Clinical trials: Aortic Disease
Cardiomyopathy
Natural History Study in Pediatric Patients With MYBPC3 Mutation-associated Cardiomyopathy
The objective of this study is to collect information on patients with cardiomyopathy (CM) due to mutations in the MYBPC3 gene, to evaluate their disease course, burden of illness, risk factors for this disease, and the quality…
- Trial name
- MyCLIMB (NCT05112237)
- Where
- 29 sites in United States, Canada and 2 more
- Volunteers
- 200 people
- Sponsor
- Tenaya Therapeutics
Aortic Aneurysm, Abdominal, Arterial Occlusive Diseases
Plasma Transfusion in Major Vascular Surgery
BACKGROUND Major blood loss is frequent in open repair of ruptured and intact abdominal aortic aneurysm (AAA) as well as in aorto-bifurcated prosthesis insertion due to aortoiliac occlusive disease.
- Trial name
- NCT04514575
- Testing
- Plasma transfusion
- Where
- Denmark
- Volunteers
- 17,000 people
- Sponsor
- Naestved Hospital
Autoimmune Disease, Crohn Disease
Fluorine F 18 Clofarabine PET/CT in Imaging Patients With Autoimmune or Inflammatory Diseases
This pilot trial studies how well fluorine F 18 clofarabine positron emission tomography (PET)/computed tomography (CT) works in imaging patients with autoimmune or inflammatory diseases.
- Conditions
- Autoimmune Disease, Crohn Disease, Inflammatory Disorder, Rheumatoid Arthritis
- Trial name
- NCT02925351
- Testing
- Computed Tomography, Fluorine F 18 Clofarabine, Positron Emission Tomography
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Ovary Cancer, Cervical Cancer
Feasibility of the "One-Finger Technique" for Identifying the Upper Left Ureter During Para-Aortic Lymphadenectomy
Para-aortic lymphadenectomy plays an important role in the surgical treatment of major gynecological malignancies (ovarian, endometrial, and cervical cancer).
- Conditions
- Ovary Cancer, Cervical Cancer, Endometrial Cancer
- Trial name
- NCT07895212
- Testing
- One-Finger Technique
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Aortic Coarctation, Cardiac Output, Low
Correlation of Cardiac Index Measured by the PRAM Method With NIRS and Lactate Levels in Pediatric Aortic Coarctation Surgery
This prospective observational study aims to evaluate the correlation between cardiac index measured by the MostCare™ system (Pressure Recording Analytical Method, PRAM) and cerebral/renal regional oxygen saturation measured by…
- Trial name
- MostCare-Ped (NCT07568431)
- Testing
- MostCare (PRAM), Near-Infrared Spectroscopy (NIRS), Arterial Blood Gas with Lactate
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Konya City Hospital
Anesthesia, Anesthesia Complication
Preoperative Blood Volume Optimization Using Transthoracic Echocardiography
Immediately following the induction of general anesthesia, arterial hypotension may occur with an incidence of about 40% in patients classified as ASA 3 or 4.
- Conditions
- Anesthesia, Anesthesia Complication, Anesthesia Induction, Arterial Hypotension
- Trial name
- EchOptimal (NCT06639737)
- Testing
- preoperative stroke volume optimization, Post induction stroke volume optimization
- Where
- France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Caen
Endometrial Cancer
Comparison Between High and Low Level Para-aortic Lymphadenectomy in High and Intermediate Risk Endometrial Carcinoma
Endometrial cancer (EC) is the most frequent gynecological malignancy in developed countries and ranks second in incidence worldwide after cervical cancer, accounting for nearly 10% of cancers in women .
- Trial name
- NCT07306195
- Testing
- high level para-aortic lymphadenectomy, low level para-aortic lymphadenectomy
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Ahmed Aouf
Aortic Arch Disease
Prospective, Multicenter, Single-Arm Study of Aortic Arch Pathology Reconstruction
A prospective ,multiple center Study about the Safety and Efficacy of the Thoracic Aortic Multi-Branch Stent Graft System, developed and manufactured by Shanghai MicroPort Endovascular MedTech (Group) Co., Ltd., in patients with…
- Trial name
- NCT07139912
- Testing
- Thoracic Aortic Multi-Branch Stent Graft System
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Shanghai MicroPort Endovascular MedTech（Group）Co., Ltd
Marfan Syndrome, Marfan Syndrome Cardiovascular Manifestations
Living With Marfans and Your Aorta: Surgical Outcomes Study
Marfan Syndrome (MFS) is a genetic disease affecting the eyes, skeleton, heart and arteries. Despite MFS affecting multiple organ systems, cardiovascular manifestations are the most serious and life threatening.
- Trial name
- LIMA II (NCT04776681)
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Barts & The London NHS Trust
Aortic Valve Disease, Myocardial Infarction
Antiplatelet Therapy for Patients Undergoing Transcatheter Aortic Valve Implantation
At present, a variety of antithrombotic regimens are prescribed in the early postprocedure period after transcatheter aortic valve implantation (TAVI).
- Conditions
- Aortic Valve Disease, Myocardial Infarction, Stroke, Bleeding
- Trial name
- POPular-TAVI (NCT02247128)
- Testing
- Aspirin + clopidogrel, Aspirin monotherapy, OAC + clopicogrel
- Where
- 17 sites in Belgium, Czechia and 2 more
- Volunteers
- 1,016 people
- Sponsor
- St. Antonius Hospital
Aortic Stenosis, TAVI(Transcatheter Aortic Valve Implantation)
Dilation Optimisation for Uniform Bioprosthetic Leaflet Expansion
The goal of this clinical trial is to discover if routine 'double tap' balloon post-dilation improves valve expansion and clinical outcomes in adults undergoing Transcatheter Aortic Valve Implantation (TAVI) with the SAPIEN…
- Trial name
- ACE-DOUBLE (NCT07430267)
- Testing
- 'Double tap' balloon post-dilation
- Where
- 3 sites in Australia
- Volunteers
- 250 people
- Sponsor
- The Alfred
Incisional Hernia, Abdominal Aortic Aneurysm
Aneurysma Hernia Study - Incidence of Incisional Hernias After Abdominal Aortic Aneurysm Repair
Principles= Prevention of incision hernias by primary closure of mid line laparotomies with the best-evidenced suture techniques.
- Trial name
- АНЕУРИЗМА (NCT02012270)
- Testing
- PRINCIPLES technique, Conventional group
- Where
- 2 sites in Poland, Serbia
- Volunteers
- 240 people
- Sponsor
- Igor Koncar
Fabry Disease
Aortic Dimensions in Patients With Fabry Disease
We will conduct a retrospective study aiming to define the characteristics, determinants, and progression of ascending aortic dilatation in adults with Fabry disease, using echocardiography and/or cardiac MRI
- Trial name
- DATA-Fab (NCT06956573)
- Testing
- aorta imaging
- Volunteers
- 200 people
- Sponsor
- University Hospital, Caen
Aortic Aneurysm
Bentley Bridging Stent Graft Study
This international, observational multi-centre observational study of the devices BeFlared FEVAR Stent Graft System (BeFlared), BeGraft Stent Graft System (BeGraft), and BeGraft Plus Stent Graft System (BeGraft Plus) will monitor…
- Trial name
- BeFab (NCT07295145)
- Testing
- endovascular aortic repair (EVAR)
- Volunteers
- 150 people
- Sponsor
- Bentley InnoMed GmbH
Kidney Injury, Acute, Transcatheter Aortic Valve Implantation
Renal Regional Oxygen Saturation During Transcatheter Aortic Valve Implantation
This prospective observational study evaluates the association of peri-procedural changes in renal regional oxygen saturation and post-procedural acute kidney injury in patients undergoing transcatheter aortic valve implantation.
- Trial name
- NCT04921475
- Testing
- Regional oxygen saturation monitoring
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Seoul National University Hospital
Severe Aortic Valve Disease, Aortic Valve Replacement (AVR)
Comparative Research of Y-Incision vs. Standard Techniques for Aortic Root EnLargement
Abstract Background: Aortic valve replacement (AVR) is crucial for patients with severe aortic valve disease. However, managing those with a small aortic annulus (SAA, i.e., annulus diameter < 22 mm) is challenging because…
- Conditions
- Severe Aortic Valve Disease, Aortic Valve Replacement (AVR), Small Aortic Annulus
- Trial name
- CRYSTAL (NCT07368322)
- Testing
- Y incision Technique (YIT), Standard surgical enlargement techniques
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- willner nadav MD
Aortic Valve Disease
Non-Invasive MOnitoring in Transcathether Aortic Valve Implantation
In patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) minimal evidence is available for invasive hemodynamic monitoring and no evidence for tools able to measure traditionally…
- Trial name
- NIMO-TAVI (NCT05840757)
- Testing
- HemoSphere ClearSight Module
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Basel
Aortic Regurgitation
Accuracy of Left Subclavian Regurgitation Evaluated by Ultrasound Doppler and 4D Flow MRI
Aortic insufficiency (IA) is defined as an abnormal regurgitation of blood from the aorta to the left ventricle in diastole, due to a lack of tightness of the aortic valves.
- Trial name
- SUBCLAR (NCT03549091)
- Testing
- transthoracic echocardiography, Cardiovascular Magnetic Resonance Imaging
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Abdominal Aortic Aneurysm
Global Fenestrated Anaconda Clinical STudy
This study is a prospective non-interventional, multi-centre study of the Vascutek Fenestrated Anaconda™ system, and is essentially a post-market study.
- Trial name
- Global FACT (NCT03180996)
- Testing
- Vascutek Fenestrated Anaconda™ Custom AAA Stent Graft System
- Where
- 11 sites in Australia, Austria and 3 more
- Volunteers
- 160 people
- Sponsor
- Vascutek Ltd.
Coronary Artery Disease
The Association Between Central Aortic Blood Pressure Indices and Severity of Coronary Artery Disease
Abstract Objectives: Primary: To study the association between central aortic blood pressure indices and coronary artery disease in patients undergoing elective angiography.
- Trial name
- CAPCAD (NCT02471768)
- Testing
- CORONARY ANGIOGRAM AND CENTRAL AORTIC WAVEFORM ANALYSIS
- Volunteers
- 623 people, healthy volunteers welcome
- Sponsor
- Government Medical College, Kozhikode
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