Clinical trials: Aortic Valve
Ascending Aortic Aneurysm
A Study of Lipid Metabolism and Mitochondrial Function in Myeloid Cells and Total Aortic Tissue in Patients With Ascending Thoracic Aortic Aneurysm (ATA) and Bicuspid (BA) or Tricuspid (TA) Aortic Valves.
Ascending aortic aneurysms (AAAs) are serious conditions that can lead to aortic dissections or ruptures, carrying a high risk of mortality.
- Trial name
- PROMETA (NCT07695545)
- Testing
- Additional blood samples, Collection of discarded ascending aortic tissue
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Severe Aortic Stenosis
Aspirin vs Clopidogrel After TAVR
Currently, the optimal antithrombotic therapy after transcatheter aortic valve replacement (TAVR) remains still unknown., The purpose of the study is to compare aspirin versus clopidogrel monoantiplatelet therapy for preventive…
- Trial name
- NCT05493657
- Testing
- Aspirin single antiplatelet therapy, Clopidogrel single antiplatelet therapy
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Yonsei University
Aortic Stenosis
Transaxillary TAVR With Solely Echocardiography Guidance
This study aims to evaluate the safety and feasibility of performing transaxillary transcatheter aortic valve replacement (TA TAVR) guided solely by echocardiography in patients with severe aortic stenosis (AS).
- Trial name
- NCT07035847
- Testing
- Echocardiography guided TAVR
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Aortic Valve Stenosis, Aortic Valve Regurgitation
Hemodynamic Matched Comparison of the Balloon-Expandable Transcatheter Heart Valves Myval and Sapien-3 for the Treatment of Aortic Stenosis
Transcatheter aortic valve implantation (TAVI) is recommended for patients with severe aortic stenosis (AS) at high to intermediate surgical risk.
- Trial name
- MATCH-BALL (NCT04548726)
- Testing
- Sapien 3 Transcather Aortic Valve Implant, Myval Transcather Aortic Valve Implant
- Where
- 6 sites in Italy, Spain
- Volunteers
- 416 people
- Sponsor
- Ignacio J. Amat Santos
Heart Diseases, Aortic Stenosis, Severe
EARLY TAVR: Evaluation of TAVR Compared to Surveillance for Patients With Asymptomatic Severe Aortic Stenosis
This study will evaluate the safety and effectiveness of the Edwards SAPIEN 3/SAPIEN 3 Ultra Transcatheter Heart Valve (THV) compared with clinical surveillance (CS) in asymptomatic patients with severe, calcific aortic stenosis.
- Trial name
- EARLY TAVR (NCT03042104)
- Testing
- Edwards SAPIEN 3 / SAPIEN 3 Ultra THV
- Where
- 77 sites in United States, Canada
- Volunteers
- 901 people
- Sponsor
- Edwards Lifesciences
Patients With a Sutureless Aortic Valve
Retrospective Observational Study of Patients With a Sutureless Aortic Valve Implanted in the Cardiovascular and Thoracic Surgery Department of Dijon CHU
The incidence of aortic valve disease is increasing steadily because of the ageing of the population. At a certain stage, replacement of the aortic valve improves symptoms and thus the quality of life of patients.
- Trial name
- ORVAS (NCT03259945)
- Testing
- Data collection, Review of ECGs
- Where
- France
- Volunteers
- 198 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Aortic Valve Disease
Factors Influencing Morbi-mortality in Right Anterior Minithoracotomy Approch for Aortic Valve Replacement
Since 2009, positive experiences with right anterior minithoracotomy as an approach to aortic valve replacement are extensively practiced in our institution.
- Trial name
- RVAOMITAVA (NCT04455165)
- Testing
- Aortic valve replacement
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier La Chartreuse
Aortic Valve Disease, Surgery--Complications
Immune Responsiveness and Outcome After Aortic Valve Surgery (Measure)
There is considerable morbidity and mortality associated with cardiac surgery. Currently little effort is made to quantify how well the immune system of an individual can cope with inflammation or infection to which they are…
- Conditions
- Aortic Valve Disease, Surgery--Complications, Immune System Disorder
- Trial name
- Measure (NCT04430972)
- Testing
- Aortic valve replacement
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Barts & The London NHS Trust
Aortic Valve Stenosis
The SAPIEN 3 Ultra System in Intermediate Risk Patients With Symptomatic, Severe Aortic Stenosis
This study will confirm the procedural safety and performance of the SAPIEN 3 Ultra System in subjects with severe, calcific AS who are at intermediate operative risk for standard aortic valve replacement.
- Trial name
- NCT03471065
- Testing
- SAPIEN 3 Ultra Delivery System with the SAPIEN 3 Ultra THV
- Where
- 6 sites in Canada, United Kingdom
- Volunteers
- 100 people
- Sponsor
- Edwards Lifesciences
Aortic Stenosis
Prediction of Long-term Outcome in Aortic Stenosis After Valve Intervention
Patients with severe aortic stenosis accepted for transcatheter intervention or open surgery are included before the intervention, and then followed up with clinical visits during the first year after intervention.
- Trial name
- NCT05629104
- Testing
- There is no intervention since it is an observational study patients are treated according to clinical praxis
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Uppsala University
Aortic Valve Stenosis
Observational Study to Collect Data of Patient Which Recieving a TAVI in TAVI Procedure
Patients with aortic valve stenosis often undergo transcatheter aortic valve implantation (TAVI) today. This biological valve can wear out or leak over time.
- Trial name
- REDO-TAVI (NCT07215143)
- Volunteers
- 300 people
- Sponsor
- IHF GmbH - Institut für Herzinfarktforschung
Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement
COronary Re-engageMent aFter randOm NavitoR alignmenT (COMFORT STUDY)
Whereas PCI before TAVR was previously recommended despite its uncertain prognostic role, recent data underline the possibility of a postponed coronary intervention using a commissural alignment technique.
- Trial name
- COMFORT (NCT05779787)
- Testing
- TAVR Aligned, TAVR Random
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Niguarda Hospital
Aortic Valve Stenosis
Evaluation of an Intervention to Reduce the Time to Treatment for TAVI Patients
Aortic stenosis (AS) is the most frequent valvulopathy in Western countries. The prevalence of AS is constantly increasing due to the aging of the population.
- Trial name
- TREAT (NCT05237804)
- Testing
- Patient component, Organisational component
- Where
- 2 sites in France
- Volunteers
- 828 people
- Sponsor
- University Hospital, Rouen
Aortic Valve Stenosis
A Study Evaluating the Effects of Ataciguat (HMR1766) on Aortic Valve Calcification
The primary objective of the current study is to determine whether Ataciguat (HMR1766) slows progression of valve calcification in patients with moderate calcific aortic valve stenosis.
- Trial name
- CAVS (NCT02481258)
- Testing
- Ataciguat (HMR1766)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Mayo Clinic
Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement
The JUMPSTART Program: Encouraging Early Mobilization and Optimizing Recovery of TAVR Patients' Post-hospital Discharge
A virtual, self-directed, and tailored early mobilization program called JUMPSTART, that aims to bridge cardiac rehabilitation intake for post-TAVR patients has been developed at the Hamilton General Hospital.
- Trial name
- NCT06040398
- Testing
- JUMPSTART exercise program
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Hamilton Health Sciences Corporation
Coronary Disease, Inflammation
Genetic Predisposition of Coronary Artery Disease -- The COROGENE-Study
The aim of this study is to identify genetic loci,or gene variations contributing to inflammation and to the development of CHD.
- Trial name
- NCT00417534
- Where
- Finland
- Volunteers
- 5,000 people
- Sponsor
- University of Helsinki
Ischemia Coronary Artery Origin
Thoracic Epidural Reduces Risks of Increased Left Ventricular Mass Index During Coronary Artery Bypass Graft Surgery
Increased left ventricular mass index (LVMI) results from aortic valve lesions as an adaptive mechanism to help limit systolic wall stress and preserve ejection fraction (EF).
- Trial name
- NCT03719248
- Testing
- thoracic epidural
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ahmed Said Elgebaly,MD
Hypertrophic Cardiomyopathy
Echocardiography-guided Percutaneous Septal Radiofrequency Ablation for Obstructive HCM After Alcohol Septal Ablation
After alcohol ablation, some HOCM patients have serious clinical symptoms and adverse complications, and need to undergo invasive surgery again when adequate drug therapy is not effective or cannot tolerate the side effects of…
- Trial name
- HCM (NCT06496633)
- Testing
- Percutaneous Intramyocardial Septal Radiofrequency Ablation
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Xijing Hospital
Coronary Artery Disease, Aortic Valve Disorder
Carpentier-Edwards PERIMOUNT Magna Ease Pericardial Bioprosthesis, Model 3300TFX
The purpose of the study is to demonstrate the long term safety and effectiveness of the Carpentier-Edwards PERIMOUNT Magna Ease Valves in patients undergoing aortic valve replacement with or without concomitant procedures…
- Conditions
- Coronary Artery Disease, Aortic Valve Disorder, Heart Failure, Aortic Valve Stenosis
- Trial name
- NCT01171625
- Testing
- Implantation of CEP Magna Ease Model 3300TFX
- Where
- 13 sites in United States, Austria and 4 more
- Volunteers
- 283 people
- Sponsor
- Edwards Lifesciences
Transcatheter Aortic Valve Replacement, Transcatheter Heart Valve Thrombosis
Low-dose Colchicine for Thromboprophylaxis After Transcatheter Aortic Valve Replacement
This prospective, randomized, open-label study aims to evaluate the efficacy and safety of low-dose colchicine (0.5 mg daily) in reducing transcatheter heart valve (THV) thrombosis in patients after TAVR.
- Conditions
- Transcatheter Aortic Valve Replacement, Transcatheter Heart Valve Thrombosis, Anti-inflammatory Therapy
- Trial name
- LoDoCo-TAVR (NCT07411768)
- Testing
- Colchicine, Standard Care
- Where
- China
- Volunteers
- 116 people
- Sponsor
- China National Center for Cardiovascular Diseases