Clinical trials: Arterial Hypotension
Coronary Artery Bypass, Off-Pump, Intraoperative Hypotension
Targeted Blood-pressure Management and Acute Kidney Injury After Coronary Artery Bypass Surgery
Acute renal injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. It is now realized that intraoperative hypotension is an important risk factor for the development of AKI.
- Conditions
- Coronary Artery Bypass, Off-Pump, Intraoperative Hypotension, Acute Kidney Injury, Preventive Medicine
- Trial name
- NCT03629418
- Testing
- Targeted blood-pressure management, Routine blood-pressure management
- Where
- China
- Volunteers
- 612 people
- Sponsor
- Peking University First Hospital
Spinal Induced Hypotension in Cesarean Delivery
Femoral Vein Collapsibility Index and Post-Spinal Hypotension in Pregnant Women: Impact of Position
This study aims to improve the safety of spinal anesthesia for pregnant patients undergoing elective cesarean delivery. Specifically, the investigators are investigating whether ultrasound measurements of a vein in the groin (the…
- Trial name
- NCT06885593
- Testing
- Supine Position, Left Lateral Tilt Position
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Mehmet Sarı
Intraoperative Hypotension, Spinal Aneshtesia
Dural Sac Area-Guided Spinal Anesthesia Dosing for TURP
This randomized controlled study will evaluate whether individualizing the dose of spinal anesthesia according to the ultrasound-derived dural sac cross-sectional area (DSCSA) can improve hemodynamic stability in patients…
- Conditions
- Intraoperative Hypotension, Spinal Aneshtesia, TURP(Transurethral Resection of Prostate)
- Trial name
- NCT07794852
- Testing
- DSCSA-Guided Individualized Spinal Anesthesia Dosing, Bupivacaine, Fentanyl (FEN)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Spinal Induced Hypotension, Elderly
Norepinephrine Versus Phenylephrine for Preventing Spinal Anesthesia Induced Hypotension in Elderly
Various regimens were used for prevention of hypotension; most of these regimens included the use of vasopressors. Ephedrine is commonly used vasopressor for management and prophylaxis of hypotension; however, ephedrine is…
- Trial name
- NCT04195321
- Testing
- Norepinephrine, phenylephrine
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Kasr El Aini Hospital
Hypotension, Point of Care Ultrasound
Sonography in Hypotension and Cardiac Arrest in the Emergency Department.
This study is designed to determine if there is any relationship between performing an abdominal ultrasound on patients who present with hypotension and their clinical outcomes (as measured by 7, 30 day and discharge mortality).
- Conditions
- Hypotension, Point of Care Ultrasound, Shock
- Trial name
- SHoC-ED (NCT01419106)
- Testing
- Ultrasound (A point of care ultrasound protocol)
- Where
- 6 sites in Canada, South Africa
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Horizon Health Network
Perinatal Death, Respiratory Distress Syndrome, Newborn
Maternal Hyperoxygenation for Intrapartum Fetal Heart Rate Tracing Abnormalities
Hyperoxygenation for resuscitation of abnormal fetal heart rate tracings has been routine obstetric practice. However, there have not been any studies to support this practice.
- Conditions
- Perinatal Death, Respiratory Distress Syndrome, Newborn, Hypoxic-Ischemic Encephalopathy, Neonatal Seizure
- Trial name
- NCT03996317
- Testing
- Room air
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Intraoperative Hypotension
Advanced Cardiovascular Management in Major Non-cardiac Surgery.
This is a single center, randomised and controlled clinical triaI whose aim is to predict and treat in advance, intraoperative hypotension episodes.
- Trial name
- NCT07134530
- Testing
- HPI-driven intraoperative hemodynamic management strategy, GDT strategy
- Where
- Italy
- Volunteers
- 534 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Hemodialysis, Interdialytic Weight Gain
This Study Evaluates the Impact of the Sodium Management Tool (SMT) on Hemodialysis Patient Outcomes Compared to Standard Care
Title of the Study: Sodium Management Tool in Hemodialysis Patients Brief Summary: The goal of this clinical trial is to learn whether the Sodium Management Tool (SMT) can improve patients clnical outcomes.
- Conditions
- Hemodialysis, Interdialytic Weight Gain, Intradialytic Hypotension
- Trial name
- SOMADIA (NCT06896786)
- Testing
- dialysis assisted with the sodium management tool
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- Luzerner Kantonsspital
Post Spinal Hypotension
Perfusion Index vs Positional Hemodynamic Changes to Predict Hypotension After Spinal Anaesthesia in Caesarean Section
Comparative Study between the Perfusion Index and Positional Haemodynamic Changes for Prediction of Hypotension after Spinal Anaesthesia in Caesarean Section
- Trial name
- NCT05587153
- Testing
- perfusion index in all parturient recruited for the study
- Where
- 2 sites in Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Adverse Effect
The Potency of Prophylactic Norepinephrine and Phenylephrine Boluses for Postspinal Anesthesia Hypotension
The purpose of this study is to investigate the potency between prophylactic norepinephrine and phenylephrine boluses for postspinal anesthesia hypotension in patients with severe preeclampsia during caesarean section.
- Trial name
- NCT05035472
- Testing
- Phenylephrine, Norepinephrine
- Volunteers
- 80 people
- Sponsor
- General Hospital of Ningxia Medical University
E03.155.253, Bispectral Index Monitor
The Use of Sedation Score and Bispectral Index for Induction in Geriatric Patients
The main objective of this clinical study is to determine the effectiveness of BIS-guided propofol administration in avoiding hypotension during propofol induction in geriatric patients.
- Conditions
- E03.155.253, Bispectral Index Monitor, Hypotension
- Trial name
- NCT06232980
- Testing
- urological surgical intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people
- Sponsor
- Ankara City Hospital Bilkent
Nasal Surgery, Anesthesia
Remifentanil vs. Nicardipine for Controlled Hypotension in Elective Nasal Surgery
This study compares remifentanil infusion versus nicardipine infusion for controlled hypotension during elective nasal surgery. Both agents are standard clinical methods.
- Conditions
- Nasal Surgery, Anesthesia, Controlled Hypotension for Nasal Surgeries
- Trial name
- NCT07660562
- Testing
- Nicardipine, Remifentanil
- Volunteers
- 44 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Multiple System Atrophy - Parkinsonian Subtype (MSA-P), Multiple System Atrophy - Cerebellar Subtype (MSA-C)
PET Imaging Study of Neurochemical and Autonomic Disorders in Multiple System Atrophy (MSA)
Multiple system atrophy (MSA) is a disorder of the nervous system of unclear cause. In MSA there is degeneration (progressive loss) of nerve cells in several brain and spinal cord regions.
- Trial name
- NCT02035761
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Michigan
Spinal Cord Injury
Autonomic Effects of Stimulation in SCI
This study aims to determine the effects of transcutaneous spinal cord stimulation to increase blood pressure and use that device to increase power output and heart rate recovery during arm cycle ergometry.
- Trial name
- NCT05664646
- Testing
- Transcutaneous Spinal Cord Stimulation (TSCS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Orthostatic Hypotension, Dysautonomic, Orthostatic Intolerance
The STAND-UP Study
Orthostatic hypotension (OH) and orthostatic intolerance (OI) are common conditions where blood pressure drops when standing up, causing dizziness, fainting, or fatigue.
- Trial name
- NCT07195903
- Testing
- Angioplasty or stenting
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- St. Francis Hospital, New York
Symptomatic Neurogenic Orthostatic Hypotension
Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension
To evaluate the time to treatment intervention in patients with Parkinson's Disease (PD), Multiple System Atrophy (MSA), Pure Autonomic Failure (PAF), Non-Diabetic Autonomic Neuropathy (NDAN) or Dopamine Beta Hydroxylase (DBH)…
- Trial name
- RESTORE (NCT02586623)
- Testing
- Droxidopa capsules
- Where
- 168 sites in United States
- Volunteers
- 453 people
- Sponsor
- H. Lundbeck A/S
Intradialytic Hypotension, Hypervolemia
Pilot Study Using a Pulse Oximeter Derived Photo-plethysmographic Waveform to Guide Hemodialysis Ultrafiltration
The purpose of this study is to use the photo-plethysmographic [PPG] waveform signal to guide the dialysis and ultrafiltration [UF] of chronic maintenance hemodialysis patients, and to further the investigators understanding of…
- Trial name
- NCT02264522
- Testing
- Place dialysis chair into position 3., Decrease dialysate temperature., Decrease ultrafiltration rate by 25%.
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Intelomed, Inc.
Hypotension, Fontan Physiology
The Hemodynamic Effects of Vasopressin in Patients With Fontan Physiology
The goal of this study is to evaluate if vasopressin can elevate systemic arterial blood pressures without having a significant effect on pulmonary arterial pressures.
- Trial name
- NCT04463394
- Testing
- Vasopressin
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Stanford University
Hypotension, Shock
Trendelenburg as a First-line Intervention in Critically Ill, Sedated, Invasively Mechanically Ventilated, Hypotensive Patients
A pilot randomized controlled trial to evaluate the efficacy and safety of Trendelenburg position in critically ill patients with hypotension, mainly patients with septic shock and post operative vasoplegia.
- Trial name
- Trend (NCT05209737)
- Testing
- Trendelenburg position, Semirecumbent position
- Where
- 2 sites in Russia
- Volunteers
- 10 people
- Sponsor
- Negovsky Reanimatology Research Institute
Hypertension
Angiotensin II in General Anesthesia
Hypotension in adult patients undergoing general anesthesia is common. This can lead to hypoperfusion of vital organs, organ damage, and states of increased metabolic duress.
- Trial name
- NCT03733145
- Testing
- Angiotensin II
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Wake Forest University Health Sciences
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