Clinical trials: Benzodiazepine
Postoperative Nausea and Vomiting, Benzodiazepine
Remimazolam and Postoperative Nausea and Vomiting in High-risk Patients
This trial aims to explore whether the intraoperative use of remimazolam can reduce the incidence of postoperative nausea and vomiting (PONV) in high-risk patients.
- Conditions
- Postoperative Nausea and Vomiting, Benzodiazepine, High-risk Patients
- Trial name
- NCT04861337
- Testing
- Remimazolam
- Where
- 10 sites in China
- Volunteers
- 552 people
- Sponsor
- Peking University First Hospital
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Benzodiazepine Deprescribing
Benzodiazepines Deprescribing in the Community Setting: Intervention Feasibility
The goal of this feasibility study is to evaluate the feasibility of an intervention, led by the pharmacist, aiming at benzodiazepines and z-drugs deprescribing in older adults living in the Belgian community setting.
- Trial name
- END-IT CS (NCT05929417)
- Testing
- END-IT intervention for the community setting
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Université Catholique de Louvain
Benzodiazepines Deprescribing
Benzodiazepines Deprescribing in Nursing Homes: Intervention Feasibility
The goal of this feasibility study is to evaluate the feasibility of a complex intervention towards benzodiazepines and Z-drugs deprescribing in older adults living in the Belgian nursing home setting.
- Trial name
- END-IT NH (NCT05929443)
- Testing
- END-IT intervention for nursing homes
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Université Catholique de Louvain
Benzodiazepine Dependence, Benzodiazepine Abuse
Prevention of Benzodiazepine Misuse in Primary Care
Benzodiazepines and benzodiazepine-like hypnotics (z-drugs) are prevalent and addictive narcotics. Guidelines recommend restricted prescription of these drugs for anxiety and insomnia.
- Conditions
- Benzodiazepine Dependence, Benzodiazepine Abuse, Substance Use Disorders
- Trial name
- NCT04533230
- Testing
- Educational intervention with prescription feedback, Information on treatment guidelines
- Where
- Sweden
- Sponsor
- Karolinska Institutet
Psychiatric Disorder, Benzodiazepine Withdrawal
Influence of Olfaction Essential Oils on the Consumption of Benzodiazepine Receptor Agonists & Z-Drugs (BZRAs) Prescribed as " if Needed " in Psychiatric Outpatients (HECBA-PSY).
The goal of this interventional study is to test the use of olfactory Essential Oils through a nasal stick as one of the non-medicinal strategies to propose to the patient to reduce the consumption of medication in a population…
- Trial name
- HECBA-PSY (NCT05583240)
- Testing
- Essences and Essential Oils
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Etablissement Public de Santé Barthélemy Durand
Benzodiazepines
Remimazolam and Scoliosis Orthopedics
Spinal cord injury is one of the most dangerous complications of scoliosis orthopedic surgery, and the Stagnara awakening test has been used in orthopedic spine surgery and is considered the "gold standard" for detecting spinal…
- Trial name
- rimazolam (NCT05519371)
- Testing
- Remimazolam, Propofol
- Volunteers
- 148 people
- Sponsor
- Beijing Chao Yang Hospital
Benzodiazepine Dependence, Benzodiazepine Dependent
Blended Care for the Discontinuation of Benzodiazepine Use
This study aims to compare two strategies performed by GPs to help patients taking benzodiazepines on a daily basis for at least six months to discontinue their use.
- Conditions
- Benzodiazepine Dependence, Benzodiazepine Dependent, Benzodiazepine Withdrawal
- Trial name
- Big Bird (NCT03937180)
- Testing
- Blended care, Usual care
- Where
- 110 sites in Belgium
- Volunteers
- 924 people
- Sponsor
- Kristien Coteur
Pregnancy Related, Benzodiazepines Causing Adverse Effects in Therapeutic Use
Maternal and Neonatal Outcomes Following Exposure to Benzodiazepines During Pregnancy
This is a nationwide cohort study to assess maternal and neonatal outcomes following exposure to benzodiazepines during pregnancy.
- Conditions
- Pregnancy Related, Benzodiazepines Causing Adverse Effects in Therapeutic Use, Congenital Anomaly
- Trial name
- NCT04856436
- Testing
- Benzodiazepine
- Where
- South Korea
- Volunteers
- 3,094,227 people, healthy volunteers welcome
- Sponsor
- Sungkyunkwan University
Poisoning by Benzodiazepines, Depression
Correlation Between Immune Metabolism in Patients With Benzodiazepine Poisoning and Patients'Mental Disorders
High-dose benzodiazepines can inhibit the central nervous system, respiratory system and cardiovascular motor center, resulting in loss of consciousness, disappearance of reflex, respiratory inhibition, decrease of blood pressure…
- Trial name
- NCT05184959
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Opioid-Related Disorders, Benzodiazepine-Related Disorders
De-prescribing Program to Evaluate Falls in Older Adults
Purpose: The proposed study will implement and evaluate the effect of an opioid and benzodiazepine (BZD) de-prescribing intervention on falls risk in older adults.
- Conditions
- Opioid-Related Disorders, Benzodiazepine-Related Disorders, Falls Injury
- Trial name
- NCT04272671
- Testing
- Educational Intervention
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Substance Use Disorders, Opiate Dependence
The Effect of Self-Forgiveness on Self-Stigma in Addiction.
This study has an experimental design and will examine the difference in pre-test and post-test data on the Self-Forgiveness Dual Process Scale (SFDPS) (Griffin, Worthington, Davis, Hook, \& Maguen, 2018) and the Substance Abuse…
- Conditions
- Substance Use Disorders, Opiate Dependence, Opiate Withdrawal Syndrome, Opioid-use Disorder
- Trial name
- NCT03971097
- Testing
- Six Step Model of Self-Forgiveness, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Pittsburgh
Benzodiazepine Refractory Status Epilepticus
Established Status Epilepticus Treatment Trial
The primary objective is to determine the most effective and/or the least effective treatment of benzodiazepine-refractory status epilepticus (SE) among patients older than 2 years.
- Trial name
- ESETT (NCT01960075)
- Testing
- Fosphenytoin, Levetiracetam, Valproic acid
- Where
- 65 sites in United States
- Volunteers
- 478 people
- Sponsor
- University of Virginia
Adverse Drug Effect of Opioids, Adverse Drug Effect of Benzodiazepines
Reducing Concurrent Opioid-Benzodiazepine Prescriptions
The purpose of this effort is to use informative e-mails to improve the process of prescribing of opioids and benzodiazepines within the National Capital Region/Military Health System (NCR/MHS), with the aim of decreasing…
- Trial name
- NCT03887247
- Testing
- E-mail Alert
- Where
- United States
- Volunteers
- 2,234 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Prevention, Benzodiazepine Dependence
Electronic Deprescribing Tool for the Prevention of PIP
This study is a cluster randomized control trial aimed to measure the effectiveness of an educational knowledge transfer intervention to prescribers on the discontinuation of two targeted classes: Benzodiazepines…
- Trial name
- NCT03192514
- Testing
- Electronic Deprescribing tool
- Where
- Portugal
- Volunteers
- 280 people
- Sponsor
- University of Beira Interior
Psychiatric Disorder, Benzodiazepine-Related Disorders
Impact of Long Term of Benzodiazepine Use on Psychiatric Manifestation
Benzodiazepines are usually a secondary drug of abuse-used mainly to augment the high received from another drug or to offset the adverse effects of other drugs.
- Trial name
- NCT04792658
- Testing
- Detailed interview with personal demographic data, Intelligence assessment using the Arabic version of the Wechsler Adult Intelligence Scale (WAIS), The Arabic version of the Structured Interview for the Five-Factor Personality Model (SIFFM)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Alcoholdependence, CIWA-R
Fixed-schedule Benzodiazepine Dosing vs Based on a CIWA-Ar Alcohol Protocol in Alcohol Detoxification.
Does the use of a symptom-triggered therapy (with assessment making use of a CIWA-Ar scale) decrease the total amount of benzodiazepines given to patients with alcohol dependence and are less patients still dependent on…
- Conditions
- Alcoholdependence, CIWA-R, Benzodiazepines
- Trial name
- NCT04777552
- Testing
- diazepam (or equivalence if other benzodiazepine)
- Volunteers
- 50 people
- Sponsor
- Universitair Ziekenhuis Brussel
Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent)
An Opioid Prescribing Nudge
Analyze baseline concurrent opioid prescribing metrics at the individual prescriber level in the Duke Health System on the identified three main outcome measures.
- Conditions
- Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent), Prescription Drug Abuse and Dependency, Health Behavior
- Trial name
- OHS (NCT04069403)
- Testing
- Automated Reports on prescription patterns for their patients
- Where
- United States
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- Duke University
Benzodiazepine Dependence, Opioid Dependence
Gabapentin Treatment of Benzodiazepine Abuse in Methadone Maintenance Patients
The aim of this project is to study the use of gabapentin in reducing benzodiazepine abuse in methadone maintenance patients. A second aim is to study the effects of gabapentin on craving, mood, anxiety, and sleep disturbance in…
- Trial name
- NCT00420771
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- New York State Psychiatric Institute
Benzodiazepine Dependence
Gabapentin Treatment of Benzodiazepine Dependence
Benzodiazepine dependence is a growing public health problem for which very few evidenced-based treatment approaches are available.
- Trial name
- NCT01893632
- Testing
- gabapentin
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute