Clinical trials: Apnea Neonatal
Apnea of Prematurity, Infant, Premature, Diseases
Effect of High Frequency Oscillatory Highflow Nasal Cannula on Desaturations and Bradycardia in Preterm Infants
This study evaluates the effect of non-invasive high frequency oscillations applied via a highflow nasal cannula ('Osciflow') compared to highflow nasal cannula without oscillations (HF) on desaturations and bradycardia in…
- Trial name
- Osciflow (NCT04327466)
- Testing
- Osciflow, Highflow
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Obstructive Sleep Apnea, Postoperative Respiratory Complications
A Multicenter Retrospective Analysis of Postoperative Respiratory Complications in Children With Obstructive Sleepapnea
This retrospective observational study aims to evaluate postoperative respiratory complications (PORC) after (adeno)tonsillectomy in children with OSA.
- Conditions
- Obstructive Sleep Apnea, Postoperative Respiratory Complications, Adenotonsillectomy, Child Obesity
- Trial name
- MRA PORC (NCT07305168)
- Where
- 2 sites in Belgium, Hungary
- Volunteers
- 200 people
- Sponsor
- University Hospital, Antwerp
Premature Birth, Asthma in Children
Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age
Despite improved survival of extremely premature infants in recent decades, neonatal intensive care unit (NICU) graduates are diagnosed with asthma, sleep disordered breathing (SDB) in childhood, and neurodevelopmental…
- Conditions
- Premature Birth, Asthma in Children, Sleep-Disordered Breathing, Neurodevelopmental Disorders
- Trial name
- NCT05336890
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Alzheimer's Disease, Obstructive Sleep Apnea
Sleep in Adults With Down Syndrome and Alzheimer's Disease
RATIONALE of the project. Adults with Down syndrome (DS) present severe sleep disorders that are under recognized by caregivers.
- Conditions
- Alzheimer's Disease, Obstructive Sleep Apnea, Sleep Disturbances
- Trial name
- NCT03942341
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cardiac Diseases, Muscular Weakness
Biomarker for Pompe Disease (BioPompe)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Pompe disease from blood (plasma)
- Conditions
- Cardiac Diseases, Muscular Weakness, Hepato-splenomegaly, Lung Disease
- Trial name
- BioPompe (NCT01457443)
- Where
- 4 sites in Germany, India and 1 more
- Sponsor
- CENTOGENE GmbH Rostock
Apnea of Prematurity, Premature Newborn
Effect of Feedings on Caffeine in Premature Infants
Almost all infants born <29 weeks gestational age develop apnea of prematurity and are treated with caffeine. Type of diet and disease states may be significant contributors of variability in caffeine metabolism and…
- Conditions
- Apnea of Prematurity, Premature Newborn, Caffeine
- Trial name
- NCT02293824
- Testing
- Caffeine
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Pediatric Obstructive Sleep Apnea, Down Syndrome (DS)
Pediatric Down Syndrome Post-Approval Study
The purpose of this Post Approval research study is to assess ongoing safety and effectiveness of the Inspire therapy in adolescents and young adults (age 13-18) with Down syndrome and severe sleep apnea.
- Trial name
- NCT06851338
- Testing
- Hypoglossal Nerve Stimulation
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Inspire Medical Systems, Inc.
Apnea of Prematurity, Intermittent Hypoxemia
Strap To Reduce Apnea in Preterm Infants: A Randomized Crossover Trial
The goal of this clinical trial is to learn if a chin strap helps reduce low oxygen episodes in premature babies receiving CPAP or NIPPV (breathing support through the nose).
- Conditions
- Apnea of Prematurity, Intermittent Hypoxemia, Bronchopulmonary Dysplasia of Newborn
- Trial name
- STRAP (NCT07895654)
- Testing
- Chinstrap
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Obstructive Sleep Apnea, Patent Foramen Ovale
Close Obstructive Sleep Apnea (OSA) Trial
The aim of this study is to evaluate the benefits of patent foramen ovale (PFO) closure on patients with obstructive sleep apnea (OSA) and persistent hypoxia despite optimal therapy.
- Trial name
- NCT06113562
- Testing
- PFO closure
- Sponsor
- University of Miami
Obstructive Sleep Apnea, Down Syndrome
Validation of Sleep Questionnaires in the Down Syndrome Population
This will be a prospective validation study of a sample of consecutive pediatric Down syndrome patients who are seen through the weekly Down syndrome clinic at OHSU/Doernbecher's.
- Trial name
- NCT03771469
- Testing
- Sleep study
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Apnea Prematurity
Nasogastric Versus Orogastric Route of Feeding in Preterm (<32 Weeks) Neonates
Enteral feeding tubes in newborns are used for feeding preterm and low birth weight babies in neonatal intensive care units as they often do not suck effectively owing to lack of coordination between sucking, swallowing and…
- Trial name
- NCT03073993
- Testing
- feeding tube insertion
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Max Super Speciality Hospital
Apnea of Prematurity
Caffeine Citrate to Improve Neonatal Outcomes.
The goal of this clinical trial to learn what dose/s of caffeine citrate works to treat preterm born babies who have episodes where they stop breathing.
- Trial name
- BabyCCINO (NCT06972849)
- Testing
- Caffeine citrate
- Volunteers
- 3,900 people
- Sponsor
- University of Melbourne
Apnea of Prematurity, Intermittent Hypoxemia
The Effect of Womb Recordings on Maturation of Respiratory Control in Preterm Infants
The aim of this proposal is to characterize the acute effect of early postnatal sound exposure on neuronal maturation of the respiratory control regions of the brain in preterm infants.
- Conditions
- Apnea of Prematurity, Intermittent Hypoxemia, Bradycardia
- Trial name
- NCT05298748
- Testing
- Womb sound recordings
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Case Western Reserve University
Sleep Apnea, Obesity
Sleep Apnea in Pregnancy Screening Study
Obstructive sleep apnea is known to be a significant source of morbidity in the general population. It has been proposed to be associated with the development of preeclampsia and fetal growth restriction.
- Trial name
- SAPSS (NCT01585844)
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Premature Newborns With Gestational Age 28 to 33 Weeks
Odors to Insufflate Life
Apneas concern about 85% of premature newborns (NB) born after less than 34 weeks of pregnancy. They are considered as an important risk factor for subsequent neuropsychological deficiency.
- Trial name
- PREMODEUR (NCT02851979)
- Testing
- Olfactory stimulations
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- Hospices Civils de Lyon
Apnea
Identifying the Relative Change in Ventilation in Newborns With Placement in Car Bed or Car Seat
The infant car restraint devices are a critical part of infant safety during transportation. The crash tolerance and the critical safety features of each seat are well established.
- Trial name
- NCT00382876
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University Medical Centre Ljubljana
Obstructive Sleep Apnea, Cleft Palate
Comparing the Side-lying Sleep Positioning to Back-lying in Infants With Cleft Palate
The craniofacial abnormalities found in infants and children with cleft palate (CP) lead to increased risk of obstructive sleep apnoea (OSA).
- Trial name
- SLUMBRS2 (NCT04478201)
- Testing
- back sleep positioning, side sleep positioning
- Where
- 11 sites in United Kingdom
- Volunteers
- 244 people
- Sponsor
- Manchester University NHS Foundation Trust
Apnea of Prematurity, Respiratory Insufficiency
Doxapram Therapy in Preterm Infants (DOXA Trial)
Preterm infants often suffer from apnea of prematurity (AOP; a cessation of breathing) due to immaturity of the respiratory system.
- Trial name
- NCT04430790
- Testing
- Doxapram
- Where
- 24 sites in Belgium, Canada and 1 more
- Volunteers
- 396 people
- Sponsor
- Erasmus Medical Center