Clinical trials: Autoimmune Diseases
Autoimmune Diseases, Cancer
The Biodistribution of 1-L-(2 Deoxy-2,- 18 Fluoroarabinofuranosyl) Cytosine ([18F]L-FAC) in Healthy Subjects and Patients With Cancer, Autoimmune and Inflammatory Diseases
The purpose of this study is to determine the biodistribution of a new agent 1-L-(2 deoxy-2,-18fluoroarabinofuranosyl) cytosine non-invasively in healthy humans and to evaluate whether it can be used to image cancer, autoimmune…
- Trial name
- NCT01180868
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Anemia, Anemia, Hemolytic
Efficacy and Safety of Levamisole Combined With Standard Prednisolone in Warm Antibody Autoimmune Hemolytic Anemia.
The purpose of this study is to determine whether Levamisole plus prednisone can further improve the efficacy，extend the remission duration and reduce the dosage of prednisone for newly diagnosed warm antibody autoimmune…
- Conditions
- Anemia, Anemia, Hemolytic, Anemia, Hemolytic, Autoimmune, Hemolysis
- Trial name
- NCT01579110
- Testing
- levamisole, Prednisone
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Down Syndrome With and Without Auto Immune Abnormalities
Pilot Study of Auto-immune Abnormalities Associated With Down Syndrome
The purpose of the study is to identify biological data linked to auto immune abnormalities associated with Down Syndrome.
- Trial name
- IMMUTRI (NCT01041469)
- Where
- 2 sites in France
- Volunteers
- 72 people
- Sponsor
- Institut Jerome Lejeune
Psoriasis Vulgaris
Safety and Efficacy of Multiple Doses of BT061 in Patients With Moderate to Severe Chronic Plaque Psoriasis
This Phase II clinical study is to test safety and efficacy of BT061 against psoriasis given as repeated doses.
- Trial name
- NCT01072383
- Testing
- BT061
- Where
- 13 sites in Czechia, Hungary
- Volunteers
- 49 people
- Sponsor
- Biotest
Type 2 Diabetes
Stem Cell Educator Therapy in Type 2 Diabetes
Type 2 diabetes is the most common form of diabetes. The prevalence of diabetes has been markedly increased in recent years. More and more children and young adults develop this devastating disease.
- Trial name
- NCT01415726
- Testing
- Stem Cell Educator
- Where
- China
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Healthy Humans
Immune and Metabolic Effects of Vitamin D Supplementation in Healthy Humans
In this placebo controlled study the investigators aim to investigate the effect of a 3 month vitamin D supplementation on parameters of the immune, endocrine and metabolic system in healthy women and men. Vitamin D.
- Trial name
- NCT01248442
- Testing
- Cholecalciferol
- Where
- Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Diabetes, Hypoglycemia
Phase 1 Study of BHT-3021 in Subjects With Type 1 Diabetes Mellitus
The purpose of this study is to determine the safety of BHT-3021 injections given weekly for 12 weeks and to evaluate the effect of BHT-3021 on antibody and immune (T cell) responses to autoantigens (e.g. insulin).
- Trial name
- NCT00453375
- Testing
- BHT-3021
- Where
- 18 sites in United States, Australia and 1 more
- Volunteers
- 80 people
- Sponsor
- Bayhill Therapeutics
Latent Autoimmune Diabetes in Adult (LADA)
Safety of Diamyd® in Patients With LADA (Latent Autoimmune Diabetes in Adult)
This is a study to investigate the safety of 20ug Diamyd® (rhGAD65 formulated in Alhydrogel®), administered subcutaneously four weeks apart in patients with Latent Autoimmune Diabetes in Adult (LADA).
- Trial name
- NCT00456027
- Testing
- rhGAD65 formulated in Alhydrogel® (Diamyd®)
- Where
- 17 sites in Sweden
- Volunteers
- 160 people
- Sponsor
- Diamyd Therapeutics AB
Keratoconjunctivitis Sicca, Sjogren's Syndrome
Six Month Clinical Research Study for Patients With Moderate or Severe Dry Eye Syndrome
A six-month clinical research trial to evaluate the effectiveness of an investigational medication for the treatment of dry eye syndrome in patients that have been diagnosed with moderate to severe dry eye syndrome, an autoimmune…
- Conditions
- Keratoconjunctivitis Sicca, Sjogren's Syndrome, Lupus Erythematosus, Systemic, Arthritis, Rheumatoid
- Trial name
- NCT00025818
- Testing
- Ophthalmic Emulsion
- Where
- 17 sites in United States
- Volunteers
- 290 people
- Sponsor
- Allergan
Autoimmune Hemolytic Disease (Cold Type) (Warm Type)
A Single-Arm Pilot Study With Low-Dose Rituximab Plus Standard Oral Prednisone In Idiopathic Autoimmune Hemolytic Anemia
The aim of this prospective study was to evaluate the activity, safety and the duration of the response of low dose rituximab associated with standard oral prednisone as first line therapy in newly diagnosed warm autoimmune…
- Trial name
- NCT01345708
- Testing
- prednisone, low dose rituximab
- Where
- 2 sites in Italy
- Volunteers
- 23 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Autoimmune Disease
Gastrointestinal and Health-related Quality of Life Outcomes in Patients With Autoimmune Diseases Treated With Mycophenolate
Treatment with the immunosuppressive drug mycophenolate mofetil (MMF) may result in gastrointestinal (GI) complications in some patients.
