Clinical trials: Behavioral Symptoms
Caregivers, Decision Making
"Safety in Dementia": An Online Caregiver Intervention
In an online randomized trial of Safety in Dementia with national recruitment and longitudinal follow-up, we will recruit informal caregivers of community-dwelling adults with dementia who have firearm access.
- Conditions
- Caregivers, Decision Making, Alzheimer Disease, Social Media
- Trial name
- NCT05173922
- Testing
- Safety in Dementia
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Depression
Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care for Depression
This study will examine multiple carefully selected clinical and biological markers, using both existing state-of-the-art technologies as well as pioneering, innovative approaches.
- Trial name
- EMBARC (NCT01407094)
- Testing
- Sertraline, BupropionXL
- Where
- 4 sites in United States
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Frailty, Sedentary Behavior
Stand if You Can: A Standing Intervention in Long Term Care
It is currently unknown if reducing sitting time, an activity that is highly prevalent in frail older adults living in long term care (LTC) facilities, is associated with an improvement in physical capacity such as walking speed.
- Conditions
- Frailty, Sedentary Behavior, Physical Disability
- Trial name
- NCT03796039
- Testing
- Standing
- Where
- Canada
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- University of New Brunswick
Cognitive Impairment, Depression
Problem Adaptation Therapy for Mild Cognitive Impairment and Depression
The present collaborative R01 study, between Cornell and Johns Hopkins, aims to compare Problem Adaptation Therapy for Mild Cognitively Impaired Older Adults (PATH-MCI) vs.
- Trial name
- PATH-MCI (NCT03043573)
- Testing
- PATH-MCI, Supportive Therapy
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Weill Medical College of Cornell University
Posttraumatic Stress Disorder
Neurosteroids for Treatment of PTSD in Veterans
This study seeks to determine if pregnenolone can improve symptoms of PTSD and other symptoms that commonly occur with PTSD in Iraq/Afghanistan-era Veterans. The total study duration for each participant is 10 weeks.
- Trial name
- NCT03799562
- Testing
- Pregnenolone
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- VA Office of Research and Development
Neurobehavioral Manifestations, Drug Related Sleep Disturbance
Acute and Residual Effects of Caffeinated Beer
The aim of this study is to develop information about the acute and residual effects of a new product being targeted to young adults.
- Conditions
- Neurobehavioral Manifestations, Drug Related Sleep Disturbance, Alcohol Intoxication
- Trial name
- NCT00515294
- Testing
- Caffeinated Alcoholic Beer, Non-Caffeinated Alcoholic Beer, Caffeinated Non-Alcoholic Beer
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Boston University
HIV Infections, Sexually Transmitted Diseases
Evaluation of Many Men, Many Voices, An STD/HIV Prevention Intervention for Black MSM
The purpose of this program evaluation is to determine whether the "Many Men, Many Voices" HIV/STD prevention intervention is effective in reducing HIV sex risk behaviors and increasing HIV testing among African-American men who…
- Trial name
- 3MV (NCT00137631)
- Testing
- Many Men, Many Voices (3MV)
- Where
- United States
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Atrial Fibrillation
Evaluate the Efficiency Impact of Conducting Active Temperature Management During Cardiac Cryoablation Procedures
Left atrial catheter ablation including pulmonary vein isolation is a standard therapy in the management of symptomatic atrial fibrillation; however thermal esophageal injury is a known potential consequence of this procedure.
- Trial name
- NCT04087122
- Testing
- Esophageal warming device (Attune Medical, Chicago, IL
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Advanced Cooling Therapy, Inc., d/b/a Attune Medical
Major Depressive Disorder
Phase 1 Evaluation of (2R,6R)-Hydroxynorketamine
A 6-cohort single ascending dose (SAD) study will be conducted in healthy volunteers utilizing a slow-infusion intravenous (IV) route of administration.
- Trial name
- NCT04711005
- Testing
- (2R,6R)-Hydroxynorketamine hydrochloride
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Heart Failure, Congestive, Chronic Heart Failure
Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure
This study will examine the effect of antidepressant medication on rates of death and disease in depressed people with chronic heart failure.
