Clinical trials: Benzodiazepine, open to volunteers
Depression - Major Depressive Disorder, Bipolar Disorder (BD)
Flumazenil for Benzodiazepine Reversal in Electroconvulsive Therapy
The goal of this study is to investigate whether administering flumazenil to reverse the effects of benzodiazepines and/or zopiclone during electroconvulsive therapy (ECT) can help reduce cognitive side effects without…
- Conditions
- Depression - Major Depressive Disorder, Bipolar Disorder (BD), Functional Magnetic Resonance Imaging (fMRI), Cognition
- Trial name
- FLEET (NCT07619092)
- Testing
- Flumazenil, Electroconvulsive therapy (ECT)
- Where
- Denmark
- Volunteers
- 145 people
- Sponsor
- Anders Jørgensen
Inappropriate Prescribing, Implementation Science
Reduction of Low-value Prescribing Through Audit and Feedback
The objective is to estimate the effect attributable to a primary care pharmacist-led audit and feedback (AF) strategy compared to the currently used AF strategy as a management tool to evaluate healthcare performance focusing on…
- Conditions
- Inappropriate Prescribing, Implementation Science, Behavioral Sciences
- Trial name
- AFFAP (NCT07336550)
- Testing
- Usual AF, Facilitated AF
- Where
- Spain
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Basque Health Service
Focal Epilepsy, Generalized Seizure
Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables
Mayo Clinic is conducting a research study to test a new approach to managing seizures in people with epilepsy whose seizures have not been fully controlled with regular medications.
- Conditions
- Focal Epilepsy, Generalized Seizure, Drug Refractory Epilepsy
- Trial name
- FORESITE (NCT07012148)
- Testing
- UNEEG SubQ device, seizure forecasts, nasal diazepam, Preventative Medication (PM)
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Mayo Clinic
Opioid Abuse, Benzodiazepine Abuse
Opioid/Benzodiazepine Polydrug Abuse: Aim 3
In this study, the investigators will measure affective, neurocognitive and behavioral outcomes related to chronic use of opioids and benzodiazepines (screening phase), and in response to the administration of the opioid…
- Conditions
- Opioid Abuse, Benzodiazepine Abuse, Polysubstance Abuse
- Trial name
- MAP (NCT05006079)
- Testing
- Morphine, Alprazolam
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wayne State University
Polysubstance Abuse
Opioid/Benzodiazepine Polydrug Abuse
Benzodiazepine (BZD)/opioid polysubstance abuse (PSA) dramatically increases risks of overdose, disability and death; however, little is known about phenotypes that could be targeted to decrease this use and these associated…
- Trial name
- NCT03696017
- Testing
- Multi-domain assessment battery
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Wayne State University
Delirium, Critical Illness
Remimazolam vs Midazolam to Reduce Delirium in Adults ≥65 Undergoing CPB Valve Surgery
"Postoperative delirium is a common and serious complication following cardiac surgery, particularly among older adults who require intensive care.
- Conditions
- Delirium, Critical Illness, Aged, Cardiopulmonary Bypass
- Trial name
- NCT07265128
- Testing
- Midazolam, Remimazolam
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Benzodiazepine Dependence
Baclofen for Improving Benzodiazepine Titration in Benzodiazepine Dependence
Benzodiazepines and related molecules are among the most prescribed psychotropic treatments in France and Europe. 13.4% of the French population had at least one reimbursement of benzodiazepines in 2015, which places France…
- Trial name
- BABET (NCT05935553)
- Testing
- Baclofen 30 mg, Baclofen 60 mg
- Where
- 2 sites in France
- Volunteers
- 93 people
- Sponsor
- Hospices Civils de Lyon
Benzodiazepine Use
Evaluation of a Clinical Support Website for the Management of Common Mental Health Conditions in Primary Care on Compliance With Benzodiazepine Prescribing Recommendations
This cluster-randomized study aims to evaluate the impact of a web-based clinical support tool on adherence to recommended maximum durations for benzodiazepine prescriptions among new users in primary care.
- Trial name
- Psycho-MG (NCT07379073)
- Testing
- Training
- Volunteers
- 100 people
- Sponsor
- MSPU de Pins-Justaret
Primary Care, Health Plan Implementation
Effectiveness of a Joint General Practitioner-Pharmacist Intervention on Benzodiazepine Deprescribing in the Elderly
Benzodiazepines or related drug (BZDR) are consumed for hypnotic or anxiolytic purposes in most cases. The consequences of BZDR are multiple with an increased risk of daytime sedation, balance disorders leading to falls and…
- Conditions
- Primary Care, Health Plan Implementation, Benzodiazepine Dependence, Elderly
- Trial name
- BESTOPH-MG (NCT05765656)
- Testing
- GP - pharmacist collaboration and pharmacist motivational interviewing
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Nantes University Hospital
Depression, Anxiety, Fear
Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression
This mechanistic study uses an anti anxiety drug and brain imaging to study the threat processing system and associated brain circuits in people with depression, anxiety disorders and comorbid depression and anxiety disorders.
- Conditions
- Depression, Anxiety, Fear, Depression, Anxiety and Fear
- Trial name
- NCT06004115
- Testing
- Lorazepam
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Benzodiazepines, Bladder Cancer
Impact of Remimazolam on Prognosis After Bladder Cancer Surgery
Bladder cancer is one of the most common genitourinary cancers. Transurethral resection of bladder tumor (TURBT) is the standard therapy for nonmuscle invasive bladder cancer.
- Conditions
- Benzodiazepines, Bladder Cancer, Delirium, Surgery
- Trial name
- NCT04532606
- Testing
- Remimazolam, Propofol
- Where
- 6 sites in China
- Volunteers
- 1,128 people
- Sponsor
- Peking University First Hospital
Benzodiazepine Withdrawal
Brief Motivational Intervention (BMI) on the Deprescription of Benzodiazepines and Related Substances in Adult Chronic Drug Users
We hypothesise that a short-term intervention by dispensing pharmacists is feasible and relatively easy to implement, and that it could have an impact on the deprescribing of BZD/Z in adult patients.
- Trial name
- BENZ_HALTE (NCT06446349)
- Testing
- Brief motivational intervention
- Where
- 20 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Grenoble
Benzodiazepine Adverse Reaction, Depression, Anxiety
Benzodiazepine Impact on Cognitive Function: fNIRs and PET/MRI Study
This study explores the impact of long-term benzodiazepine (BZDs) use on cognitive function and associated neuroimaging markers.
- Conditions
- Benzodiazepine Adverse Reaction, Depression, Anxiety, Benzodiazepine Dependence
- Trial name
- NCT06250842
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Intoxication by Drug
Hemadsorption to Enhance Drug Elimination in Intoxications
In this trial the investigators assess the effectiveness of applying a hemadsorber (cytosorb®) in removing benzodiazepines or tricyclic antidepressants in intoxicated patients admitted to ICU with prolonged impaired…
- Trial name
- MATRIX (NCT06922786)
- Testing
- Hemadsorption filter
- Where
- Belgium
- Volunteers
- 18 people
- Sponsor
- Universitair Ziekenhuis Brussel
Benzodiazepine-Related Disorders
Informative Exhibition for Deprescribing Benzodiazepines
The goal of this trial is to determine if an interactive and informative exhibition in the waiting room of a Primary Care Clinic can reduce the use of benzodiazepines in adults.
- Trial name
- ESUB (NCT06467019)
- Testing
- Informative Session
- Where
- Spain
- Volunteers
- 6,410 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Geriatric Patients
Attitudes and Beliefs Related to Benzodiazepine Deprescribing
The use of benzodiazepines in older adults is associated with an increased risk of adverse effects due to age-related physiological changes.
- Trial name
- BENZ-AC (NCT07474532)
- Testing
- Patient rPATD Benzo questionnaire, Geriatrician rPATD Benzo questionnaire
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Hospices Civils de Lyon
Seizure
Levetiracetam Versus Phenobarbital in Benzodiazepines Unresponsive Paediatric Prolonged Seizures
Convulsive prolonged seizures in children are the most common life-threatening neurological emergencies. The aim of active management of seizure control is to prevent irreversible neuronal damage as early as possible.
- Trial name
- NCT07098728
- Testing
- Levetiracetam IV, Phenobarbital
- Where
- 2 sites in Burma
- Volunteers
- 180 people
- Sponsor
- Ministry of Health and Sports, Myanmar