Clinical trials: Ards
ARDS, Human
Feasabilty and Physiological Effects of a Ventilation Strategy Combining PEEP and Tidal Volume Titration According to Inspiratory and Expiratory Transpulmonary Pressures in ARDS Patients.
Expiratory or inspiratory transpulmonary pressures have been proposed to optimize ventilator settings in patients with ARDS. The aim of this study is to assess the feasibility and the physiological effects of a new method based…
- Trial name
- PULMOESO (NCT05337059)
- Testing
- PEEP and Tidal Volume Titration
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Angers
Transient Tachypnea of the Newborn
Diagnosis of Transient Tachypnea of Newborn
Transient tachypnea of the newborn (TTN) is the most common cause of respiratory distress in fullterm newborn. TTN is a diagnosis of exclusion, It is primarily diagnosed based on medical history and typical clinical presentation.
- Trial name
- NCT05538780
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
ARDS, Human
Advisory Lead ARDS Respirator Management
A advisory will be activated in the ICUs patient data management system. The trial will be conducted as observational cohort trial. During the first six month all patients with a LIPS ≥ 4 will be included in the control group.
- Trial name
- ALARM (NCT04274296)
- Testing
- Activation of Advisory
- Where
- Austria
- Volunteers
- 472 people
- Sponsor
- Mathias Maleczek
Preterm Birth, Premature
Comparison of the Acute Effects of Chest Physiotherapy Methods Applied in Different Positions in Preterm Newborns
Infants in the neonatal intensive care unit (NICU) may be lost due to risks such as being sensitive, frequent exposure to birth complications and being prone to infection.
- Conditions
- Preterm Birth, Premature, Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
- Trial name
- therapy (NCT05036603)
- Testing
- chest physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sanko University
Covid19, ARDS
Dexamethasone Vs Methylprednisolone for the Treatment of Patients With ARDS Caused by COVID-19
A randomized clinical trial designed and intended to evaluate the efficacy of Dexamethasone and Methylprednisolone as a treatment for severe Acute Respiratory Distress Syndrome (ARDS) caused by coronavirus disease 19 (COVID-19).
- Trial name
- NCT04499313
- Testing
- Dexamethasone, Methylprednisolone
- Where
- 2 sites in Bangladesh
- Volunteers
- 60 people
- Sponsor
- Chattogram General Hospital
Respiratory Distress Syndrome, Adult
Efficacy and Safety of FP-1201-lyo (Interferon Beta-1a) in Patients Having Acute Respiratory Distress Syndrome (ARDS)
In this study effectiveness and safety of a new drug FP-1201-lyo (recombinant human interferon beta-1a) is compared to placebo. Investigation is conducted with patients who have acute respiratory distress syndrome (ARDS).
- Trial name
- INTEREST (NCT02622724)
- Testing
- Interferon beta-1a
- Where
- 71 sites in Belgium, Czechia and 6 more
- Volunteers
- 301 people
- Sponsor
- Faron Pharmaceuticals Ltd
ARDS, Human, Mechanical Ventilation Complication
Smartphone Application for Initiation of Protective Ventilation. Clinical Impact of Instrumental Dead Space Reduction
Clinical evaluation of a new educative tools (Smartphone application) based on impact of instrumental dead space reduction after initiation of protective ventilation during mechanical ventilation.
- Conditions
- ARDS, Human, Mechanical Ventilation Complication, Humidifier Lung
- Trial name
- Ventilo (NCT04390360)
- Testing
- Protective ventilation implementation, Protective ventilation with HME, Protective ventilation with Heated humidifier
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Laval University
Respiratory Distress Syndrome
High Flow Nasal Cannula (HFNC) Versus Nasal Intermittent Mandatory Ventilation (NIMV)for Respiratory Distress Syndrome (RDS): a Randomized, Controlled, Prospective Study
The investigators hypothesize that while the extremely low birthweight (ELBW) infants (<1000 g) may need NIMV for the treatment of RDS, larger infants or the smaller ones post extubation may enjoy the comfort benefits associated…
- Trial name
- NCT01189162
- Testing
- NIMV with SLE ventilator vs HFNC via Vapotherm
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Bnai Zion Medical Center
Respiratory Distress Syndrome, Hyperoxia
Clinical Evaluation of a Closed Loop Oxygen Controller for Neonatal Respiratory Care
Nearly forty years ago Berran and coworkers tested an analog oxygen controller to maintain incubator oxygen levels for infants suffering neonatal respiratory disease in order to prevent hyperoxia.
- Conditions
- Respiratory Distress Syndrome, Hyperoxia, Prematurity
- Trial name
- NCT00887731
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Acute Lung Injury, Acute Respiratory Distress Syndrome
Soluble Forms and Ligands of RAGE in ALI/ARDS (SoLiRAGE).
RAGE, the receptor for advanced glycation end products, is a novel marker of alveolar epithelial type I cell injury. Soluble RAGE (sRAGE) is elevated in the plasma and in the pulmonary edema fluid from patients with ALI/ARDS, but…
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Mechanical Ventilation
- Trial name
- SoLiRAGE (NCT01270295)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
COVID-19, ARDS
Assessment of Analgesics and Sedatives in Mechanically Ventilated Patients With COVID-19
The analgesic and sedation requirements in critically ill patients with COVID-19 have yet to be described. There are various factors that are likely affecting the agents being utilized for analgesia and sedation in these patients…
- Conditions
- COVID-19, ARDS, Withdrawal Syndrome, Iatrogenic Disease
- Trial name
- NCT05336656
- Where
- United States
- Volunteers
- 353 people
- Sponsor
- Wilkes University
Transfusion Related Acute Lung Injury
A Open Label, Post Marketing Surveillance Study Following Transfusion of INTERCEPT Platelet Components
This study is a prospective, non-randomized sequential cohort, open label, multi-center, non-inferiority, Phase IV surveillance study following transfusion of INTERCEPT PCs.
- Trial name
- PIPER (NCT02549222)
- Testing
- Standard of Care
- Where
- 15 sites in United States
- Volunteers
- 2,291 people
- Sponsor
- Cerus Corporation
Acute Respiratory Distress Syndrome, Septic Shock
Assessment of Preload Responsiveness in ARDS Patients During Prone Position
Evaluation of preload responsiveness in ARDS patients during prone position is difficult and only one study showed Trendelenburg manoeuvre can be used in this group of patients.
- Conditions
- Acute Respiratory Distress Syndrome, Septic Shock, Hemodynamic Instability
- Trial name
- PR-ARDS-PP (NCT04457739)
- Testing
- Tidal volume challenge, End-expiratory occlusion test, Trendelenburg maneuver
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Bicetre Hospital
Infant, Premature, Diseases, Respiratory Distress Syndrome
Pain Assessment During Less-Invasive-Surfactant-Administration
Primary aims of the study are to evaluate the feasibility of Skin conductance (SC) measurements and its correlation to Neonatal Pain and Distress Scale (N-PASS) - scores during the Less-Invasive-Surfactant-Administration…
- Conditions
- Infant, Premature, Diseases, Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal, Pain
- Trial name
- PALISA (NCT06150586)
- Testing
- Skin Conductance (SC) Measurement, Video Recording
- Where
- Switzerland
- Volunteers
- 21 people
- Sponsor
- University of Zurich
Respiratory Distress Syndrome, Adult
Individualized Positive End-expiratory Pressure Guided by End-expiratory Lung Volume in the Acute Respiratory Distress Syndrome
During the acute respiratory distress syndrome (ARDS), patients' response to positive end-expiratory pressure (PEEP) is variable according to different degrees of lung recruitability.
- Trial name
- IPERPEEP (NCT04012073)
- Testing
- Invasive Mechanical ventilation, Neuromuscular Blocking Agents, Prone positioning
- Where
- 10 sites in Italy
- Volunteers
- 18 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Respiratory Distress Syndrome (ARDS)
The Relationship Between Positive End Expiratory Pressure and Cardiac Index in Patients With Acute Respiratory Distress Syndrome (ARDS) Managed on a Fluid Protocol
The objective of this study is to evaluate the association between positive end-expiratory pressure (PEEP) setting and cardiac function, as measured by cardiac index, in patients with acute respiratory distress syndrome (ARDS)…
- Trial name
- NCT01714583
- Where
- United States
- Volunteers
- 367 people
- Sponsor
- Yale University
Acute Respiratory Distress Syndrome
Comparison of Positive End Expiratory Pressure Titration Methods in ARDS Patients
This study aims at assessing the short-term physiological effects of 2 positive end expiratory pressure titration strategies in patients with ARDS.
- Trial name
- ELSE (NCT03281473)
- Testing
- Strategy 1, Strategy 2
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Angers
ARDS, Human, Coronavirus
Sevoflurane in COVID-19 ARDS (SevCov)
The purpose of this trial is to study the effect of initial temporary sevoflurane sedation on mortality and persistent organ dysfunction (POD) in survivors at day 28 after ICU admission in the population of patients suffering…
- Trial name
- NCT04355962
- Testing
- Sevoflurane, Intravenous drug
- Where
- 4 sites in Switzerland
- Volunteers
- 68 people
- Sponsor
- University of Zurich
Respiratory Distress Syndrome, Ventilation Therapy; Complications
Changes in Lung Aeration and Inspiratory Effort With and Without Awake Prone
The investigators aimed to investigate the ventilation homogeneity and transpulmonary pressure during treatments of High-flow nasal cannula(HFNC) and (CPAP) on supine and prone position for COVID-19 or non-COVID-19 patients with…
- Trial name
- NCT05719103
- Testing
- With and Without Awake Prone Positioning
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Shanghai Zhongshan Hospital
Acute Respiratory Distress Syndrome, Ventilator Lung
FCV vs PCV in Moderate to Severe ARDS
The goal of this clinical trial is to compare flow-controlled ventilation (FCV) and pressure-controlled ventilation (PCV) in patients with moderate to severe acute respiratory distress syndrome on the intensive care unit.
- Trial name
- NCT06051188
- Testing
- Flow-controlled ventilation
- Where
- 2 sites in Netherlands
- Volunteers
- 15 people
- Sponsor
- Erasmus Medical Center