Clinical trials: Biliary Obstruction
Biliary Tract Carcinoma, Biliary Obstruction
Endobiliary Percutaneous Cryobiopsy in Malignant Biliary Obstruction
The rationale of the study is to explore the safety and efficacy of percutaneously performed endobiliary cryobiopsy in patiens with histologically unverified biliary stenosis.
- Trial name
- BICRYOB (NCT06047990)
- Testing
- Cryobiopsy catheter
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Brno University Hospital
Malignant Biliary Obstruction
EUS - Guided Choledocho-duodenostomy Versus ERCP With Covered Metallic Stents in Patients With Unresectable Malignant Distal Common Bile Duct Strictures
EUS - guided choledocho-duodenostomy (ECDS) is an established option for bile duct drainage in unresectable malignant distal CBD strictures when endoscopic retrograde cholangiopancreatography (ERCP) fails.
- Trial name
- DRAMBO (NCT03000855)
- Testing
- EUS-guided choledocho-duodenostomy, Endoscopic retrograde cholangiopancreatography with covered metallic stent
- Where
- 6 sites in Australia, Belgium and 3 more
- Volunteers
- 77 people
- Sponsor
- Chinese University of Hong Kong
Extrahepatic Cholangiocarcinoma, Malignant Biliary Obstruction
Spyglass+RFA Versus Cytobrush+RFA for Extrahepatic Cholangiocarcinoma
With the development of endoscopic technology, endoscopic retrograde cholangiopancreatography (ERCP) has been widely used in the diagnosis and treatment of extrahepatic cholangiocarcinoma.In patients with extrahepatic…
- Trial name
- NCT05233293
- Testing
- Spyglass + RFA, Cytobrush + RFA
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First People's Hospital of Hangzhou
Biliary Obstruction
EUS Biliary Drainage vs. ERCP
Endoscopic ultrasound guided biliary drainage (EUS-BD) is an evolving field that has grown in popularity in the management of malignant biliary obstruction.
- Trial name
- NCT03870386
- Testing
- EUS-BD with LAMS, ERCP
- Where
- 11 sites in Canada, France
- Volunteers
- 144 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Biliary Obstruction, Pancreas Neoplasm
EUS-guided Choledochoduodenostomy for Primary Drainage of Malignant Distal Biliary Obstruction
A prospective single-centre pilot study investigating the feasibility and safety of EUS-guided choledochostomy as primary drainage strategy in patients with distal malignant biliary obstruction using a FCSEMS through LAMS to…
- Conditions
- Biliary Obstruction, Pancreas Neoplasm, Distal Cholangiocarcinoma
- Trial name
- SCORPION-II-p (NCT05595122)
- Testing
- EUS-CDS
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Malignant Biliary Obstruction
EUS-guided Hepatico-gastrostomy With Hot Giobor
Endoscopic ultrasonography-guided hepaticogastrostomy (EUS-HGS) is a method of obtaining biliary drainage in patients with failed or difficult endoscopic retrograde cholangiopancreatography (ERCP).
- Trial name
- NCT05804201
- Testing
- EUS-guided hepatico-gastrostomy would be performed with Niti-S HOT Giob
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Biliary Obstruction, Complication of Treatment
Treatment of Postsphincterotomy Bleeding With a Novel Self-assembling Peptide Hemostatic Gel.
The aim of this observational study is to evaluate safety and efficacy of a novel self-assembling peptide hemostatic gel in reduction of bleeding after endoscopic sphincterotomy during ERCP (endoscopic retrograde…
- Trial name
- ERCPURA (NCT05886127)
- Testing
- A novel hemostatic agent (Purastat®)
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- General University Hospital, Prague
Malignant Biliary Obstruction
The ID- RFA Trial: A Trial of Intraductal Radio-frequency Ablation (ID-RFA) Plus Biliary Stenting Versus Biliary Stenting Alone for the Treatment of Malignant Biliary Obstruction.
Cancers of the liver, pancreas and gall bladder can partially or fully block the bile duct leading to jaundice. Where these tumours are inoperable, maintaining adequate bile duct drainage is an important factor in survival, both…
- Trial name
- NCT04941924
- Testing
- Intraductal Radio-Frequency Ablation, Biliary Stent Placement
- Where
- 2 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- University Hospitals Dorset NHS Foundation Trust
Malignant Biliary Obstruction
EUS-guided Biliary Drainage vs. ERCP Assisted Transpapillary Drainage for Malignant Biliary Obstruction
Purpose of the study: To compare efficacy, stent patency, re-intervention rate, cost, quality of life, survival time, and adverse events between EUS-guide biliary drainage (EUS-BD) and ERCP assisted trans-papillary drainage for…
- Trial name
- NCT03812250
- Testing
- ERCP assisted trans-papillary drainage for malignant biliary obstruction, EUS-guide biliary drainage for malignant biliary obstruction
- Where
- China
- Volunteers
- 88 people
- Sponsor
- First People's Hospital of Hangzhou
Malignant Biliary Obstruction, Hepatocellular Carcinoma
Efficacy and Safety of a Fully Covered Self-Expandable Metal Stent for Unresectable HCC
The effectiveness and safety of fully covered metal stent in malignant biliary obstruction caused by HCC are still unknown. These would be clarified in this prospective cohort study.
