Clinical trials: Apathy
Depression and Quality of Life, Treatment Resistant Depression (TRD)
Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression
This observational study investigates the use of Esketamine Intranasal Spray in patients with Treatment-Resistant Depression in Real-World Settings.
- Conditions
- Depression and Quality of Life, Treatment Resistant Depression (TRD), Anhedonia, Apathy
- Trial name
- ESKPSY (NCT07146503)
- Testing
- Esketamine (Intranasal Spray)
- Where
- 5 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Riccardo Guglielmo
Apathy, Mild Cognitive Impairment
Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment:Pilot Study
Mild cognitive impairment (MCI) is a precursor of dementia. Apathy, a profound loss of motivation, is a common behavioral problem in MCI.
- Trial name
- NCT02190019
- Testing
- Neurostar repetitive transcranial magnetic stimulator
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Central Arkansas Veterans Healthcare System
Alzheimer's Disease
Contribution of Actigraphy and Recognition Video in Apathy Assessment of Alzheimer's Disease : Experimental Research
Neuropsychiatric symptoms form part of the clinical picture of Alzheimer's disease (AD) and other dementias. Irrespective of the severity of the disease, the most frequently encountered symptom is apathy.
- Trial name
- 09-PP-06 (NCT01049555)
- Testing
- Actigraphy and video recording signal
- Where
- France
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Parkinson Disease, Apathy
A Randomized Double-Blind Active-Controlled Crossover Trial of Respiratory-Gated Versus Non-Gated Transcutaneous Auricular Vagus Nerve Stimulation for the Treatment of Motor and Non-Motor Symptoms in Parkinson's Disease
The goal of this clinical trial is to compare the effects of different modes and frequencies of transcutaneous auricular vagus nerve stimulation (taVNS) on motor and non-motor symptoms in people with Parkinson's disease.
- Conditions
- Parkinson Disease, Apathy, Sleep Disorder, Motor Disorders
- Trial name
- NCT06642454
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Anhui Medical University
Schizophrenia, Apathy
Apathy in Schizophrenia
Apathy, defined as a quantitative reduction of voluntary, goal-directed behaviours (GDB), is a core component of negative symptoms.
- Trial name
- NCT01689181
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Apathy in Parkinson Disease
Apathy in Parkinson Disease: Clinical, Physiopathological and Pharmacological Study
Apathy has been reported to occur after subthalamic nucleus stimulation (STN-DBS), a treatment of motor complications in advanced Parkinson's disease (PD).
- Trial name
- NCT01020682
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Grenoble
Parkinson Disease, Deep Brain Stimulation
VC/VS for Apathy in PD
Apathy is a disabling neuropsychiatric symptom marked by reduced goal-directed behavior, including diminished interest, motivation, emotional expression, and social engagement.
- Conditions
- Parkinson Disease, Deep Brain Stimulation, Apathy
- Trial name
- NCT06991335
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Nora Vanegas
Parkinson Disease, Apathy
Evolution of Hypodopaminergic Syndrome in Early Parkinson's Disease
The objective of this study is to describe the evolution of hypodopaminergic syndrome in patients with Parkinson's disease.
- Trial name
- IMPACT (NCT03141944)
- Testing
- Starkstein scale of Apathy
- Where
- 4 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Grenoble
Dementia, Accidental Falls
Exploring the Use of Transdermal Methylphenidate to Reduce Fall Risk in Patients With Dementia.
Falls in the elderly are a very common and serious health problem with devastating consequences. Those with dementia are 5 times more likely to experience falls than older people without significant cognitive impairment.
- Conditions
- Dementia, Accidental Falls, Apathy
- Trial name
- NCT01825577
- Testing
- Transdermal Methylphenidate
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- St. Louis University
Frontotemporal Dementia, Behavioral Variant, Alzheimer Disease
ECOCAPTURE for the Assessment of Apathy Under Real-life Conditions
ECOCAPTURE@HOME is a study which is currently being developed with the objective to capture the behavioral signature of apathy in everyday life context through remote monitoring of participants' behavior for about one month.
- Trial name
- @HOME (NCT04865172)
- Testing
- Remote collection of passive and active data for 28 consecutive days
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Frontotemporal Lobar Degeneration
Treatment Study of Frontotemporal Dementia
Objectives. The proposed clinical study has two goals: First, to assess the efficacy of a central nervous system stimulant and an atypical antipsychotic in treating the behavioral symptoms of FTD and second, to further…
- Trial name
- NCT00088751
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease
Accelerated rTMS for Apathy in Parkinson's Disease
This single-site, open-label pilot study will evaluate the feasibility, tolerability, and preliminary efficacy of accelerated intermittent theta-burst stimulation (iTBS) targeting the dorsomedial prefrontal cortex (dmPFC) for…
- Trial name
- NCT07399496
- Testing
- Accelerated intermittent theta-burst stimulation (iTBS) rTMS to left dorsomedial prefrontal cortex (dmPFC)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Medical University of South Carolina