Clinical trials: Basal Ganglia Diseases
Parkinson Disease
Asymmetric Targeted DBS for PD With PIGD
The purpose of this study is to compare the effectiveness of the deep brain stimulation of asymmetric targets [subthalamic nucleus (STN) in the right hemisphere while globus pallidus interna (GPi) in the left] versus the…
- Trial name
- ATS-PIGD (NCT05397340)
- Testing
- Deep brain stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ruijin Hospital
Parkinson's Disease (Disorder)
Effect of Deep Brain Stimulation on Neuropsychiatric Fluctuations in Patients With Parkinson's Disease
Retrospective, monocentric, observational study designed to evaluate the effects of Bilateral Subthalamic Nucleus Deep Brain Stimulation (DBS STN) on Neuropsychiatric fluctuations in Patients with Parkinson's Disease (PD)
- Trial name
- PSYCHOSTIM (NCT04608123)
- Testing
- none (observational study)
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Grenoble
Lewy Body Dementia (LBD), Alzheimer Dementia (AD)
Targeting Neuroinflammation as a Contributing Pathology in Alzheimer's Disease Dementia and Related Dementias
This study is being done to research the usefulness of PET/CT imaging for measuring brain inflammation and its relation to Alzheimer's Disease Dementia and related dementias.
- Trial name
- NCT04786223
- Testing
- C-11 ER-176, Blood Test
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Val Lowe
Parkinson Disease
Effects of Osteopathic Visceral Manipulation on the Autonomic Nervous System, Balance and Gastrointestinal Disturbances in Individuals With Parkinson's Disease
Introduction: Parkinson's disease (PD) is responsible for several changes in the body, such as balance, gastrointestinal and autonomic disorders and are associated with impairments in the clinical prognosis of these individuals.
- Trial name
- NCT05047796
- Testing
- Intervention Protocol
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Instituto Docusse de Osteopatia e Terapia Manual
Parkinson Disease
Core Stability and Parkinson Disease
Patients with Parkinson's Disease frequently present impaired postural control that leads to loss of stability and increased risk of falls.Core system, includes passive structures of the thoracolumbar spine and pelvis that work…
- Trial name
- NCT03580096
- Testing
- Core stability, Standard intervention
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Universidad de Granada
Parkinson Disease, Electroencephalogram
Predicting Outcomes From tDCS Intervention in Parkinson' Disease Using Electroencephalographic Biomarkers and Machine Learning Approach: the PREDICT Study Protocol
Parkinson's disease (PD) is a progressive and disabling neurodegenerative disease, clinically characterized by motor and non-motor symptoms.
- Conditions
- Parkinson Disease, Electroencephalogram, Transcranial Direct Current Stimulation
- Trial name
- PREDICT (NCT04819061)
- Testing
- tDCS Active
- Volunteers
- 56 people
- Sponsor
- Federal University of Paraíba
Parkinson Disease
Cognitive Exercise Therapy Approach (BETY) in Parkinson's Disease
Considering the impact of motor and non-motor findings on movement problems in the disease management of people living with PD, biopsychosocial evaluation and treatment approaches are essential.
- Trial name
- NCT06893120
- Testing
- BETY
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Orkun Tüfekçi
Parkinson Disease, Respiration
Telerehabilitation Based Exercise Training in Parkinson's Patients
Parkinson's disease (PD) is the second most common progressive disease after Alzheimer's disease.It is a progressive, multisystemic and neurodegenerative disease. The prevalence of Parkinson's disease increases with age.
- Conditions
- Parkinson Disease, Respiration, Gait Disorders, Neurologic
- Trial name
- NCT05621642
- Testing
- Breathing exercises, Core stabilization exercises, Balance and strengthening exercises
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Healthy Volunteers
Phase 1 Study of NPT200-11 in Healthy Subjects
The purpose of this study is to determine the safety, tolerability and blood levels of orally administered NPT200-11 in healthy subjects. In addition, the maximally tolerated dose will be determined.
- Trial name
- NCT02606682
- Testing
- NPT200-11
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Neuropore Therapies Inc.
Parkinson Disease
Genetic Study in Young Onset Parkinson's Disease
Parkinson's disease (PD) is the second most frequent neurodegenerative disorder after Alzheimer's disease. It causes motor dysfunctions, such as bradykinesia, resting tremor, rigidity and postural instability.
- Trial name
- NCT01529970
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Lewy Body Dementia, Parkinson Disease
Anti-Diabetic Medications to Fight PD and LBD
The purpose of this study is to test the hypothesis that DPP4 inhibitors and SGLT2 inhibitors are well tolerated and have beneficial neurological effects, specifically for Parkinson's disease and Lewy body dementia.
- Trial name
- NCT06263673
- Testing
- Sitagliptin, Dapagliflozin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Deep Brain Stimulation, Parkinson Disease
Apraxia in Parkinson's Disease Patients With Deep Brain Stimulation
Deep brain stimulation (DBS) of the subthalamic nucleus or globus pallidus internus can improve motor symptoms Parkinson's disease (PD).
- Conditions
- Deep Brain Stimulation, Parkinson Disease, Apraxia, Motor
- Trial name
- Apraxia DBS (NCT04725773)
- Testing
- Deep brain stimulation effect on apraxia
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Florida
Parkinson Disease
The Effectiveness of LSVT-BIG Training in Improving Balance and Gait in Parkinson's Patients
Parkinson's disease (PD) is a chronic, progressive disease that causes motor and non-motor symptoms due to dopaminergic neuron loss.
- Trial name
- NCT05520541
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people
- Sponsor
- Gazi University
Deep Brain Stimulation
SIS Evaluation of the MRI Defined Subthalamic Nucleus*
Retrospective review of images used to target the STN during DBS procedure and ability of the Surgical Information Sciences ("SIS") system to visualize the STN location.
- Trial name
- STN (NCT03907319)
- Testing
- SIS System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Surgical Information Sciences Inc.
Amyotrophic Lateral Sclerosis, Brainstem Stroke
Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit
This project adds to non-invasive BCIs for communication for adults with severe speech and physical impairments due to neurodegenerative diseases.
- Conditions
- Amyotrophic Lateral Sclerosis, Brainstem Stroke, Muscular Dystrophies, Parkinson's Disease and Parkinsonism
- Trial name
- BCI-FIT (NCT04468919)
- Testing
- BCI-FIT multi-modal access, BCI-FIT adaptive signal modeling, BCI-FIT active querying
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
PARKINSON DISEASE (Disorder)
Feasibility of a Community-Based Multimodal Exercise Programme in Parkinson's Disease
This study aims to evaluate the feasibility and preliminary effectiveness of a multimodal, group-based but individualised therapeutic exercise programme for people with Parkinson's disease delivered within a real-world…
- Trial name
- NCT07618728
- Testing
- Exercise Group
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Universidad Rey Juan Carlos
Parkinson Disease
Impact of Subthalamic Nucleus Deep Brain Stimulation on Pain in Parkinson Disease
Pain is a common symptom of Parkinson's disease (PD) but the physiology remains poorly understood. Recent work suggests that subthalamic nucleus deep brain stimulation (STN-DBS) could make a profit on the pain in PD.
- Trial name
- NCT02885194
- Testing
- Laser-Evoked potential
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Parkinson Disease
Neuro-immune Interactome in Parkinson's Disease
This study will be observational and have a prospective case-control longitudinal design. Eligible subjects with idiopathic REM behavior disorder (RBD), Parkinson's disease with RBD, and healthy controls will be recruited.
- Trial name
- NCT07026929
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Yale University
Parkinson's Disease
Nocturnal Parkinson's Disease Symptoms Study Group
To study associate factor of Noctural Parkinson's Disease Symptoms and quality of life in Parkinson's disease patients and caregivers.
- Trial name
- NCT01662427
- Testing
- Questionaire to assess Noctural Parkinson's Disease Symptoms
- Where
- Thailand
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Parkinson's Disease
Spinal Cord Stimulation in the Treatment of Parkinson's Disease
Parkinson's disease affects between 100'000 and 150'000 people in France. Drug therapy (L-Dopa and other drugs) is effective to improve motor symptoms but after an initial 'honeymoon period' lasting a few years, motor symptoms…
- Trial name
- STIMUPARK (NCT02381951)
- Testing
- spinal cord stimulation (St Jude Medical)
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
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