Clinical trials: Automated Drug Delivery
Advanced Parkinson's Disease, Refractory Epilepsy
An Automated Navigation System for Deep Brain Electrode Implantation
1. Analysis of the correlation between imaging and electrophysiological signals. 2. Real time analysis method for optimal implantation position. 3. Simultaneous Imaging and electrophysiology navigation. 4.
- Conditions
- Advanced Parkinson's Disease, Refractory Epilepsy, Obsessive-compulsive Disorder
- Trial name
- NCT06396494
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Hepatocellular Carcinoma
CT/MR-US Automatic Fusion System in Pre-procedure Planning for Radiofrequency Ablation
To prospectively evaluate the technical success rate of real-time computed tomography/CT/magnetic resonance imagingMR and -ultrasound (CT/MRI-US) automatic fusion system and the long-term therapeutic efficacy of radiofrequency…
- Trial name
- NCT04844112
- Testing
- automatic CT/MRI-US fusion system guided radiofrequency ablation
- Volunteers
- 139 people
- Sponsor
- Seoul National University Hospital
Traumatic Brain Injury (TBI) Patients, Severe Traumatic Brain Injury
SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain Injury
Objective: This prospective interventional study introduces "SeeMe," an automated, high-resolution computer vision platform designed to objectively quantify microscopic, auditory command-evoked movements in patients with…
- Trial name
- NCT07560631
- Testing
- SeeMe Multimodal Auditory Command Protocol
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Diabetes
Artificial Pancreas in Latin America
The purpose of this study is to use closed-loop systems with the algorithms designed by the University of Virginia and by the Instituto Tecnologico de Buenos Aires (ITBA)/ Universidad Nacional de La Plata (UNLP)/ Universidad…
- Trial name
- NCT02994277
- Testing
- 1° Phase: UVa algorithm 2° Phase: ITBA/UNLP algorithm
- Volunteers
- 5 people
- Sponsor
- Hospital Italiano de Buenos Aires
Type 1 Diabetes
Short Term Closed-loop Glucose Control in Adults With Type 1 Diabetes
The main objective of this study is to determine the feasibility, efficacy and safety of automated closed-loop glucose control in the home setting over a short term period.
- Trial name
- AP@home02 (NCT01666028)
- Testing
- FlorenceD or similar closed loop glucose control system, CSII with real-time CGM
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 18 people
- Sponsor
- University of Cambridge
Breast Cancer Screening
Evaluation of an mHealth Intervention to Promote Participation in Breast Cancer Screening in Argentina
We carried out with a mixed-method study including a pragmatic randomized controlled trial to evaluate effectiveness of the intervention and quantitative and qualitative evaluation of the implementation from women and…
- Trial name
- NCT06500936
- Testing
- SMS
- Where
- Argentina
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Centro de Estudio de Estado y Sociedad
Asthma
Automated Inhaler Monitoring for Asthma Medication Usage
The goal of this clinical trial is to evaluate the aflo™ digital platform's ability to improve inhaler use technique and asthma control for children, adolescents, and adults with uncontrolled asthma.
- Trial name
- AIM (NCT06825871)
- Testing
- Smart Inhaler Monitoring Platform for Asthma Management
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Boston Children's Hospital
Diabetes Type 1
A Clinical Trial to Evaluate The Effects of Semaglutide and Empagliflozin Combined to Automated Insulin Delivery on Diabetes Control in Adults Living With Type 1 Diabetes
The goal of this clinical trial is to learn if Empagliflozin and Semaglutide, individually and combined, added to Automated Insulin Delivery (AID) works to improve time-in-range in adults living with Type 1 Diabetes.
- Trial name
- SEMPA (NCT06894784)
- Testing
- Intervention Period 1: Semaglutide + Empagliflozin
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Sleep Apnea Syndromes
ScreenOX - An Automated At-home Screening Test for Adult Sleep Apnea Using Nocturnal Oximetry
The sleep apnea-hypopnea syndrome (SAHS) is a respiratory disorder characterized by frequent breathing cessations (apneas) or partial collapses (hypopneas) during sleep.
