Clinical trials: Aortic Dissection Type A
Acute Kidney Injury, Nitrous Oxide
Perioperative Nitric Oxide Prevents Acute Kidney Injury in Acute Type A Aortic Dissection Patients
The goal of this clinical trial is to determine the effectiveness of exogenous nitric oxide therapy in reducing the occurrence of acute kidney injury in patients with acute type A aortic dissection.
- Conditions
- Acute Kidney Injury, Nitrous Oxide, Acute Type A Aortic Dissection
- Trial name
- NCT06622291
- Testing
- Nitric Oxide
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Beijing Anzhen Hospital
Type A Aortic Dissection With Residual Type B Dissection, Chronic Type B Aortic Dissection
Creation of a Digital Twin for Predicting the Progression of Patients With Chronic Thoracic Aortic Dissection
Aortic dissection causes a tear in the inner layers of the aorta, leading to the formation of a true and false lumen. There are two types of dissection: type A, which affects the ascending aorta, and type B, which affects the…
- Trial name
- ADEPT (NCT07315178)
- Testing
- MRI with 4D flow imaging, blood sampling
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Aortic Dissection Type B
Study of the RelayPro Thoracic Stent-Graft in Subjects With an Acute, Complicated Type B Aortic Dissection
This clinical trial is a prospective, multicenter, non-blinded, non-randomized study designed to assess the RelayPro thoracic endografts in the treatment of acute, complicated type B aortic dissection.
- Trial name
- NCT03033043
- Testing
- Relay Pro Stent-Graft
- Where
- 21 sites in United States
- Volunteers
- 56 people
- Sponsor
- Bolton Medical
Aortic Dissection Type B
TEAVR With False Lumen Embolization for Aortic Dissection
This multicenter, prospective, observational study aims to evaluate the efficacy and safety of thoracic endovascular aortic repair (TEVAR) combined with false lumen embolization using vascular plugs in patients with acute type B…
- Trial name
- NCT07198295
- Testing
- TEAVR with false lumen embolization
- Volunteers
- 72 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Type A Aortic Dissection, Organ Failure, Multiple
Sivelestat Treatment for Postoperative Organ Protection in Type A Aortic Dissection
The goal of this multicenter, double-blind, randomized controlled trial is to learn if sivelestat sodium (Siv) can protect the organ function in patients suffered operation for acute type A aortic dissection.
- Trial name
- STOP (NCT07156656)
- Testing
- Conventional treatment, Sivelestat sodium
- Where
- 6 sites in China
- Volunteers
- 236 people
- Sponsor
- Shanghai Zhongshan Hospital
Aortic Dissection Type B
EndoVascular Aortic Dissection Early vs Delayed
This is a prospective, multicenter, non-inferior, parallel-controlled observational study. This study aims to compare clinical outcomes of endovascular treatment for acute high-risk type B aortic dissection in the acute phase…
- Trial name
- EVADE (NCT07143071)
- Testing
- Acute Phase, Subacute Phase
- Where
- China
- Volunteers
- 4,068 people
- Sponsor
- Shanghai Zhongshan Hospital
Aortic Aneurysm, Thoracic, Chronic Type B Dissection
Evaluation of the Valiant Mona LSA Thoracic Stent Graft System in Descending TAA and Chronic Dissections
The purpose of the Feasibility study is to characterize the safety of the Valiant Mona LSA Thoracic Stent Graft System, including an assessment of the safety and effectiveness of the device acutely and at the 30 day visit in the…
- Trial name
- NCT02365467
- Testing
- Valiant Mona LSA Thoracic Stent Graft System
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Medtronic Cardiovascular
Acute Stanford Type A Aortic Dissection
Hybrid vs. Conventional Surgery for Type A Aortic Dissection
This is a prospective, randomized controlled trial designed to compare the clinical efficacy and short-term outcomes of one-stop hybrid surgery versus conventional total arch replacement with frozen elephant trunk (FET) in…
- Trial name
- NCT07107711
- Testing
- One-Stop Hybrid Surgery, Conventional Total Arch Replacement with Frozen Elephant Trunk
- Where
- China
- Volunteers
- 140 people
- Sponsor
- The First Hospital of Hebei Medical University
Type B Aortic Dissection
Real-World Prospective Parallel Controlled Study on Endovascular Therapy for Improving Perfusion and Remodeling of TBAD
There are both common and individual characteristics in patients with type B aortic dissection. Currently, for all subtypes of acute type B dissection, proximal endovascular repair is mostly performed during the subacute phase…
- Trial name
- NCT07022145
- Testing
- Endovascular repair
- Volunteers
- 438 people
- Sponsor
- Shanghai Zhongshan Hospital
Type B Aortic Dissection
Safety and Efficacy of Exercise in Type-B Aortic Dissection
This is a pilot study. The goal of this clinical trial is to evaluate the safety and efficacy of exercise-based cardiac rehabilitation in patients with Type-B Aortic dissection or intramural hematoma or penetrating ulcer and…
- Trial name
- SECRET-Pilot (NCT07009067)
- Testing
- Exercise-based Cardiac Rehabilitation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Guangdong Provincial People's Hospital
Aortic Dissection Type A, Transfusions
Use of PRP in Open Surgery for Type A Aortic Dissection
The goal of this clinical trial is to determine if autologous platelet rich plasma (PRP) can reduce the need for blood transfusions in patients undergoing open surgery for Type A aortic dissection.
