Clinical trials: Atrial Enlargement
Atrial Fibrillation, Thoracoscopic Ablation
Thoracoscopic Versus Catheter Ablation in Persistent Atrial Fibrillation With Enlarged Left Atrium
This is a prospective, single-center, open-label, randomized controlled trial comparing thoracoscopic surgical ablation with percutaneous endocardial catheter ablation as the first rhythm-control procedure in patients with…
- Conditions
- Atrial Fibrillation, Thoracoscopic Ablation, Endocardial Ablation
- Trial name
- NCT07783984
- Testing
- Thoracoscopic ablation, Percutaneous catheter ablation
- Where
- South Korea
- Volunteers
- 194 people
- Sponsor
- Samsung Medical Center
Persisent Atrial Fibrillation, Reversal of Atrial Enlargement
Left Atrial Volume Changes Who Underwent Cardioversion and Recurrence of AF After RF Ablation in Persistent AF (SAFE-AF)
Electrical/pharmacological cardioversion improves structural remodeling of left atrium. We hypothesize that persistent atrial fibrillation (AF) patients with more significant left atrial size reduction after cardioversion have…
- Conditions
- Persisent Atrial Fibrillation, Reversal of Atrial Enlargement, Recurrence of Atrial Fibrillation
- Trial name
- SAFE-AF-ABL (NCT06523738)
- Testing
- 1. electrical/pharmacological cardioversion. 2.pulmonary vein isolation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Hypertrophic Cardiomyopathy
Insertable Cardiac Monitors in Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is associated with sudden cardiac death and an increased risk of atrial fibrillation and subsequent embolic event.
- Trial name
- ElucidateHcm (NCT03259113)
- Testing
- Insertable cardiac monitor
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Region Gävleborg
4-electrode Tablet-based Electrocardiogram (ECG) System, Electrical Activity of the Heart
4-electrode ECG (DigitalCardio®) vs Standard 10-electrode ECG: Evaluating Ease of Use and Recording Quality
The goal of this clinical trial is to compare the time required to record a complete Electrocardiogram (ECG) trace using the DigitalCardio (CardioSecur®) tablet device versus a standard 12-lead ECG device in eligible patients.
- Conditions
- 4-electrode Tablet-based Electrocardiogram (ECG) System, Electrical Activity of the Heart, Atrial or Ventricular Arrhythmias, Intracardiac Conduction Abnormalities
- Trial name
- FAST-ECG (NCT07732283)
- Testing
- standard 10-electrode ECG acquisition, 4-electrode DigitalCardio acquisition
- Where
- 2 sites in France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Clinique Bizet
Heart Failure, Congestive
BNP Testing in Patients With SOB on Presentation to ED
A trial to examine whether a new heart failure blood test can improve the outcome of patients presenting to the Emergency Department with shortness of breath.
- Trial name
- NCT00163709
- Testing
- BNP test
- Where
- Australia
- Volunteers
- 600 people
- Sponsor
- Bayside Health
Atrial Fibrillation, Hypertrophic Cardiomyopathy
HCM-AF Ablation With ACUTUS
BACKGROUND About 1/4 of patients with hypertrophic cardiomyopathy (HCM) seem to develop atrial fibrillation (AF) over their life-span.
- Trial name
- NCT04090437
- Testing
- Catheter ablation procedure
- Volunteers
- 20 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Embolic Stroke of Undetermined Source
Cardea SOLOTM for Paroxysmal Atrial Fibrillation Diagnosis in ESUS Patients With Left Atrial Enlargement
The aim of the study is to evaluate the efficacy and safety of the Cardea SOLO Compared to 12 lead EKG for Paroxysmal Atrial Fibrillation Diagnosis in ESUS patients with Left Atrial Enlargement.
- Trial name
- NCT05431972
- Testing
- Cardea SOLO, 12 Lead EKG
- Where
- South Korea
- Volunteers
- 257 people
- Sponsor
- Asan Medical Center
Atrial Fibrillation, Persistent
Adjunctive Right Atrial Ablation for Persistent Atrial Fibrillation
Persistent atrial fibrillation (PerAF) can induce right atrial (RA) enlargement. Our previous study demonstrated patients with PerAF and RA enlargment may benefit from adjunctive RA ablation.
- Trial name
- NCT05883722
- Testing
- Catheter ablation
- Volunteers
- 200 people
- Sponsor
- Xu Liu
Atrial Fibrillation, Hypertrophic Cardiomyopathy
Antiarrhythmic Therapy Versus Catheter Ablation for Atrial Fibrillation in Hypertrophic Cardiomyopathy
Paroxysmal or chronic atrial fibrillation (AF) develops in about 20- 25% of adult patients with hypertrophic cardiomyopathy (HCM) and represents an important complication in the clinical course of the disease, with adverse…
- Trial name
- NCT00821353
- Testing
- RF catheter ablation, Antiarrhythmic drugs
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Atrial Fibrillation
Prevalence of Sub-Clinical Atrial Fibrillation Using an Implantable Cardiac Monitor
The primary objective of the study is to determine the rate of detection of sub-clinical atrial fibrillation (≥ 5 minutes)within an average of 12 months following implant of the St.
- Trial name
- ASSERT-II (NCT01694394)
- Testing
- Implantable Cardiac Monitor (Confirm ICM model 2102)
- Where
- 19 sites in Canada, Netherlands
- Volunteers
- 256 people
- Sponsor
- Population Health Research Institute
Persistent Atrial Fibrillation, Right Atrial Enlargement
Adjunctive Right Atrial Ablation for Persistent Atrial Fibrillation With Right Atrial Enlargement
This is retrospective cohort study testing whether patients with persistent atrial fibrillation and right atrial enlargement may benefit from adjunctive right atrial ablation.
- Trial name
- NCT05227586
- Testing
- Circumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + left atrial driver ablation, Circumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + left atrial driver ablation + right atrial driver ablation
- Where
- China
- Volunteers
- 195 people
- Sponsor
- Shanghai Chest Hospital
Hypertension, Left Ventricular Hypertrophy
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric…
- Conditions
- Hypertension, Left Ventricular Hypertrophy, Left Ventricular Dysfunction, Left Atrial Dilatation
- Trial name
- PHRASE (NCT04752293)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Aortic Valve Stenosis, Heart Failure
Left Atrial Volume Index in Asymptomatic Aortic Stenosis
Aortic stenosis results in increased filling pressures of the heart. Size and function of the left atrium may be a marker for more advanced heart disease (heart failure) in patients with severe aortic stenosis, not presenting any…
- Trial name
- LAVIAS (NCT02395107)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Atrial Fibrillation
Safety and Efficacy of Left Atrial Appendage Occlusion Devices
Atrial fibrillation (AF) is the most common cardiac rhythm disorder in clinical practice. In the last two decades the number of hospitalizations for AF has increased two- to three-fold.
- Trial name
- NCT01695564
- Testing
- LARIAT LAA, WATCHMAN
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Kansas City Heart Rhythm Institute
Cardiomyopathy, Hypertrophic
The Role of Heart Stiff and Weak Atrium on Exercise Capacity in Patients With Hypertrophic Cardiomyopathy
This study will examine how heart stiffness and a weak atrium affect exercise capacity and symptoms in patients with hypertrophic cardiomyopathy (HCM).
- Trial name
- NCT00074880
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertension, Atrial Fibrillation
Effect of Azilsartan on Atrial Fibrillation in Patients With Hypertension
Hypertension and atrial fibrillation (AF) are two major public health problems worldwide. Hypertension is an important risk factor for AF, and the combination of which could significantly increase the risk of cardiovascular…
- Trial name
- AZAF (NCT05841654)
- Testing
- Azilsartan or antihypertensive drugs other than ACEI, ARB or ARNI
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Atrial Fibrillation
Ablation and Left Atrium Reduction During Mitral Valve Surgery for Atrial Fibrillation
The purpose of this study is to estimate left atrial volume reduction surgery concomitant with the maze procedure and mitral valve repair/replacement in patients with atrial fibrillation with an enlarged left atria.
- Trial name
- ALARM-vs-AF (NCT02047279)
- Testing
- maze procedure, mitral valve surgery, left atrial reduction
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation