Clinical trials: Apical Periodontitis
Post-Op Complication, Endodontic Inflammation
Postoperative Pain After Using NiTi Instruments
The aim of this randomized clinical trial was to compare the incidence, intensity and duration of postoperative pain following the removal of root canal obturation materials canals using rotary (ProTaper Universal or Hyflex EDM)…
- Conditions
- Post-Op Complication, Endodontic Inflammation, Endodontically Treated Teeth, Apical Periodontitis
- Trial name
- NCT04700995
- Testing
- NiTi instruments
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Trakya University
Periodontal Diseases, Periodontitis, Apical, Chronic Nonsuppurative
Diode Laser Study for Periodontal Maintenance Patients
This study tries to determine whether the additional use of laser with "cleaning" (known as scaling and root planning) will result in the reduction of inflammation, reduction of bleeding upon examination and reduction of pocket…
- Conditions
- Periodontal Diseases, Periodontitis, Apical, Chronic Nonsuppurative, Suppuration of Gingival Crevice
- Trial name
- NCT01215201
- Testing
- Scaling and Root Planing, Diode Laser + Scaling and Root Planing
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Nebraska
Apical Periodontitis
Assessment of Regenerative Potential of Mature Permanent Teeth With Necrotic Pulps Using Two Revascularization Protocols. (In Vivo Study)
Regenerative endodontic procedures have been used to successfully treat human mature permanent teeth with necrotic pulps and apical periodontitis.
- Trial name
- NCT04158232
- Testing
- Method
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Minia University
Apical Periodontitis
Antibacterial Activity of Calcium Hydroxide and Betamethasone in Apical Periodontitis
Apical periodontitis is a chronic inflammatory disease caused by bacterial infection of the root canal system. Although mechanical cleaning and shaping reduce most microorganisms, bacteria may persist in areas that are difficult…
- Trial name
- NCT07351682
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Duygu Degirmencioglu
Biomarkers
Accuracy of Host-derived Biomarkers in Diagnosing Symptomatic and Asymptomatic Apical Periodontitis
Apical lesions usually present clinically as a chronic infection, remaining as asymptomatic apical periodontitis(AAP). Because the balance among inflammation and bacteria is a dynamic process, AAP may undergo an acute…
- Trial name
- NCT06187324
- Testing
- biomarkers
- Where
- Iraq
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Pulp Necrosis, Root Canal Infection
Frankincense Versus Sodium Hypochlorite for Root Canal Disinfection
This research study is being done to find out if a natural ingredient called frankincense can clean infected root canals as effectively as the standard cleaning solution currently used in dentistry.
- Conditions
- Pulp Necrosis, Root Canal Infection, Apical Periodontitis
- Trial name
- FSHRCD: RCT (NCT07823868)
- Testing
- Sodium hypochlorite 3%, Frankincense-based irrigant
- Where
- Oman
- Volunteers
- 30 people
- Sponsor
- Oman Dental College
Pain, Postoperative, Irreversible Pulpitis
Can Instrumentation Kinematics Affect Post Operative Pain and Substance P Levels? A Randomized Controlled Trial
The aim of this study was to evaluate the effect of continuous rotation and reciprocation kinematics on post operative pain and difference in substance P levels in patients with irreversible pulpitis with symptomatic apical…
- Conditions
- Pain, Postoperative, Irreversible Pulpitis, Apical Periodontitis
- Trial name
- NCT06081335
- Testing
- EdgeEndo x7 continuous rotation files, EdgeOne Fire reciprocating files
- Where
- 2 sites in Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Apical Periodontitis, Postoperative Pain
Effect of Diode Laser on Post-operative Pain After Endodontic Treatment in Teeth With Apical Periodontitis
Aim: This study aims to assess the effect of root canal disinfection with a 980 µm diode laser following chemomechanical root canal preparation on the severity of pain after root canal treatment (RCT).
- Trial name
- NCT04486196
- Testing
- Medency Primo Diode Laser Device (Medency, Vicenza, Italy), 2.5% NaOCl, %17 EDTA, Distilled water, 30-gauge, side-opening needle (Canal Clean, Biodent, South Korea),
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Biruni University
Apical Periodontitis
Intraoral Cryotherapy on Cytokine Levels and Postoperative Endodontic Pain
The aim of this study is to evaluate the effects of intraoral cryotherapy on the inflammatory cytokine levels during root canal treatment and postoperative pain intensity and incidence.
- Trial name
- NCT05017064
- Testing
- Cryotherapy group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Apical Periodontitis, Wound Heal
The Effect of MTA and PRF Application in Periapical Lesions
A total of 40 periapical lesions from the 33 patient undergoing apical surgery were randomly selected from December 2016-November 2017. Patients were informed about the surgical procedure and signed a consent form.
- Trial name
- NCT03743987
- Testing
- control group, MTA group, PRF group
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Periodontitis, Fistula
Evaluation of Photodynamic Therapy in Pieces With Presence of Fistula.
The goal of this clinical trial is to learn if adjuvant antimicrobial photodynamic therapy (aPDT) can help in the treatment in patients with pieces with apical periodontitis and the presence of fistula, in terms of reducing…
- Trial name
- aPDT (NCT06413836)
- Testing
- aPDT, Endodontic treatment
- Where
- Uruguay
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Apical Periodontitis, Insulin Resistance
Serum Pro-Diabetes Inflammation Biomarkers in Patients With Apical Periodontitis.
Inflammation is a common factor of chronic periodontitis and diabetes. However, to date, there is no scientific evidence supporting a causal effect of the inflammation created by apical periodontitis on the onset of insulin…
- Conditions
- Apical Periodontitis, Insulin Resistance, PreDiabetes, Diabetes; Stable
- Trial name
- NCT04824209
- Where
- 2 sites in Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Asymptomatic Apical Periodontitis
Antimicrobial Effect of Calcium Silicate and Pectin as Intracanal Medications in Necrotic Teeth With Periapical Lesions
It is tackling antimicrobial resistance in endodontics, specifically comparing different intracanal medications used in root canal treatment.
- Trial name
- NCT07423663
- Testing
- Calcium Hydroxide Intracanal medication, Calcium silicate based intracanal medication, Pectin
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Post Operative Pain, Apical Periodontitis
Influence of Sonic Activation of Root Sealers on Post-Operative Pain
Aim: This clinical study aims to compare post-operative pain after single-visit root canal treatment of teeth with asymptomatic apical periodontitis using epoxy-resin based AH Plus and calcium silicate based Endosequence BC…
- Trial name
- NCT06403293
- Testing
- Root canal treatment (AH Plus-NA), Root canal treatment (AH Plus-EA), Root canal treatment (BC-NA)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Apical Periodontitis
The Effect of Human Umbilical Cord Mesenchymal Stem Cells and Exosomes on the Healing of Postoperative Pain and Periapical Lesions in the Treatment of Apical Periodontitis: Randomized Controlled Clinical Study
The main purpose of this study is to evaluate the effect of Mesenchymal Stem Cells (MSCs) isolated from the umbilical cord and exosomes derived from these cells on the success of the treatment in the regenerative endodontic…
- Trial name
- NCT06764004
- Testing
- Stem Cell Product, Bleeding and clots
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Pulpitis, Periapical Periodontitis
Comparative Evaluation of Different File Systems in Postoperative Pain
Postoperative pain is a frequent complication associated with root canal treatment. The apical extrusion of irrigant and debris, including bacteria and necrotic tissue, may lead to postoperative pain, periapical inflammation, and…
- Conditions
- Pulpitis, Periapical Periodontitis, Necrotic Pulp
- Trial name
- NCT03708081
- Testing
- ProTaper Next, TF Adaptive
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bulent Ecevit University
Necrotic Teeth With Chronic Apical Periodontitis
Regenerative Endodontics in Mature Necrotic Teeth
The goal of this clinical trial is to learn if nanochitosan can achieve regeneration in mature necrotic teeth. It will also provide data about the healing potential \& postoperative pain after using different irrigation…
- Trial name
- NCT07584928
- Testing
- Intervention 1: 1% nanochitosan, Intervention 2: 1% nanochitosan & 17% EDTA
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Suez Canal University
Pulpitis - Irreversible
The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo
Aim. To compare the outcome of preoperative administration of single-dose ketorolac, non-steroidal anti-inflammatory drug and placebo on postoperative pain in teeth with irreversible pulpitis and apical periodontitis.
- Trial name
- PreOp (NCT03116672)
- Testing
- one dose ketorolac 10 mg, One dose Diclofenac
- Where
- Mexico
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Endodontically Treated Teeth, Calcium Hydroxide
Multiple-Visit RCT in Teeth With SAP: Interappointment Dressing or Not?
The aim of the study is to evaluate the effectiveness of calcium hydroxide as an intracanal medicament in the clinical and radiographic healing of periapical tissues in teeth diagnosed with symptomatic apical periodontitis.
- Trial name
- RCTCa(OH)2 (NCT06447519)
- Testing
- Ca(OH)2 as intracanal medicament
- Where
- Greece
- Volunteers
- 110 people
- Sponsor
- Aristotle University Of Thessaloniki
Chronic Apical Periodontitis
Single Versus Multiple Visits Regenerative Endodontics in Mature Teeth
The goal of this clinical trial is to learn whether regenerative endodontic treatment (RET) should be performed in one visit or two visits in people with mature permanent teeth with chronic apical periodontitis.
- Trial name
- NCT07480226
- Testing
- Single-Visit Regenerative Endodontic Treatment, Multiple-Visit Regenerative Endodontic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Marmara University