Clinical trials: Appendicitis Acute
Appendicitis
The Role of Imaging in the Diagnosis of Acute Appendicitis During the COVID-19 Pandemic
This is a retrospective observational study in the form of a cohort study evaluating the use of pre-operative imaging for the diagnosis of acute appendicitis in a tertiary centre during the first and second waves of the COVID-19…
- Trial name
- NCT05205681
- Testing
- Pre-operative imaging
- Where
- United Kingdom
- Volunteers
- 313 people
- Sponsor
- University College London Hospitals
Laparoscopic Surgery, Acute Appendicitis With Rupture
Open to Laparoscopic Reverse Conversion of Perforated Appendicitis
A Prospective Randomized Controlled Trial of Reverse Conversion (Open to Laparoscopic) in management of Acute Perforated Appendicitis
- Conditions
- Laparoscopic Surgery, Acute Appendicitis With Rupture, Sepsis, Abdominal Abscess
- Trial name
- reverse (NCT05283733)
- Testing
- reverse conversion technique
- Where
- Egypt
- Volunteers
- 426 people
- Sponsor
- Zagazig University
Suspected Appendicitis
Preoperative Methylprednisolone to Patients Suspected of Appendicitis Undergoing Laparoscopy
To test whether 125 mg preoperative methylprednisolone intravenously can reduce postoperative pain after laparoscopy for suspected appendicitis and to test whether preoperative methylprednisolone can reduce postoperative fatigue…
- Trial name
- NCT02711449
- Testing
- Methylprednisolone, 0.9% Saline
- Where
- 2 sites in Denmark
- Volunteers
- 78 people
- Sponsor
- Jakob Kleif
Appendicitis
Safety and Efficacy Study of Single Port Laparoscopic Appendectomy in Acute Appendicitis
The aim of this study is to investigate the safety and efficacy of single port laparoscopic appendectomy compared with conventional laparoscopic appendectomy in adults with acute appendicitis.
- Trial name
- NCT01007318
- Testing
- Single port laparoscopic appendectomy, 3 port laparoscopic appendectomy
- Where
- South Korea
- Volunteers
- 194 people
- Sponsor
- Kyunghee University Medical Center
Covid19, Appendicitis
Operative vs Non-Operative Management of Acute Appendicitis and Acute Cholecystitis in COVID-19 Positive Patients
This study evaluates operative and non-operative management of acute appendicitis (infection or inflammation of the appendix) and acute cholecystitis (inflammation/infection of the gallbladder) in patients with active mild to…
- Conditions
- Covid19, Appendicitis, Cholecystitis, Acute, Cholecystitis; Gallstone
- Trial name
- NCT04748120
- Testing
- Operative management, Non-operative management
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The Cleveland Clinic
Complicated Appendicitis, Acute Appendicitis
Antibiotic Instillation in Appendicitis
Appendicitis (inflammation of the wall of the appendix, causing pain and tenderness in the abdomen) has a range of severity that goes from simple to complicated.
- Trial name
- NCT05470517
- Testing
- Ceftriaxone, Intra-peritoneal Fluid Aspiration
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- Johns Hopkins All Children's Hospital
Acute Uncomplicated Appendicitis
Pilot Trial of Antibiotics Versus Surgery for Treating Acute Appendicitis
The major goal of the project is to demonstrate the feasibility of conducting a multi-center randomized clinical trial of antibiotic therapy versus appendectomy for the treatment of patients with acute uncomplicated appendicitis…
- Trial name
- NCT02447224
- Testing
- 1 gm IV ertapenem at enrollment, 1 gm IV ertapenem at Day 2 and oral metronidazole and cefdinir to complete 10 days, Appendectomy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Olive View-UCLA Education & Research Institute
Appendicitis Acute
Comparison of Open and Laparoscopic Appendectomy in Pediatric Population
Introduction: In the era of minimally invasive surgery, changing trends are towards laparoscopic surgery, first introduced in 1983.
- Trial name
- Appendicitis (NCT06363318)
- Testing
- Laparoscopic appendicectomy
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- King Edward Medical University
Appendicitis Acute
Low vs Medium Pressure Pneumoperitoneum
The purpose of this study is to asses whether the pressure used for the pneumoperitoneum during laparoscopic surgery in children affects their postoperative pain levels.
- Trial name
- LoMePneu (NCT04949659)
- Testing
- Laparoscopic appendectomy
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- University Children's Hospital, Zurich
Telemedicine
The Feasibility Study for Real-time Remote CT Reading for Suspected Acute Appendicitis Using iPhone
1. Purpose The investigators aim to evaluate the feasibility of iPhone based remote control system as a real-time remote CT reading tool for suspected appendicitis under 3G network and the suboptimal illumination. 2.
- Trial name
- Telemedicine (NCT02108717)
- Testing
- Remote CT reading using the iPhone, CT reading using LCD monitor
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hanyang University
Acute Appendicitis
Acute Appendicitis and Microbiota - Etiology of Appendicitis and Antibiotic Therapy Effects
Appendicectomy has been the treatment of acute appendicitis for over a hundred years. Appendicectomy, however, includes operative and postoperative risks despite being a routine procedure.
