Clinical trials: Autoimmune Encephalitis
Paraneoplastic Neurological Syndrome, Autoimmune Encephalitis
Metabolic Imaging for Diagnosis and Prognostication of Autoimmune encephalitiS
Autoimmune encephalitis (AE) is a rare neurological disorder mediated by autoimmune antibody response against neuronal cell surface and intraneuronal proteins associated with specific brain areas, resulting in severe inflammation…
- Trial name
- MIDAS (NCT06432803)
- Testing
- PET-Scan analysis
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Hospices Civils de Lyon
Multiple Sclerosis
Difference in Efficacy of Natalizumab Versus Fingolimod for the Treatment of Multiple Sclerosis
Under the escalation treatment strategy when a patient displays breakthrough disease parameters under first line therapy, MS physicians are allowed by the EMEA to switch for Natalizumab (NTZ) or fingolimod (FGL).
- Trial name
- BEST-MS (NCT01981161)
- Testing
- biological samples and clinical data
- Where
- 12 sites in France, Germany and 1 more
- Volunteers
- 307 people
- Sponsor
- University Hospital, Toulouse
Autoimmune Encephalitis
Mechanisms of Auto-immune Encephalitis
Neurological and psychiatric diseases are one of the major health problems worldwide. Decades of fundamental and clinical research have led to the model that these disorders results from synaptic imbalance between excitatory…
- Trial name
- MECANO (NCT02905136)
- Testing
- Fundamental research
- Where
- France
- Volunteers
- 253 people
- Sponsor
- Hospices Civils de Lyon
CASPR2-Antibody, Encephalitis Autoimmune
CASPR2 Encephalitis Initial Symptoms
Auto-immune encephalitides involve auto-antibodies targeting the central nervous system, and particularly the synapse and its structure, such as protein CASPR2.
- Conditions
- CASPR2-Antibody, Encephalitis Autoimmune, Paraneoplastic Syndromes
- Trial name
- iniCASPR2 (NCT04653571)
- Testing
- CASPR2 encephalitis
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Hospices Civils de Lyon
Acute Disseminated Encephalomyelitis, Encephalitis Autoimmune
High-throughput Omic Technology for Identification of Biomarkers of Relapsing Acute Disseminated Encephalomyelitis in Immune Cell Network
Acute disseminated encephalomyelitis (ADEM) is a neuroinflammatory disorder of the central nervous system, manifesting itself as impaired consciousness, even to the point of coma, and multifocal neurological deficits.
- Trial name
- HOT-BRAIN (NCT06863974)
- Testing
- Blood test
- Where
- 8 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Angers
Autoimmune Encephalitis, Paraneoplastic Neurological Syndrome
Epidemiology of Autoimmune Encephalitides and Paraneoplastic Neurological Syndromes in Sweden
Autoimmune encephalitis and paraneoplastic neurological syndromes are rare diseases caused by an abnormal immune response toward the nervous system.
- Trial name
- NCT04708626
- Testing
- Description and analysis
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- Uppsala University
Neuromyelitis Optica Spectrum Disorders (NMOSD), Multiple Sclerosis
Cohort Study on Neuroimmune Diseases in the Reproductive Age
Neuroimmune diseases are more prevalent among women of reproductive age. Studies have shown that neuroimmune diseases may impact fertility.
- Conditions
- Neuromyelitis Optica Spectrum Disorders (NMOSD), Multiple Sclerosis, Autoimmune Encephalitis, Myasthenia Gravis
- Trial name
- RANID (NCT07653984)
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Meningitis, Encephalitis
The Effectiveness and Safety of Human Lumbar Puncture Assist Device (LPat)
The purpose of this study is to proof and investigate the effectiveness and safety of the invented device named "Human Lumbar Puncture Assist Device (LPat)" as an assist tool to be utilized to improve the success rate of…
- Conditions
- Meningitis, Encephalitis, Guillain-Barré, Subarachnoid Hemorrhage
- Trial name
- LPat (NCT03710278)
- Testing
- LPat Device
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Spartanburg Regional Healthcare System
Rheumatic Diseases, Lupus Erythematosus, Systemic
Pain Phenotyping of Rheumatic Diseases - An Observational Study
Background: Rheumatic diseases can affect the joints, ligaments, tendons, bones, muscles, and skin. They can also cause inflammation, damage body tissues, and change nerve signals in the brain.
