Clinical trials: Biliary Stents
Malignant Biliary Obstruction, Pancreatic Cancer Resectable
EUS-guided Choledochoduodenostomy vs ERCP as First Line in Malignant Distal Obstruction in Resectable Disease (CARPEDIEM-1 Trial)
The aim of this clinical trial is to evaluate temporal delay (days) between biliary drainage (EUS-CDS vs ERCP as first line therapy) and surgery in patients with resectable distal malignant biliary obstruction.
- Conditions
- Malignant Biliary Obstruction, Pancreatic Cancer Resectable, Biliary Tract Neoplasms
- Trial name
- NCT06375928
- Testing
- Endoscopic biliary drainage, Self-expandable metallic stent (SEMS), Lumen-apposing metal stent (LAMS) and double-pigtail plastic stent (DPPS)
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Hospital Universitari de Bellvitge
Malignant Biliary Obstruction
A Comparison of a Fully Covered Self-expandable Metal Stent With an External Anchoring Plastic Stent and Uncovered Stent
Multi-center, randomized controlled study fc-SEMS with anchoring plastic stent vs uc-SEMS in malignant biliary obstruction
- Trial name
- NCT05220475
- Testing
- fully covered self-expandable metal stent with an anchoring external plastic stent, uncovered self-expandable metal stent
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Seoul National University Hospital
Pancreatic Carcinoma
Preoperative Biliary Drainage in Resectable Pancreatic or Periampullary Cancer
The purpose of this study is to demonstrate that preoperative biliary drainage using self-expanding metal stents (SEMS) does not negatively impact overall surgical outcomes in patients undergoing pancreaticoduodenectomy for…
- Trial name
- NCT01774019
- Testing
- WallFlex™ Biliary RX Fully Covered/Uncovered Stent System
- Where
- 11 sites in United States, Australia and 7 more
- Volunteers
- 284 people
- Sponsor
- Boston Scientific Corporation
Pancreatic Cancer, Endoscopy
Plastic Stent Within a Lumen-Apposing Stent for Malignant Biliary Obstruction
There are doubts concerning the possible benefits derived from the insertion of double-pigtail plastic stents (DPS) within the lumen-apposing metal stents (LAMS) in the EUS-guided transmural biliary drainage (BD).
- Conditions
- Pancreatic Cancer, Endoscopy, Oncologic Disorders, Therapy Related Neoplasms
- Trial name
- LAMSpigBil (NCT04420039)
- Testing
- Endoscopic biliary transmural drainage
- Where
- 3 sites in Spain
- Volunteers
- 39 people
- Sponsor
- Hospital Universitari de Bellvitge
Malignant Distal Biliary Obstruction, Malignant Biliary Obstruction
12-mm Partial Covered Versus Bare Self-Expandable Metallic Stents for Malignant Distal Biliary Obstruction
Metallic stents are commonly used for biliary drainage in patients with unresectable malignant distal biliary obstruction. However, it is unclear whether a 12-mm partially covered self-expandable metallic stent or a 12-mm bare…
- Conditions
- Malignant Distal Biliary Obstruction, Malignant Biliary Obstruction, Biliary Obstruction
- Trial name
- PCSEMS-12 (NCT07559968)
- Testing
- 12-mm partially covered self-expandable metallic stent, 12-mm bare self-expandable metallic stent
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Chung-Ang University Hospital
Pancreatic Neoplasms, Biliary Tract Neoplasms
Comparing Endoscopic Based Stent Strategy Versus Bypass Surgery in Non-resectable Periampullary Cancer
Randomized study comparing endoscopic stent insertion strategy versus double-bypass surgery in non-resectable periampullary cancer
- Conditions
- Pancreatic Neoplasms, Biliary Tract Neoplasms, Duodenal Neoplasms
- Trial name
- NCT00487851
- Testing
- surgery, endoscopic strategy
- Where
- Sweden
- Sponsor
- Karolinska Institutet
Esophageal Stenosis in Children
Biliary Stent For Management Of Esophageal Stricture In Children
All patients will subjected to the followings: patients were selected by randomization method, full history taking, Complete physical examination, laboratory investigations (complete blood picture, liver and kidney functions…
- Trial name
- NCT07373522
- Testing
- endoscopic stenting of esophageal stricture by fully covered self expanding metallic stent
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Zagazig University
To Evaluate Patency of the Viaduct Stent in Comparison to Metal Stents
Comparison of a Plastic Stent Without Central Lumen With Self Expandable Metal Stents in Patients With Malignant Distal Biliary Obstruction
This is a non-inferiority randomized study to compare a plastic stent without central lumen (VIADUCT) with self-expandable metal stents for treatment of malignant obstruction of the common bile duct.
- Trial name
- VIADUCT (NCT01063634)
- Where
- Germany
- Volunteers
- 76 people
- Sponsor
- Kliniken Ludwigsburg-Bietigheim gGmbH
Pancreatic Cancer, Unresectable Biliary-pancreatic Malignancies
Endoscopic Biliary Co-axial Stent Placement Plus/Minus Use of Radiofrequency Ablation (RFA) for Clearance of Occluded Self Expandable Metal Stents (SEMS) in Patients With Distal Biliary Obstruction From Unresectable Biliary-pancreatic Malignancies
The purpose of this study is to compare the effects good and/or bad of combining radiofrequency ablation with placement of a second stent, versus a second stent alone.
- Trial name
- NCT02340728
- Testing
- ERCP with SEMS plus radiofrequency ablation, ERCP with SEMS alone (standard of care)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Obstructive Jaundice, Pancreatic Cancer
Trial Comparing Metal Versus Plastic Stents for Preoperative Biliary Decompression
Compare the performance of full covered metal stents and plastic stents for preoperative biliary decompression
- Trial name
- NCT01675908
- Testing
- Stent Dysfunction, Complications
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- AdventHealth
Endoscopic Biliary Sphincterotomy, Bleeding
Treatment of Post Sphincterotomy-bleeding by Epinephrine-injection Versus Insertion of an Plastic Stent
Post sphinterotomy-bleeding (PSB) occurs in 1-2 % of Endosocpic Retrograde Cholangiopancreaticography (ERCP) and usually needs no blood transfusion after endoscopic therapy but can be life-threatening in some rare cases.
- Trial name
- NCT03725319
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Theresienkrankenhaus und St. Hedwig-Klinik GmbH
Resectable Pancreatic Cancer With Biliary Obstruction
A Prospective Randomized Multi-center Study for Efficacy of Metallic Biliary Stent Compared to Plastic Stent in Patients Receiving Neoadjuvant Chemotherapy for Resectable Pancreatic Cancer
Pancreatic cancer is the eighth most common occurrence in Korea. In the United States, pancreatic cancer is expected to be the number two cause of death from cancer in 2030.
- Trial name
- NCT04911647
- Testing
- ERCP using plastic stent, ERCP using metal stent
- Where
- South Korea
- Volunteers
- 196 people
- Sponsor
- Yonsei University
Acute Cholangitis
Impact of Positive Bile Cultures on Plastic Biliary Stent Exchange
This prospective, unicenter, randomized controlled trial evaluates whether a positive bile culture at index ERCP with plastic stenting identifies patients who benefit from earlier stent exchange.
- Trial name
- TEMPEST 2 (NCT07379749)
- Testing
- stent exchange, Scheduled biliary stent exchange at one month
- Where
- Romania
- Volunteers
- 140 people
- Sponsor
- Clinical Hospital Colentina
Obstructive Jaundice, Cholangitis
Cholangioscopic Assessment of Occluded Biliary Stent and Role of Biliary Radiofrequency Ablation
Primary Objective: To document state-of- the-art multi-modality management of occluded biliary SEMS aiming to minimize number of reinterventions while providing symptom relief without procedure-related serious adverse events.
- Trial name
- NCT03133026
- Testing
- Single operator cholangioscopy, Endoscopic biliary RFA
- Where
- India
- Volunteers
- 4 people
- Sponsor
- Asian Institute of Gastroenterology, India
Distal Bile Duct Obstruction
Covered vs Uncovered Metal Stents for Palliative Biliary Decompression in Inoperable Malignant Distal Bile Duct Obstruction
The purpose of this study is to compare the rate of long-term stent failure, defined as need for repeat biliary intervention following placement of C-SEMS vs U-SEMS for palliation of inoperable malignant distal bile duct…
- Trial name
- NCT01905384
- Testing
- Covered Self-expanding metal biliary stents (C-SEMS), Uncovered Self-expanding metal biliary stents (U-SEMS)
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Vanderbilt University Medical Center
Choledocholithiasis
CBD Stenting vs Non-Stenting for Choledocholithiasis
The role of prophylactic biliary stenting after complete clearance of common bile duct stones in patients awaiting cholecystectomy remains controversial.
- Trial name
- NCT07331142
- Testing
- Temporary Plastic Biliary Stent Placement, Endoscopic Retrograde Cholangiopancreatography with Stone Clearance
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- National Liver Institute, Egypt
Biliary Tract Neoplasms, Pancreatic Neoplasms
Malignant Obstruction ZILVER Against Routine Therapy (MOZART I)
This study compares the 6 mm nitinol Zilver biliary endoprostheses and the 10 mm nitinol Zilver biliary endoprostheses to the 10 mm Wallstent in appropriate patients in need of palliative treatment of malignant obstructive…
- Conditions
- Biliary Tract Neoplasms, Pancreatic Neoplasms, Jaundice, Obstructive
- Trial name
- NCT00196105
- Testing
- 6 mm Nitinol Zilver Stent, 10 mm Nitinol Zilver Stent, 10 mm Stainless Steel Wallstent
- Where
- United States
- Volunteers
- 241 people
- Sponsor
- Cook Group Incorporated
Malignant Biliary Obstruction, Pancreatic Cancer
EUS-guided CDS vs ERCP as First Line in Malignant Distal Obstruction in Borderline Disease (CARPEDIEM-2 Trial)
The aim of this clinical trial is to evaluate temporal delay (days) between biliary drainage (EUS-CDS vs ERCP as first line therapy) and chemotherapy start in patients with borderline distal malignant biliary obstruction.
- Conditions
- Malignant Biliary Obstruction, Pancreatic Cancer, Biliary Tract Neoplasms
- Trial name
- NCT06375954
- Testing
- Endoscopic biliary drainage, Self-expandable metallic stent (SEMS), Lumen-apposing metal stent (LAMS) and double-pigtail plastic stent (DPPS)
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Hospital Universitari de Bellvitge
Stenosis of the Bilio-biliary Anastomosis After Orthotopic Liver Transplantation
cSEMS vs. NEPS in Stricture of Biliary Anastomosis After Liver Transplantation
Stenosis at the bilio-biliary anastomosis occurs in up to 30% of patients after orthotopic liver transplantation. This study compares endoscopic treatment with implantation of multiple plastic endoprostheses vs.
- Trial name
- NCT01393067
- Testing
- Non-expandable plastic stent (plastic endoprosthesis), Covered self-expandable metal stent (cSEMS)
- Where
- 4 sites in Finland, Germany and 1 more
- Volunteers
- 60 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Cholangiocarcinoma, Pancreas Cancer
RFA for Malignant Biliary Obstruction
Pancreatic cancer and cholangiocarcinoma are the most common causes of malignant biliary obstruction. They are diseases of increasing incidence and unfavorable prognosis.
- Trial name
- NCT03166436
- Testing
- Radiofrequency ablation, Biliary stenting
- Where
- Czechia
- Volunteers
- 140 people
- Sponsor
- Institute for Clinical and Experimental Medicine