Clinical trials: Benzodiazepine-Related Disorders
Substance-Related Disorders
Benzodiazepines in Opiate Replacement Therapy
Drug-related deaths (DRD) are a significant and increasing public health problem in Scotland. Benzodiazepines and BZD-type substances (BZD) are increasingly implicated in DRD.
- Trial name
- BENZORT (NCT04622995)
- Testing
- Benzodiazepine
- Where
- United Kingdom
- Volunteers
- 46,899 people, healthy volunteers welcome
- Sponsor
- University of Stirling
Substance Use Disorders
Distress Tolerance for Benzodiazepine Discontinuation
The proposed study is a clinical trial, designed to pilot test a Distress Tolerance-Benzodiazepine Discontinuation (DT-BD) intervention for patients on opioid agonist therapy (OAT) who currently use benzodiazepines versus a…
- Trial name
- DT-BD (NCT05250570)
- Testing
- Distress Tolerance - Benzodiazepine Discontinuation (DT-BD), Relaxation Therapy
- Where
- 3 sites in United States
- Volunteers
- 1 people
- Sponsor
- University of Pittsburgh
Benzodiazepine Dependence, Benzodiazepine Abuse
Prevention of Benzodiazepine Misuse in Primary Care
Benzodiazepines and benzodiazepine-like hypnotics (z-drugs) are prevalent and addictive narcotics. Guidelines recommend restricted prescription of these drugs for anxiety and insomnia.
- Conditions
- Benzodiazepine Dependence, Benzodiazepine Abuse, Substance Use Disorders
- Trial name
- NCT04533230
- Testing
- Educational intervention with prescription feedback, Information on treatment guidelines
- Where
- Sweden
- Sponsor
- Karolinska Institutet
Alcohol Dependence, Alcohol Withdrawal Syndrome
Assessment of Valproate on Ethanol Withdrawal
Alcohol use disorder, or heavy drinking, is commonly seen in patients who present to trauma centers. These patients are at risk for Alcohol Withdrawal Syndrome (AWS), which is collection of symptoms that can range from anxiety…
- Conditions
- Alcohol Dependence, Alcohol Withdrawal Syndrome, Trauma, Heavy Drinking
- Trial name
- PAVE (NCT03235531)
- Testing
- Valproate, Lorazepam
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- CAMC Health System
Substance-Related Disorders
Rapid Benzodiazepine Detoxification Using Flumazenil - 1
The purpose of this study is to verify the hypothesis that the benzodiazepine antagonist, flumazenil, will reduce acute benzodiazepine withdrawal.
- Trial name
- NCT00000246
- Testing
- Flumazenil
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Inappropriate Prescribing
Effectiveness of a Community Intervention in the Chronic Use of Benzodiazepines: (BENZOSTOPJUNTOS)
This study aimed to assess the effectiveness of a comprehensive, multicomponent intervention utilizing education and support for Benzodiazepines withdrawal compared to standard care.
- Trial name
- BENZOSTOP (NCT06209827)
- Testing
- Intervention for reducing benzodiazepines long-term use.
- Where
- Spain
- Volunteers
- 472 people, healthy volunteers welcome
- Sponsor
- Andalusian Health Service
Opioid-Related Disorders, Benzodiazepine-Related Disorders
De-prescribing Program to Evaluate Falls in Older Adults
Purpose: The proposed study will implement and evaluate the effect of an opioid and benzodiazepine (BZD) de-prescribing intervention on falls risk in older adults.
- Conditions
- Opioid-Related Disorders, Benzodiazepine-Related Disorders, Falls Injury
- Trial name
- NCT04272671
- Testing
- Educational Intervention
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV-Dementia, HIV-Associated Cognitive Motor Complex
PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [11C]PBR28 in HIV-Seropositive Patients With (MCMD)
The purpose of this protocol is to measure a receptor in the brain using positron emission tomography (PET) that is involved in inflammation.
- Conditions
- HIV-Dementia, HIV-Associated Cognitive Motor Complex, AIDS Encephalopathy, AIDS Dementia Complex
- Trial name
- NCT00459693
- Testing
- [11C]PBR28
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Opioid Abuse, Benzodiazepine Abuse
Opioid/Benzodiazepine Polydrug Abuse: Aim 3
In this study, the investigators will measure affective, neurocognitive and behavioral outcomes related to chronic use of opioids and benzodiazepines (screening phase), and in response to the administration of the opioid…
- Conditions
- Opioid Abuse, Benzodiazepine Abuse, Polysubstance Abuse
- Trial name
- MAP (NCT05006079)
- Testing
- Morphine, Alprazolam
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wayne State University
Drug Dependence
How to Ease the Withdrawal of Tranquilizers Among Older Consumers?
Benzodiazepines (BZD) are widely used to treat anxiety, insomnia, and depression. These drugs can have very serious side effects if they are taken over a long period of time.
- Trial name
- NCT02281175
- Testing
- Psychosocial intervention, a weekly physician intervention
- Where
- Canada
- Volunteers
- 114 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Neonatal Abstinence Syndrome
Buprenorphine for Treatment of Neonatal Abstinence Syndrome in Infants With In Utero Exposure to Benzodiazepines
The opioid neonatal abstinence syndrome (NAS) is a condition of withdrawal symptoms after utero exposure to opioids. Sublingual buprenorphine shows promise as a new treatment in NAS.
- Trial name
- MOPPlus (NCT01671410)
- Testing
- oral morphine, sublingual buprenorphine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Thomas Jefferson University
Anxiety, Prescription Drug Abuse and Dependency
Prescription of Benzodiazepines by General Practitioners: Characteristics of Prescribing Trend and Implementation of an Online Educational Program
Portugal has the highest benzodiazepine utilization compared to other European countries. The high utilization of benzodiazepines has been a concern due to reported side effects of long-term use and dependence.
- Trial name
- NCT04925596
- Testing
- ePrimaPrescribe online educational program, ComunicaSaudeMental online educational program
- Where
- Portugal
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Substance Use Disorders
Benzodiazepine Discontinuation in Opioid Agonist Therapy
The proposed study is a clinical trial, designed to pilot test a Distress Tolerance-Benzodiazepine Discontinuation (DT-BD) intervention for patients on opioid agonist therapy who currently use benzodiazepines.
- Trial name
- BZD-OAT (NCT04109118)
- Testing
- Distress Tolerance - Benzodiazepine Discontinuation (DT-BD), BZD discontinuation protocol
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Boston Medical Center
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Chronic Pain
Accuracy of Point of Care (POC) or In-office Urine Drug Testing (Immunoassay) in Chronic Pain Patients
Accuracy of Point of Care (POC) or In-office Urine Drug Testing (Immunoassay) in Chronic Pain Patients: A Prospective Analysis of Immunoassay and Liquid Chromatography Tandem Mass Spectometry (LC/MS/MS)
- Trial name
- NCT01052155
- Testing
- Urine Drug Testing
- Volunteers
- 1,000 people
- Sponsor
- Pain Management Center of Paducah
Alcohol Withdrawal, Alcohol Withdrawal Delirium
Phenobarbital vs Ativan for Alcohol Withdrawal in the Intensive Care Unit
Our aim is to compare outcomes of patients with benzodiazepine-refractory alcohol withdrawal syndrome who are treated with either a phenobarbital-based or a lorazepam based protocol.
- Trial name
- PARTI (NCT04156464)
- Testing
- Phenobarbital, Lorazepam
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- OSF Healthcare System
Benzodiazepine Dependence, Opioid Dependence
Gabapentin Treatment of Benzodiazepine Abuse in Methadone Maintenance Patients
The aim of this project is to study the use of gabapentin in reducing benzodiazepine abuse in methadone maintenance patients. A second aim is to study the effects of gabapentin on craving, mood, anxiety, and sleep disturbance in…
- Trial name
- NCT00420771
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- New York State Psychiatric Institute
Sleep Apnea, Obstructive, Obesity
Propofol vs Propofol + Benzo/Opiates in High Risk Group
This will be a randomized controlled trial that compares the rates of sedation related complications in high risk patients (ASA greater or equal to 3, BMI greater or equal to 30, those at risk for OSA) undergoing advanced…
- Trial name
- NCT01315158
- Testing
- Propofol Alone, Propofol+Benzo/Opioids
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Washington University School of Medicine
Psychiatric Disorder, Benzodiazepine-Related Disorders
Impact of Long Term of Benzodiazepine Use on Psychiatric Manifestation
Benzodiazepines are usually a secondary drug of abuse-used mainly to augment the high received from another drug or to offset the adverse effects of other drugs.
- Trial name
- NCT04792658
- Testing
- Detailed interview with personal demographic data, Intelligence assessment using the Arabic version of the Wechsler Adult Intelligence Scale (WAIS), The Arabic version of the Structured Interview for the Five-Factor Personality Model (SIFFM)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Opioid-use Disorder, Acceptability of Health Care
Patients' Attitudes Toward and Experiences With Buprenorphine Treatment
This study will disseminate five surveys collecting individual's attitudes and experiences during buprenorphine treatment for Opioid Use Disorder during the COVID-19 pandemic.
- Conditions
- Opioid-use Disorder, Acceptability of Health Care, Opioid-Related Disorders
- Trial name
- NCT05121428
- Where
- United States
- Volunteers
- 817 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance