Clinical trials: Berberine
Prediabetic State
RCT of a Polyherbal Dietary Supplement for Prediabetes
The primary purpose of this study is to evaluate the impact of a polyherbal dietary supplement (Designs for Health - GlucoSupreme™ Herbal) on markers of glycemic control and other structure/function outcomes among a sample of…
- Trial name
- NCT03388762
- Testing
- GlucoSupreme™ Herbal
- Where
- 4 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Diabetes Mellitus
Berberine on the Secretion of Incretin
Berberine (BBR) is the main active ingredient of the ancient Chinese herb medicine Coptis. The hypoglycemic effect of BBR has been demonstrated in numerous studies.
- Trial name
- NCT05947370
- Testing
- Berberine Chloride
- Where
- 2 sites in China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Drug Absorption
Effect of Gamma-cyclodextrin on the Bioavailability of Berberine
In this study, we will evaluate the relative bioavailability of Berberine (BB) from capsules containing Indian Barberry (Berberis aristate DC.) Bark and Root Extract in the blood plasma of healthy subjects after oral…
- Trial name
- NCT04918667
- Testing
- Berberine incorporated in gamma cyclodextrin, Berberine
- Where
- 4 sites in Armenia, Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- EuroPharma, Inc.
Pharmacokinetic Study in Healthy Volunteers
Sex Differences in Berberine Pharmacokinetics
The influence of genetic variants of the CYP2D6 enzyme and the Organic Cation Transporter 1 on the kinetics of berberine (BERKI-1) has recently been studied.
- Trial name
- BERKI-2 (NCT05845931)
- Testing
- Berberine
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Berberine, Sprint Training
Berberine Supplementation, Sprint Interval Training, and Immune Function Study
The purpose of this clinical trial is to investigate the effects of a 2-week intervention involving berberine supplementation or sprint training in isolation as well as berberine combined with sprint training on well-being…
- Conditions
- Berberine, Sprint Training, Wellbeing, Anaerobic Power
- Trial name
- NCT07480018
- Testing
- Berberine, Sprint Interval Training
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Northern Colorado
Glycemia
Bioavailability of Berberine and Dihydroberberine and Their Impact on Glycemia
The purpose of this study is to determine the bioavailability of berberine and dihydroberberine and their impact on changes in plasma concentrations of glucose and insulin.
- Trial name
- BBD (NCT05021341)
- Testing
- Berberine, Dihydroberberine 200, Dihydroberberine 100
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Obesity & Overweight, Circadian Rhythm Disorders
Effects of Akkermansia Muciniphila and Berberine Supplementation on Insulin Sensitivity in Night-shift Workers
Night shift work is associated with an increased risk of obesity, insulin resistance, and cardiometabolic disorders, largely due to circadian misalignment, disrupted sleep, and altered eating patterns.
- Conditions
- Obesity & Overweight, Circadian Rhythm Disorders, Gut Microbiota Modulation, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
- Trial name
- Shift2Health (NCT07440147)
- Testing
- Verum (A)
- Where
- Austria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- FH Joanneum Gesellschaft mbH
Helicobacter Pylori Infection, Chronic Gastritis
Study on The Efficacy and Safety of Vonoprazan-containing Berberine Triple Therapy in Helicobacter Pylori First-Line Eradication
The purpose of this study was to evaluate the efficacy and safety of the triple therapy of berberine hydrochloride, vonorasan and amoxicillin for the primary eradication of Helicobacter pylori.It is hypothesized that berberine…
- Trial name
- NCT06514274
- Testing
- Berberine, Vonoprazan, Amoxicillin
- Where
- China
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Diabetes Mellitus
Berberine Hyperglycemic Clamp
Berberine (BBR) is a traditional Chinese medicine used to treat diabetes mellitus for thousands of years in China. The glucose-lowering effect of BBR has been confirmed in numerous studies.
