Clinical trials: Autonomic Nervous System
Complex Regional Pain Syndromes
Infrared Imaging in Complex Regional Pain Syndrome
This research proposal aims to investigate the potential use of Infrared (FLIR) imaging to monitor the successful achievement of the sympathetic blockade in patients with complex regional pain syndrome (CRPS).
- Trial name
- NCT05693337
- Testing
- Forward Looking Infrared Radar (FLIR) thermal imaging
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hospital for Special Surgery, New York
Symptomatic Neurogenic Orthostatic Hypotension, MSA
Phase 3 Clinical Effect Durability of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure
A Phase 3, 22-week, Multi-center, Randomized Withdrawal Study of ampreloxetine in Treating Symptomatic Neurogenic Orthostatic Hypotension in Subjects with Primary Autonomic Failure
- Conditions
- Symptomatic Neurogenic Orthostatic Hypotension, MSA, Parkinson's Disease (PD), Pure Autonomic Failure (PAF)
- Trial name
- REDWOOD (NCT03829657)
- Testing
- ampreloxetine
- Where
- 82 sites in United States, Australia and 17 more
- Volunteers
- 203 people
- Sponsor
- Theravance Biopharma
Complex Regional Pain Syndrome Type I
Mirror Therapy in Complex Regional Pain Syndrome Type I
The aim is to evaluate the efficacy of Mirror Therapy on pain reduction and hand function in subjects with unilateral upper extremity Complex Regional Pain Syndrome Type I.
- Trial name
- NCT06100107
- Testing
- Mirror Therapy exercise
- Volunteers
- 27 people
- Sponsor
- University Hospital, Motol
Heart Rate Control, Recovery Following Exercise
Recovery of Heart Rate Variability in Handball Players
This study aimed to compare the acute effects of manual massage (MM) and foam rolling (FR) on heart rate variability (HRV) following a 20 m shuttle run test (20m-SRT) in elite male handball players.
- Trial name
- HRV-HANDBAll (NCT07648966)
- Testing
- Manul Massage (MM), Foam Rolling (FR)
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Uludag University
Cardiac Pacemaker, Artificial, Cardiac Rhythm Disorder
Aveir DR i2i Study
Prospective, non-randomized, multi-center, international study designed to evaluate the safety and effectiveness of the Aveir™ Dual-Chamber (DR) Leadless Pacemaker system.
- Conditions
- Cardiac Pacemaker, Artificial, Cardiac Rhythm Disorder, Bradycardia
- Trial name
- NCT05252702
- Testing
- Aveir DR Leadless Pacemaker System
- Where
- 78 sites in United States, Austria and 11 more
- Volunteers
- 464 people
- Sponsor
- Abbott Medical Devices
Diabetes, Hypertension
Effects of Intralipid Versus Olive Oil Infusions on Endothelial Function, Immune Function, Inflammatory Markers
Recent evidence suggests that increased levels of a circulation fat (free fatty acids or FFAs) can cause high blood pressure and cardiac complications. Intralipid is the only type of fat approved by the FDA for clinical use.
- Conditions
- Diabetes, Hypertension, Obesity
- Trial name
- NCT00989339
- Testing
- Twenty-four Hour TPN and Saline Infusion
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Spinal Cord Injury
CE-STAND: Cervical Epidural STimulation After Neurologic Damage
CE-STAND aims to address three areas under-represented in research: chronic, cervical, and autonomic dysfunction. It is both significant and highly impactful, as treating autonomic dysfunction could substantially improve function…
- Trial name
- NCT06410001
- Testing
- Epidural Spinal Cord Stimulation System
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Minnesota
Systemic Lupus Erythematosus, Autoimmune Disorder
Modelling and Control of Non-invasive Vagus Nerve Stimulation for Autoimmune Diseases (1A)
The overall goal of this clinical trial is to evaluate the causality relationship between the non vagus nerve stimulation waveform parameters and the therapeutic effect.
- Conditions
- Systemic Lupus Erythematosus, Autoimmune Disorder, Vagus Nerve Autonomic Disorder
- Trial name
- VaNeSA (NCT05704153)
- Testing
- Parasym 1Hz, Parasym 30Hz
- Where
- Spain
- Volunteers
- 18 people
- Sponsor
- Hospital Clinic of Barcelona
Autonomic Nervous System Imbalance, Heart Rate Variability (HRV)
Evaluating the Feasibility, Acceptability, and Preliminary Outcomes of Heart Rate Variability Biofeedback for Individuals With Opioid Use Disorder.
The goal of this clinical trial is to evaluate the feasibility, acceptability, and preliminary outcomes of a heart rate variability biofeedback (HRVB) intervention among adults with opioid use disorder (OUD) receiving residential…
- Conditions
- Autonomic Nervous System Imbalance, Heart Rate Variability (HRV), Opioid Use Disorder, Breathing Techniques
- Trial name
- NCT07361731
- Testing
- Heart rate variability biofeedback
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Arizona State University
Complex Regional Pain Syndromes
Spatially Transcriptomics Reveals Molecular Signatures in CRPS
This observational study aims to understand phenotype-specific molecular signatures in patients with complex regional pain syndrome (CRPS).