- Trial name
- NCT05729867
- Testing
- Endoscpic biliary drainage using fully covered metal stent
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Biliary Obstruction
Dormia Basket Versus Extraction Ballon in Proximally Migrated Biliary Stents
Dormia basket versus extraction ballon in proximally migrated biliary stents:A randomized controlled clinical trial
- Trial name
- NCT05634772
- Testing
- dormia basket, Extraction biliary ballon
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Kafrelsheikh University
Biliary Obstruction
Efficacy and Safety of Lumen Apposing Metal Stents
Endoscopic ultrasonography (EUS) has revolutioned the management of gastroenterological patients and is acquiring an increasingly important role.
- Trial name
- LAMS (NCT03903523)
- Testing
- Lumen apposing metal stent (LAMS)
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Istituto Clinico Humanitas
Biliary Stricture, Biliary Anastomotic Stenosis
DIGEST I Drug Coated Balloon for Biliary Stricture
DIGEST I Pilot study is a feasibility study for evaluating the safety and efficacy of DCBs.
- Conditions
- Biliary Stricture, Biliary Anastomotic Stenosis, Biliary Obstruction, Biliary Disease
- Trial name
- DIGEST (NCT03997994)
- Testing
- GIE Drug Coated Balloon
- Where
- Paraguay
- Volunteers
- 8 people
- Sponsor
- GIE Medical
Biliary Obstruction, Oddi's Sphincter Constriction
clınıcal Effects of High-flow Nasal Oxygen Use ın gerıatrıc patıents
It is designed to monitor the efficacy of nasal cannula or hıgh-flow nasal oxygen in geriatric patients for endoscopıc retrograde cholangıopancreatography procedures.
- Conditions
- Biliary Obstruction, Oddi's Sphincter Constriction, Biliary Stones
- Trial name
- HFNO (NCT05432661)
- Testing
- HİGH-FLOW NASAL OXYGEN USE (HFNO)
- Volunteers
- 120 people
- Sponsor
- Yunus Emre
Distal Malignant Biliary Obstruction
Fesibility of EUS-guided Gallbladder Drainage With a New-type of Electrocautery LAMS in the Treatment of Malignant Distal Biliary Obstruction
Distal malignant biliary obstruction results from different types of tumors including pancreatic cancer, biliary tract cancer (BTC), gallbladder cancer, and metastasis, which can lead to obstructive jaundice.
- Trial name
- DC LAMS (NCT05271994)
- Testing
- endoscopic biliary drainage
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Clinico Humanitas Mater Domini
Hilar Cholangiocarcinoma, Biliary Obstruction
Efficacy of Intraductal Radiofrequency Ablation in Combination With Metallic Biliary Stenting in Advanced Hilar Cholangiocarcinoma
The study aim to evaluate the efficacy of intraductal radiofrequency ablation for unresetable hilar cholangiocarcinoma in addition to biliary stenting.
- Trial name
- NCT04611100
- Testing
- ELRA endoluminal radiofrequency ablation electrode (Taewoong, Seoul, Korea)
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Malignant Biliary Obstruction
Palliation of Gastric Outflow Obstruction in Case of Concomitant Biliary Obstruction.
EUS-guided drainages has been largely widespread during the last 10 years, even thanks to the advent of dedicated devices, such as lumen apposing metal stents (LAMSs).
- Trial name
- B-GOOD (NCT05142839)
- Testing
- EUS-CD, EUS-GEA
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Istituto Clinico Humanitas
Malignant Biliary Obstruction
A Comparison of a Fully Covered Self-expandable Metal Stent With an External Anchoring Plastic Stent and Uncovered Stent
Multi-center, randomized controlled study fc-SEMS with anchoring plastic stent vs uc-SEMS in malignant biliary obstruction
- Trial name
- NCT05220475
- Testing
- fully covered self-expandable metal stent with an anchoring external plastic stent, uncovered self-expandable metal stent
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Seoul National University Hospital
Liver Transplant; Complications, Biliary Duct Obstruction
Clinical Usefulness of Digital Single-operator Cholangioscopy(SpyGlass™) for Post-liver Transplant Anastomotic Stricture
Liver transplantation (LT) is an essential treatment for end-stage liver disease. Although clinical outcomes of LT recipients have markedly improved, anastomotic biliary strictures (ABS) are still occurred in 10-40% of post-LT…
- Conditions
- Liver Transplant; Complications, Biliary Duct Obstruction, Anastomosis, Obstructed
- Trial name
- NCT05065125
- Testing
- digital single-operator cholangioscopy
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Resectable Pancreatic Cancer With Biliary Obstruction
A Prospective Randomized Multi-center Study for Efficacy of Metallic Biliary Stent Compared to Plastic Stent in Patients Receiving Neoadjuvant Chemotherapy for Resectable Pancreatic Cancer
Pancreatic cancer is the eighth most common occurrence in Korea. In the United States, pancreatic cancer is expected to be the number two cause of death from cancer in 2030.
- Trial name
- NCT04911647
- Testing
- ERCP using plastic stent, ERCP using metal stent
- Where
- South Korea
- Volunteers
- 196 people
- Sponsor
- Yonsei University