Clinical trials: Aphasia
Aphasia, Stroke
Transcranial Alternating Current Stimulation (tACS) in Aphasia
This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functions.
- Trial name
- NCT04375722
- Testing
- tACS
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Aphasia, Spatial Neglect
Prism Adaptation in Left Brain Stroke
Of the 15,000 Veterans who are hospitalized for stroke each year more than half experience spatial and motor impairments and pain.
- Conditions
- Aphasia, Spatial Neglect, Stroke
- Trial name
- NCT04387162
- Testing
- Prism Adaptation Treatment
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- VA Office of Research and Development
Aphasia, Stroke
fMRI of Language Recovery Following Stroke in Adults
The purpose of this study is to test the effectiveness of constraint-induced aphasia therapy.
- Trial name
- NCT00843427
- Testing
- CIAT
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Alabama at Birmingham
Aphasia
Effect of Verb Network Strengthening Treatment (VNeST) on Lexical Retrieval in Aphasia
The purpose of this study is to evaluate the effect of Verb Network Strengthening Treatment (VNeST) on the ability to produce sentences and connected speech in persons with aphasia.
- Trial name
- VNeST (NCT01300624)
- Testing
- Verb Network Strengthening Treatment
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Alzheimer's Disease, Primary Progressive Non-fluent Aphasia
A Medium Chain Triglyceride Intervention for Patients With Alzheimer Disease
The purpose of this study is to determine safety, tolerability, and pharmacokinetics/dynamics of a ketogenic dietary supplement containing medium chain triglycerides (MCTs) in patients with Alzheimer disease (AD).
- Conditions
- Alzheimer's Disease, Primary Progressive Non-fluent Aphasia, Frontotemporal Dementia (FTD)
- Trial name
- MINT-01 (NCT02912936)
- Testing
- Ketogenic medium chain triglyceride drink (MCT drink)
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- University of British Columbia
Stroke, CVA (Cerebrovascular Accident)
MORbidity PRevalence Estimate In StrokE
Information regarding the likely progress of post-stroke symptoms is vitally important to stroke survivors to allow them to plan for the future and to adjust to life after stroke.
- Conditions
- Stroke, CVA (Cerebrovascular Accident), CVA; Sequelae, Stroke, Ischemic
- Trial name
- MORe PREcISE (NCT03605381)
- Where
- 3 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- Aneurin Bevan University Health Board
Aphasia, CVA
Treatment Intensity - Apraxia of Speech
A growing neurorehabilitation literature suggests that intense treatment may be desired to maximize the effects of therapy following neurologic injury.
- Conditions
- Aphasia, CVA, Apraxia of Speech
- Trial name
- NCT02332915
- Testing
- Sound Production Treatment (SPT)
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Primary Progressive Aphasia
Remotely Supervised Transcranial Direct Current Stimulation (tDCS) for Primary Progressive Aphasia (PPA)
The purpose of this study is to establish the feasibility of a program of remotely supervised transcranial direct current stimulation (RS-tDCS) paired with language skills practice for people living with the semantic or logopenic…
- Trial name
- NCT05615922
- Testing
- Transcranial Direct Current Stimulation (tDCS), Word-Naming Activity
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- NYU Langone Health
Aphasia, Stroke
Transcranial Direct Current Stimulation (tDCS) With Verb Network Strengthening Treatment (VNeST) in Chronic Aphasia
The purpose of this study is to assess changes in language abilities of participants with chronic, post-stroke aphasia following an 8-week therapy period combined with brain stimulation.
- Trial name
- NCT04142866
- Testing
- Anodal transcranial direct current stimulation, Speech-Language Therapy (SLT)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- City University of New York
Primary Progressive Aphasia
The Effects of a Multimodal Approach for the Treatment of PPA
Primary Progressive Aphasia (PPA) is an untreatable neurodegenerative disorder that disrupts language functions. Available therapies are mainly symptomatic and recently attention has been gained by new techniques that allow for…
- Trial name
- ACROSS (NCT04187391)
- Testing
- Active tDCS, Language training, Unstructured cognitive training
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Aphasia, Global, Stroke
tDCS and Speech Therapy to Improve Aphasia
To study the effect of combined tDCS plus speech therapy compared to sham-tDCS plus speech therapy in subacute stroke patients suffering from moderate or severe aphasia.
- Conditions
- Aphasia, Global, Stroke, Transcranial Direct Current Stimulation, Speech Therapy
- Trial name
- MP-LOGA (NCT02395874)
- Testing
- tDCS + speech therapy
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- Medical Park AG
Broca's Aphasia
Virtual Reality Based Sensorimotor Speech Therapy
The purpose of this study is to determine whether VR based language rehabilitation scenario based on the core premises of ILAT has a beneficial effect on the linguistic performance (faster retrieval of the target lexicon and…
- Trial name
- NCT02928822
- Testing
- VR-based sensorimotor aphasia therapy, Control Group (conventional aphasia rehabilitation)
- Where
- 2 sites in Spain
- Volunteers
- 18 people
- Sponsor
- Universitat Pompeu Fabra
Aphasia
Effect of Music on Reading Comprehension for Patients With Aphasia
This investigation uses a single-subject, adapted alternating research design to compare two different experimental conditions using music with lyrics combined with visual stimulation of the written lyrics, to extend the…
- Trial name
- EMRA1 (NCT02875938)
- Testing
- Simultaneous music and reading lyrics, Priming with music, Control
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Carilion Clinic
Aphasia, Non-fluent Aphasia
Combining tDCS and CILT in Non-fluent Aphasia
The long-term goal of this work is to determine if combining a highly intensive, task-specific behavioral language intervention with modulation of the efferent cerebellar-cortical pathway using transcranial direct current…
- Conditions
- Aphasia, Non-fluent Aphasia, Stroke, Brain Injuries
- Trial name
- NCT05561400
- Testing
- tDCS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Minnesota
Aphasia
Effects of Transcranial Direct Current Stimulation in Post-stroke Aphasia
This study aims to determine whether transcranial direct current stimulation (tDCS) paired with speech-language therapy is more beneficial than speech-language therapy alone in acute and chronic post-stroke aphasia.
- Trial name
- NCT02622945
- Testing
- Active tDCS plus Speech-Language Therapy
- Where
- United States
- Sponsor
- Johns Hopkins University
Logopenic Variant Primary Progressive Aphasia, Non-Fluent Primary Progressive Aphasia
rTMS as a Treatment for PPA
Primary progressive aphasia (PPA) includes three variants. Two such variants, the non-fluent/agrammatic variant (nfvPPA) and the logopenic variant (lvPPA), are characterized by progressive word-finding difficulties and effortful…
- Trial name
- NCT03406429
- Testing
- Active rTMS
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
Alzheimer's Disease, Aphasia
Effect of Repetitive Transcranial Magnetic Stimulation on Language in Alzheimer's Disease
The investigators wish to investigate the efficacy of targeted repetitive transcranial magnetic stimulation (rTMS) on expressive language in patients with Alzheimer's disease (AD).
- Conditions
- Alzheimer's Disease, Aphasia, Dementia
- Trial name
- NCT00814697
- Testing
- Repetitive Transcranial Magnetic Coil Stimulation (rTMS)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The New York Memory Services
Post Stroke Aphasia
Effect of High Frequency Transcranial Magnetic Stimulation on Recovery of Chronic Post-Stroke Aphasia
high frequency excitatory rTMS applied over the dominant hemisphere in chronic post stroke aphasic patients to help the restoration of function by the left hemisphere
- Trial name
- NCT04708197
- Testing
- rTMS (repetitive transcranial magnetic stimulation )
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Stroke, Aphasia
TMS as a Biological Marker of Neuroplasticity
TMS is a non-invasive brain stimulation technique, which can be used to change the activity of a person's brain cells without needles or surgery.
- Trial name
- NCT02867670
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Pennsylvania
Aphasia, Broca
Effects of PACE Technique in Patients With Aphasia
Aphasia, a communication disorder often resulting from him brain injury such as stroke, impacts an individual's ability to understand or produce language.
- Trial name
- NCT07521098
- Testing
- experimental, control group conventional therapy
- Where
- Pakistan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Riphah International University