Clinical trials: Atrophy, Disuse
Muscle Atrophy, Disuse Atrophy (Muscle) of Lower Leg
The Regulation of Human Skeletal Muscle Mass by Contractile Perturbation
It is well known that periods of weight training lead to increases in skeletal muscle size and strength. In contrast, periods of inactivity such as bed rest or immobilization result in losses of skeletal muscle size and strength.
- Trial name
- HYPAT (NCT03046095)
- Testing
- Unilateral Resistance Exercise, Immobilization
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- McMaster University
Immobilization, Muscle Disuse Atrophy
Neuromuscular Electrical Stimulation During Immobilization Due to Ankle Fractures
Rationale: Situations such as fractures of the lower extremity can necessitate a prolonged period of immobilization in otherwise healthy individuals.
- Trial name
- ANKL-ES (NCT02469506)
- Testing
- Neuromuscular Electrical Stimulation (NMES)
- Where
- Netherlands
- Volunteers
- 1 people
- Sponsor
- Maastricht University Medical Center
Disuse Osteoporosis, Atrophy, Disuse
Activity Dependent Rehabilitation Model to Improve Bone and Muscle Outcomes
For many after spinal cord injury (SCI) there is immobilization, muscle atrophy, bone loss, fracture risk during transferring (or falls), and the risk of secondary complications, and increase in attendance care and cost.
- Conditions
- Disuse Osteoporosis, Atrophy, Disuse, Nervous System, Structural; Marker
- Trial name
- NCT02309983
- Testing
- Electrical Stimulation, Stand Retraining with Body Weight Support (BWS)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Kessler Foundation
Atrophy, Disuse, Insulin Resistance
Bedrest, Feeding Pattern, and Insulin Sensitivity
In the present study, the investigators will assess the impact of two different feeding patterns (continuous vs intermittent) on insulin sensitivity and muscle mass following bedrest.
- Trial name
- NCT02521025
- Testing
- Intermittent feeding pattern, Continuous feeding pattern
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Disuse Atrophy
Bed-rest, Muscle Mass and Insulin Sensitivity
In the present study, the effects of 7 days of bed rest on muscle mass, muscle fiber characteristics and insulin sensitivity will be determined.
- Trial name
- NCT02109380
- Testing
- Bed rest
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Knee Osteoarthritis, Disuse Atrophy
Effects of Kneehab 12-week Peri-operative Total Knee Arthroplasty
Determine the efficacy of neuromuscular electrical stimulation (NMES, Kneehab) in promoting accelerated recovery of quadriceps function in patients recovering from total knee arthroplasty (TKA) as measured by increases in…
- Trial name
- KneehabTKA (NCT01096524)
- Testing
- Standard Physiotherapy, Kneehab
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Bio-Medical Research, Ltd.
Disuse Atrophy, Aging
Immobilization and Protein Supplementation (IM-PRO)
In the present study, the effects of 5 days of lower limb immobilization with or without twice-daily protein supplementation on muscle mass and muscle fiber characteristics will be determined.
- Trial name
- IM-PRO (NCT01588808)
- Testing
- Immobilization
- Where
- Netherlands
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Disuse Atrophy, Immobilization
Electrical Stimulation During Immobilization
In the present study, the effects of 5 days of lower limb immobilization with or without daily neuromuscular electrical stimulation on muscle mass and muscle fiber characteristics will be determined.
- Conditions
- Disuse Atrophy, Immobilization, Neuromuscular Electrical Stimulation
- Trial name
- ESDIM (NCT01513486)
- Testing
- immobilization
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Disuse Atrophy
Leucine Supplementation and Skeletal Muscle Disuse
Leucine supplementation is widely known for promoting strong influence on skeletal muscle remodeling. This study aims to evaluate the effect of leucine supplementation on disuse-induced skeletal muscle atrophy.
- Trial name
- NCT01192009
- Testing
- Leucine
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Multifidus Disuse Atrophy
Short Arc Multifidus Study
Patients will be performing Logan short arc banding protocols to see the effect on multifidus size
- Trial name
- NCT00846664
- Testing
- Logan Short Arc Banding
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Logan College of Chiropractic