Clinical trials: Articular Cartilage Disorder
Osteoarthritis
A Study of Orthotic Shoe Inserts for Controlling Osteoarthritic Knee Pain
Osteoarthritis is a degenerative joint disease and is the most common form of arthritis. This study will evaluate the effectiveness of customized shoe inserts in controlling and relieving the pain of knee osteoarthritis.
- Trial name
- NCT00076453
- Testing
- Lateral wedge orthotic shoe inserts, Standard orthotic shoe inserts
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Arthralgia
Changes in Knee Articular Cartilage Volume in Women on Aromatase Inhibitors
Many women with breast cancer are treated with a class of drugs called aromatase inhibitors (mainly letrozole or anastrozole), which lowers the amount of estrogen being produced in the body.
- Trial name
- NCT00111241
- Testing
- aromatase inhibitors (letrozole, anastrozole)
- Where
- Australia
- Volunteers
- 115 people
- Sponsor
- Monash University
Malignant Neoplasm of Bone and Articular Cartilage, Malignant Neoplasms of Female Genital Organs
Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases
Any time the words "you," "your," "I," or "me" appear, it is meant to apply to the potential participant. The goal of this clinical research study is to find the highest tolerable dose of gemcitabine that can be given by…
- Conditions
- Malignant Neoplasm of Bone and Articular Cartilage, Malignant Neoplasms of Female Genital Organs, Malignant Neoplasms of Independent (Primary) Multiple Sites, Malignant Neoplasms of Lip Oral Cavity and Pharynx
- Trial name
- NCT03093909
- Testing
- Gemcitabine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- M.D. Anderson Cancer Center
Knee Osteoarthritis
A Safety and Efficacy Study of Anti-inflammatory (Canakinumab) and Cartilage Stimulating (LNA043) Drugs Injected Into the Knee Joint of Participants With Knee Osteoarthritis (OA)
The study was established to show safety and efficacy of canakinumab and LNA043 in patients with knee osteoarthritis (OA).
- Trial name
- NCT04814368
- Testing
- canakinumab, LNA043
- Where
- 11 sites in United States, Czechia and 4 more
- Volunteers
- 23 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis, Hip, Femoroacetabular Impingement
Early Feasibility Study of Cartilage Defect Repair
Any patient aged 14 or older up to 64 years of age with hip disease, resulting in loss of articular cartilage integrity on the femoral head (e.g., femoroacetabular impingement or other structural deformity), has failed…
- Conditions
- Osteoarthritis, Hip, Femoroacetabular Impingement, Osteonecrosis, Legg-Calvé-Perthes Disease
- Trial name
- NCT06823089
- Testing
- ReNew Hip Implant
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Cytex Therapeutics, Inc.
Obesity, Osteoarthritis
Reducing Obesity and Cartilage Compression in Knees
OA is a degenerative joint disease that involves the degradation of articular cartilage and underlying subchondral bone. Obesity is identified as a critical and potentially modifiable risk factor for the development and…
- Conditions
- Obesity, Osteoarthritis, Knee Osteoarthritis
- Trial name
- ROCCK (NCT04730557)
- Testing
- Weight Loss
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Duke University
Anterior Knee Pain Syndrome
Use of Hyaluronic Acid Injection in Lateral Patellar Compression With Femoral Condylar Degenerative Changes After Arthroscopic Release
Ninety patients are involved in this study, who underwent arthroscopic lateral patellar release for lateral patellar compression syndrome and they had patellofemoral degenerative lesion, which diagnoses by MRI preoperatively and…
- Trial name
- NCT04134611
- Testing
- Hyaluronic acid injection, No injection of Hyaluronic acid
- Where
- Iraq
- Volunteers
- 90 people
- Sponsor
- Hawler Medical University
Osteoarthritis
Quantitative Ultrasonography (US) Evaluation on Femoral Condyle Cartilage
The purpose of this study is to investigate the feasibility of using quantitative ultrasonography (US) evaluation to determine the severity of osteoarthritic femoral condyle cartilage erosion.
- Trial name
- US (NCT00630604)
- Sponsor
- Kaohsiung Medical University
Sprain, Strain
Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Soft Tissue Injury
Imprimis Pharmaceuticals is investigating a proprietary, topical cream formulation consisting of 10% ketoprofen (containing 100 mg of ketoprofen in 1gram of cream) for the local treatment of acute musculoskeletal pain.
- Conditions
- Sprain, Strain, Acute Soft Tissue Injury
- Trial name
- NCT00765700
- Testing
- Topical Ketoprofen 10% Cream
- Where
- United States
- Volunteers
- 364 people
- Sponsor
- Imprimis Pharmaceuticals, Inc.
Osteoarthritis, Osteoarthritis (OA) of the Knee
Effect of Autologous Ear Cartilage Micrografting in Knee Osteoarthritis
The goal of this clinical trial is to learn if a single injection of autologous cartilage micrografts suspension, obtained through processing with a specialized technology patient's own small piece of ear cartilage, can improve…
- Conditions
- Osteoarthritis, Osteoarthritis (OA) of the Knee, Moderate Osteoarthritis
- Trial name
- EAR2KNEE (NCT07755579)
- Testing
- Mytocel MSK - Autologous Ear Cartilage Micrografting
- Where
- Hungary
- Volunteers
- 33 people
- Sponsor
- Regenera Activa Worldwide S.L.
