Clinical trials: Atrium; Fibrillation
Atrial Fibrillation
Inhibition of Aldosterone to Reduce Myocardial Diffuse Fibrosis in Patients With Paroxysmal and Persistent Atrial Fibrillation in Preventing Recurrent Episodes of Atrial Fibrillation
A randomized, double-blinded, placebo-controlled study to evaluate the effect of spironolactone in addition to conventional treatment compared with placebo in patients with paroxysmal and persistent atrial fibrillation with…
- Trial name
- INSPIRE-AF (NCT02764619)
- Testing
- Spironolactone
- Where
- Denmark
- Volunteers
- 125 people
- Sponsor
- Svendborg Hospital
Non-valvular Atrial Fibrillation (AF)
Watchman FLX Pro CT Pilot Study
The primary objective of this study is to measure device tissue coverage post-implantation of the WATCHMAN FLX™ Pro Left Atrial Appendage Closure (LAAC) Device (WATCHMAN FLX Pro) using the serial advanced imaging modalities of…
- Trial name
- NCT05567172
- Testing
- Left atrial appendage closure device WM FLX Pro
- Where
- Denmark
- Volunteers
- 43 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation, Stroke
Transesophageal Echocardiography to Identify pAtients With Low Risk of Stroke in Atrial Fibrillation - TIARA Pilot Study
In this multi centre pilot study we will perform TEE in patients with AF who are eligible for VKA treatment. TTE will be used as pre-screening: if TTE shows left atrial abnormalities or aortic plaque, patients will be excluded…
- Trial name
- TIARA (NCT00224757)
- Testing
- Transoesophageal echocardiography
- Where
- 10 sites in Netherlands
- Volunteers
- 227 people
- Sponsor
- The Interuniversity Cardiology Institute of the Netherlands
Atrial Fibrillation, Lung Cancer
Study of Amiodarone Given Before Lung Surgery to Prevent Atrial Fibrillation After Lung Resection
Atrial fibrillation is a very common complication of pulmonary resection. Patients who develop atrial fibrillation require additional treatment and are more likely to stay in the hospital for longer period of time increasing the…
- Trial name
- NCT00300495
- Testing
- Amiodarone, Control arm, standard care
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Beth Israel Deaconess Medical Center
Colorectal Cancer, Atrial Fibrillation New Onset
Atrial Fibrillation After Surgery for Colorectal Cancer
This study will report the incidence of atrial fibrillation after elective colorectal cancer resection in the over 65 age group.
- Trial name
- AFAR (NCT04037319)
- Testing
- 24 Hour Holter Monitor
- Where
- United Kingdom
- Volunteers
- 720 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Atrial Fibrillation
Cryoballoon vs. Rhythmia Guided Ablation for Recurrent AFib
The purpose of this research is to evaluate whether cryoballoon ablation vs. radiofrequency ablation guided by high-fidelity mapping (Rhythmia) is the best treatment strategy to perform repeat ablation for recurrent atrial…
- Trial name
- NCT03811795
- Testing
- ECG monitoring with a Kardia Mobile monitor
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Valley Health System
Chronic B-cell Malignancies, BTK Inhibitors
Zanubrutinib and Acalabrutinib Use and Risk of Atrial Fibrillation in Patients With Chronic B-cell Malignancies
Background. Zanubrutinib and acalabrutinib are both associated with an increased risk of atrial fibrillation (AF) but AF comparative risk between these 2 BTK inhibitors (BTKis) remains largely unknown. Objectives.
- Conditions
- Chronic B-cell Malignancies, BTK Inhibitors, Cardiovascular Diseases
- Trial name
- NCT07283965
- Testing
- Zanubrutinib, Acalabrutinib
- Volunteers
- 15,000 people
- Sponsor
- University Hospital, Caen
Atrial Fibrillation (AF)
Accuracy of Cardiac Wearables Devices to Detect Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia. This study is to assess the heart rhythm device accuracy of five cardiac wearable devices (Apple Watch, Kardia Mobile/Kardia Mobile 6L, Fitbit Sense, Samsung Galaxy…
- Trial name
- NCT04809922
- Testing
- cardiac wearable devices
- Where
- Switzerland
- Volunteers
- 312 people
- Sponsor
- University Hospital, Basel, Switzerland
Atrial Fibrillation, Atrial Arrhythmia
Clinical and Healthcare Economic OutcoMes From ReAl-worlD Use in Europe of an AI Software During AF Ablation
The goal of this Observational Prospective Multi-center Study is to observe the acute and long-term safety and performance outcomes after spatiotemporal dispersion-based AF/AT ablation utilizing the Volta Medical AI software in…
- Conditions
- Atrial Fibrillation, Atrial Arrhythmia, Arrhythmias, Cardiac
- Trial name
- COMRADE-AI (NCT06083012)
- Testing
- Cardiac mapping
- Where
- 7 sites in France, Germany
- Volunteers
- 186 people
- Sponsor
- Volta Medical
Atrial Fibrillation, Periodontal Disease
Tooth Extraction in Patients With Atrial Fibrillation in Use of New Oral Anticoagulants
The purpose of this study is to evaluate the safety of a protocol which does not suspend the new oral anticoagulants (dabigatran, rivaroxaban and apixaban) in front of dental extractions in patients with non-valvular atrial…
- Conditions
- Atrial Fibrillation, Periodontal Disease, Hemorrhage
- Trial name
- NCT03181386
- Testing
- Rivaroxaban, Dabigatran and Apixaban, Warfarin
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Atrial Fibrillation
A Clinical Trial Screening for Atrial Fibrillation (AF-CATCH)
1. Study name:A randomized clinical trial on atrial fibrillation screening by using an automated electrocardiogram system in an elderly Chinese population 2.
- Trial name
- AF-CATCH (NCT02990741)
- Where
- China
- Volunteers
- 4,348 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Hypertension and Atrial Fibrillation
ARB and CCB Longest Combination Treatment on Ambulatory and Home BP in Hypertension With Atrial Fibrillation -Multicenter Study on Time of Dosing (ACROBAT)
Evaluation of 24-hour antihypertensive effect of long-acting ARB-CCB tablet administrated to hypertensive patients with atrial fibrillation, and comparison of 24-hour antihypertensive effect of long-acting ARB-CCB tablet between…
- Trial name
- ACROBAT (NCT01748253)
- Testing
- Telmisartan-amlodipine tablet administration group (morning), Telmisartan-amlodipine tablet administration group (bedtime)
- Where
- Japan
- Volunteers
- 80 people
- Sponsor
- Acrobat Trial Group
Atrial Fibrillation
Study of Normal Conditions of Use, Dosing, and Safety of Intravenous (IV) Administration of Vernakalant (MK-6621-049)
This non-interventional prospective study is a post-authorization safety study (PASS) of vernakalant conducted to collect information about normal conditions of use and appropriate dosing, and to quantify possible medically…
- Trial name
- NCT01370629
- Testing
- Vernakalant
- Where
- 6 sites in Austria, Denmark and 4 more
- Volunteers
- 2,015 people
- Sponsor
- Correvio International Sarl
Atrial Fibrillation
Coagulation Activity and Thrombogenesis in Patients With Atrial Fibrillation
Atrial fibrillation confers up to 5-fold increased risk of stroke in the absence of valvular heart disease. Although epidemiological studies have linked various clinical and echocardiographic risk factors to stroke, the exact…
- Trial name
- NCT02451254
- Testing
- circumferential ablation, SVT ablation
- Where
- 2 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Deep Sedation, Oxygen Therapy
HFNC Vs LFNC in Patients with AF Undergoing RFCA Under Deep Sedation.
Oxygen supplementation through high flow nasal cannula (HFNC) may reduce the incidence of desaturation and hypoxemia during deep sedation at radiofrequency catheter ablation (RFCA procedures).This study is designed to test the…
- Conditions
- Deep Sedation, Oxygen Therapy, Radiofrequency Ablation
- Trial name
- NCT04842253
- Testing
- High flow nasal cannula
- Where
- Netherlands
- Volunteers
- 141 people
- Sponsor
- Maastricht University Medical Center
Atrial Fibrillation
Impact of Cardiac Prehabilitation, REhabilitation and Patient EDucation on Outcomes in Patients Undergoing First-time AF Ablation
Atrial fibrillation (AF) is a term used to describe an irregular, and often very rapid, heartbeat. AF increases the risk of a number of diseases associated with the heart and cardiovascular system.
- Trial name
- CREED AF (NCT06042231)
- Testing
- Exercise Intervention, Education Intervention
- Where
- United Kingdom
- Volunteers
- 107 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Paroxysmal Atrial Fibrillation
STOP AF First Post-Approval Study
The STOP AF First PAS is a prospective, global, multi-center, observational trial.
- Trial name
- NCT05227053
- Testing
- Arctic Front™ Cardiac Cryoablation Catheter
- Where
- 11 sites in United States
- Volunteers
- 142 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Atrial Fibrillation (AF)
Augmented Reality Aided Remote Access and Technical Support for Complex Ablation Procedures
Prospective, randomized, controlled, single-center pilot study evaluating the feasibility and safety of augmented reality-based remote technical support using the Microsoft HoloLens and EnSite™ Connected Care compared with…
- Trial name
- HOLO-Remote (NCT07777042)
- Testing
- HoloLens supported catheter ablation, On-site supported catheter ablation
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Luebeck
Atrial Fibrillation, Heart Failure, Diastolic
Atrial Fibrillation Ablation
Objective. Atrial fibrillation (AF) recurrence after catheter ablation (CA) is a relevant clinical problem. Methods. 123 patients with paroxysmal AF will be identified and screened for participation in this randomized…
- Trial name
- NCT03410966
- Testing
- trans cateheter ablation
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Campania Luigi Vanvitelli
Persistent Atrial Fibrillation
Epicardial Mini-Maze Versus Catheter Ablation for the Management of Persistent Atrial Fibrillation
This study will assess the efficacy of catheter ablation versus the Wolf Mini-Maze surgical ablation for rhythm control in patients with persistent afib.
- Trial name
- EMMCAF (NCT03446222)
- Testing
- Catheter ablation, Mini-maze surgical procedure
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston