Clinical trials: Arrhythmia Atrial
Atrial Fibrillation
Prediction of the COBRRA AF Anticoagulant Trial in Healthcare Claims Data
Investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials.
- Trial name
- NCT05256797
- Testing
- Rivaroxaban, Apixaban
- Where
- United States
- Volunteers
- 353,980 people
- Sponsor
- Brigham and Women's Hospital
Atrial Fibrillation
Use of Colchicine to Decrease Atrial Fibrillation Recurrence After Ablation
Ablation of atrial fibrillation (AFib) has been recommended as a therapeutic option when rhythm maintenance strategy is sought. One of the main objectives of an AFib ablation procedure is electrical isolation of the pulmonary…
- Trial name
- NCT05459974
- Testing
- Colchicine 0.6 mg
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Stony Brook University
Paroxysmal Atrial Fibrillation, Atrial Fibrillation
Adjunctive Ganglionated Plexus Ablation in Redo-Pulmonary Vein Isolation
The investigator propose to test the efficacy of adjunctive ET-GP ablation in patients undergoing redo PVI for paroxysmal AF.
- Trial name
- ADD-GP (NCT03535818)
- Testing
- Radiofrequency ablation
- Where
- United Kingdom
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Paroxysmal Atrial Fibrillation
POLARx Post Approval Study (POLARx PAS)
To collect clinical data on safety, effectiveness and procedural success of Boston Scientific's Cardiac Cryoablation System (includes all BSC commercially available POLARx/POLARx Fit catheters) when used to perform pulmonary vein…
- Trial name
- NCT06170606
- Testing
- Boston Scientific Cardiac Cryoablation System
- Where
- 11 sites in United States
- Volunteers
- 200 people
- Sponsor
- Boston Scientific Corporation
Embolic Stroke of Undetermined Source
Identification of New Markers of Atrial Myopathy in Patients With Embolic Stroke of Undetermined Source (ESUS) From MRI 4D Data
Atrial myopathy is considered to be the underlying cause of a large proportion of embolic strokes of undetermined source. However, the definition of this atrial condition is not well delineated while its identification could lead…
- Trial name
- IRM 4D-AVC (NCT04717843)
- Testing
- 4D Flow MRI, Medical consultation with 12 leads ECG, Holter ECG
- Where
- 3 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Paroxysmal Atrial Fibrillation
Oral Anticoagulation Therapy Pilot Study
The objective of this study is to determine the safety of discontinuing oral anticoagulation therapy in high risk patients who have had a successful cardiac ablation and remain AF recurrence free for 3 months post ablation.
- Trial name
- OAT (NCT01959425)
- Testing
- Off OAT Group (Test), On OAT Group (Control)
- Volunteers
- 80 people
- Sponsor
- Biosense Webster, Inc.
Atrial Flutter
Cardiovascular Magnetic Resonance-Guided Radiofrequency-Ablation for Atrial Flutter II
The purpose of this clinical study is to assess the safety and performance of the Vision-MR Ablation Catheter, the primary safety endpoint will measure the rate of serious adverse events related to the device or procedure; the…
- Trial name
- 2016-IMR (NCT03078985)
- Testing
- ablation for typical atrial flutter, catheter ablation with study device
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- University of Leipzig
Atrial Fibrillation
Retrospective Observational Registry of Patients With Atrial Fibrillation From Vigo´s Health Area
Registry of all consecutive patients with atrial fibrillation from Heath Area of Vigo, since 2013 to 2020, in order to study therapy, mortality, cardiovascular complications and bleeding events.
- Trial name
- CardioCHUVI-AF (NCT04364516)
- Testing
- Anticoagulation
- Where
- Spain
- Volunteers
- 15,000 people
- Sponsor
- Hospital Álvaro Cunqueiro
Atrial Fibrillation (AF)
The Modified "Pills-in-the-Pocket" Strategy
This is a multicentre, prospective, randomised controlled study of 328 patients with non-paroxysmal AF (within 5 years of first diagnosis of AF) with recurrent atrial arrhythmias after first catheter ablation, randomly divided in…
- Trial name
- ABD-AF (NCT06657404)
- Testing
- use Amiodarone, Bisoprolol and Digoxin
- Where
- China
- Volunteers
- 328 people
- Sponsor
- Yumei Xue
Atrial Fibrillation
A Study to Evaluate Effectiveness and Safety of Edoxaban in Patients 80 Years of Age or Older With Nonvalvular Atrial Fibrillation
Non-valvular atrial fibrillation (NVAF) increases the risk of stroke by three- to five-fold, especially in elderly patients, creating a huge burden on medical system as well as a negative impact on patients' lives.
- Trial name
- SILVERCARE_AF (NCT05804747)
- Testing
- Edoxaban
- Where
- 33 sites in South Korea
- Volunteers
- 1,204 people
- Sponsor
- Daiichi Sankyo
Valvular Heart Surgery
Prediction of Fluid Responsiveness in Atrial Fibrillation Patients Who Underwent Valvular Heart Surgery: Peep-induced Increase in Central Venous Pressure vs. Passive Leg Raising
Dynamic indices of preload depending on the heart-lung interaction require sinus rhythm and cannot be applied to patients with atrial fibrillation.
- Trial name
- NCT02224378
- Testing
- peep induced CVP, passive leg raising(PLR)
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Yonsei University
Atrial Fibrillation
Changes of Left Atrial Function and Quality of Life After Transcatheter Closure of Left Atrial Appendage in Patients With Atrial Fibrillation
A total of 105 (AF) patients with atrial fibrillation are scheduled to undergo surgery and will be divided into three groups. Left atrial appendage occlusion ((LAAC)), radiofrequency ablation guided by three-dimensional mapping…
- Trial name
- NCT04376606
- Testing
- Left atrial appendage closure, Radiofrequency ablation, LAAC combined with radiofrequency ablation group
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Ruiqin xie
Atrial Fibrillation
Reaching the Frail Elderly for the Management of Atrial Fibrillation
The overall objective of the project is to develop a collaboration model between the patient, the patient's General Practitioner (GP) and the cardiologist at the hospital in a seamless collaborative model dubbed the "Cardio-relay…
- Trial name
- REAFEL (NCT04162548)
- Where
- Denmark
- Volunteers
- 344 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Cardiovascular Diseases, Atrial Fibrillation
Pharmacogenetics and Cardiovascular Events
To assess interactions between selected cardiovascular medications and genes in the incidence of heart attack, stroke, and atrial fibrillation, an irregular heartbeat.
- Conditions
- Cardiovascular Diseases, Atrial Fibrillation, Cerebrovascular Accident, Heart Diseases
- Trial name
- NCT00094198
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease, Atrial Fibrillation
Postoperative Lactate and Atrial Fibrillation After CABG
Postoperative atrial fibrillation (POAF) is associated with increased mortality and morbidity in patients undergoing isolated coronary artery bypass grafting (CABG).
- Trial name
- NCT05448521
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Cryptogenic Stroke, Atrial Fibrillation
Incidence and Predictors of Recurrent Stroke in Cryptogenic Stroke Patients With Atrial Fibrillation
Brief Summary: This study aimed to investigate the risk and factors that predict recurrent stroke in patients who initially had a stroke with no clear cause (called cryptogenic stroke) and were later found to have atrial…
- Conditions
- Cryptogenic Stroke, Atrial Fibrillation, Recurrent Ischemic Stroke
- Trial name
- NCT07126184
- Testing
- Extended Cardiac Monitoring
- Where
- Pakistan
- Volunteers
- 109 people
- Sponsor
- Nangarhar University
Atrial Fibrillation
Safety and Effectiveness of Left Atrial Appendage Occlusion
This study is to evaluate acute and long-term safety and effectiveness of Left atrial appendage occlusion (LAA)with the AtriCure LAA Occlusion System.
- Trial name
- NCT00567515
- Testing
- AtriCure LAA Exclusion System
- Where
- Switzerland
- Volunteers
- 41 people
- Sponsor
- AtriCure, Inc.
Atrial Fibrillation, Atrial Flutter
Prevalence of Primary Aldosteronism in Hypertensive Patients Presenting With Atrial Flutter or Fibrillation
Primary objective of the PAPPHY Study is to establish the prevalence of primary aldosteronism (PA) in consecutive hypertensive patients referred for 'lone' paroxysmal, persistent or permanent atrial flutter or fibrillation (AFF).
- Conditions
- Atrial Fibrillation, Atrial Flutter, Aldosteronism
- Trial name
- PAPPHY (NCT01267747)
- Where
- 2 sites in Italy
- Volunteers
- 411 people
- Sponsor
- University Hospital Padova
Atrial Fibrillation, Mild Cognitive Impairment
Cognitive Impairment in Atrial Fibrillation
This study aims to compare the incidence of new-onset cognitive impairments and change in existing impairment status between AF patients undergoing either catheter ablation or remaining on anti-arrhythmic drugs (AAD) as assessed…
- Conditions
- Atrial Fibrillation, Mild Cognitive Impairment, Dementia
- Trial name
- DIAL-F (NCT01816308)
- Where
- United States
- Volunteers
- 888 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation
REPRESENT-PF Registry
This pragmatic, prospective, single-arm, multi-center, observational registry will evaluate the safety and effectiveness of PFA for the treatment of atrial fibrillation in underrepresented minority patients using FDA approved…
- Trial name
- REPRESENT-PF (NCT07535268)
- Testing
- FARAWAVE Pulsed Field Ablation Catheter
- Where
- 2 sites in United States
- Volunteers
- 275 people
- Sponsor
- Vivek Reddy