Clinical trials: Arterial Hypotension
Hypotension on Induction
PPV for Predicting PIH in the Elderly
The purpose of this observational study is to investigate the predictive power of pulse pressure variability during forced inhalation（PPVfi） on the occurrence of hypotension in elderly patients after induction of general…
- Trial name
- PPVfi-PIH (NCT07166562)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Second Xiangya Hospital of Central South University
Perioperative Bleeding, Venous Thrombosis
PeriOperative ISchemic Evaluation-3 Trial
This study is a multicentre, international, randomized controlled trial of tranexamic acid (TXA) versus placebo and, using a partial factorial design, of a perioperative hypotension-avoidance versus hypertension-avoidance…
- Conditions
- Perioperative Bleeding, Venous Thrombosis, Arterial Thrombosis
- Trial name
- POISE-3 (NCT03505723)
- Testing
- Tranexamic Acid, Perioperative hypotension-avoidance strategy, Perioperative hypertension-avoidance strategy
- Where
- 114 sites in United States, Australia and 21 more
- Volunteers
- 9,535 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Hypotension Drug-Induced
Is Labetalol More Effective Than Metoprolol for Controlled Hypotensive Anesthesia During Endoscopic Nasal Surgeries?
Background: Mucosal bleeding is the most frequent complication with endoscopic nasal surgeries, as it interferes with the optimal visualization of the intranasal anatomy, leading to increased complications, operation duration…
- Trial name
- NCT05368376
- Testing
- Labetalol Hydrochloride Oral Tablet, Metoprolol Tartrate Oral Tablet
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour Teaching Hospital
Spinal Anesthesia-induced Hypotension
Predicting if the Blood Pressure Will Drop After Spinal Anesthesia Using Ultrasound of the Neck
After a spinal injection, blood pressure might drop for a short time, similar to what happens with general anesthesia. This drop can be different for each person.
- Trial name
- NCT06711289
- Testing
- Carotid ultrasound measurement, Vital sign measurement, Spinal anesthesia
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Post-spinal Hypotension, Orthopedic Surgery
Ketamine for Preventing Post-Spinal Hypotension in Orthopedic Surgery
This randomized, double-blind, controlled clinical trial investigates the efficacy of a sub-anesthetic dose of ketamine (0.5 mg/kg IV) in preventing post-spinal hypotension in patients undergoing elective orthopedic surgeries…
- Conditions
- Post-spinal Hypotension, Orthopedic Surgery, Spinal Aneshtesia
- Trial name
- NCT06995690
- Testing
- Ketamine, Normal Saline
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Spinal Cord Injury
Blood Pressure, Cerebral Blood Flow and Cognition in Spinal Cord Injury
Following spinal cord injury autonomic regulation of the cardiovascular system is impaired, which results in a variety of measurable abnormalities in blood pressure.
- Trial name
- NCT02307565
- Testing
- Midodrine
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Autonomic Failure, Pure Autonomic Failure
CPAP for the Treatment of Supine Hypertension
This study aims to learn about the effects of continuous positive airway pressure (CPAP) on people with autonomic failure and high blood pressure when lying down (supine hypertension) to determine if it can be used to treat their…
- Conditions
- Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy, Parkinson Disease
- Trial name
- NCT05489575
- Testing
- Active CPAP, Sleeping in a head-up tilt (HUT) position
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Vanderbilt University Medical Center
Intra-dialytic Hypotension
Mannitol - Potential Role in Hemodialysis Initiation for Reduction of Intra-dialytic Hypotension
Kidney failure can result from a variety of conditions and can be temporary or permanent. Hemodialysis is available as a replacement treatment to perform the work that the kidneys normally do.
- Trial name
- NCT01520207
- Testing
- Mannitol (20%), 0.9% saline
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Brigham and Women's Hospital
Hypotension on Induction
Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery
Primary research hypothesis: Patients who continue their chronic ACEI therapy up to and including the morning of a non-cardiac, non-vascular surgery will experience more intraoperative hypotension than those who transiently hold…
- Trial name
- NCT01669434
- Testing
- ACEI continuation, ACEI omission
- Where
- United States
- Volunteers
- 291 people
- Sponsor
- University of Nebraska
Acute Kidney Injury, Dialysis Hypotension
Outpatient Recovery From Acute Kidney Injury Requiring Dialysis
There are currently no therapies to improve the chances of recovering enough kidney function to come off of dialysis after severe acute kidney injury.
- Trial name
- ORKID (NCT05158153)
- Testing
- ORKID Bundled Intervention, Furosemide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, San Francisco
Cardiac Surgery, Vasoplegia
Reducing Cardiac-surgery Associated Acute Kidney Injury Occurence by Administering Angiotensin II
The study intervention focuses on exploring the use of angiotensin II as a primary vasopressor compared to norepinephrine in cardiac surgery patients to investigate whether angiotensin II can reduce the occurrence of…
- Trial name
- PAN-AKI (NCT06615102)
- Testing
- Angiotensin II, Noradrenalin
- Where
- 4 sites in Germany
- Volunteers
- 1,022 people
- Sponsor
- Universität Münster
Intradialytic Hypotension
The Clinical Study of Improving the Thirst and Hypotension of Hemodialysis Patients
This clinical study is to observe the improvement of MHD (maintenance hemodialysis) patients, quality of life，after applying therapy combining Auriculotherapy and Shengmai capsule.
- Trial name
- NCT02583802
- Testing
- Ear pills, Shengmai capsule
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Beijing University of Chinese Medicine
Intradialytic Hypotension, End-Stage Renal Disease
The Efficacy and Safety of Guilu Erxian Jiao in the Treatment of Intradialytic Hypotension
The goal of this clinical trial is to learn if Guilu Erxian Jiao, a traditional Chinese herbal medicine, can help manage intradialytic hypotension (IDH), a drop in blood pressure that occurs during hemodialysis in adults.
- Conditions
- Intradialytic Hypotension, End-Stage Renal Disease, Hemodialysis
- Trial name
- NCT06980922
- Testing
- Guilu Erxian Jiao
- Where
- Taiwan
- Volunteers
- 34 people
- Sponsor
- Chang Gung Memorial Hospital
Intradialytic Hypotension
A Preliminary Randomized Study of Tianjiu (Auto-moxibustion) Effects in Patients With Intradialytic Hypotension
Intradialytic hypotension (IDH) is a most frequent complication of hemodialysis (HD) and may contribute to cardiovascular events and high mortality.
- Trial name
- NCT02210377
- Testing
- Tianjiu
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Chang Gung Memorial Hospital
Oxygen Saturation
Comparison of Volatile Anesthetics on Cerebral Oxygenation During Controlled Hypotension
Controlled hypotension is a preferred method for reducing surgical bleeding during septoplasty operations however, the level of hypotension and bradycardia should not disrupt cerebral oxygenation.
- Trial name
- NCT02834845
- Testing
- Sevoflurane, Desflurane
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people
- Sponsor
- Ufuk University
Geriatrics, Hypotension on Induction
Carotid Artery Corrected Flow Time and Inferior Vena Cava Collapsibility Index for Prediction of Hypotension After Induction of General Anesthesia in Geriatric Patients Undergoing Elective Surgery
In this observational study, we will assess cFT by Carotid ultrasound and IVC collapsibility index for prediction of hypotension after induction of general anesthesia in geriatric patients undergoing elective surgery.
- Conditions
- Geriatrics, Hypotension on Induction, General Anesthetic Drug Adverse Reaction, Elective Surgery
- Trial name
- NCT06814054
- Testing
- Carotid Artery Corrected Flow Time measurement, Inferior vena cava collapsibility index
- Where
- Egypt
- Volunteers
- 189 people
- Sponsor
- Tanta University
Cerebrospinal Fluid Leaks
A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment
The goal of this randomized controlled trial (RCT) is to compare the efficacy of CT fluoroscopy-guided targeted epidural patching for treatment of imaging-confirmed spinal CSF leaks to that of a simulated procedure without…
- Trial name
- NCT03276975
- Testing
- TISSEEL
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Duke University
Perioperative/Postoperative Complications
Ability of Hypotension Prediction Index to Predict Hypotension Events in Thoracic Surgery
Investigators design this prospective observational study to exam the ability of hypotension prediction index in predicting intraoperative hypotension events in each phase of thoracic surgery
- Trial name
- NCT05117151
- Testing
- hypotension prediction index
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Unstable Blood Pressure, Hypotension
Noninvasive Continuous BP Monitoring in Newborns Based on Pulsatile Signal Morphological Features Using NIRS
The goal of this study is to evaluate if a novel near-infrared spectroscopy (NIRS) device can accurately estimate blood pressure in newborns at risk for unstable blood pressure.
- Trial name
- NCT06994494
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Symptomatic Neurogenic Orthostatic Hypotension
Study of the Fed-Fast Pharmocokinetics and Bioequivalance of 300mg Capsules of Droxidopa
One purpose of this study is to determine if taking droxidopa after eating will have an effect on how the body processes (absorbs and eliminates) the drug in healthy elderly subjects.
- Trial name
- NCT01149629
- Testing
- Droxidopa
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chelsea Therapeutics
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