Clinical trials: Autism
Attention Deficit Disorder With Hyperactivity (ADHD), Autism Spectrum Disorder (ASD)
External Trigeminal Nerve Stimulation for Children With ASD + ADHD to Reduce Elevated Symptoms
The goal of this clinical trial is to learn if external trigeminal nerve stimulation (eTNS) works to treat ADHD symptoms in children on the autism spectrum (ASD).
- Trial name
- eTNS CARES (NCT07214545)
- Testing
- Trigeminal Nerve Stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Autism Spectrum Disorder (ASD
Monitoring Daily Mobility in Children With Autism
Children with autism spectrum disorder (ASD) often show motor abnormalities and sleep disturbances that affect behavior, learning, and family quality of life.
- Trial name
- SIMBA (NCT07519369)
- Testing
- placement of a wearable wrist sensor
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Autism Spectrum Disorder
FMS-CrossFit Training Program (FCTP) to Improve School Readiness in Preschool Children With Autism Spectrum Disorder
Autism spectrum disorder (ASD) is an increasing public health concern, with preschool children often exhibiting persistent deficits in school readiness.
- Trial name
- NCT07532395
- Testing
- FCTP program, treatment as usual (TAU) (Control Group)
- Where
- 2 sites in China
- Volunteers
- 184 people
- Sponsor
- Peking University
Autism Spectrum Disorder
Structured Sensory-Based Occupational Therapy in Children With Autism
This controlled clinical study will investigate the effects of a 12-week structured sensory-based occupational therapy intervention on occupational performance, sensory processing, gross motor development, and eating behaviors in…
- Trial name
- NCT07789704
- Testing
- Structured Sensory-Based Occupational Therapy, Individualized Home Activity Program
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emre DANSUK
Autism Spectrum Disorder (ASD)
Expression Intensity Modulates Social Intention Understanding in ASD Children
Children watch videos of a single model playing with toys, judge whether the model desires a new toy based on observing the model's varying expression intensities, and form a judgment on whether the model intends to obtain a new…
- Trial name
- NCT07884032
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Autism Spectrum Disorder
Individualized Parent-Based Nutrition Education in Preschool Children With Autism Spectrum Disorder
Feeding difficulties, such as food selectivity and refusal to try new foods, are common among preschool children with autism spectrum disorder (ASD).
- Trial name
- NCT07884097
- Testing
- Individualized Parent-Based Nutrition Education Programme
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Firat University
Neurodevelopmental Disorders, Intellectual Disability
Multi-Omics Genetic Investigation Strategies to Enhance the Diagnostic Workflow for Rare Diseases
LEOPARD is a multicenter study aimed at improving the genetic diagnosis of patients with neurodevelopmental disorders (NDDs) of unknown etiology, particularly those with moderate-to-severe intellectual disability.
- Conditions
- Neurodevelopmental Disorders, Intellectual Disability, Autism Spectrum Disorder, Genetic Diseases, Inborn
- Trial name
- LEOPARD (NCT07884227)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Giannina Gaslini
Autism, Autism Spectrum Disorder
Optimizing Outcomes for Young Autistic Children
The overarching goal of the proposed study is to: (a) determine how best to sequence two parent-mediated interventions: a social communication intervention (Project ImPACT, Improving Parents as Communication Teachers) and a…
- Trial name
- NCT05926687
- Testing
- Social Communication, Disruptive Behavior, Social Communication + Reduce Frequency
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Autism Spectrum Disorder (ASD), Anxiety
Adapted Group Therapy Compared With Usual Care for Anxiety and Depression in Adults With an Autism Diagnosis
The goal of this clinical trial is to learn whether an adapted group therapy works to treat anxiety and depression in adults with an autism diagnosis. The therapy is a form of cognitive behavioral therapy (CBT).
- Conditions
- Autism Spectrum Disorder (ASD), Anxiety, Depression
- Trial name
- CoMind (NCT07880028)
- Testing
- Autism-adapted group cognitive behavioral therapy
- Volunteers
- 154 people
- Sponsor
- Lovisenberg Diakonale Hospital
Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP)
French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls
The goal of this study is to learn whether people living with severe psychiatric disorders can be grouped into more homogeneous subgroups, across usual diagnostic categories, based on two key dimensions: social withdrawal and…
- Conditions
- Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP), Bipolar Disorder (BD), Major Depressive Disorder (MDD
- Trial name
- FRENCH-MINDS (NCT07881016)
- Testing
- 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments
- Where
- 17 sites in France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fondation FondaMental
Autism Spectrum Disorder
Reducing Challenging Behaviors in Children With Autism Through Digital Health
School-based behavioral approaches to managing challenging behaviors in children with ASD are limited by three key factors: 1) children with ASD often have difficulties communicating their emotions; 2) it is challenging to…
- Trial name
- NCT05277194
- Testing
- KeepCalm app
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Pennsylvania
Autism Spectrum Disorder (ASD, Prospective Study
Prospective Clinical Study on Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Childhood Autism
This clinical study aims to evaluate whether a nasal spray containing exosomes derived from human umbilical cord mesenchymal stem cells (hUC-MSC-EXOs) can safely and effectively improve core symptoms in children aged 3-7 years…
- Trial name
- EXO-ASD (NCT07243561)
- Testing
- hUC-MSC-Exos Nasal Spray
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Dongfang People's Hospital
Autism Spectrum Disorder
Mobile App-Based Intervention to Improve Toothbrushing in Children and Teens With Autism
The goal of this clinical trial is to test whether the autism-friendly app improves toothbrushing outcomes compared to a control app with only a digital mirror and countdown timer among children and teens (ages 8-17 years) with…
- Trial name
- BU (NCT07446413)
- Testing
- Brush Up App, Brush Down App
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of Washington
Autism Spectrum Disorder, Anxiety
Heart Rate Variability Biofeedback for Anxiety in Autistic Youth
Heart rate variability biofeedback (HRVB) is a breathing-based intervention that reduces anxiety in a range of populations. Second-generation wearable HRVB devices not only deliver scheduled biofeedback practice sessions but also…
- Trial name
- NCT07812233
- Testing
- Lief Smart Patch
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Autism Spectrum Disorder
Cognitively Enhanced Tai Chi for Executive Function in Children With Autism Spectrum Disorder
This study compares three exercise courses for children aged 8-11 years with autism spectrum disorder: Tai Chi with added cognitive challenges, standard Tai Chi, and general exercise.
- Trial name
- NCT07322952
- Testing
- Cognitively Enhanced Tai Chi, Standard Tai Chi, General Exercise
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Jinan University Guangzhou
Schizophrenia, Autism-Related Irritability
A Study to Evaluate the Long-term Safety and Tolerability of Xanomeline and Trospium Chloride for the Treatment of Psychiatric Disorders in Children and Adolescents
The purpose of this study is to evaluate the long-term safety and tolerability of Xanomeline and Trospium Chloride for the treatment of psychiatric disorders in children and adolescents
- Trial name
- NCT07424404
- Testing
- KarXT, KarX-EC
- Where
- 104 sites in United States, Australia and 9 more
- Volunteers
- 400 people
- Sponsor
- Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Autism Spectrum Disorder, Childhood
Preliminary Exploration of the Usability of a Structured Plate to Improve Eating Behaviors in Children With Autism Spectrum Disorder and Its Impact on the Family: A Pilot Study
This completed single-arm pilot study examined the usability of a structured plate during routine classroom mid-morning snacks in children with autism spectrum disorder and feeding difficulties.
- Conditions
- Autism Spectrum Disorder, Childhood, Feeding Difficulties
- Trial name
- PlaTEA (NCT07516431)
- Testing
- Structured Plate
- Where
- Spain
- Volunteers
- 6 people
- Sponsor
- Universidad de Zaragoza
Autism, Intervention (Training) Condition
Parent-Mediated Social Cognition Intervention for Young Children With Autism Spectrum Disorder
This study evaluates the efficacy of the Companion Mind-Drawing Cooperative Game Program, a parent-mediated, home-based structured play intervention targeting social cognitive development in young children with autism spectrum…
- Conditions
- Autism, Intervention (Training) Condition, Social Cognition, Cognition Improvement
- Trial name
- PMSC-ASD (NCT07708246)
- Testing
- Companion Mind-Drawing Cooperative Game Program
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Fudan University
Autism
Interactive Massage Intervention in Toddlers With Autism Spectrum Disorder
This randomized controlled trial aims to evaluate the efficacy of a 3-month maternal interactive massage intervention in toddlers aged 18-24 months with autism spectrum disorder (ASD).
- Trial name
- IMI-ASD (NCT07876245)
- Testing
- Maternal Interactive Massage, Behavioral
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Autism Spectrum Disorder (ASD), Motivation
Motivation for Daily Living Skills
The goal of this clinical trial is to enhance motivation to complete daily living skills among 16 to 25-year-old autistic teens and young adults.
- Trial name
- NCT07159308
- Testing
- Intrinsic Motivation Treatment, Extrinsic Motivation Treatment, Combined Intrinsic and Extrinsic Motivation Treatment
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Children's Hospital of Philadelphia