- Trial name
- NCT00351377
- Testing
- Enteric-coated Mycophenolate Sodium
- Where
- Germany
- Volunteers
- 111 people
- Sponsor
- Novartis Pharmaceuticals
Diabetes Mellitus, Insulin-Dependent
Safety and Efficacy of Mesenchymal Stem Cells in Newly-diagnosed Type 1 Diabetic Patients
Type 1 diabetes mellitus results from the autoimmune destruction of the insulin producing pancreatic β-cells. The autoimmune response begins months or even years before the presentation of hyperglycemic symptoms.
- Trial name
- NCT01322789
- Testing
- Intravenous Mesenchymal stem cell infusion
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Glomerulonephritis, Autoimmune Diseases
Calcitriol in the Treatment of Immunoglobulin A Nephropathy
Immunoglobulin A (IgA) nephropathy is the common primary glomerulonephritis in the world. Much literature suggests that vitamin D and its analogs have profound effects on immune system function and glomerular mesangial cell…
- Trial name
- NCT00862693
- Testing
- Calcitriol
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University First Hospital
Thymoma Staging, Clinical Presentations
Characteristics of Patients With Thymoma in Chulalongkorn Hospital
The purpose of this study is to study characteristics of patients with thymoma in Chulalongkorn hospital between 2003-2007.
- Conditions
- Thymoma Staging, Clinical Presentations, Associated Disorders, Laboratory Findings
- Trial name
- NCT01123590
- Where
- Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Cold Agglutinin Disease
Therapy for Chronic Cold Agglutinin Disease
Chronic cold agglutinin disease (CAD) is a type of autoimmune hemolytic anemia (anemia due to destruction of red blood cells by abnormal antibodies).
- Trial name
- NCT00373594
- Testing
- Rituximab, Fludarabine
- Where
- 6 sites in Norway, Russia
- Volunteers
- 30 people
- Sponsor
- University of Bergen
Autoimmune Thyroiditis
Low-Level Laser Therapy in Chronic Autoimmune Thyroiditis
The purpose of this study is to evaluate whether low-level Laser therapy is effective in ameliorating the thyroid function of patients with hypothyroidism caused by chronic autoimmune thyroiditis.
- Trial name
- NCT01129492
- Testing
- Low-level Laser therapy
- Where
- Brazil
- Volunteers
- 43 people
- Sponsor
- University of Sao Paulo General Hospital
Inflammation, Cancer
Ashwagandha: Effects on Stress, Inflammation and Immune Cell Activation
Ayurvedic medicine has been practiced in for more than 2,500 years. Ashwagandha is one of the most widely utilized herbs in the system. It is thought to affect the endocrine, immune, nervous, and cardiopulmonary systems.
- Conditions
- Inflammation, Cancer, Autoimmune Diseases
- Trial name
- NCT00817752
- Testing
- Ashwagandha
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
Raynaud's Disease, Raynaud's Disease Secondary to Scleroderma
A Study of a Topical Form of Nitroglycerin and Placebo in the Treatment and Prevention of Raynaud's Phenomenon
The purpose of this research study is to test the safety, tolerability, and effectiveness of Topical AmphiMatrix with Nitroglycerin (MQX0503) to relieve Raynaud's symptoms and increase blood flow to the fingers.
- Conditions
- Raynaud's Disease, Raynaud's Disease Secondary to Scleroderma, Raynaud's Disease Secondary to Other Autoimmune Disease
- Trial name
- NCT00577304
- Testing
- Nitroglycerin, Topical AmphiMatrix
- Where
- 17 sites in United States
- Volunteers
- 200 people
- Sponsor
- MediQuest Therapeutics
Diabetes Mellitus, Type 1
Islet Transplantation for Patients With Type 1 Diabetes
This protocol will test whether Type 1 diabetes (T1DM) can be reversed in patients with stable renal allografts by islet transplantation.
- Trial name
- NCT00073281
- Testing
- Islet transplantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Proteinuria, Diabetic Nephropathy
Effect of Renin Angiotensin System Blockade on the Fas Antigen (CD95) and Asymmetric Dimethylarginine (ADMA) Levels in Type-2 Diabetic Patients With Proteinuria
In recent years, diabetic nephropathy, which may lead to dialysis treatment, is the most prevalent underlying disease of people in developed countries.
- Conditions
- Proteinuria, Diabetic Nephropathy, Chronic Kidney Disease
- Trial name
- NCT00893425
- Testing
- ramipril
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine