Clinical trials: Arteriosclerosis
Chest Pain, Stable Angina Pectoris, CCS Class I to III
Randomized Evaluation of Patients With Stable Angina Comparing Diagnostic Examinations
This randomized, controlled, diagnostic, multicenter trial will compare two diagnostic imaging pathways--coronary computed tomography angiography (CCTA) and single photon emission tomography (SPECT) myocardial perfusion imaging…
- Conditions
- Chest Pain, Stable Angina Pectoris, CCS Class I to III, Angina Equivalent, Coronary Artery Disease
- Trial name
- RESCUE (NCT01262625)
- Testing
- CCTA, SPECT MPI/ICA
- Where
- 3 sites in United States
- Volunteers
- 1,050 people
- Sponsor
- American College of Radiology
Atherosclerotic Cardiovascular Disease
Heme Oxygenase (HO) Activity and Adenosine Induced Vasodilation
The purpose of this study is to determine whether heme oxygenase 1 induction by heme arginate treatment is of influence on adenosine induced vasodilation in healthy individuals.
- Trial name
- NCT00856817
- Testing
- L-arginine + heme arginate, Heme arginate + L-arginine
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Peripheral Arterial Disease, Critical Limb Ischemia
A Study of the TEmporary Spur StEnt System for the Treatment of Lesions Located in the InfraPoplitEal ARteries Using a LIMUS-base DCB
This is a non-randomized, prospective, single center pilot study designed to evaluate the safety of the Temporary Spur Stent System to treat patients with infrapopliteal arterial disease, when used in conjunction with a…
- Trial name
- DEEPER LIMUS (NCT04162418)
- Testing
- Temporary Spur Stent System
- Where
- Austria
- Volunteers
- 26 people
- Sponsor
- ReFlow Medical, Inc.
Atherosclerosis, Hypercholesterolemia
The Effect of Fasudil on Vascular Function in Humans
The purpose of the study is to evaluate how the rho kinase inhibitor, fasudil, affects vascular function in patients with atherosclerosis and hyperlipidemia.
- Trial name
- NCT00120718
- Testing
- fasudil
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
CHD - Coronary Heart Disease
Assessment of the Usefulness of Hemopatch in Coronary Artery Bypass Graft Surgery
The study aim is to assess polyethylene glycol (PEG) coated collagen patch (Hemopatch) on the quality of drainage after surgery, the length of hospital stay, the number of reoperations due to haemorrhage and treatment cost.
- Trial name
- Hemopatch (NCT03340090)
- Testing
- Medical Device Hemopatch-PEG-coated collagen patch
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Lodz
Coronary Artery Disease
Antiplatelet Effects of Ticagrelor Versus Clopidogrel in American Indian Patients
Assess the pharmacodynamic effect of ticagrelor vs. Clopidogrel in American Indian patients with stable coronary artery disease.
- Trial name
- NCT01706510
- Testing
- Ticagrelor, Clopidogrel
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Rapid City Regional Hospital, Inc
Hypercholesteremia, Coronary Artery Disease
Lipitor Phase 4 Clinical Trial in Hypercholesteremia Patients With Yellow Coronary Plaque
To evaluate the efficacy of intensive lipid-lowering therapy with Lipitor on the changes of characteristics of yellow coronary plaque in subjects with hypercholesteremia accompanying coronary artery disease
- Trial name
- NCT00408382
- Testing
- atorvastatin, Lipitor
- Where
- 2 sites in Japan
- Volunteers
- 50 people
- Sponsor
- Astellas Pharma Inc
Critical Limb Ischemia
Autologous Stem Cells for the Treatment of No Option Critical Limb Ischemia
The trial is a phase 1b, open label, uncontrolled, non-randomized dose-escalation study of autologous bone marrow-derived MSCs. Following informed consent, patients who meet the criteria will be screened and enrolled.
- Trial name
- NCT03455335
- Testing
- 20 million hMSCs, 40 million hMSCs, 80 million hMSCs
- Where
- Ireland
- Volunteers
- 12 people
- Sponsor
- National University of Ireland, Galway, Ireland
Peripheral Arterial Disease, Vascular Diseases
Road Mapping Guided Puncture Versus Ultrasound Guided Puncture During Retrograde Angioplasty Feasibility and Safety
The study aims to compare the technical feasibility and safety of road mapping-guided versus ultrasound-guided retrograde arterial puncture in patients with (CLTI) as measured by: Puncture success rate Access-related complication…
- Trial name
- NCT07427108
- Testing
- Road-map guided versus US guided retrograde access
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Sohag University
Coronary Disease, Heart Diseases
Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO IV-EPIC 38)
This international, multicenter, open-label, randomized clinical trial evaluates the safety and efficacy of single antiplatelet therapy (SAPT) compared to dual antiplatelet therapy (DAPT) in elderly or high bleeding risk patients…
- Conditions
- Coronary Disease, Heart Diseases, Cardiovascular Diseases, Myocardial Ischemia
- Trial name
- PIV-EPIC (NCT06535568)
- Testing
- Drug-coated balloon, Single antiplatelet therapy (SAPT), Dual antiplatelet therapy (DAPT)
- Where
- Italy
- Volunteers
- 576 people
- Sponsor
- Fondazione Ricerca e Innovazione Cardiovascolare ETS
Hot Weather; Adverse Effect, Healthy
Characterization of Myocardial Blood Flow During Heat Exposure
The purpose of this study is to determine the increase in myocardial blood flow during heat exposure and how this response is affected by age and coronary artery disease.
- Conditions
- Hot Weather; Adverse Effect, Healthy, Coronary Artery Disease, Aging
- Trial name
- PET-Heat (NCT04549974)
- Testing
- Heat exposure
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Atherosclerosis, Hypercholesterolemia
Comparison of Co-administration of Ezetimibe Plus Simvastatin Versus Simvastatin Alone in Primary Hypercholesterolemia (P03476)
This study will assess whether the daily co-administration of ezetimibe 10 mg with ongoing treatment of simvastatin 20 mg will be more effective than treatment with simvastatin 20 mg alone in further reducing LDL-C concentrations.
- Conditions
- Atherosclerosis, Hypercholesterolemia, Coronary Heart Disease
- Trial name
- NCT00651274
- Testing
- Ezetimibe
- Volunteers
- 144 people
- Sponsor
- Organon and Co
Coronary Artery Disease, Native Coronary Artery Stenosis
MagicTouch™Sirolimus-Coated Balloon for Treatment of Coronary Artery Lesions in Small Vessels
This is a multicenter, randomized, single-blind pivotal study to evaluate the safety and efficacy of the MagicTouchTM Drug coated balloon in treatment of small vessels in patients with coronary artery disease.
- Conditions
- Coronary Artery Disease, Native Coronary Artery Stenosis, Cardiovascular Diseases
- Trial name
- MAGICAL SV (NCT06271590)
- Testing
- Sirolimus Drug Coated Balloon, Drug eluting stents (DES)
- Where
- 24 sites in United States
- Volunteers
- 1,605 people
- Sponsor
- Concept Medical Inc.
Peripheral Arterial Disease
Functional MRI of the Lower Extremities
In this project, the investigators propose to use high-resolution magnetic resonance imaging (MRI) to measure blood perfusion in different groups of calf muscle.
- Trial name
- NCT03423316
- Testing
- Supervised exercise therapy
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Coronary Artery Disease (CAD)
Impact of CYP2C19 Genotype-guided Clopidogrel and Ticagrelor Treatment on Platelet Function Test and Metabolomics Profile
Several studies have shown that pharmacodynamic (PD) response varies between patients treated with clopidogrel and that individuals with reduced response have an increased risk of recurrent ischemic events, particularly in…
- Trial name
- NCT05516784
- Testing
- Clopidogrel, Ticagrelor
- Where
- Malaysia
- Volunteers
- 80 people
- Sponsor
- Universiti Sains Malaysia
Diabetes Mellitus, Coronary Artery Disease
Periprocedural Glycemic Control in Patients Undergoing Coronary Angiography
There are 24 million people with diabetes mellitus (DM) in the United States. Over one-third of patients presenting for coronary angiography have known DM, and an additional 20% of patients without known DM present with…
- Trial name
- NCT01419652
- Testing
- hold hypoglycemic meds
- Where
- United States
- Volunteers
- 351 people
- Sponsor
- NYU Langone Health
Myocardial Infarction, Coronary Artery Disease
Arrhythmias in Post-Myocardial Infarction Patients
Patients are screened for significant arrhythmias and other possibly significant ECG-patterns directly after discharge and two weeks after myocardial infarction using wearable devices.
- Conditions
- Myocardial Infarction, Coronary Artery Disease, Arrythmia, ECG Electrical Alternans
- Trial name
- NCT03231826
- Where
- Finland
- Volunteers
- 445 people
- Sponsor
- Tampere University
Myocardial Infarction, Coronary Artery Disease
TIMELY: a Patient-centred Lifestyle Program for Patients With Coronary Artery Disease
Study design: A randomized controlled trial will be used, where patients will be randomized (1:1) to either the control group receiving usual care or the intervention group in which patients will receive usual care in combination…
- Trial name
- TIMELY (NCT05955625)
- Testing
- TIMELY
- Where
- 3 sites in Germany, Netherlands and 1 more
- Volunteers
- 358 people
- Sponsor
- Tilburg University
Endothelial Progenitor Cells, Coronary Artery Disease
Tracking Endothelial Cells in Arterial Injury
We plan to track the migratory behaviour of culture-expanded enothelial outgrowth cells in the context of vascular injury sustained during elective coronary angiography.
- Conditions
- Endothelial Progenitor Cells, Coronary Artery Disease, Vascular Injury, Coronary Angiography
- Trial name
- NCT02975518
- Testing
- Administration of radio labelled endothelial outgrowth cells
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Edinburgh
Dementia, Alzheimer's Disease
Evaluating the Effects of Music Interventions on Hospitalised People With Dementia
Dementing syndromes are, for the most part, incurable. People with dementia become highly dependent and frequently have to move from their homes into residential aged care facilities.
- Conditions
- Dementia, Alzheimer's Disease, Dementia, Vascular, Lewy Body Disease
- Trial name
- NCT00448318
- Testing
- Music Therapy
- Where
- Australia
- Volunteers
- 180 people
- Sponsor
- National Ageing Research Institute, Australia