- Conditions
- Heart Failure, Congestive, Chronic Heart Failure, Depression
- Trial name
- SADHART-CHF (NCT00078286)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 469 people
- Sponsor
- Duke University
Musculoskeletal Pain, Pain
Brief Cognitive Behavioral Therapy for Chronic Pain to Improve Functioning Among Veterans
Chronic pain is very common among primary care Veterans and can seriously impact overall patient functioning and well-being. Currently, behavioral treatments for pain management are not often provided in primary care because they…
- Trial name
- NCT04724694
- Testing
- Brief CBT for Chronic Pain, Treatment as usual
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- VA Office of Research and Development
Menopause, Depression
Impact of Hot Flashes on Sleep and Mood Disturbance
We plan to enroll premenopausal women in a trial investigating the impact of hot flashes developed in response to an injection of a gonadotropin-releasing hormone agonist (GnRHa), leuprolide (brand name: Lupron), on sleep…
- Conditions
- Menopause, Depression, Hot Flashes
- Trial name
- NCT01116401
- Testing
- leuprolide
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Anxiety Disorder, Seizures
Buspirone Therapy for Localized Epilepsy
Background: Buspirone is a drug that is approved for the treatment of anxiety in adults. Studies suggest that buspirone might act on parts of the brain that can increase certain levels of brain activity.
- Conditions
- Anxiety Disorder, Seizures, Epilepsy, Partial Epilepsy
- Trial name
- NCT01496612
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Depression
Medication Treatment for Depression in Nursing Home Residents
This study will examine therapeutic and adverse effects of continuing versus discontinuing antidepressant medication in nursing home residents who have had no more than a single episode of depression and who no longer have…
- Trial name
- NCT00076622
- Testing
- Antidepressant medication, No antidepressant medication
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of Pennsylvania
Depression
Brain Energy Metabolism in Individuals With Major Depressive Disorder Receiving Escitalopram
This study will evaluate changes in brain energy metabolism due to treatment with escitalopram in people with major depressive disorder.
- Trial name
- NCT00183677
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Insomnia, Depression
Reducing Suicidal Ideation Through Insomnia Treatment
Epidemiologic reports have linked insomnia to suicidal ideation and suicide death. However, no studies have determined whether treating insomnia decreases the risk of suicidality.
- Conditions
- Insomnia, Depression, Suicidal Ideation
- Trial name
- REST-IT (NCT01689909)
- Testing
- Zolpidem-CR
- Where
- 4 sites in United States
- Volunteers
- 103 people
- Sponsor
- Augusta University
PreDiabetes, Weight Loss
The National Diabetes Prevention Program in Rural Communities
The purpose of this pilot trial is to compare feasibility and effectiveness of remote delivery (social media or video conferencing) of the National Diabetes Prevention Program (N-DPP) to adults in rural communities.
- Conditions
- PreDiabetes, Weight Loss, Lifestyle Risk Reduction
- Trial name
- Rural NDPP (NCT05387434)
- Testing
- Diabetes Prevention Program-Remote (DPP-R), Diabetes Prevention Program-Facebook (DPP-FB)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Kansas Medical Center
Depression, Problematic Alcohol Use
Scaling Up Science-based Mental Health Interventions in Latin America
Conduct systematic, multi-site mental health implementation research in both rural and urban primary care settings with a broad group of stakeholders in the US and Latin America.
- Trial name
- DIADA (NCT03392883)
- Testing
- Laddr
- Where
- 6 sites in Colombia
- Volunteers
- 1,348 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Autistic Disorder
Study of Aripiprazole in the Treatment of Children and Adolescents With Autistic Disorder (AD).
This study will compare the effectiveness (how well the drug works) of aripiprazole, flexibly dosed with a placebo, in reducing serious behavioral problems in children and adolescents with a diagnosis of autistic disorder (AD).
- Trial name
- NCT00332241
- Testing
- Aripiprazole
- Where
- 9 sites in United States
- Volunteers
- 98 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Stress, Anxiety
The Effects of Smell on Mood and Physical Responses
The purpose of this study is to examine the body's response to relaxing and stimulating fragrances commonly used in aromatherapy.
- Conditions
- Stress, Anxiety, Depression
- Trial name
- NCT00097253
- Testing
- Exposure to relaxant and stimulant odors
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
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