Osteearthritis, OA
Value of Adding T2 Mapping Routine MRI in Assessment of Knee Articular Cartilage Early Osteoarthritis
This work aims at elucidating the role of MRI complementary T2 mapping in assessment of the articular knee cartilage for improving sensitivity of detection of early stage of osteoarthritis
- Conditions
- Osteearthritis, OA, OA Knee
- Trial name
- T2 mapping OS (NCT07316257)
- Testing
- MRI
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assiut University
Osteoarthritis, Knee
FibroFix Cartilage P Knee Implant Study
This is a multi-center first-in-human prospective clinical investigation to evaluate the safety and performance of the FibroFix™ Cartilage P Implant and Drill Set. The Implant is a medical device designed by Orthox Ltd.
- Trial name
- FFLEX (NCT05560490)
- Testing
- FibroFix Cartilage P Knee Implantation
- Where
- 2 sites in Hungary, United Kingdom
- Volunteers
- 2 people
- Sponsor
- Orthox Limited
Disorders of Synovium, Multiple Sites, Disorders of Subchondral Bone, Multiple Sites
Articular Sonography: Healthy Subjects Versus Rheumatoid Arthritis Patients
The purpose of this study is to establish the normality of sonographic synovial measures in joints more affected in rheumatoid arthritis patients and establish, in those joints, a sonographic value of synovium predictive of…
- Conditions
- Disorders of Synovium, Multiple Sites, Disorders of Subchondral Bone, Multiple Sites, Disorders of Cartilage, Hand Joints, Arthritis, Rheumatoid
- Trial name
- NCT01476865
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Osteoarthritis
Effect of Methyl-Sulphonyl-Methane on Osteoarthritis and Cartilage
To delineate the effect of MSM on osteoarthritis
- Trial name
- msm (NCT01836757)
- Testing
- MethylSulfonylMethane (MSM)
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- G.Papanikolaou Research Group
Defect of Articular Cartilage, Cartilage Injury
Synovium Brushing to Augmented Microfracture for Improved Cartilage Repair
This is a proof-of-concept study to determine the safety and efficacy of a novel device to increase the reparative capacity of the knee.
- Conditions
- Defect of Articular Cartilage, Cartilage Injury, Osteoarthritis, Knee
- Trial name
- AURA (NCT02696876)
- Testing
- Arthroscopic synovial brushing, Microfracture
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- University of Leeds
Osteoarthritis
PRP vs HA Intra-articular Knee Injections for Cartilage Defects
Study Title: A cohort comparison study Comparing Platelet Rich Plasma vs Hyaluronic Acid Intra-articular Knee Injections for Early Cartilage Defects in the knee.
- Trial name
- NCT02012530
- Testing
- HA, PRP
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Shetty-Kim Research Foundation
Rheumatoid Arthritis
The SPECTRA Study
The purpose of this study is to compare IL-1ra and the combination of IL-1ra and PEGsTNF-RI with respect to their ability to reduce inflammation and bone and cartilage destruction in the synovium of subjects with rheumatoid…
- Trial name
- NCT00537667
- Testing
- anakinra, anakinra and PEG sTNF-R1
- Volunteers
- 22 people
- Sponsor
- Amgen
Developmental Dysplasia of the Hip
Evaluation of T1rho Magnetic Resonance Imaging for Diagnosis of Cartilage Lesions in Hips With Developmental Dysplasia
One of the leading causes of hip arthritis is developmental dysplasia of the hip (DDH). DDH can lead to major damage in the hip joint and may result in hip arthritis later in life.
- Trial name
- NCT02185365
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Ottawa Hospital Research Institute
Anterior Knee Pain Syndrome
10-year Follow-up After Tibial Tubercle Transposition
Patellofemoral pain is a common complaint especially in young adults. It can be caused by patellar maltracking. Part of this is a patella alta.
- Trial name
- TTTfollow-up (NCT05629754)
- Testing
- MRI, radiological assessment
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Centre for Orthopaedic Research Alkmaar
Osteoarthritis, Knee, Breast Cancer
Assessment of 99mTc-NTP 15-5 Uptake on Cartilage, a New Proteoglycan Tracer
This study is a phase I clinical trial aimed to determine the recommended dose of 99mTc-NTP 15-5 to obtain the best tracer joints contrast on images without any toxicity.
- Trial name
- CARSPECT (NCT04481230)
- Testing
- 99mTc-NTP 15-5 at a diagnostic activity of 5 MBq/kg, 99mTc-NTP 15-5 at a diagnostic activity of 10 MBq/kg, 99mTc-NTP 15-5 at a diagnostic activity of 15 MBq/kg
- Where
- 2 sites in France
- Volunteers
- 6 people
- Sponsor
- Centre Jean Perrin