Clinical trials: Atelectasis
Postoperative Pulmonary Atelectasis, Negative Pressure Therapy
Evaluation of the Effect of Novel Recruitment Maneuver Therapy for Postoperative Pulmonary Atelectasis
1. Oxygenation index and bedside ultrasound would be used to evaluate the therapeutic effect of novel recruitment maneuver therapy in the patients with pulmonary atelectasis after cardiac surgery. 2.
- Trial name
- NCT06049173
- Testing
- Negative extra-abdominal pressure (NEXAP)-based lung recruitment maneuver, stepwise positive end-expiratory pressure (PEEP)-based lung recruitment maneuver
- Where
- China
- Volunteers
- 77 people
- Sponsor
- Jilai Xiao
Atelectasis
Does High Intraoperative Inspired Oxygen Reduce Postoperative Arterial Oxygen Saturation?
The purpose of this study is to determine whether breathing high levels of oxygen during surgery affects oxygen levels after surgery.
- Trial name
- NCT00715741
- Testing
- FiO2 (fraction of inspired oxygen) 0.3 plus PEEP (positive end expiratory pressure) 3 -5 cm water, FiO2 0.3 without PEEP, FiO2 >0.9 with 3-5 cm water PEEP
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Utah
Atelectasis, Cesarean Section
The Effect of Oxygen Therapy on Atelectasis
In pregnancy, cephalal shift of the diaphragm caused by the enlarged uterus reduces the functional residual capacity and may increase the closure volume and predispose the pregnant woman to airway closure, leading to atelectasis.
- Conditions
- Atelectasis, Cesarean Section, Hypotension
- Trial name
- NCT05509764
- Testing
- lung ultrasound score
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Respiratory Distress Syndrome, Preterm Pregnancy
Less Invasive Surfactant Administration in Late Preterm or Early Term Born Infants
The aim of this study is to see if giving less invasive surfactant administration (LISA) during high-flow nasal cannula (HFNC) oxygen treatment reduces the need for invasive ventilation in babies with breathing problems born 2-6…
- Conditions
- Respiratory Distress Syndrome, Preterm Pregnancy, Surfactant Deficiency Syndrome Neonatal
- Trial name
- NCT06421506
- Testing
- Less invasive surfactant administration during high flow nasal cannula treatment
- Where
- United Kingdom
- Volunteers
- 245 people
- Sponsor
- King's College Hospital NHS Trust
Neoplasms, Pulmonary, Thoracic Diseases
The Need of Fiberoptic Bronchoscopy for Placing an Endobronchial Blocker
The need of fiberoptic bronchoscopy for placing an endobronchial blocker. Endobronchial blockers (EBB) have been presented effective and safe alternative for lung separation in vedio-assisted thoracoscopic (VATS) operations.
- Trial name
- NCT02133235
- Testing
- conventional, auscultation
- Where
- Taiwan
- Volunteers
- 112 people
- Sponsor
- National Taiwan University Hospital
Atelectasis, Lung Cancer
Study of the Application of CPAP to Reduce Complications and Improve Lung Cancer Ablation Radiofrequency Treatment
The project aims to study whether the application of a continuous positive airway pressure (CPAP) of 4 cm water vapor is a safe method in pulmonary radiofrequency intervention (PRF) lung cancer under conscious sedation compared…
- Trial name
- CPAP-RFP (NCT02117908)
- Testing
- RESMED AUTOSET S9
- Where
- Spain
- Volunteers
- 47 people
- Sponsor
- Sara Varea
Postoperative Pulmonary Atelectasis
Evaluation of Perioperative Lung Ultrasound Scores in Laparoscopic Pediatric Surgeries
Laparoscopic surgeries require carbon-dioxide into the abdomen which may occasionally lead to atelectasis. The extent of this atelectasis is not well documented in peri-operative period although it has been extensively researched…
- Trial name
- NCT06072885
- Testing
- Lung Ultrasound Scoring
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University
Neuromuscular Blockade, Postoperative Pulmonary Atelectasis
Rocuronium vs Cis-atracurium: Do Rocuronium Still 'ROCKS' In Coronary Artery Bypass Grafting
The current trend in most cardiac surgeries was to use rocuronium as it provides faster recovery in train-of-four ratio compared to other aminosteroid non-depolarising neuromuscular blocker.
- Conditions
- Neuromuscular Blockade, Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complication, Coronary Artery Disease
- Trial name
- NCT06102915
- Testing
- Rocuronium Bromide 10 MG/ML, Nimbex 10 MG in 5 ML Injection
- Where
- Malaysia
- Volunteers
- 289 people
- Sponsor
- Institut Jantung Negara
Pulmonary Atelectasis, Postoperative
Individual Optimal Positive End-expiratory Pressure During Robot-assisted Laparoscopic Radical Prostatectomy
During robot-assisted radical prostatectomy, pneumoperitoneum with Trendelenburg position is used. However, perioperative atelectasis and respiratory complications may occur with high incidence due to general anesthesia and…
- Trial name
- NCT04085146
- Testing
- Individualized optimal positive end-expiratory pressure, Conventional positive end-expiratory pressure
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Artificial Intelligence, Lung Diseases
Retrospective Study of Carebot AI CXR Performance in Preclinical Practice
The purpose of this study is to describe the design, methodology and evaluation of the preclinical test of Carebot AI CXR software, and to provide evidence that the investigated medical device meets user requirements in…
- Conditions
- Artificial Intelligence, Lung Diseases, Pneumothorax, Pleural Effusion
- Trial name
- NCT05594485
- Testing
- Carebot AI CXR
- Where
- Czechia
- Volunteers
- 127 people
- Sponsor
- Carebot s.r.o.
Postoperative Pulmonary Complications
Consensus Statements on Definition, Components and Grading of Postoperative Pulmonary Complications
An international team of experts is working on a project called PrECiSIOn to develop a clear, consistent definition of PPCs. The goals of this study are to: Define postoperative pulmonary complications in a way that makes sense…
- Trial name
- PrECiSIOn (NCT06916598)
- Testing
- Delphi study, Structured Interview
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Postoperative Atelectasis
GO2 PEEP Study: Bidirectional Oxygenation Valve in Postoperative Atelectasis
This study compares a novel breathing device, called the GO2 Mouthpiece, to the standard breathing tool called the incentive spirometer, thus improving respiratory dynamics of the postoperative patient.
- Trial name
- NCT04253834
- Testing
- Incentive spirometer, GO2 Mouthpiece
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Atelectasis
High Fresh Gas Flow After Intubation
Atelectasis is common during and after general anesthesia. Atelectasis develops early if preoxygenation with 100% oxygen is used and continuously used during induction until endotracheal intubation.
- Trial name
- NCT02216006
- Testing
- Control group, conventional ventilatory settings, High fresh gas flow, high minute ventilation
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Region Västmanland
Atelectasis
Role of Lung Ultrasound Imaging in the Comparison of Two Mechanical Ventilation Strategies During Laparotomy
The use of positive end-expiratory pressure (PEEP) and recruitment maneuvers during laparotomy will limit the development of atelectasis and therefore improve the aeration score.
- Trial name
- NCT02055807
- Testing
- PEEP and recruitment maneuvers, ZEEP (no PEEP nor recruitment maneuver)
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Atelectasis, Hypertension
Pulmonary Evaluation With Ultrasound in Different Levels of PEEP
Patients submitted to general anesthesia and artificial ventilation almost always develop pulmonary atelectasis, which can determine adverse consequences both intraoperatively and postoperatively.
- Conditions
- Atelectasis, Hypertension, Lung Edema
- Trial name
- EVALUS (NCT03211936)
- Testing
- PEEP TITRATED, Use ultrasound, Impedance tomography
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Obesity, Abdominal, Anesthesia Morbidity
CPAP in Patients With Severe Obesity After Anesthesia
The goal of this study is to compare two continuous positive airway pressure (CPAP) settings on heart and lung function in patients with severe obesity after anesthesia. The main questions it aims to answer are: 1.
- Conditions
- Obesity, Abdominal, Anesthesia Morbidity, Apnea, Obstructive Sleep, Atelectases, Postoperative Pulmonary
- Trial name
- NCT06287632
- Testing
- Recruitment/ITP-CPAP (Intervention A), Standard CPAP (Intervention B), Atmospheric Pressure
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Neonates and Preterm Infants, Infant Respiratory Distress Syndrome
Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minutes Versus 5 Minutes
Respiratory distress syndrome (RDS) is common in very preterm infants due to surfactant deficiency. Surfactant replacement therapy is lifesaving, and current guidelines recommend the less invasive surfactant administration (LISA)…
- Conditions
- Neonates and Preterm Infants, Infant Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal, Surfactant
- Trial name
- SurfStab I (NCT07261787)
- Testing
- Poractant alfa (Curosurf®) - 1-minute administration, Poractant alfa (Curosurf®) - 5-minute administration
- Where
- Austria
- Volunteers
- 76 people
- Sponsor
- Medical University of Graz
Neonatal Respiratory Distress
Aerosolized Infasurf Treatment Protocol: Aerosolized Infasurf for Spontaneously Breathing Patients With Early RDS (AERO-03)
Surfactant replacement therapy can be life-saving for newborn infants born with symptomatic lung surfactant deficiency causing Respiratory Distress Syndrome (RDS).
- Trial name
- NCT03582930
- Testing
- Infasurf Aero
- Where
- 5 sites in United States
- Sponsor
- ONY
Atelectasis, General Aneshesia
Effects of Anesthesia on Atelectasis
We know that respiratory functions of patients are affected under general anaesthesia. Although there are many underlying causes of ventilation-perfusion mismatch in the airways, the main cause is atelectasis during general…
- Trial name
- NCT06790901
- Testing
- LUNG ULTRASOUND
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Lung Collapse
Individualized PEEP and Driving Pressure Ventilation on Postoperative Lung Complications in Robot Prostatectomy Surgery
In the case of robotic prostate cancer surgery under general anesthesia, the surgical posture is extreme Trendelenburg. Therefore, airway pressure is very high during mechanical ventilation, and there is a possibility of…
- Trial name
- NCT06909630
- Testing
- Driving pressure group
- Where
- South Korea
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital