Clinical trials: Appendicitis
Appendicitis, Surgery
Sugammadex vs Neostigmine Reversal in Pediatric Appendectomy
This study is designed as a randomized controlled trial with patients assigned to neuromuscular reversal with either sugammadex or neostigmine/glycopyrrolate reversal.
- Trial name
- NCT05256901
- Testing
- Sugammadex, Neostigmine/Glycopyrrolate
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Emory University
Appendicitis
Conservative Versus Operative ManageMent of Acute Uncomplicated Appendicitis
This study aims to compare antibiotic treatment versus surgery for patients with uncomplicated appendicitis.
- Trial name
- COMMA (NCT02916134)
- Testing
- Laparoscopic +/- Open Appendicectomy, Antibiotic treatment
- Where
- Ireland
- Volunteers
- 186 people
- Sponsor
- Beaumont Hospital
Appendicitis Acute
Low vs Medium Pressure Pneumoperitoneum
The purpose of this study is to asses whether the pressure used for the pneumoperitoneum during laparoscopic surgery in children affects their postoperative pain levels.
- Trial name
- LoMePneu (NCT04949659)
- Testing
- Laparoscopic appendectomy
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- University Children's Hospital, Zurich
Appendicitis
Perforated Appendicitis With Delayed Presentation
There is no consensus among pediatric surgeons regarding the optimal treatment for children with complicated appendicitis with delayed diagnosis.
- Trial name
- NCT01068288
- Testing
- Laparoscopic or open appendectomy, Expectant Management
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- The Hospital for Sick Children
COVID-19, Complicated Appendicitis
Complicated Appendicitis During the COVID-19 Pandemic in Jordan
Comparing the incidence of complicated appendicitis between two groups, the pandemic and pre-pandemic groups.
- Trial name
- NCT05375058
- Testing
- Observational Study
- Where
- Jordan
- Volunteers
- 257 people
- Sponsor
- Jordan University Hospital
Appendicitis
Non-operative Management of Early Appendicitis in Children
The purpose of this study is to determine the feasibility of non-operative management of early appendicitis in children. We hypothesize that non-operative management of early appendicitis in children with antibiotics alone will…
- Trial name
- NCT01718275
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Peter Minneci
Appendicitis Perforated, Appendectomy, Laparoscopic
Piperacillin/Tazobactam Versus Ceftriaxone and Metronidazole for Children With Perforated Appendicitis
The ALPACA-MC trial is a blinded, multicentre randomized controlled trial comparing two postoperative antibiotic treatments for children undergoing laparoscopic appendectomy for perforated appendicitis.
- Conditions
- Appendicitis Perforated, Appendectomy, Laparoscopic, Antibiotic, Pediatric
- Trial name
- ALPACA-MC (NCT07869095)
- Testing
- Piperacillin/Tazobactam, Ceftriaxone + Metronidazole
- Volunteers
- 180 people
- Sponsor
- McMaster Children's Hospital
Acute Appendicitis
Appendicectomy Versus Antibiotics in the Treatment of Acute Uncomplicated Appendicitis
Appendicectomy has been the treatment of acute appendicitis for over a hundred years. Appendicectomy, however, includes operative and postoperative risks despite being a "routine" operation.
- Trial name
- APPAC (NCT01022567)
- Testing
- Appendicectomy, Ertapenem
- Where
- 6 sites in Finland
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Acute Appendicitis
Laparoscopic Appendectomy by Multi-port vs Single Port.
Laparoscopic appendectomy (LA) is nowadays considered the gold standard in fertile women affected by uncomplicated appendicitis. The level of evidence for benefits from LA in this subgroup is high.
- Trial name
- AMUSING (NCT01720082)
- Testing
- Single incision laparoscopic appendectomy, Multiport laparoscopic appendectomy
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Associazione Chirurghi Ospedalieri Italiani
Appendicitis
Structured Management of Patients With Suspicion of Appendicitis Using a Clinical Score and Selective Imaging
Patients with acute abdominal pain and suspicion of appendicitis are common. The management of these patients is controversial with large variations between hospitals.
- Trial name
- STRAPPSCORE (NCT00971438)
- Testing
- Diagnostic imaging
- Where
- Sweden
- Volunteers
- 1,312 people
- Sponsor
- Ryhov County Hospital
Acute Appendicitis, Appendicitis Perforated
Bilirubin Levels to Diagnose Appendicitis and Predict Appendiceal Perforation
The goal of this study is to learn if serum bilirubin levels can aid in the diagnosis of acute appendicitis and predict appendiceal perforation
- Trial name
- NCT06956638
- Testing
- Non-interventional
- Where
- Nepal
- Volunteers
- 98 people
- Sponsor
- Nepalese Army Institute of Health Sciences
Non-specific Abdominal Pain
Study Comparing Early Laparoscopy With Active Observation in Acute Non-specific Abdominal Pain
Patients with acute abdominal pain comprise a significant proportion of attendances at emergency departments. These patients account for about a third of general surgical admissions in a typical day.
- Trial name
- FLO (NCT01675466)
- Testing
- early laparoscopy, General anaesthesia, Laparoscopic instruments
- Where
- Ireland
- Volunteers
- 17 people
- Sponsor
- Mid Western Regional Hospital, Ireland
Acute Appendicitis
Acute Appendicitis: The Influence of C-reactive Protein and Leucocytes on Clinical Decision-making
Aim: To investigate if the results of CRP and leucocytes had any positive or negative influence on the surgeon's decision-making when handling patients with suspected AA.
- Trial name
- NCT02304653
- Testing
- Clinical descision making
- Where
- Denmark
- Volunteers
- 226 people
- Sponsor
- Odense University Hospital
Acute Appendicitis, Abdominal Pain
Free Text Prediction Algorithm for Appendicitis
Computer-aided diagnostic software has been used to assist physicians in various ways. Text-based prediction algorithms have been trained on past medical records through data mining and feature analysis.
- Trial name
- NCT03414853
- Testing
- Free text prediction algorithm for appendicitis
- Where
- Singapore
- Volunteers
- 689 people
- Sponsor
- National University Hospital, Singapore
Appendicitis
A Trial to Assess the Efficacy and Safety of Morinidazole in Patients With Appendicitis
To assess the efficacy, safety, tissue distribution of target organ and Population Pharmacokinetic (PPK) of morinidazole and sodium chloride injection with surgery in patients with suppurative or gangrenous appendicitis
- Trial name
- NCT03380793
- Testing
- morinidazole
- Where
- China
- Volunteers
- 614 people
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Acute Appendicitis
Technical Modifications of Appendicular Stump Closure During Laparoscopic Appendectomy
Laparoscopic appendectomy (L-APPE) presents a golden standard in the treatment of acute appendicitis nowadays. However, there are ongoing controversies regarding the ideal technique of appendicular stump closure during L-APPE in…
- Trial name
- CAS (NCT03750032)
- Testing
- Stapler appendectomy, Endoloop, Hem-O-Lock
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Ostrava
Appendicitis, Cholelithiasis
Minimally Invasive Surgery: Using Natural Orifice Translumenal Endoscopic Surgery (NOTES)
This is an observational study of pain and outcomes from patients undergoing transgastric NOTES removal of their appendix or gallbladder.
- Trial name
- NOTES (NCT00531219)
- Testing
- Transgastric Appendectomy, Transgastric Cholecystectomy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Acute Appendicitis
Patient Time and In-hospital Delay of Surgery Association With Complicated Appendicitis
This is a retrospective observational study with its main aim of evaluating possible factors associated with complicated appendicitis.
- Trial name
- NCT04689906
- Testing
- surgery
- Volunteers
- 3,137 people
- Sponsor
- Rambam Health Care Campus
Perforated Appendicitis
The Management of Perforated Acute Appendicitis in Adult and Pediatric Populations
Patients admitted at Marshall Health - Cabell Huntington Hospital with the diagnosis of acute perforated appendicitis or appendicular abscess larger than 3cm will be admitted and treated with percutaneous drainage and the IV…
- Trial name
- NCT04253899
- Testing
- Appendectomy, Observation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Marshall University
Acute Appendicitis
Presentation and Outcomes of Acute Appendicitis During COVID Pandemic
Acute appendicitis (AA) is a frequent cause of acute abdominal pain in emergency rooms around the world [1]. The lifetime risk of developing AA is estimated to be about 8% [1-3].
- Trial name
- AA (NCT05104346)
- Testing
- appendectomy
- Where
- Egypt
- Volunteers
- 1,945 people
- Sponsor
- Mansoura University