- Trial name
- ScreenOX (NCT03295149)
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Hospital del Rio Hortega
Tobacco Use Cessation
Ask Advise Connect (AAC) Harris Heath CPRIT
The goal of this behavioral research study is to learn about the outcomes of smoking cessation treatment. Researchers want to learn how many smokers stopped smoking after taking part in smoking cessation treatment with the Texas…
- Trial name
- NCT01788787
- Testing
- Quitline-Delivered Proactive Telephone Counseling, Follow-Up Phone Call, Smoking Cessation Training
- Where
- United States
- Volunteers
- 5,212 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Bradycardia, Sick Sinus Syndrome
Beluga - Clinical Observations of Automatic Algorithms for Cardiac Pacing
This study shall evaluate in daily medical practice the clinical results of the AV delay hysteresis search algorithm in patients with a INSIGNIA ULTRA or AVT pacemaker implanted for one of the three following indications: sinus…
- Conditions
- Bradycardia, Sick Sinus Syndrome, Heart Block
- Trial name
- NCT00286858
- Testing
- Insignia Ultra and Insignia AVT
- Where
- 40 sites in France, Guadeloupe
- Volunteers
- 903 people
- Sponsor
- Boston Scientific Corporation
Type 1 Diabetes
Low cArbohydraTe dIeT and aUtomated Insulin Delivery System for Type 1 DiabetEs
This is a randomized, controlled study in people living with type 1 diabetes using an automated insulin delivery (AID) system. Participants will be assigned to a control diet (45% carbohydrate) or a low carb diet (25%…
- Trial name
- LATITUDE (NCT05449678)
- Testing
- Low-carb diet
- Volunteers
- 38 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Disorder of Consciousness, Consciousness, Loss of
SeeMe: An Automated Tool to Detect Early Recovery After Brain Injury
Early prediction of outcomes after acute brain injury (ABI) remains a major unsolved problem. Presently, physicians make predictions using clinical examination, traditional scoring systems, and statistical models.
- Conditions
- Disorder of Consciousness, Consciousness, Loss of, Trauma, Brain, Traumatic Brain Injury
- Trial name
- NCT06083441
- Testing
- SeeMe, Coma Recovery Scale-Revised (CRS-R)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Hepatocellular Carcinoma
Study of Automatic Image Fusion of a CT Volume With Ultrasound During Percutaneous Ablation Treatment of Hepatic Tumors
The automatic fusion of the ultrasound with a cone-beam CT volume will guide the positioning of the electrodes, despite the visibility of the tumor in ultrasound, in patients treated with irreversible electroporation in the…
- Trial name
- IAT (NCT04420026)
- Testing
- Interact Active Tracker
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypoxaemia, Chronic Lung Disease
Effects of an Automatic Oxygen Titration System in People With Hypoxemia During Exercise Training
Long-term oxygen therapy is a fundamental treatment modality for patients with chronic hypoxaemic lung disease. Typically, oxygen is administered at a constant flow rate.
- Trial name
- NCT06545851
- Testing
- Oxygen therapy - constant oxygen flow, Oxygen therapy - automatic titrating oxygen flow
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Type 1 Diabetes
Closed Loop Insulin Therapy in Type 1 Diabetics Based on Blood Microdialysis, Online Sensors and an eMPC Algorithm
The EU funded project CLINICIP (Closed Loop Insulin Infusion for Critically Ill Patients) aims to develop a low-risk monitoring and control device which allows maintaining metabolic control in intensive care units.
- Trial name
- NCT00535483
- Where
- Austria
- Volunteers
- 4 people
- Sponsor
- Medical University of Graz
Neonatal Respiratory Distress, Very Low Birth Weight Infant
PRICO: OPTI Target Range
The aim of the study is to determine if a narrower SpO2 Target Range setting automated control of FiO2 (A-FiO2) is more effective than a wider SpO2 Target Range
- Trial name
- POSTR (NCT06207994)
- Testing
- Narrow TR, Shifted TR
- Where
- Czechia
- Volunteers
- 11 people
- Sponsor
- Czech Technical University in Prague
Secondary Peritonitis
Treatment of Peritonitis in Automated Peritoneal Dialysis
The main infectious complication of peritoneal dialysis (PD) is bacterial peritonitis, which increases morbidity, mortality and conversion to hemodialysis. In Mexico, 485 patients per million people undergo PD.
- Trial name
- NCT04077996
- Testing
- Peritonitis treatment placed in APD, Peritonitis treatment with one exchange in CAPD
- Where
- 3 sites in Mexico
- Volunteers
- 64 people
- Sponsor
- Universidad de Colima
Diabetes Mellitus, Type 1
Effect of Inhaled Technosphere Insulin vs RAA Insulin on Exercise-Induced Hypoglycemia in Adults With T1D Using Automated Insulin Delivery
This investigator-initiated study will enroll about 30 adults 18 to 65 years of age with type 1 diabetes (T1D) who are using the Tandem t:slim X2 insulin pump or Tandem Mobi insulin pump with Control-IQ or Control-IQ+ technology…
- Trial name
- INHALE-AIDEx (NCT06880835)
- Testing
- Control IQ + sleep or exercise activity with TI
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Jaeb Center for Health Research
Type 1 Diabetes Mellitus, Sleep Quality
Safety and Effectiveness of the Luna System in People With Type 1 Diabetes Mellitus
The purpose of this research is to evaluate the effect of a wearable insulin pump on blood sugar levels during sleep. The study device works with continuous glucose monitors (CGM) to calculate and deliver rapid-acting insulin…
- Trial name
- AID4MDI (NCT06627517)
- Testing
- Episodic overnight patch pump
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Luna Diabetes