- Trial name
- BBR HC (NCT03972215)
- Testing
- Berberine Chloride
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Jin-Kui Yang
Pharmacokinetic Study in Healthy Volunteers
Impact of OCT1 and CYP2D6 Genotypes on Pharmacokinetics of Berberine in Healthy Volunteers
This study should investigate the differences of berberine pharmacokinetic parameters in three cohorts of healthy volunteers with distinct genotypes of the organic cation transporter 1 (OCT1) gene and the cytochrome P450 2D6…
- Trial name
- BERKI-1 (NCT05463003)
- Testing
- Berberine
- Where
- Germany
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Glucose Metabolism Disorders
Berberine and Altered Fasting Glucose
The aim of the study was to evaluate the effectiveness of a food supplement, berberine phytosome, which contributes to the control of blood sugar and the improvement of insulin resistance.
- Trial name
- NCT05031715
- Testing
- Berberine Phytosome
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Cardiometabolic Syndrome
Effects of Berberine on Cardiometabolic Outcomes
Cardiovascular disease, type 2 diabetes mellitus and associated diseases combined are the leading health burden and cause of mortality worldwide; therefore, the necessity for an intervention is paramount.
- Trial name
- NCT07541898
- Testing
- Berberine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Central Lancashire
Pharmacokinetic Study in Healthy Volunteers
Impact of Food Intake on Berberine Kinetics
The influence of genetic variants of the CYP2D6 enzyme and the Organic Cation Transporter 1 (OCT-1) on the kinetics of berberine (BERKI-1) has recently been studied. A significant sex difference was observed.
- Trial name
- BERKI-3 (NCT06273241)
- Testing
- food intake
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Helicobacter Pylori Infection, Chronic Gastritis
Study on The Efficacy and Safety of Berberine-containing Triple Therapy in Helicobacter Pylori First-Line Eradication
The purpose of this study is to assess the efficacy and safety of berberine, amoxicillin and vonoprazan containing triple therapy in Helicobacter Pylori first-line eradication.
- Trial name
- NCT05014334
- Testing
- Berberine, Vonoprazan, Amoxicillin
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Diabetes Mellitus, Obesity
Gymnema Sylvestre vs Berberine in Obesity Gene Expression of Adipokines
Obesity is a disease that affects a large part of the world's population and is a risk factor for the development of metabolic, cardiovascular, oncological, and neurodegenerative diseases.
- Trial name
- GS VS BBR A (NCT06426966)
- Testing
- Berberine, Gymnema sylvestre
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Polytechnic Institute, Mexico
Safety
Safety Profile of a New Berberine Formulation with Improved Bioavailability
This study aims to evaluate important safety markers related to liver- and kidney function in healthy individuals after treatment with a new formulation, LipoMicel Berberine.
- Trial name
- Berberine Safe (NCT06732908)
- Testing
- LipoMicel Berberine
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Isura
Helicobacter Pylori Infection, Chronic Gastritis
Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori.
The aim of this study is to evaluate the efficacy and safety of a quadruple therapy consisting of berberine hydrochloride, minocycline, esomeprazole, and colloidal bismuth tartrate for the first phase eradication of Helicobacter…
- Trial name
- NCT06603688
- Testing
- esomeprazole, Bismuth, Amoxicillin
- Where
- China
- Volunteers
- 548 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Healthy
The Absorption of Bioactive Berberine in Human
Berberine from medicinal plants has therapeutic activities against multiple chronic diseases. But its absorption rate is very low.
- Trial name
- NCT03438292
- Testing
- Berberine, TPGS emulsified berberine, Quillaja extract emulsified berberine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Florida
Phase I and Phase II Metabolites of Berberine
Metabolic Differences Between Dihydroberberine and Micellar Berberine
Differences in metabolites of dihydroberberine (DHB) and micellar berberine (LipoMicel®, LMB) are investigated through a randomized study involving human volunteers.
- Trial name
- NCT06202157
- Testing
- LMB, DHB
- Where
- Canada
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Factors Group of Nutritional Companies Inc.
Colorectal Adenomas, Colorectal Cancers
Effects of Berberine on the Human Gut Microbiome
Berberine hydrochloride is a conventional component in Chinese medicine. In recent years, anticancer activity of berberine hydrochloride have been explored.
- Trial name
- NCT07519681
- Testing
- Berberine Hydrochloride
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jing-yuan Fang, MD, Ph. D