Clinical trials: Atypical Hyperplasia
Breast Cancer
Protocol for Women at Increased Risk of Developing Breast Cancer
A pilot study to assess the effects of six months of letrozole on breast tissue risk markers in postmenopausal women on hormone replacement therapy at high risk of developing breast cancer.
- Trial name
- NCT00291135
- Testing
- letrozole
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Carol Fabian, MD
Malignant Mesothelioma, Metastatic Cancer
Mesothelin and Osteopontin as Diagnostic Markers in Patients With Mesothelioma or Atypical Mesothelial Hyperplasia
RATIONALE: Studying levels of mesothelin and osteopontin in samples of blood from patients with mesothelioma or atypical mesothelial hyperplasia may help doctors identify biomarkers related to cancer.
- Trial name
- NCT00899613
- Testing
- laboratory biomarker analysis, study of high risk factors
- Where
- France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Caen
High Grade Squamous Intraepithelial Neoplasia, Stage 0 Uterine Corpus Cancer
Megestrol in Treating Patients With Endometrial Neoplasia or Endometrial Hyperplasia
This randomized phase II trial is studying how well megestrol works in treating patients with endometrial neoplasia or endometrial hyperplasia. Estrogen can cause the growth of endometrial cancer cells.
- Trial name
- NCT00503581
- Testing
- Biopsy, Laboratory Biomarker Analysis, Megestrol Acetate
- Where
- 50 sites in United States
- Volunteers
- 9 people
- Sponsor
- Gynecologic Oncology Group
Endometrial Neoplasms, Atypical Endometrial Hyperplasia
GnRHa + Letrozole in Non-obese Progestin-insensitive Endometrial Cancer and Atypical Hyperplasia Patients
To investigate the efficacy of GnRHa plus letrozole vs Diane-35 plus metformin in non-obese progestin-insensitive early-stage endometrial cancer (EEC) and atypical hyperplasia(EAH) patients asking for conservative treatment.
- Conditions
- Endometrial Neoplasms, Atypical Endometrial Hyperplasia, Progesterone Resistance
- Trial name
- NCT05316935
- Testing
- GnRHa, Letrozole 2.5mg, Diane-35
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Xiaojun Chen
Endometrial Neoplasms, Atypical Endometrial Hyperplasia
GnRHa + Letrozole in Obese Progestin-insensitive Endometrial Cancer Patients
To investigate the efficacy of GnRHa plus letrozole in obese progestin-insensitive EEC patients.
- Conditions
- Endometrial Neoplasms, Atypical Endometrial Hyperplasia, Progesterone Resistance, Obesity
- Trial name
- NCT06379113
- Testing
- GnRH antagonist, Letrozole 2.5mg
- Where
- 2 sites in China
- Volunteers
- 29 people
- Sponsor
- Xiaojun Chen
Female, Endometrial Hyperplasia Without Atypia
Longitudinal Follow-up in Women With Endometrial Hyperplasia Without Atypia
This study will prospectively enroll a total of 1000 patients (200 per year) simple hyperplasia/complex hyperplasia (SH/CH) without atypia.
- Trial name
- NCT05292573
- Testing
- Metformin
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- Chang Gung Memorial Hospital
Normal Vulval Skin, Lichen Sclerosus
Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease
Can vibrational spectroscopy be used to accurately assess vulval skin conditions? Vulval skin disorders are common and the diagnosis of these conditions can be difficult.
- Conditions
- Normal Vulval Skin, Lichen Sclerosus, High Grade Dysplasia - Usual Type ('VIN 2-3'), High Grade Dysplasia - Differentiated Type ('VIN 2-3')
- Trial name
- Vulval VS (NCT02223975)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Gloucestershire Hospitals NHS Foundation Trust
Endometrial Cancer, Hereditary Non-polyposis Colon Cancer (hmsh2, hmlh1, hpms1, hpms2)
Intrauterine Levonorgestrel and Observation or Observation Alone in Preventing Atypical Endometrial Hyperplasia and Endometrial Cancer in Women With Hereditary Non-Polyposis Colorectal Cancer or Lynch Syndrome
RATIONALE: The use of intrauterine levonorgestrel may prevent atypical endometrial hyperplasia and endometrial cancer in women with hereditary non-polyposis colorectal cancer or Lynch syndrome.
- Trial name
- NCT00566644
- Testing
- levonorgestrel-releasing intrauterine system, questionnaire administration, observation
- Where
- 20 sites in United Kingdom
- Volunteers
- 600 people
- Sponsor
- St George's, University of London
Atypical Lobular Hyperplasia, Atypical Ductal Hyperplasia
Molecular Breast Imaging in Women With Atypia and LCIS
We aim to determine if Molecular Breast Imaging (a new nuclear medicine technique developed at Mayo) can identify malignant breast lesions in women who have atypical ductal hyperplasia, atypical lobular hyperplasia, or lobular…
- Conditions
- Atypical Lobular Hyperplasia, Atypical Ductal Hyperplasia, Lobular Carcinoma in Situ
- Trial name
- NCT00620087
- Testing
- Molecular Breast Imaging, Screening Mammography
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Breast Cancer
Protocol for Postmenopausal Women at Increased Risk of Developing Breast Cancer
To examine nipple aspirate fluid for secretions that may be identified as a high risk indicator for development of breast cancer, and compare those to serum analysis.
- Trial name
- NCT00291083
- Where
- United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Carol Fabian, MD
Breast Cancer, Precancerous Condition
Breast Cancer Registry for Participants With Breast Cancer or Characteristics of Hereditary Breast Cancer
RATIONALE: Gathering information about patients with breast cancer and their families may help the study of breast cancer in the future.
- Trial name
- BCCR (NCT00666731)
- Testing
- medical chart review, questionnaire administration, study of socioeconomic and demographic variables
- Where
- 65 sites in United States
- Volunteers
- 4,945 people
- Sponsor
- University of Nebraska
Atypical Endometrial Hyperplasia
Metformin Plus Megestrol Acetate As a Fertility-sparing Treatment in Patients with Atypical Endometrial Hyperplasia
To verify whether metformin could improve the effect of progestin as fertility-sparing treatment in patients with atypical endometrial hyperplasia(AEH).
- Trial name
- NCT04607252
- Testing
- Metformin plus Megestrol acetate, Megestrol Acetate
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Fudan University
Mouth Diseases
Evaluation of Oral Potentially Malignant Disorders (OPMDs) with STRATICYTE™
The purpose of this study is to validate the ability of the STRATICYTE™ predictive model to predict the transformation of oral potentially malignant disorders (OPMDs) to oral squamous cell carcinoma (OSCC) in a retrospective…
- Trial name
- NCT05853783
- Testing
- STRATICYTE™ Test
- Where
- 5 sites in United States
- Volunteers
- 180 people
- Sponsor
- Proteocyte Diagnostics Inc.
Endometrial Hyperplasia, Fertility Issues
A Pilot Study on Fertility Conservative Treatment of Atypical Endometrial Hyperplasia in Singapore
The investigators' objective is to determine the regression rate, side effects and acceptability of Mirena compared to megace in the treatment of atypical endometrial hyperplasia among women desiring fertility.
- Conditions
- Endometrial Hyperplasia, Fertility Issues, Disease Regression, Treatment Side Effects
- Trial name
- NCT05492487
- Testing
- Mirena, Megace
- Where
- 3 sites in Singapore
- Volunteers
- 60 people
- Sponsor
- KK Women's and Children's Hospital
Endometrioid Endometrial Cancer, Atypical Endometrial Hyperplasia
Canagliflozin Plus Progestin for Atypical Endometrial Hyperplasia and Early-Stage Endometrial Cancer
This study aims to evaluate whether the addition of canagliflozin to levonorgestrel-releasing intrauterine system (LNG-IUS) treatment, as compared with matching placebo or with the addition of metformin, increases the rate of…
- Trial name
- NCT07890064
- Testing
- LNG-IUS: levonorgestrel intrauterine system, Metformin, Canagliflozin
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Wang Yingmei
Atypical Endometrial Hyperplasia, Fertility Issues
Weight Management Plus LNG-IUS/Megestrol Acetate in Endometrial Atypical Hyperplasia
To investigate the efficacy of weight management plus levonorgestrel intrauterine system (LNG-IUS) or megestrol acetate (MA) in obese patients with endometrial atypical hyperplasia (EAH) asking for conservative therapy.
- Conditions
- Atypical Endometrial Hyperplasia, Fertility Issues, Overweight and Obesity
- Trial name
- NCT05316493
- Testing
- Intensive Lifestyle Intervention (ILI), Megestrol Acetate 160 MG Oral Tablet, Levonorgestrel-Releasing Intrauterine Contraceptive System (Mirena), 52 Mg
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Xiaojun Chen
Grade 1 Endometrial Endometrioid Adenocarcinoma, Grade 2 Endometrial Endometrioid Adenocarcinoma
The Effect of Neoadjuvant DMPA on Glandular Cellularity in Women Awaiting Hysterectomy
Objective: To compare pre- and post-treatment glandular cellularity in women with complex atypical hyperplasia or grade 1-2 endometrial adenocarcinoma who are treated with intramuscular depot medroxyprogesterone acetate (DMPA)…
- Conditions
- Grade 1 Endometrial Endometrioid Adenocarcinoma, Grade 2 Endometrial Endometrioid Adenocarcinoma, Complex Atypical Endometrial Hyperplasia
- Trial name
- NCT02335203
- Testing
- Depot medroxyprogesterone acetate
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Breast Cancer
Protocol for Postmenopausal Women at Increased Risk of Developing Breast Cancer
A study to examine the potential associations between common single nucleotide polymorphisms and pre-cancerous conditions in breast tissue specimens from postmenopausal women.
- Trial name
- NCT00329017
- Testing
- Fine needle aspiration
- Where
- United States
- Sponsor
- Carol Fabian, MD
Atypical Endometrial Hyperplasia and Endometrial Cancer
Conservative Treatment for Atypical Endometrial Hyperplasia and Early Endometrial Cancer
Exploring the efficacy and pregnancy outcomes of conservative treatment for atypical endometrial hyperplasia and endometrial cancer. Study the factors related to predicting treatment efficacy.
- Trial name
- NCT06170684
- Volunteers
- 100 people
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
DCIS, LCIS
Molecular Analysis of the Sloane Project
The Sloane Project is a UK wide prospective audit of screen detected non-invasive and atypical breast hyperplasias named after John Sloane an eminent pathologist interested in the field.
- Conditions
- DCIS, LCIS, Atypical Ductal Hyperplasia, Atypical Lobular Hyperplasia
- Trial name
- NCT05868252
- Where
- United Kingdom
- Volunteers
- 1,500 people
- Sponsor
- King's College London