- Trial name
- NCT05986461
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University
Solid Tumors, Breast Cancer
A Phase I/II Study of BGT226 in Adult Patients With Advanced Solid Malignancies Including Patients With Advanced Breast Cancer
This is a phase I/II clinical research study with BGT226, an inhibitor of phosphatidylinositol 3'-kinase (PI3K). The study consists of a Phase I dose escalation part followed by a safety expansion part and a Phase II expansion…
- Conditions
- Solid Tumors, Breast Cancer, Cowden Syndrome
- Trial name
- NCT00600275
- Testing
- BGT226
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 57 people
- Sponsor
- Novartis Pharmaceuticals
Complex Regional Pain Syndromes
Prognostic Factors for Complex Regional Pain Syndrome
The investigators would like to examine the role of some relevant biopsychosocial factors in the development of persistent CRPS.
- Trial name
- CRPSPrognosis (NCT05337501)
- Testing
- Collecting data
- Where
- Belgium
- Volunteers
- 113 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Parkinson's Disease (PD)
Music Therapy in Parkinson's Disease
This study aims to examine whether individual music therapy - involving the slow, gentle bowing of a string instrument, accompanied by the music therapist's singing and lyre playing - can have a relaxing and calming effect on…
- Trial name
- NCT07734181
- Testing
- Music therapy
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Siegward -M. Elsas
Migraine, Cluster Headache
Saccadometry in Primary Headache Syndromes
Migraine is one of the commonest neurological disorders, affecting up to 12% of the general population, but remains relatively under-diagnosed and under-treated.
- Conditions
- Migraine, Cluster Headache, Control, Menstrual Migraine
- Trial name
- NCT01395264
- Where
- 2 sites in United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Tim Young
Chronic Pain, Neuropathic Pain
Intraoperative Neuromonitoring Recording With a Novel SCS Paddle
The purpose of this study is to demonstrate safety and efficacy of a new spinal cord stimulation paddle electrode which is able to target the dorsal horns, dorsal nerve roots, and dorsal columns.
- Conditions
- Chronic Pain, Neuropathic Pain, Failed Back Surgery Syndrome, Complex Regional Pain Syndromes
- Trial name
- NCT05045625
- Testing
- HD Study Electrode
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Albany Medical College
Arthroscopic Knee Surgery, Lower Limb Fractures
Comparison of Gait Parameters Between Floor and Sponge Surfaces and Special Shoes
This study compares the gait pattern of individuals with weight bearing difficulties walking on the floor, a soft surface, or with special shoes (Kyboot).
- Conditions
- Arthroscopic Knee Surgery, Lower Limb Fractures, Back Pain and Asymmetric Gait, Complex Regional Pain Syndrome
- Trial name
- NCT02742376
- Testing
- Soft surface, Floor, Kyboot shoes
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Myocardial Ischemia, Myocardial Infarction
Optimizing Patient Experience During Myocardial Perfusion Imaging
The present study focusses on the effects of the diagnostic testing environment on psychological wellbeing, cardiac symptoms and patient satisfaction during cardiac stress testing (CST) in patients who are referred to the…
- Conditions
- Myocardial Ischemia, Myocardial Infarction, Autonomic Dysfunction
- Trial name
- OPTIMIZE (NCT05896982)
- Testing
- Care as usual with information support, Care as usual with supportive coaching, Care as usual with information support and supportive coaching
- Where
- Netherlands
- Volunteers
- 149 people
- Sponsor
- Tilburg University
Parkinson Disease
Effects of Osteopathic Visceral Manipulation on the Autonomic Nervous System, Balance and Gastrointestinal Disturbances in Individuals With Parkinson's Disease
Introduction: Parkinson's disease (PD) is responsible for several changes in the body, such as balance, gastrointestinal and autonomic disorders and are associated with impairments in the clinical prognosis of these individuals.
- Trial name
- NCT05047796
- Testing
- Intervention Protocol
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Instituto Docusse de Osteopatia e Terapia Manual
Type 2 Diabetes, Diabetes With Diabetic Autonomic Neuropathy (Diagnosis)
The Ameliorative Effects of GLP-1RA on Diabetic Cardiac Autonomatic Neuropathy
Diabetic cardiac autonomic neuropathy (DCAN) is a common chronic complication that reduces survival in patients with diabetes. Epidemiological surveys have shown that the prevalence of DCAN is 25-75% in people with type 2…
- Trial name
- NCT06461377
- Testing
- Glucagon-like peptide-1 receptor agonist：Semaglutide
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Pain Management
LASER Effects Blood Flow
This study investigate the potential impact of low power laser (LPL), an non-invasive physical therapy, on the cardiovascular system by focusing on its effect on heart rate and autonomic tone.
- Trial name
- LASERBF (NCT07369843)
- Testing
- physical therapy (low power LASER)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Saint Paul's Hospital, Congregation Of The Sisters Of Saint Paul De Chartres