- Conditions
- Rheumatic Diseases, Lupus Erythematosus, Systemic, Lupus Vasculitis, Central Nervous System, Arthritis
- Trial name
- NCT07829497
- Testing
- Bedside quantitative sensory testing
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Systemic Lupus Erythematosus
Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus
The purpose of this study is to determine whether Libman-Sacks endocarditis (inflammation of the heart valves) is the cause of neuropsychiatric manifestations (stroke, transient ischemic attacks, cognitive dysfunction, seizures…
- Trial name
- NCT00858884
- Testing
- Clinical and laboratory evaluations, transesophageal echocardiography, carotid duplex, transcranial duplex, and magnetic resonance of the brain
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of New Mexico
Anti-NMDA Receptor Encephalitis
Transcranial Direct Current Stimulation on Cortical Plasticity in Patients With Anti-NMDA Receptor Encephalitis
Patients suffering from anti-NMDA receptor encephalitis show impaired NMDA-receptor dependent neuronal transmission. Furthermore, they often have cognitive deficits of different magnitude.
- Trial name
- NCT01865578
- Testing
- tDCS
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Encephalitis, Encephalitis, Viral
Efficacy and Safety of Calculus Bovis Sativus (CBS) for Adult Encephalitis (CBSinEncephalitis)
Based on the records of traditional Chinese medicine, CBS has the functions of purifying the heart, eliminating phlegm, stimulating bile secretion, and soothing the nerves.
- Conditions
- Encephalitis, Encephalitis, Viral, Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody, Autoimmune Encephalitis
- Trial name
- NCT06584045
- Testing
- Calculus bovis sativus (CBS)
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Autoimmune Encephalitis
Efficacy and Safety of Adjunctive Minocycline in the Treatment of Autoimmune Encephalitis
Autoimmune encephalitis (AE) is an immune-mediated brain disorder characterized by varied clinical manifestations that correlate with specific types of antibodies.Typical symptoms include acute behavioral changes, psychosis…
- Trial name
- NCT06033846
- Testing
- Minocycline
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
NMDAR Autoimmune Encephalitis
Long-term Impact of NMDAR Encephalitis, Level 3
NMDA receptor antibody encephalitis is a rare autoimmune neurological disease of the central nervous system with an estimated incidence of 1.5 people per million per year.
- Trial name
- SAPIENCE 3 (NCT07158229)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Autoimmune Encephalitis
Neuro-ophthalmology and Autoimmune Encephalitis (NODE)
Autoimmune encephalitis represents a group of rare and heterogeneous neurological disorders. Pathophysiological mechanisms in these diseases are still unknown. Recently, oculomotor and neurovisual disorders have been described.
- Trial name
- NODE (NCT03872284)
- Testing
- oculomotor movement recordings, neurovisual assessment
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Hospices Civils de Lyon
Autoimmune Encephalitis (AE), Autoimmune Cerebellitis
Efficacy and Safety of Low-Dose Blinatumomab in the Treatment of Refractory Autoimmune Encephalitis and Autoimmune Cerebellitis
This is a multicenter, single-arm, continuous, prospective, interventional registry study designed to systematically evaluate the efficacy and safety of low-dose blinatumomab in patients with antibody-mediated refractory…
- Trial name
- NCT07686042
- Testing
- Blinatumomab
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Beijing Tiantan Hospital
Anti NMDA Receptor Encephalitis
Clinical-immunological Features of Anti-NMDAR Encephalitis
Using a retrospective cohort of 501 patients with anti-NMDAR encephalitis to assess clinical and immunological prognostic biomarkers
- Trial name
- Bio-NMDAr (NCT05738668)
- Testing
- Description of clinical characteristic
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Hospices Civils de Lyon
Autoimmune Encephalitis
BRIEF TITLE * (in English and Sufficiently Descriptive) Role of MRI in Anti-LGI1 Encephalitis
The term "autoimmune encephalitis" denotes an heterogenous group of diseases commonly associated with autoantibodies targeting neural or glial antigens.
- Trial name
- LGI1-IRM (NCT05825690)
- Testing
- Retrospective evaluation of specific brain MRI features
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Paraneoplastic Neurological Syndrome, Autoimmune Encephalitis
Diagnostic Performance of a Commercial Assay for the Detection of Neuronal Antibodies
Detection of autoantibodies targeting neuronal surface or intracellular antigens is a keystone for the diagnosis and the treatment of auto-immune encephalitis and paraneoplastic neurological syndromes.
- Trial name
- IFINEURO (NCT05783947)
- Testing
- Indirect immunofluorescence assay on tissue slides and cell-based assays with CSF and/or sera
- Where
- 2 sites in France
- Volunteers
- 34 people
- Sponsor
- Hospices Civils de Lyon