Clinical trials: Aspirin Prophylaxis
Uncomplicated Peptic Ulcer
The Risk of Uncomplicated Peptic Ulcer in a Cohort of Secondary Prevention Aspirin Users
This study is conducted in a cohort of low dose aspirin (ASA) users previously ascertained. The aims of the post hoc analyses are: To estimate the incidence of uncomplicated peptic ulcer (UPU) in a cohort of low-dose ASA for…
- Trial name
- NCT01814943
- Where
- Spain
- Volunteers
- 39,000 people
- Sponsor
- AstraZeneca
Preeclampsia
Oral Progesterone and Low Dose Aspirin in the Prevention of Preeclampsia
This study investigates whether low dose aspirin combined with progesterone will decrease the risk of preeclampsia in pregnant women with a history of preeclampsia in a previous pregnancy.
- Trial name
- NCT00719537
- Testing
- Aspirin, Progesterone
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- John Uckele
Stroke, Cerebral Infarction
Antiplatelet Therapy to Prevent Stroke in African Americans
The African-American Antiplatelet Stroke Prevention Study is designed to prevent recurrent strokes by administration of aspirin or ticlopidine.
- Trial name
- NCT00004727
- Testing
- aspirin, ticlopidine
- Where
- United States
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Venous Thromboembolism
VTE Prevention Following Total Hip and Knee Arthroplasty
Consented patients undergoing elective total hip and total knee arthroplasty will be randomized to receive either aspirin alone or aspirin and rivaroxaban for prevention of venous thromboembolism.
- Trial name
- EPCATIII (NCT04075240)
- Testing
- Rivaroxaban 10 MG and acetylsalicylic acid 81 mg, acetylsalicylic acid 81 mg
- Where
- Canada
- Volunteers
- 5,429 people
- Sponsor
- Sudeep Shivakumar
Colorectal Cancer
Aspirin and/or Folic Acid in Preventing Recurrent Colorectal Polyps
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of aspirin and/or folic acid may be effective in preventing recurrent polyps in patients who have…
- Trial name
- NCT00033319
- Testing
- folic acid, acetylsalicylic acid
- Where
- 32 sites in United Kingdom
- Sponsor
- Queen's Medical Center
Myocardial Infarction, Stroke
Testing a Community Intervention to Increase Aspirin Use
This research will test the effect of mass media or mass media plus a clinic based education program will improve appropriate aspirin use for cardiovascular disease prevention.
- Trial name
- NCT02607917
- Testing
- Mass Media plus clinic intervention., Media
- Where
- United States
- Volunteers
- 10,800 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hypertension
Effectiveness of Night Administration of Low Dose Aspirin in Hypertensive Patients
The goal is to investigate in patients with high blood pressure, BP, namely, those with systolic blood pressure and diastolic blood pressure, SBP/DBP higher than or equal to 140/90 mmHg, and high cardiovascular risk, under…
- Trial name
- TAHPS (NCT01741922)
- Testing
- ASA evening, Acetylsalicylic morning
- Where
- 3 sites in Spain
- Volunteers
- 230 people
- Sponsor
- Basque Health Service
Secondary Prevention, Stroke
Epidemiological Study on the Safety of Aspirin in The Health Improvement Network (THIN)
To investigate the risk of major bleeding (including gastrointestinal and intracranial bleeding episodes) among new users of low-dose acetylsalicylic acid (ASA) in clinical practice
- Conditions
- Secondary Prevention, Stroke, Ischemic Heart Disease, Coronary Heart Disease
- Trial name
- EPISAT (NCT02550717)
- Testing
- Acetylsalicylic Acid (Aspirin, BAYE4465), Clopidogrel, Oral Anticoagulants, NSAIDs and SSRIs
- Where
- United Kingdom
- Volunteers
- 398,158 people
- Sponsor
- Bayer
Peptic Ulcer
Efficacy and Safety of PMK-S005 in the Prevention of Recurrent Peptic Ulcer in Low-dose Aspirin Users
The purpose of this study is to evaluate the efficacy and safety by comparing prevention of recurrent peptic ulcer in low-dose aspirin users between PMK-S005 and Placebo.
- Trial name
- NCT02342470
- Testing
- PMK-S005 1, PMK-S005 2, PMK-S005 3
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- PharmaKing
Preeclampsia
Low Doses of Aspirin in the Prevention of Preeclampsia
Preeclampsia (PE) is a morbid and potentially lethal complication of pregnancy and is more common in women with specific risk factors.
- Trial name
- ASAPP (NCT04070573)
- Testing
- acetylsalicylic acid
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- Weill Medical College of Cornell University
Venous Thromboembolism, Ovarian Cancer
Aspirin for Prevention of Venous Thromboembolism Among Ovarian Cancer Patients Receiving Neoadjuvant Chemotherapy
This is a pilot study to determine the safety and efficacy of low dose aspirin for the prevention of venous thromboembolism among women with advanced ovarian cancer receiving neoadjuvant chemotherapy.
- Trial name
- NCT04352439
- Testing
- Aspirin
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Duke University
Sickle Cell Disease
Aspirin Prophylaxis in Sickle Cell Disease
Neurologic complications secondary to cerebrovascular damage are prevalent in children with sickle cell disease. These patients experience both clinically overt cerebrovascular accidents and "silent infarctions" demonstrated by…
- Trial name
- START (NCT00178464)
- Testing
- aspirin
- Volunteers
- 11 people
- Sponsor
- University of Rochester
Stroke, Prevention
Rivaroxaban Plus ASA in Embolic Stroke of Undetermined Source(AREST-ESUS)
Approximately 17% of all patients with stroke are classified as having ESUS, which is associated with a considerable rate of stroke recurrence 4-5 % per year.
- Trial name
- AREST-ESUS (NCT04273516)
- Testing
- Rivaroxaban 2.5 Mg Oral Tablet
- Where
- Iran
- Volunteers
- 42 people
- Sponsor
- Mazandaran University of Medical Sciences
Atherosclerosis, Thromboembolism
Aspirin and Statins for Prevention of Atherosclerosis and Arterial Thromboembolism in Systemic Lupus Erythematosus
The purpose of this trial is to study if aspirin and statins (lipid-lowering agents) can reduce the progression of subclinical atherosclerosis in patients with systemic lupus erythematosus (SLE).
- Conditions
- Atherosclerosis, Thromboembolism, Systemic Lupus Erythematosus
- Trial name
- NCT00371501
- Testing
- Rosuvastatin, aspirin
- Where
- Hong Kong
- Volunteers
- 72 people
- Sponsor
- Tuen Mun Hospital
Gastroesophageal Reflux
ASTERIX: Low Dose ASA and Nexium
The purpose of the study is to evaluate the effect of esomeprazole 20 mg od versus placebo for the prevention of gastric and/or duodenal ulcers in patients taking low-dose ASA.
- Trial name
- NCT00251966
- Testing
- Esomeprazole
- Where
- 94 sites in Australia, Bulgaria and 9 more
- Volunteers
- 960 people
- Sponsor
- AstraZeneca
Colorectal Neoplasia
A Trial of Omeprazole and Low Dose Aspirin to Identify Colorectal Biomarkers of Preventive Efficacy
This trial will obtain biomarker data on the possible preventive effects of omeprazole and low-dose aspirin in colorectal tissue.
- Trial name
- NCT06378398
- Testing
- Omeprazole, Aspirin
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- University of Michigan Rogel Cancer Center
Complication of Cardiac Defibrillator, Disorder of Cardiac Pacemaker System
Prevention of Venous Obstruction After Implantation of Cardiac Pacemaker and Defibrillator
The purpose of this study is to determine whether Aspirin or Clopidogrel are effective in the prevention of venous obstruction after implantation of cardiac pacemaker or defibrillator.
- Conditions
- Complication of Cardiac Defibrillator, Disorder of Cardiac Pacemaker System, Venous Occlusion
- Trial name
- NCT02331511
- Testing
- Aspirin 80 mg daily, Clopidogrel 75 mg daily
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Primary Prevention, Vascular Calcification
GUIDE-CAC: Statin-Ezetimibe Without Aspirin vs. Statin Monotherapy With Aspirin in High Coronary Calcification
A Multicenter, randomized trial comparing the efficacy and safety of intensive lipid-lowering therapy using a statin-ezetimibe combination without aspirin versus statin monotherapy with aspirin in asymptomatic patients with…
- Trial name
- NCT06722521
- Testing
- Pitavastatin 4mg and ezetimibe 10mg, taken once daily, Pitavastatin 2 mg with aspirin 100 mg, taken once daily.
- Where
- South Korea
- Volunteers
- 7,435 people
- Sponsor
- Asan Medical Center
Preeclampsia, Hypertensive Disorders of Pregnancy (HDP)
Clinician Notification to Increase Aspirin Prophylaxis for Preeclampsia Prevention
Preeclampsia is a leading cause of maternal morbidity and mortality. Low-dose aspirin prophylaxis reduces preeclampsia risk among high-risk pregnant individuals but remains underused in routine clinical practice.
- Conditions
- Preeclampsia, Hypertensive Disorders of Pregnancy (HDP), Pregnancy Complications, Aspirin Prophylaxis
- Trial name
- NCT07614893
- Testing
- Clinician notification of elevated preeclampsia risk
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Massachusetts General Hospital
Preeclampsia
Comparison of Pregnancy Outcomes in Primigravida Receiving Low-Dose Aspirin for the Prevention of Preeclampsia.
Local data on the effectiveness of low-dose aspirin in high-risk primigravida are limited. The present study was planned to compare pregnancy outcomes between high-risk primigravida receiving low-dose aspirin (75 mg/day) from 12…
- Trial name
- NCT07852585
- Testing
- Low-dose aspirin, No-Aspirin
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- Muhammad Aamir Latif