Clinical trials: Asthma Exacerbations
Childhood Asthma With Acute Exacerbation
Antibiotic Treatment of Recurrent Episodes of Asthma in Children
Copsac has discovered that asthmatic exacerbations are as closely linked to bacterial as to viral infection. The current study will examine whether treatment of asthmatic exacerbations with macrolide antibiotics - in the abscence…
- Trial name
- AB-studie (NCT01233297)
- Testing
- Azithromycin
- Where
- 2 sites in Denmark
- Volunteers
- 70 people
- Sponsor
- Copenhagen Studies on Asthma in Childhood
Asthma, Asthma Chronic
Improving the Quality of Care for Asthma Patients at Risk of Exacerbations
The goal of this trial test two known effective asthma strategies. Treatment guidelines recommend combination therapy of inhaled corticosteroids (ICS) with a long-acting beta-agonist (LABA) inhaled medications.
- Conditions
- Asthma, Asthma Chronic, Asthma Severe Persistent With Exacerbation, Asthma Moderate Persistent With Exacerbation
- Trial name
- iCARE (NCT06596512)
- Testing
- PARTICS using a single ICS add on, MART
- Where
- 6 sites in United States
- Volunteers
- 4,100 people
- Sponsor
- Brigham and Women's Hospital
Childhood Asthma, Asthma Control
Pollution Intervention to Impact Kids Asthma Study
The goal of this clinical trial is to learn if adding Air Quality Index (AQI) information to asthma action plans works to improve asthma outcomes in children.
- Conditions
- Childhood Asthma, Asthma Control, Asthma Exacerbation, Air Pollution, Risk Reduction Behaviors
- Trial name
- PIKAS (NCT07261423)
- Testing
- EPA-AQI, Commerical-AQI, Education and plan
- Where
- United States
- Volunteers
- 351 people
- Sponsor
- University of Pittsburgh
Infections, Heart Failure
Advancing Health Information Exchange (HIE) During Inter-hospital Transfer (IHT) to Improve Patient Outcomes
Sub-optimal transfer of clinical information during inter-hospital transfer (IHT, the transfer of patients between acute care hospitals) is common and can lead to patient harm.
- Conditions
- Infections, Heart Failure, COPD Exacerbation, Asthma
- Trial name
- NCT05443321
- Testing
- Health Information Exchange (HIE) platform
- Where
- United States
- Volunteers
- 1,006 people
- Sponsor
- Brigham and Women's Hospital
Asthma Exacerbations, Severe Asthma
Bronchial Thermoplasty for Adults With Severe Asthma in the Biologic Era
Rationale: For patients with severe asthma that remain uncontrolled with exacerbations despite biologics or patients who are not eligible for biologics, there is no reimbursed treatment other than pulmonary rehabilitation in the…
- Conditions
- Asthma Exacerbations, Severe Asthma, Bronchial Thermoplasty
- Trial name
- BOOSTER (NCT07292805)
- Testing
- Bronchial thermoplasty
- Where
- 2 sites in Netherlands
- Volunteers
- 90 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Exacerbation of Asthma
Dexamethasone Versus Prednisolone in Acute Exacerbation of Childhood Asthma
Because of insufficient local comparative data, this study was designed to determine the outcome of intravenous dexamethasone in contrast to oral prednisolone in acute exacerbation of asthmatic children.
- Trial name
- NCT07275593
- Testing
- Dexamethasone, Prednisolone
- Where
- Pakistan
- Volunteers
- 224 people
- Sponsor
- Muhammad Aamir Latif
Pulmonary Edema, Pneumonia
Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU
Dynamic digital radiography (DDR) is a new advanced version of chest radiography that captures dynamic images at a rate of 15 frames per second.
- Conditions
- Pulmonary Edema, Pneumonia, Atelectasis, Pleural Effusion
- Trial name
- NCT06538376
- Testing
- Portable Dynamic Digital Radiography (DDR)
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Brigham and Women's Hospital
Asthma, Asthma Attack
Individualizing Treatment for Asthma in Primary Care (Full Study)
While asthma therapy is becoming more individualized based on asthma phenotypes, more research is needed to tailor newer therapies to individuals.
- Conditions
- Asthma, Asthma Attack, Asthma Exacerbations
- Trial name
- iTREAT-PC (NCT07052942)
- Testing
- Inhaled corticosteroid (ICS), Azithromycin, Asthma Symptom Monitoring Web-based Application
- Where
- 13 sites in United States
- Volunteers
- 3,200 people
- Sponsor
- DARTNet Institute
Asthma Exacerbations
Nursing Interventions to Mitigate Climate Change-related Effects on Symptom Severity and Physical Capacity
Randomize controlled, parallel, double-blind, with two arms, which purpose is verify the nursing educational intervention effects to reduce asthma severity symptoms in older adults.
- Trial name
- climate effect (NCT07111143)
- Testing
- nursing intervention
- Where
- Saudi Arabia
- Volunteers
- 120 people
- Sponsor
- Norther Private Collage of Nursing
Persistent Asthma, Asthma in Children
Asthma Research in Children and Adolescents
The purpose of this study is to assess the evolution of disease control, health-related quality of life, and the risk of severe asthma exacerbations in children and adolescents with persistent asthma in Spain at short, mid and…
- Conditions
- Persistent Asthma, Asthma in Children, Asthma Exacerbation
- Trial name
- ARCA (NCT04480242)
- Testing
- Inhaled Corticosteroids (ICs), Fixed-Dose Combination of Inhaled Corticosteroids and Long- Acting Beta-agonist (ICs/LABA), Other treatments
- Where
- 15 sites in Spain
- Volunteers
- 525 people
- Sponsor
- Parc de Salut Mar
Asthma, Asthma Exacerbations
Vitamin D In the Prevention of Viral-induced Asthma in Preschoolers
In this 7-month randomized controlled trial, children aged 1 to less than 6 years, with recurrent asthma attacks triggered mostly by colds, will receive a high dose of vitamin D or a placebo every 3.5 months during their usual…
- Conditions
- Asthma, Asthma Exacerbations, Preschool Child, Vitamin D
- Trial name
- DIVA (NCT03365687)
- Testing
- Vitamin D
- Where
- 9 sites in Canada
- Volunteers
- 323 people
- Sponsor
- Professor Francine Ducharme
Acute Respiratory Infection, Asthma Exacerbations
Reusable Face Masks to Reduce Risk of Viral Respiratory Infections and Asthma Exacerbations
REMASK trial is a Trial within Cohort study (TwiCs), nested within the COVIDENCE UK longitudinal study. It has been designed to determine whether the offer of a free reusable, elastomeric face mask to adults with asthma and other…
- Trial name
- REMASK (NCT06885229)
- Testing
- FloMask - reuseable face mask
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Childhood Asthma With Acute Exacerbation
Azithromycin Treatment of Hospitalized Children With Asthmatic Symptoms
The purpose of this double-blind, randomized, controlled clinical trial is to investigate the effect of a three-day azithromycin treatment versus placebo treatment in children aged 1-5 years who are hospitalized due to…
- Trial name
- COPSACazt (NCT05028153)
- Testing
- Azithromycin Oral Liquid Product
- Where
- Denmark
- Volunteers
- 320 people
- Sponsor
- Copenhagen Studies on Asthma in Childhood
Asthma Exacerbation, Children
A Comparative Study of Adding Ipratropium to Salbutamol for the Treatment of Asthma Attack in Children
The goal of this clinical trial was to determine if adding ipratropium bromide to salbutamol improves asthma treatment in children.
- Trial name
- NCT06918418
- Testing
- Salbutamol (Ventolin®), salbutamol + ipratropium bromide nebules
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Children's Hospital and Institute of Child Health, Multan
Childhood Asthma With Acute Exacerbation
Comparison of Nebulizers vs Metered-Dose Inhalers With Spacer Device For Treatment Of Childhood Wheeze
The goal of this randomized controlled trial is to compare two different devices for the administration of the standard protocol drug.
- Trial name
- NCT06201156
- Testing
- Metered Dose Inhaler With Spacer Device
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- Khyber Teaching Hospital
COPD Exacerbation Acute, Asthma Acute
Study on Acupuncture Treatment of Chronic Airway Diseases(Asthma and Chronic Obstructive Pulmonary Disease)
For patients in the acute phase of chronic airway diseases, on the basis of guideline-directed treatment, the experimental group was given acupuncture treatment, while the control group was given sham acupuncture treatment.
- Trial name
- NCT06869525
- Testing
- Acupuncture
- Volunteers
- 576 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Asthma Exacerbations
DOSE Trial: Optimal Dose of Oral Corticosteroids to Treat Asthma Exacerbations
Patients with severe asthma frequently experience exacerbations of their disease. The heterogeneity of asthma exacerbations represents a major challenge for patients and healthcare providers, making treatment difficult.
- Trial name
- DOSE (NCT06833814)
- Testing
- Prednisone
- Volunteers
- 36 people
- Sponsor
- Andréanne Côté
Anaemia, Asthma Exacerbations
Study on Effect of Papworth Technique in Anemic Asthmatic Pediatrics
As asthma is chronic condition which interferes with quality of life and exercise tolerance, so it is important to find out cost-effective alternative for the management of asthma due to increased prevalence and rising health…
- Trial name
- NCT06750354
- Testing
- papworth technique, aerobic training
- Volunteers
- 40 people
- Sponsor
- Cairo University
Asthma; Status, Asthma in Children
Pragmatic RCT of High-dose Oral Montelukast for Moderate and Severe Pediatric Acute Asthma Exacerbations
Objective: To determine the extent to which high-dose (30mg) oral montelukast, added to standard treatment in children with moderate and severe acute exacerbations improves outcomes.
- Conditions
- Asthma; Status, Asthma in Children, Asthma Acute, Asthma Attack
- Trial name
- NCT03277170
- Testing
- Montelukast Oral Granules
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Acute Exacerbation of Asthma
Randomized Controlled Trial of Intravenous Magnesium Sulfate Versus Terbutaline for Children in the Management of Acute Exacerbation of Asthma
This study aimed to fill this gap by comparing the effectiveness of intravenous magnesium sulfate versus terbutaline in children with acute asthma exacerbations, providing evidence-based guidance for clinicians in emergency…
- Trial name
- NCT06626620
- Testing
- Magnesium Sulphate infusion, Terbutaline Infusion
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Muhammad Aamir Latif