Clinical trials: Biliary Obstruction
Laparoscopic Cholecystectomy, Cholelithiasis
Comparison of Oblique Subcostal, Posterior or Dual Transversus Abdominis Plane Block in Laparoscopic Cholecystectomy
The aim of the study is to evaluate the difference of postoperative analgesic effects and opioid consumption between ultrasound-guided unilateral oblique subcostal, posterior, or dual TAP blocks in patients undergoing…
- Conditions
- Laparoscopic Cholecystectomy, Cholelithiasis, Postoperative Analgesia
- Trial name
- NCT04693156
- Testing
- unilateral ultrasound-guided oblique subcostal TAP block with %0.5 Bupivacaine 10ml + %1 Prilocaine 10ml + %0.9 NaCl 10ml, unilateral ultrasound-guided oblique subcostal TAP block with %0.9 NaCl 30ml, unilateral ultrasound-guided posterior TAP block with %0.5 Bupivacaine 10ml + %1 Prilocaine 10ml + %0.9 NaCl 10ml
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people
- Sponsor
- Ceylan Saygili
Pancreatic Ductal Adenocarcinoma, Liver, Cancer of, Primary Resectable
Celiac plExus Block to Reduce OpioID Consumption Following Hepato-pancreato-biliary Mini-invasive Surgery
The goal of this study is to assess the efficacy of intraoperative celiac plexus block (CPB) to reduce opioid consumption following laparoscopic hepato-pancreato-biliary surgery
- Trial name
- CEBOIDS (NCT06214533)
- Testing
- Ropivacaine 0.5%, Normal Saline
- Volunteers
- 60 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Pancreas Cancer, Biliary Tract Cancer
Surgery Plus Celiac Nerve Block for Long-term Pancreatic Cancer Pain Control
This is a randomized study of surgery plus chemical nerve block versus surgery plus placebo for pain control in subjects with pancreatic cancer.
- Trial name
- NCT02002806
- Testing
- Alcohol Injection
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Cholelithiasis, Cholecystitis
STALL vs Sole Local Wound Infiltration in Laparoscopic Cholecystectomy
This trial is a prospective randomized superiority trial comparing sole ropivacaine based local trocar site infiltration to local infiltration combined with laparoscopic ropivacaine TAP block (STALL) in LCC.
- Conditions
- Cholelithiasis, Cholecystitis, Gallbladder Cancer
- Trial name
- STALL (NCT06123117)
- Testing
- single transversus abdominis laparoscopy-guided plane block, local trocar site ropivacaine infiltration
- Where
- Finland
- Volunteers
- 850 people
- Sponsor
- Helsinki University Central Hospital
Cholangiocarcinoma, Pancreas Cancer
RFA for Malignant Biliary Obstruction
Pancreatic cancer and cholangiocarcinoma are the most common causes of malignant biliary obstruction. They are diseases of increasing incidence and unfavorable prognosis.
- Trial name
- NCT03166436
- Testing
- Radiofrequency ablation, Biliary stenting
- Where
- Czechia
- Volunteers
- 140 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Malignant Bile Duct Obstruction
Sems Placement With and Without Biliary Sphincterectomy in Patients With Malignant Biliary Obstruction
Placement of biliary self expanding metal stent (SEMS) is indicated when malignant common bile duct obstruction is encountered [1].
- Trial name
- SEMS (NCT04805450)
- Testing
- ES before fully covered SEMS placement, no ES before fully covered SEMS placement
- Where
- Italy
- Volunteers
- 1,075 people
- Sponsor
- Istituto Clinico Humanitas
Acute Cholecystitis, Acute Cholecystitis With Obstruction
Patient Satisfaction After Ambulatory Emergency Laparoscopic Cholecystectomy
Acute cholecystitis is a common surgical emergency that, if left untreated, can result in significant morbidity and even death. It is characterized by inflammation of the gallbladder, usually caused by gallstones.
- Trial name
- NCT07616713
- Testing
- Laparoscopic Cholecystectomy
- Where
- Mexico
- Volunteers
- 25 people
- Sponsor
- Hospital General de Chihuahua - Dr. Salvador Zubirán Anchondo
Malignant Hilar Stricture
ERCP With and Without EUS Guided HGS for Bilateral Biliary Decompression in Malignant Hilar Biliary Obstruction
A prospective randomized clinical trial to evaluate efficacy and safety of combined EUS-HGS and ERCP compared to ERCP for bilateral biliary decompression in advanced malignant hilar biliary obstruction.
- Trial name
- NCT06613945
- Testing
- ERCP biliary drainage, Combined ERCP and EUS-HGS biliary drainage
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Mansoura University
Malignant Biliary Obstruction, Malignant Biliary Stricture
Endoscopic Ultrasound Guided Hepaticogastrostomy With or Without Antegrade Stenting for Palliation of Malignant Distal Biliary Obstruction: Randomized Controlled Trial
The purpose of this study is to compare the efficacy and safety between EUS-HGAS and EUS-HGS. We hypothesized that EUS-HGAS provides lower recurrent biliary obstruction (RBO) rate but with a comparable safety profile to EUS-HGS.
- Trial name
- EASE-MBO (NCT07832045)
- Testing
- HGAS, HGS
- Where
- Taiwan
- Volunteers
- 88 people
- Sponsor
- National Taiwan University Hospital
DISTAL MALIGNANT BILIARY OBSTRUCTION
Eus-giuded Biliary Drainage With Ec-lams vs ERCP as a Primary Intervention for Endoscopic Treatment of Patinets With Distal Malignant Biliary Obstruction
Endoscopic retrograde cholangiopancreatography (ERCP) is the gold standard for the management of jaundice in patients with distal malignant biliary obstruction.
- Trial name
- EUS-BD (NCT04099862)
- Testing
- ERCP, EUS-BD
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- Istituto Clinico Humanitas
Acute Appendicitis, Acute Cholecystitis
Web-based International Register of Emergency Surgery and Trauma
The WIRES-T project (Web-based International Registry of Emergency General Surgery and Trauma) has been set up to allow to all the EGS (Emergency General Surgery) and Trauma surgeons to register their activity and to obtain a…
- Conditions
- Acute Appendicitis, Acute Cholecystitis, Acute Diverticulitis, Post-operative Complications
- Trial name
- WIRES-T (NCT03643718)
- Testing
- Emergency General Surgery
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Pancreatic Cancer
Endoscopic Stenting Versus Surgical Bypass for Low Bile Duct Obstruction by Cancer of the Pancreatic Head
The prognosis of patients with unresectable pancreatic cancer is dismal. Hence, palliation of tumor-associated symptoms, in particular jaundice due to low bile duct obstruction and gastric outlet obstruction, is the primary aim…
- Trial name
- STENTBY (NCT00753441)
- Testing
- Surgical bypass, Endoscopic stenting
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Heidelberg University
Biliary Obstruction Due to Common Bile Duct Stone, Malignant Bile Duct Obstruction
Needle-Knife Fistulotomy Vs. Standard Cannulation Trial
Needle-knife fistulotomy (NKF) is traditionally used to achieve biliary access when standard cannulation (SC) techniques are unsuccessful.
- Trial name
- NCT06694038
- Testing
- Needle Knife Fistulotomy, standard biliary cannulation
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Thomas Jefferson University
Biliary Stasis, Extrahepatic
The Effect of Aspirin on Patency of Metal Stent in Malignant Distal Bile Duct Obstruction
The aim of this study is to determine whether administration of aspirin can help maintain the patency of metallic stents for distal malignant common bile duct obstruction.
- Trial name
- NCT03279809
- Testing
- Aspirin
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Woo Hyun Paik
Biliary Tract Neoplasms, Jaundice, Obstructive
Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents
Endoscopic retrograde biliary drainage (ERBD) is now widely accepted as the standard intervention for the relief of obstructive jaundice in patients with unresectable malignant biliary obstruction.
- Trial name
- NCT01315522
- Testing
- ComVi stent, Uncovered SEMS
- Where
- 3 sites in South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
Cholangiocarcinoma, Pancreatic Cancer
Radio Frequency Ablation in the Management of Pancreatico-biliary Disorders: A Multicenter Registry
The objective of this protocol is to establish a multicenter registry to evaluate the impact of radiofrequency ablation in the management of patients with pancreatico-biliary disorders including malignancies.
- Conditions
- Cholangiocarcinoma, Pancreatic Cancer, Bile Duct Cancer, Biliary Stricture
- Trial name
- RFA-Registry (NCT01439698)
- Testing
- Radio Frequency ablation Probe
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Pancreatic Neoplasms, Cholestasis
Pharmacokinetic and Safety Study of Nab®-Paclitaxel (ABI-007) Plus Gemcitabine in Subjects With Advanced Pancreatic Cancer Who Have Cholestatic Hyperbilirubinemia
The purpose of this study is to determine the safety and pharmacokinetic profile of nab®-paclitaxel (ABI-007) plus gemcitabine in subjects with advanced pancreatic cancer who have cholestatic hyperbilirubinemia secondary to bile…
- Trial name
- NCT02267707
- Testing
- nab-paclitaxel, Gemcitabine
- Where
- 6 sites in United States, Germany
- Volunteers
- 1 people
- Sponsor
- Celgene
Biliary Obstruction
Cost Analysis for Endoscopic Retrograde Cholangiopancreatography (ERCP)
The purpose of the study is to determine if endoscopist notification of accessory cost results in altered resource utilization related to the total cost and number of accessories used in ERCP.
- Trial name
- ERCP (NCT02127229)
- Testing
- Endoscopist informed of cost per procedure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Oklahoma
Cholecystitis, Cholecystitis, Acute
M-Tapa Block vs External Oblique Intercostal Block for Laparoscopic Cholesistectomy
Ultrasound (US)-guided Modified Perichondral Approach Thoracoabdominal Nerve (M-TAPA) block is a novel block that provides effective analgesia in the anterior and lateral abdominal walls after laparoscopic surgery, and local…
- Trial name
- NCT05502159
- Testing
- M-TAPA, EOB
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Extrahepatic Cholangiocarcinoma, Malignant Biliary Obstruction
Spyglass+RFA Versus Cytobrush+RFA for Extrahepatic Cholangiocarcinoma
With the development of endoscopic technology, endoscopic retrograde cholangiopancreatography (ERCP) has been widely used in the diagnosis and treatment of extrahepatic cholangiocarcinoma.In patients with extrahepatic…
- Trial name
- NCT05233293
- Testing
- Spyglass + RFA, Cytobrush + RFA
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First People's Hospital of Hangzhou