Clinical trials: Aortic Dissection Type A
Aortic Dissection
Registry of Patients With Acute/Subacute Type B Aortic Dissection Treated by Means of the STABILISE Technique (STABILISE)
The aim of the study is to evaluate results of patients treated with the STABILISE technique for acute/subacute aortic dissection.
- Trial name
- STABILISE (NCT03707743)
- Where
- 34 sites in United States, Australia and 12 more
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Hypoxemia, Ventilator Lung
Driving Pressure-guided Lung Protective Ventilation
The study, named as "The Efficacy of Driving Pressure-guided Lung Protective Ventilation in Surgical Repair of Acute Type A Aortic Dissection: an open-label, randomized control clinical trial", aims to investigate whether driving…
- Trial name
- DPV (NCT06361420)
- Testing
- Driving pressure-guided positive end expiratory pressure, Optimal oxygenation-guided positive end expiratory pressure, Ventilation strategy
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Yong Lin, PhD
Aortic Dissection
Optimal Strategy for Repair of Type A Acute Aortic Dissection
Acute type A aortic dissection (TAAD) persists as a clinicopathologic entity with high lethality in the current era. Several procedures are presently used to repair the TAAAD.
- Trial name
- TARAD (NCT05912608)
- Testing
- Conservative TAAAD-R, Extensive TAAAD-R
- Where
- France
- Volunteers
- 900 people
- Sponsor
- Centre Cardiologique du Nord
Aortic Dissection
Percutaneous Plug-based Femoral Arteriotomy Closure Device Use in Surgery for Acute Type A Aortic Disection
A single-center prospective study. Patients undergoing surgery for acute type A aortic dissection with femoral arterial cannulation between 2017 and 2022 at the Karolinska University Hospital in Stockholm, Sweden are eligible.
- Trial name
- NCT05482555
- Testing
- Percutaneous arteriotomy closed using a plug-based arteriotomy closure device, Surgical cut-down and arterial puncture under direct vision
- Where
- Sweden
- Volunteers
- 171 people
- Sponsor
- Karolinska University Hospital
Aortic Dissection Type A, Acute Kidney Injury Cardiac Surgery
Preoperative Ankle-Brachial Index and Renal Adverse Events After Acute Type A Aortic Dissection Surgery
This single-centre retrospective observational cohort study evaluated the association between preoperative cuff-derived ankle-brachial index (ABI) and postoperative acute kidney injury (AKI) in adults undergoing emergency repair…
- Trial name
- NCT07668830
- Testing
- Preoperative Ankle-Brachial Index
- Where
- China
- Volunteers
- 516 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Type B Aortic Dissection
EXtensive mulTilayer stEnt treatmeNt in Aortic disSectiOn
This clinical trial is a prospective, multicenter, open label study designed to evaluate the effectiveness and the safety of the Allay® Aortic Stent as adjunctive endovascular treatment of Type B aortic dissection in patients…
- Trial name
- EXTENSO (NCT06675617)
- Testing
- Allay Aortic Stent
- Where
- 21 sites in Austria, Belgium and 6 more
- Volunteers
- 72 people
- Sponsor
- Intressa Vascular SA
Aortic Dissection Type A, Chest Pain
Triage and Recognition of Acute Aortic Dissection in Chest Pain by Electrocardiogram-Artificial Intelligence
The goal of this prospective multicenter observational study is to learn whether an artificial intelligence model based on electrocardiograms (ECGs) can help diagnose acute type A aortic dissection (TAAD) in adults who come to…
- Trial name
- TRACE (NCT07536932)
- Volunteers
- 10,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Acute Lung Injury
Xenon Against Postoperative Oxygen Impairment
Acute lung injury (ALI) is the vital complication of Stanford type A aortic dissection. It is confirmed that Xenon has the significant protective effect on important organs and has no suppression on the cardiovascular system.
- Trial name
- NCT02468531
- Testing
- oxygen, Xenon
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Beijing Anzhen Hospital
Type A Aortic Dissection
European Registry of Type A Aortic Dissection
Acute Stanford type A aortic dissection (TAAD) is a life-threatening condition. Surgery is usually performed as a salvage procedure and is associated with significant postoperative early mortality and morbidity.
- Trial name
- ERTAAD (NCT04831073)
- Testing
- Surgery on the ascending aorta with or without repair of the aortic root and/or aortic arch
- Where
- 20 sites in Belgium, Czechia and 6 more
- Volunteers
- 3,902 people
- Sponsor
- Helsinki University Central Hospital
Cardiomyopathy, Hypertrophic, Cardiomyopathy, Dilated
National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry
The goal of this observational study is to develop a registry of Brazilian patients with hereditary cardiovascular diseases, combining clinical and genomic data.
- Conditions
- Cardiomyopathy, Hypertrophic, Cardiomyopathy, Dilated, Cardiomyopathy Restrictive, Arrhythmogenic Right Ventricular Dysplasia
- Trial name
- RENOMICA-Hcor (NCT06546137)
- Testing
- whole genome sequencing
- Where
- 27 sites in Brazil
- Volunteers
- 1,211 people
- Sponsor
- Hospital do Coracao
Type B Aortic Dissection
Real-World Prospective Parallel Controlled Study on Endovascular Therapy for Improving Perfusion and Remodeling of TBAD
There are both common and individual characteristics in patients with type B aortic dissection. Currently, for all subtypes of acute type B dissection, proximal endovascular repair is mostly performed during the subacute phase…
- Trial name
- NCT07022145
- Testing
- Endovascular repair
- Volunteers
- 438 people
- Sponsor
- Shanghai Zhongshan Hospital
Acute Aortic Dissection
Perioperative Eosinophils Their Recovery in Type A Acute Aortic Dissection Prognosis
Type A acute aortic dissection (TA-AAD) patients are prone to life-threatening complications and death during the acute phase. Currently, little evidence is available with regards to the relationship between eosinophils (EOS) and…
- Trial name
- NCT05409677
- Testing
- This was a retrospective study with no intervention other than normal treatment
- Where
- 2 sites in China
- Volunteers
- 274 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Type A Aortic Dissection
BioGlue as an Adjunct for Structural Repair and Hemostasis in Chinese Acute Type A Aortic Dissections Patients
A multi-center, randomized, controlled clinical trial is designed to investigate the safety and efficacy of BioGlue as an adjunct for structural repair and hemostasis to traditional surgical repair in Chinese subject with Acute…
- Trial name
- CHINA (NCT03369977)
- Testing
- BioGlue Surgical Adhesive, Traditional Surgical Repair
- Where
- 7 sites in China
- Volunteers
- 202 people
- Sponsor
- CryoLife, Inc.
Aortic Dissection Type A
Total Arch Replacement With Frozen Elephant Trunk Versus Hemiarch Replacement in the Management of Acute Type A Aortic Dissection
Acute Type A aortic dissection (ATAAD) and its complications are life-threatening conditions that cause more than 1400 hospital admissions and 300 deaths every year in Hong Kong and cause 172,927 deaths globally in 2019.
- Trial name
- TARFET-TAAD (NCT06676371)
- Testing
- Conventional hemiarch replacement, E-vita® Open Neo; Artivion, Thoraflex Hybrid; Terumo
- Where
- 3 sites in Austria, Hong Kong and 1 more
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Type B or Non-A Non-B Aortic Dissection;Thoracic Aortic Aneurysm
Aspirin for Prevention of Stroke After Endovascular Aortic Arch Repair: a Multicenter, Double-Blind, Randomized Controlled Trial
ABSTRACT Introduction Endovascular aortic arch repair (EAAR) and the endovascular reconstruction of arch branch vessels represent a new trend in managing aortic arch pathologies, due to advantages such as minimal invasiveness…
- Trial name
- NCT07205250
- Testing
- enteric-coated aspirin tablets (100 mg once daily, Bayer Healthcare, specification: 100 mg/tablet)
- Volunteers
- 224 people
- Sponsor
- The General Hospital of Western Theater Command
Aortic Dissection Type B
WeFlow-EndoSeal™ Aorta Vascular Plug System for the Treatment of Stanford Type B Aortic Dissection
The goal of this prospective, multicenter, randomized controlled clinical trial is to evaluate the safety and efficacy of the WeFlow-EndoSeal™ vAorta Vascular Plug System combined with thoracic endovascular aortic repair (TEVAR)…
- Trial name
- NCT07658651
- Testing
- WeFlow-EndoSeal™ Aorta Vascular Plug System, Thoracic Endovascular Aortic Repair（TEVAR）
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Hangzhou Endonom Medtech Co., Ltd.
Acute Type A Aortic Dissection
Comparative Study of Antegrade Versus Retrograde Cerebral Perfusion in Acute Type A Aortic Dissection: A Prospective Study
This prospective study investigated the comparison of effectiveness of antegrade cerebral perfusion (ACP) and retrograde cerebral perfusion (RCP) in providing cerebral protection during the surgical treatment of acute Type A…
- Trial name
- NCT06870513
- Testing
- Antegrade Cerebral Perfusion via Axillary Artery, Retrograde Cerebral Perfusion via Superior Vena Cava
- Where
- Egypt
- Volunteers
- 116 people
- Sponsor
- Yusuf Shieba
Aortic Dissection
Hemiarch vs Extended Arch in Type 1 Aortic Dissection
HEADSTART is a prospective, open-label, non-blinded, multicenter, randomized controlled trial that compares a composite of mortality and re-intervention in patients undergoing hemiarch and extended arch repair for acute DeBakey…
- Trial name
- HEADSTART (NCT03885635)
- Testing
- Hemiarch repair, Extended arch repair
- Where
- 5 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Multiple Organ Dysfunction Syndrome
Mesenchymal Stem Cells for Multiple Organ Dysfuntion Syndrome After Surgical Repaire of Acute Type A Aortic Dissection
Multiple organ dysfunction syndrome (MODS) after surgical repaire for acute type A aortic dissection(ATAAD) is a life-threatening condition.
- Trial name
- NCT03552848
- Testing
- MSC
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fujian Medical University
Aortic Dissection Type B
EndoVascular Aortic Dissection Early vs Delayed
This is a prospective, multicenter, non-inferior, parallel-controlled observational study. This study aims to compare clinical outcomes of endovascular treatment for acute high-risk type B aortic dissection in the acute phase…
- Trial name
- EVADE (NCT07143071)
- Testing
- Acute Phase, Subacute Phase
- Where
- China
- Volunteers
- 4,068 people
- Sponsor
- Shanghai Zhongshan Hospital