Clinical trials: Behavior and Behavior Mechanisms
Inactivity, Physical, Sedentary Behavior
The YourMove Study: Optimizing Individualized and Adaptive mHealth Interventions Via Control Systems Engineering Methods
The purpose of this study is to determine the efficacy of a new digital health tool that uses a phone and smartwatch to encourage physical activity and increase weekly amounts of Moderate to Vigorous Physical Activity (MVPA) over…
- Trial name
- YourMove (NCT05598996)
- Testing
- COT-Based Intervention
- Where
- United States
- Volunteers
- 386 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Cognition
Effect of Normal Aging on Language Processing
The purpose of this study is to understand the effect of age on language abilities. The investigators aim at investigating the cerebral modifications that take place in normal aging, at the functional an anatomical level.
- Trial name
- SEMVIE (NCT02189460)
- Where
- France
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Exercise
Expression of BNDF Through Stretching and Recovery
The phenomena of biological adaptation and overtraining are closely related terms, that is why in sport it is possible to identify two types of overtraining.
- Trial name
- BDNF&Exe (NCT04059120)
- Testing
- Experimental group whit specific stretching, Control group whit out specific stretching
- Where
- Mexico
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Universidad de Colima
Obsessive Compulsive Disorder
Fear Extinction and Mechanisms of Change in Obsessive Compulsive Disorder
The purpose of this study is to find out more about how the brain stores emotional learning in obsessive-compulsive disorder (OCD). In particular, we would like to understand how human beings learn not to fear.
- Trial name
- NCT02467374
- Testing
- Behavior Therapy
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Smoking
Neuroimaging Reward, Behavioral Treatment, and Smoking Cessation
The goal of this study is to evaluate the effects of a smoking cessation intervention combining behavioral treatment with low nicotine cigarettes on neuroimaging measures of reward function and smoking cessation outcomes.
- Trial name
- NCT02927847
- Testing
- Nicotine Patch, SPECTRUM Nicotine Research Cigarettes (.03 mg), Behavioral Activation
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Maggie M Sweitzer, PhD
Depression, Anxiety
Mechanism of Antidepressant-Related Dysfunctional Arousal in High-Risk Youth
A 16-week double blind, placebo-controlled investigation of escitalopram in adolescents with depression and/or anxiety with a family history of Bipolar Disorder.
- Conditions
- Depression, Anxiety, Bipolar Disorder
- Trial name
- NCT02553161
- Testing
- Escitalopram, Cognitive behavioral Psychotherapy
- Where
- 2 sites in United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Cachexia, Neoplasms
Cancer-associated Muscle Mass - Molecular Factors and Exercise Mechanisms
Muscle mass loss is a common adverse effect of cancer. Muscle mass loss occurs with or without reduction in body weight. Cancer cachexia (CC) is the involuntary loss of body weight of >5% within 6 months and it occurs in 50-80%…
- Conditions
- Cachexia, Neoplasms, Exercise, Metabolism
- Trial name
- PANACEA (NCT05307367)
- Testing
- Exercise training
- Where
- Denmark
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Physical Inactivity, Walking
Daily Goal Setting to Increase Everyday Physical Activity and Promote Cognitive Health in Midlife
The purpose of this study is to determine whether interaction with an adaptive Fitbit-based goal setting application can increase levels of everyday light intensity physical activity in middle-aged adults.
- Conditions
- Physical Inactivity, Walking, Cognitive Health, Self-regulation
- Trial name
- NCT05826379
- Testing
- Adaptive Daily Goal Setting, Interim Goal Prompt
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Drug Addiction, Nicotine Dependence
Assessing Top Down and Bottom Up Attention Mechanisms in Smokers Using Nicotine Nasal Spray
Background: Smoking is the leading cause of preventable death in the United States, and researchers are interested in gaining a better understanding of the perceived beneficial effects of nicotine to help improve treatment…
- Trial name
- NCT01136642
- Testing
- Nicotrol
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Use, Underage, Alcohol Problem Drinking
Mindfulness for at Risk Youth: Understanding Substance Use and Important Mechanisms of Change
This study will be the first to explore mindfulness as a prevention intervention among transition age youth and those with previous involvement in the juvenile or criminal justice system with substance use problems and history of…
- Conditions
- Alcohol Use, Underage, Alcohol Problem Drinking, Substance Use
- Trial name
- NCT04160754
- Testing
- Mindfulness Based Relapse Prevention, Control (CTL)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Alcohol Drinking
Effects of Topiramate on Adolescent Alcohol Use: Efficacy and Mechanisms
This study will help to determine whether the medication, topiramate, reduces alcohol use among adolescents with alcohol dependence.
- Trial name
- IMPACT (NCT01641445)
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Brown University
Elderly, Sedentary
Mechanisms and Functional Outcomes of Exercise Progression Models in the Elderly
The aim of this study is to devise a sufficiently high intensity training program that provided an optimal stimulus to remove the peripheral factors known to reduce functional capacity, and can be cardiovascular and…
- Trial name
- FIT (NCT01899586)
- Testing
- Regional Specific Training Stimulus (RSTS), Aerobic Exercise Regimen (AE)
- Where
- 2 sites in United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Duke University
PrEP, Discrimination, Racial
PrEP Awareness, Barriers and Facilitators for PrEP Uptake, and Dosing Mechanisms on Willingness to Take PrEP Among MSM
The investigators are conducting a one and one-half year mixed-methods study to evaluate self-reported sexual risk, knowledge and barriers/facilitators of PrEP use, and preferences of oral, injectable, and implantable PrEP…
- Conditions
- PrEP, Discrimination, Racial, Stigma, Social
- Trial name
- MSM (NCT04719364)
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Drexel University
Parkinson Disease, Movement Disorders
Multimodal Image Technologies Investigate the Role and Mechanism of Probiotics in Improving RBD with Parkinson's Disease
Rapid eye movement sleep behavior disorder (RBD) is important non-movement feature, and also the important risk factor of Parkinson's disease (PD).
- Conditions
- Parkinson Disease, Movement Disorders, Rapid Eye Movement Sleep Behavior Disorder, Gut Microbiomes
- Trial name
- NCT06710574
- Testing
- PD-RBD, iRBD
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Type 1 Diabetes
Mechanisms of Hypoglycemia Associated Autonomic Dysfunction Question 2
The purpose of this study is to determine the way by which Alprazolam (Xanax) an anti-anxiety drug affects specialized molecules in your brain called GABA (A) receptors that alter your body's ability to defend itself from low…
- Trial name
- Alp Ex (NCT00574639)
- Testing
- Alprazolam
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Neuropsychiatric Symptom
Dissecting Immunological and Autoimmune Mechanisms of Neuropsychiatric Diseases
The goal of this observational cohort study is to investigate the role of immune system in neuropsychiatric symptoms (NPS) and to identify immunological biomarkers that may improve the diagnosis, prognosis, and future treatment…
- Trial name
- DIAMOND (NCT07791212)
- Where
- 2 sites in United Kingdom
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- King's College London
Stress, Learning, Spatial
Influence of Stress on Encoding and Prediction
The purpose of this study is to investigate the neural mechanisms by which acute stress influences statistical learning and episodic encoding.
- Trial name
- NCT05920161
- Testing
- Socially Evaluated Cold Pressor Test, Control
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Yale University
Obesity, Appetitive Behavior
Regulation of Energy Balance and Metabolism - Mechanisms Behind and Beyond Obesity and Weight Loss
The study aims to investigate homeostatic and hedonic mechanisms regulating appetite, energy balance and metabolism in obesity and the effects of three distinct obesity treatments on these regulatory mechanisms.
- Trial name
- BALANCE (NCT03550339)
- Testing
- SURG, DIET, HAES
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Behavior Change, Dietary Behaviour
Novel Personalised Nutrition Intervention With Tailored Behavioural Support
The aim of this study is to test the efficacy of a novel personalised nutrition intervention with tailored behavioural support compared to a control personalised nutrition intervention for improving adherence to sustainable and…
- Conditions
- Behavior Change, Dietary Behaviour, Personalised Nutrition, Sustainable Healthy Diet
- Trial name
- P-NUTS (NCT07417254)
- Testing
- Personalised sustainable and healthy dietary recommendations with standardised and tailored behavioural support., Personalised sustainable and healthy dietary recommendations with standardised behavioural support.
- Where
- Ireland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Internet Gaming Disorder
The Behavioral and Brain Mechanism of IGD
This project aims to investigate whether anodal tDCS of dlPFC enhances cognitive regulation over craving an emotions.
- Trial name
- NCT02550405
- Testing
- Craving behavioral intervention
- Where
- China
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Beijing Normal University