- Trial name
- MAPPAC (NCT03257423)
- Testing
- Ertapenem followed by levofloxacin and metronidazole, Moxifloxacin, Appendectomy
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Turku University Hospital
Abscess, Intra-Abdominal, Abdominal Abscess
A Safety and Tolerability Study of Doripenem Compared With Meropenem in Children Hospitalized With Complicated Intra-abdominal Infections
The purpose of the study is to evaluate the safety and tolerability of doripenem compared with meropenem in children hospitalized with complicated intra-abdominal infections.
- Conditions
- Abscess, Intra-Abdominal, Abdominal Abscess, Abdomen, Acute, Abdominal Pain
- Trial name
- NCT01110382
- Testing
- Doripenem, Meropenem, Amoxicillin/clavulanate potassium
- Where
- 19 sites in United States, Argentina and 6 more
- Volunteers
- 41 people
- Sponsor
- Janssen Research & Development, LLC
One Hundred Patients Aged 65 and Older Who Underwent Emergency General Surgical Interventions, Clinical Utility of These Scoring Systems
A Comparative Study of CCI, EmSFI, and FTRST Scoring Systems
Frailty assessment tools and comorbidity indices play a crucial role, particularly in predicting outcomes for elderly patients undergoing emergency surgery.
- Conditions
- One Hundred Patients Aged 65 and Older Who Underwent Emergency General Surgical Interventions, Clinical Utility of These Scoring Systems, Gastrointestinal Neoplasms, Appendicitis Acute
- Trial name
- NCT06943924
- Testing
- Frailty assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Acute Appendicitis, Acute Appendicitis With Rupture
Prioritisation of Acute Appendicitis Using Appendistat Score
Introduction Although non-operative management of acute appendicitis may be appropriate in selected cases, surgery remains the gold standard treatment.
- Trial name
- APEX (NCT07197489)
- Where
- 2 sites in United Kingdom
- Volunteers
- 592 people
- Sponsor
- University College, London
Appendicitis Acute, Peritonitis
Appendicitis in Adults and Children in France-A Prospective Study by the French Surgical Association Multicenter Cohort
Acute appendicitis still represents a surgical challenge, despite profound changes in practice in recent decades. The objective of this study was comprehensively document current surgical practices aimed at improving the…
- Trial name
- APPEA (NCT04214340)
- Testing
- evaluation of practices
- Volunteers
- 2,285 people
- Sponsor
- Association Francaise de Chirurgie
Acute Appendicitis
Non-operative vs. Operative Management of Acute Appendicitis in Vulnerable Patient Populations
The overall project goal is to conduct a pilot randomized clinical trial of operative (laparoscopic appendectomy) vs nonoperative (antibiotic) management of uncomplicated acute appendicitis for vulnerable populations.
- Trial name
- NCT05724628
- Testing
- Laparoscopic appendectomy, Antibiotics (IV transitioned to oral)
- Sponsor
- University of Texas Southwestern Medical Center
Conservative Management
Risk Factors of Failure of Conservative Treatment in Acute Non Complicated Appendicitis
From this study, it can be concluded that patients who meet the following criteria are more likely to fail expectant management and thus should not be considered for the NOM of uncomplicated acute appendicitis.
- Trial name
- appendicitis (NCT06828952)
- Testing
- ceftriaxone, ceftriaxone 1 gm/12 hourly and IV metronidazole 500 mg/8 hourly
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ahmed Mohammed Hussein Sayed
Appendicitis
A Comparison of UGBRS Block and Local Infiltration
In this research study, the investigators are trying to find out which of the two methods of injecting local anesthetics (at the site of the belly button cut or by ultrasound guided rectus sheath block) will provide better pain…
- Trial name
- NCT02352519
- Testing
- UGBRSB, Local Infiltration
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Appendicitis
Conservative Versus Operative ManageMent of Acute Uncomplicated Appendicitis
This study aims to compare antibiotic treatment versus surgery for patients with uncomplicated appendicitis.
- Trial name
- COMMA (NCT02916134)
- Testing
- Laparoscopic +/- Open Appendicectomy, Antibiotic treatment
- Where
- Ireland
- Volunteers
- 186 people
- Sponsor
- Beaumont Hospital
Appendicitis Acute, Appendicitis Perforated
Enhanced Recovery After Surgery (ERAS) for Complicated Appendicitis
The exploratory objective of this pilot study is to evaluate the feasibility and safety of an enhanced recovery protocol that will allow adult patients to be discharged to home on an oral antibiotic regimen for three days…
- Conditions
- Appendicitis Acute, Appendicitis Perforated, Appendicitis With Perforation, Appendicitis Suppurative
- Trial name
- NCT06948071
- Testing
- Discharge on oral antibiotics
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center