- Conditions
- Aortic Dissection Type A, Transfusions, Platelet Rich Plasma (PRP), Organ Protection
- Trial name
- NCT07005661
- Testing
- Autologous Platelet Rich Plasma, Standard Blood Management
- Volunteers
- 250 people
- Sponsor
- Beijing Anzhen Hospital
Acute Type A Aortic Dissection
Comparative Study of Antegrade Versus Retrograde Cerebral Perfusion in Acute Type A Aortic Dissection: A Prospective Study
This prospective study investigated the comparison of effectiveness of antegrade cerebral perfusion (ACP) and retrograde cerebral perfusion (RCP) in providing cerebral protection during the surgical treatment of acute Type A…
- Trial name
- NCT06870513
- Testing
- Antegrade Cerebral Perfusion via Axillary Artery, Retrograde Cerebral Perfusion via Superior Vena Cava
- Where
- Egypt
- Volunteers
- 116 people
- Sponsor
- Yusuf Shieba
Acute Type A Aortic Dissection
Efficacy of Bilateral Modified Catheter Antegrade Cerebral Perfusion in Acute Type A Aortic Dissection Surgery
This retrospective cohort study aims to evaluate the efficacy of a Bilateral Modified Catheter Antegrade Cerebral Perfusion (Modified bACP) technique in acute Type A aortic dissection surgery.
- Trial name
- NCT06943716
- Testing
- Modified Catheter Antegrade Cerebral Perfusion (Modified bACP), Conventional Brain Perfusion
- Where
- Taiwan
- Volunteers
- 273 people
- Sponsor
- China Medical University Hospital
Acute Type A Aortic Dissection
A Prediction Model of Prolonged Mechanical Ventilation Following Acute Type A Aortic Dissection Surgery
The goal of this observational study is to develop and validate a predictive model for prolonged mechanical ventilation (PMV) following acute type A aortic dissection (ATAAD) surgery. The main questions it aims to answer are: 1.
- Trial name
- NCT06929780
- Where
- China
- Volunteers
- 1,400 people
- Sponsor
- China-Japan Friendship Hospital
Aortic Dissection Type B
Safety and Efficacy of TEVAR Combined With Long Bare-metal Stents in the Intervention of ATBAD
The primary objective of this study is to evaluate the safety and efficacy of the TEVAR combined with extended bare-metal stenting (distal landing zone ≥2 cm below renal arteries) in patients with acute complicated type B aortic…
- Trial name
- SAFE-COVER (NCT06892730)
- Testing
- Hybrid TEVAR combined with long bare-metal stent intervention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Yan'an Affiliated Hospital of Kunming Medical University
Type B Aortic Dissection
Study of Prognostic Factors in Aortic Dissection Type B
Clinical outcomes of chronic type B aortic dissections are unknown, especially in case of false lumen expansion and risk of rupture. Data of literature give us some indications about prognosis.
- Trial name
- TEDAC (NCT01984905)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Caen
Aortic Dissection Type B, Intramural Hematoma
CRATOS - Evaluation of Cratos™ Branch Stent Graft System in Treatment of Descending Aorta Lesions
The goal of this prospective, interventional, multicentre, single-arm performance objective study is to evaluate efficacy and safety of Cratos™ Branch Stent Graft System in treatment of lesions (dissection, IMH and PAU in…
- Conditions
- Aortic Dissection Type B, Intramural Hematoma, Penetrating Aortic Ulcer
- Trial name
- NCT05874206
- Testing
- Cratos™ Stent Graft
- Where
- Switzerland
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Shanghai MicroPort Endovascular MedTech（Group）Co., Ltd
Type B Aortic Dissection
LSA Reconstruction With Laser Fenestration During the TEVAR
This study aims to evaluate the feasibility, effectiveness, and safety of in-situ laser-assisted fenestration on the left subclavian artery during the procedure of thoracic artery endovascular repair
- Trial name
- LLTEVAR (NCT03845829)
- Testing
- In situ laser assisted fenestration
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Type B Aortic Dissection
Conventional TEVAR Versus FABULOUS RCT
For High-risk Type B aortic dissections, a multicenter, prospective, randomized controlled study is conducted to compare the clinical outcomes of conventional proximal endovascular repair (TEVAR) alone versus the Fabulous system…
- Trial name
- NCT06740565
- Testing
- thoracic endovascular aortic repair
- Volunteers
- 392 people
- Sponsor
- Shanghai Zhongshan Hospital
Acute Aortic Syndrome, Type a Aortic Dissection
Protective Effect of Ulinastatin Against Negative Inflammatory Response and Organ Dysfunction After Acute Type a Aortic Dissection Surgery (PANDA I)
Acute Aortic Syndrome (AAS) is a common feature of acute aortic wall events, including aortic dissection, intramural hematoma, aortic ulceration and aortic trauma, and occurs in up to 35 cases per 100,000 cases per year between…
- Trial name
- PANDA (NCT04711889)
- Testing
- Ulinastatin, Blank control
- Where
- 2 sites in China
- Volunteers
- 203 people
- Sponsor
- Nanjing Medical University