Formulations of PF-02341066
The study will be an open-label, randomized, 2-period, 2-treatment, 2-sequence, cross-over, single-dose study employing administration of two PF-02341066 formulations in the fasted state to healthy adult volunteers.
- Trial name
- NCT00939731
- Testing
- PF-02341066
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Analgesia Disorder
Study of PHN131 in Healthy Volunteers
To evaluate the safety and to investigate the pharmacokinetic properties and bioavailability of PHN131 in healthy volunteers
- Trial name
- NCT02192151
- Where
- Taiwan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- PhytoHealth Corporation
Healthy
A Phase 1 First in Human Study to Assess Safety and Tolerability of AL101
A first in human phase 1 study in healthy volunteers to assess AL101 safety, tolerability, bioavailability, pharmacokinetics, and pharmacodynamics
- Trial name
- NCT04111666
- Testing
- AL101
- Where
- 2 sites in United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Alector Inc.
Healthy
A Study to Assess the Relative Bioavailability of 4 Formulations of Fentanyl Transdermal System Compared Against DUROGESIC Fentanyl Transdermal Patch After Single Application in Healthy Volunteers
The purpose of this study is to evaluate the pharmacokinetics and relative bioavailability of 4 new formulations of fentanyl transdermal patch in healthy participants after a single application for 72 hours.
- Trial name
- NCT01717157
- Testing
- Treatment A: DUROGESIC (8.4 mg fentanyl), Treatment B: Transdermal System-Concept 1 (6.2 mg fentanyl), Treatment C: Transdermal System-Concept 2 (6.2 mg fentanyl)
- Where
- Belgium
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC