Clinical trials: Artificial Pancreas
Type 1 Diabetes Mellitus
A Study of an Automated Insulin Delivery System in Adult Participants With Type 1 Diabetes
The purpose of this early feasibility study is to assess the predictive low glucose suspend (PLGS) feature's safety, functionality and performance.
- Trial name
- NCT03890003
- Testing
- AID System, Insulin Lispro
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes
Simplified Meal Approach Using Hybrid Closed-loop Insulin Delivery in Youth and Young Adults With Type 1 Diabetes
The purpose of the study is to examine whether a simplified meal approach (as compared to exact carbohydrate counting) can alleviate the need of carbohydrate counting without worsening postprandial control in youth and young…
- Trial name
- SMASH (NCT05481034)
- Testing
- SMA bolus option, Exactly estimated carbohydrate content bolus option
- Where
- 2 sites in Switzerland
- Volunteers
- 46 people
- Sponsor
- Lia Bally
Type 1 Diabetes Mellitus, Hypoglycemia
Exercise Physiology Study
People with type 1 diabetes often find exercise very difficult to manage, because of the high risk for low blood glucose levels.
- Trial name
- NCT03090451
- Testing
- Aerobic Exercise
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes
The Performance of an Artificial Pancreas at Home in People With Type 1 Diabetes
The overall aim of the study is to evaluate the performance of Artificial Pancreas or Closed Loop Glucose-Sensing Insulin-Delivery system in comparison to current best available technology represented by Sensor Augmented Pump…
- Trial name
- NCT02040571
- Testing
- Closed Loop, Open Loop
- Where
- Australia
- Volunteers
- 28 people
- Sponsor
- St Vincent's Hospital Melbourne
Diabetes Mellitus, Diabetes Mellitus, Type 1
Efficacy and Safety of Android Artificial Pancreas System in Adult Patients With Type 1 Diabetes Mellitus in China
This is a 26-week randomized, free-living, open-label, two-arm, two-phase, crossover trial. Participants will receive two interventions at different phases, including the Android artificial pancreas system(AndroidAPS-rt-CGM) and…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- NCT05726461
- Testing
- AndroidAPS-rt-CGM;, sensor augmented pump(SAP);
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Type 1 Diabetes
Blood Glucose Target Before and During Exercise in Adults With Type 1 Diabetes Using an Artificial Pancreas
Despite major technological advances in type 1 diabetes (artificial pancreas), the management of hypoglycemia remains a major challenge, especially during and after physical activity.
- Trial name
- GUARDIA (NCT05821322)
- Testing
- Physical activity trial intervention
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 1 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) for 12 Days in Adults With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT02846831
- Testing
- 12-day intervention with sensor-augmented pump therapy, 12-day intervention with single-hormone closed-loop strategy, Insulin pump
- Where
- 2 sites in Canada
- Volunteers
- 36 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Hypoglycemia
PK/PD Study With G-Pump (Glucagon Infusion) in T1DM Patients
The purpose of the study is to assess the safety, speed of absorption, and onset of action of G-Pump™ (glucagon infusion) at three subcutaneous doses as compared to Novo GlucaGen®, all delivered via an OmniPod® infusion pump to…
- Trial name
- NCT02081001
- Testing
- Novo Nordisk GlucaGen®, G-Pump™ (glucagon infusion)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Xeris Pharmaceuticals
Type1 Diabetes Mellitus
Using an Artificial Pancreas System in Older Adult Type 1 Diabetes Mellitus Patients
To demonstrate that a new insulin pump system can prevent low glucose episodes and improve brain function in aged Type 1 diabetes mellitus subjects.
- Trial name
- T1DM AP (NCT03353792)
- Testing
- CL/AP system, usual diabetic care
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Yale University
Type 1 Diabetes Mellitus
Comparison of the Efficacy of Rapid-acting Aspart and Faster Acting Aspart Within the Context of Single-hormone Closed-loop Strategy at Regulating Postprandial Glucose Levels
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT03335501
- Testing
- Insulin pump, Continuous glucose monitoring system, 11-hour intervention with the single-hormone artificial pancreas
- Sponsor
- Institut de Recherches Cliniques de Montreal
Diabetes Mellitus Type 1
Efficacy and Safety of the APGO Algorithm for Automated Insulin Delivery
The Medtrum TouchCare Nano system with the APGO algorithm is the only patch pump-based automated insulin delivery system available in the Czech Republic.
- Trial name
- NCT07320495
- Testing
- Device: Insulin pump TouchCare Nano A8 with the APGO system
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Charles University, Czech Republic
Diabetes Complications, Diabetes Mellitus, Type 1
Quantifying Artificial Pancreas-related Changes in Diabetic Neuropathy
A complication of diabetes mellitus is damage to nerves called neuropathy. There are several mechanisms involved that will lead to the development of neuropathy. Neuropathy can lead to foot ulcers, infections and amputations.
- Conditions
- Diabetes Complications, Diabetes Mellitus, Type 1, Diabetic Neuropathies
- Trial name
- QUANT-AP (NCT05951283)
- Testing
- Hybrid Closed Loop Insulin Pump
- Where
- United Kingdom
- Volunteers
- 102 people
- Sponsor
- Manchester University NHS Foundation Trust
Type 1 Diabetes
Ultrarapid Insulin Administered by a Bihormonal Closed Loop System in Patients With Type 1 Diabetes
The main objective is to determine the efficacy of Lyumjev (insulin) in a bi-hormonal reactive closed loop system for automated glucose regulation (artificial pancreas; AP®) in patients with diabetes mellitus type 1.
- Trial name
- FAST 1 (NCT05508061)
- Testing
- Insulin Lispro Cartridge [Lyumjev], Insulin Lispro Cartridge
- Where
- 3 sites in Netherlands
- Volunteers
- 12 people
- Sponsor
- Inreda Diabetic B.V.
Type 1 Diabetes Mellitus
Adaptive Biobehavioral Control (ABC) of Automated Insulin Delivery
The purpose of this pilot study is to test the safety and feasibility of using two or three research modules in conjunction with an automated insulin delivery device (AID).
- Trial name
- NCT04784637
- Testing
- Web Simulation Tool (WST), Behavioral Adaptation Module (BAM), Auto Titration Module (ATM)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1
Efficacy and Safety of an Artificial-pancreas-like Learning-based Control in Type 1 Diabetes on Multiple Daily Injection Therapy
This study is designed as a blinded, multi-center, non-inferiority randomized controlled clinical trial. It aims to enroll hospitalized T1D diabetes patients, ensuring an equal distribution with a 1:1 ratio between the…
- Trial name
- ELITE (NCT06418464)
- Testing
- AP-A Dosage Decision Support System
- Volunteers
- 120 people
- Sponsor
- Peking University People's Hospital
Type 1 Diabetes Mellitus
The Artificial Pancreas in Very Young Children With T1D - Pilot (KidsAP01)
The suggested clinical trial is part of the KidsAP project funded by the European Commission's Horizon 2020 Framework Programme.
- Trial name
- NCT03101865
- Testing
- FlorenceM
- Where
- 7 sites in Austria, Germany and 2 more
- Volunteers
- 24 people
- Sponsor
- University of Cambridge
Type 1 Diabetes
Study for the Artificial Pancreas Project : Determination of a Tuning Strategy of Metabolic Profiles
The Artificial Pancreas Project developed by SUPELEC and the University Hospital of Rennes is focused on the evaluation of an original control algorithm that computes appropriate subcutaneous insulin infusion in response to…
- Trial name
- NCT01282567
- Testing
- Blood samples
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Rennes University Hospital
Type 1 Diabetes Mellitus
A Study of t:Slim X2 With Control-IQ Technology
The purpose of this study is to learn whether an investigational automated insulin delivery system ("study system") for children with type 1 diabetes can safely improve blood glucose (sometimes called blood sugar) control.
- Trial name
- DCLP5 (NCT03844789)
- Testing
- t:slim X2 with Control-IQ Technology & Dexcom G6 CGM, Control Group
- Where
- 4 sites in United States
- Volunteers
- 101 people
- Sponsor
- University of Virginia
Diabetes Mellitus Type 1
Mixed Meal Test in Type 1 Diabetes: Optimization of Artificial Pancreas-Pilot Study
Physiology studies will be performed in patients with type 1 diabetes to define during a standardized mixed meal test: 1. The relationship between fast insulin analogue administration by i.v.
- Trial name
- NCT01800734
- Testing
- Clamp-Mixed Meal Arm
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Type 2 Diabetes
Closed-loop in Adults With T2D Not Requiring Dialysis
The main objective of this study is to determine the efficacy, safety and utility of fully automated closed-loop glucose control in the home setting over an 8 week period in adults with type 2 diabetes (T2D).
- Trial name
- AP-Renal (NCT04701424)
- Testing
- CamAPS HX Closed-loop, Multiple Daily Insulin Injections (Control)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Cambridge