Clinical trials: Aortic Arch Dissection
Type A Aortic Dissection, Ascending Aortic Dissection
Outcomes of Aortic Dissection Repair
Type A aortic dissection (TAAD) is a potentially life-threatening pathology associated with significant risk of mortality and morbidity.
- Conditions
- Type A Aortic Dissection, Ascending Aortic Dissection, Aortic Diseases, Aortic Arch
- Trial name
- STAAD (NCT05927090)
- Testing
- Conservative Root- Sparing Aortic Valve Resuspension with or without Hemiarch Repair, Extensive Ascending Aorta Replacement (AAR) with Aortic Root Replacement (ARR), Extensive Ascending Aorta Replacement (AAR) with Total Arch Replacement (TARP)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Centre Cardiologique du Nord
Acute Aortic Dissection
Triple-branch Stent Graft Placement and Total-arch Replacement for the Treatment of Acute DeBakey I Aortic Dissection
The purpose of this study is to compare triple-branched stent placement with total-arch replacement in the treatment of acute DeBakey I aortic dissection .
- Trial name
- TBSGPATART (NCT02622750)
- Testing
- triple-branched stent graft, four-branched Dacron graft
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Liang-Wan Chen MD
Aortic Aneurysm, Aortic Dissection
Thoraflex™ Hybrid IDE Study
The study will assess the effectiveness, safety and clinical outcomes of the Thoraflex™ Hybrid Device in the treatment of aortic disease affecting the aortic arch and the descending thoracic aorta, with or without involvement of…
- Conditions
- Aortic Aneurysm, Aortic Dissection, Aortic Rupture
- Trial name
- NCT02724072
- Testing
- Thoraflex™ Hybrid Device
- Where
- 12 sites in United States
- Volunteers
- 84 people
- Sponsor
- Bolton Medical
Aortic Dissection, Aortic Arch Aneurysm
Clinical Study for Evaluating the Safety and Efficacy of Total Endovascular Aortic Arch Repair
Aortic disease is a kind of cardiovascular diseases with very high mortality rate and high risk of surgical treatment. At present, the surgical and endovascular treatment for diseases in the ascending aorta, descending aorta and…
- Conditions
- Aortic Dissection, Aortic Arch Aneurysm, Ulcer, Pseudoaneurysm
- Trial name
- NCT03347812
- Testing
- Endovascular Aortic Repair, Total Arch Replacement
- Where
- 4 sites in China
- Volunteers
- 400 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Aortic Aneurysm, Aortic Dissection
Cerebral Protection in Aortic Arch Surgery
Aortic arch repair surgery is a technically complex and challenging procedure to treat aortic pathologies. Despite advancements in perioperative care, detrimental neurological complications occur during or after surgery.
- Conditions
- Aortic Aneurysm, Aortic Dissection, Aortic Arch, Aortic Diseases
- Trial name
- NCT04966247
- Testing
- Microdialysis
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Barts & The London NHS Trust
Thoracic Aortic Aneurysm, Aortic Dissection
Biomechanical Reappraisal of Planning for Thoracic Endovascular Aortic Repair
Thoracic endovascular aortic repair (TEVAR) for disease involving the aortic arch remains complex and challenging due the angulation and tortuosity of the arch and its peculiar biomechanical environment.
- Conditions
- Thoracic Aortic Aneurysm, Aortic Dissection, Aortic Diseases
- Trial name
- MALAN (NCT03824626)
- Testing
- TEVAR patients
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Ospedale San Donato
Complex Aortic Aneurysms, Thoracoabdominal Aneurysms
Complex Aortic Aneurysm Repair Using Physician Modified Endografts and Custom Made Devices
The purpose of this study is to evaluate the safety and efficacy of custom made devices, Zenith t-Branch devices and physician modification of FDA approved off-the-shelf endovascular grafts in the treatment of patients with…
- Conditions
- Complex Aortic Aneurysms, Thoracoabdominal Aneurysms, Pararenal Aneurysms, Juxtarenal Aneurysms
- Trial name
- CARPE-CMD (NCT02050113)
- Testing
- Custom Made Fenestrated or Branched Stent Graft
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Andres Schanzer
Aortic Aneurysm and Dissection
Guo's Endovascular Aortic Arch Replacement of Aortic Dissection by WeFlow-Tribranch Endoprothesis: a Multicenter Pilot Study(GRAFT Study)
To explore the effect and prognosis of endovascular interventional therapy in high-risk patients with aortic arch dissection and aneurysm
- Trial name
- NCT05754541
- Testing
- WeFlow-Tribranch Aortic Arch Stent Graft System
- Where
- 4 sites in China
- Volunteers
- 20 people
- Sponsor
- Hangzhou Endonom Medtech Co., Ltd.
Dissection of Thoracic Aorta, Dissection of Thoracic Descending Aorta
European Multi-Centre Post-Market Registry on Thoracic Endovascular Arch Repair Using Castor™ and Cratos™
The Castor™ and Cratos™ Branched Aortic Stent Graft Systems are medical devices designed for the minimally invasive endovascular treatment of thoracic aortic pathologies in the descending aorta.
- Conditions
- Dissection of Thoracic Aorta, Dissection of Thoracic Descending Aorta, Aneurysm of Aorta, Thoracic, Penetrating Aortic Ulcers (PAUs)
- Trial name
- CEDAR (NCT07668687)
- Testing
- Implantation with Castor™ stent graft, Implantation with Cratos™ stent graft
- Where
- 4 sites in Germany, Switzerland
- Volunteers
- 100 people
- Sponsor
- Shanghai MicroPort Endovascular MedTech（Group）Co., Ltd
Type A Aortic Dissection, Circulatory Arrest
Antegrade Cerebral Perfusion and Retrograde Inferior Vena Caval Perfusion for Total Aortic Arch Replacement
This study is designed as a multicenter, randomized, assessor- blinded clinical trial.The primary aim of this trial is to assess whether retrograde inferior venal caval perfusion combined selective antegrade cerebral…
- Conditions
- Type A Aortic Dissection, Circulatory Arrest, Hypothermia
- Trial name
- CARTAR (NCT03607786)
- Testing
- Retrograde Inferior Vena Caval Perfusion, Select antegrade cerebral perfusion
- Where
- China
- Volunteers
- 600 people
- Sponsor
- West China Hospital
Aortic Dissection, Aneurysm, Aortic Arch
Concave Supra-arch Branched Stent-Graft System for Treatment of Aortic Arch Diseases
There are no endoluminal stent systems available on the Chinese market for the effective treatment of aortic arch lesions (involving aortic arch aneurysms, aortic coarctation, aortic pseudoaneurysms, aortic ulcers, and intermural…
- Conditions
- Aortic Dissection, Aneurysm, Aortic Arch, Aortic Pseudoaneurysm, Aortic Ulcer, Penetrating
- Trial name
- NCT05996354
- Testing
- Concave Supra-arch Branched stent-graft system
- Where
- 3 sites in China
- Volunteers
- 10 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Type A Aortic Dissection, Hypothermia
Arch-Clamping Technique Under Mild Hypothermia in Treating With Acute Type A Aortic Dissection
The study is a multicenter, three-arm, open-label, randomized, parallel-controlled trial, which plans to enroll 306 participants diagnosed with acute type A aortic dissection (ATAAD) from 7 hospitals in China.
- Conditions
- Acute Type A Aortic Dissection, Hypothermia, Total Aortic Arch Replacement, Frozen Elephant Trunk
- Trial name
- AHEAD (NCT07150559)
- Testing
- Arch-Clamping Technique under Mild Hypothermia, Arch-Clamping Technique under Moderate Hypothermia, Total Arch Replacement combined Frozen Elephant Trunk Implantation using Bilateral Antegrade Cerebral Perfusion under Moderate Hypothermic Circulatory Arrest
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Beijing Anzhen Hospital
Juxtarenal Aortic Aneurysm, Suprarenal Aortic Aneurysm
Evaluation of the Cook Custom Aortic Endograft, the Zenith t-Branch Endovascular Graft, and Surgeon-Modified Endograft in Treating Aortic Pathologies
This is a single-center study to evaluate the safety and effectiveness of three investigational devices, the Cook Custom Aortic Endograft, the Zenith t-Branch Endovascular Graft, and the Surgeon-Modified Endografts in the…
- Conditions
- Juxtarenal Aortic Aneurysm, Suprarenal Aortic Aneurysm, Thoracoabdominal Aortic Aneurysm, Penetrating Aortic Ulcer
- Trial name
- NCT02043691
- Testing
- Cook Custom Aortic Endograft, Zenith t-Branch Endovascular Graft, Surgeon-Modified Endograft
- Where
- United States
- Volunteers
- 410 people
- Sponsor
- University of Alabama at Birmingham
Aortic Dissection Type A
Total Arch Replacement With Frozen Elephant Trunk Versus Hemiarch Replacement in the Management of Acute Type A Aortic Dissection
Acute Type A aortic dissection (ATAAD) and its complications are life-threatening conditions that cause more than 1400 hospital admissions and 300 deaths every year in Hong Kong and cause 172,927 deaths globally in 2019.
- Trial name
- TARFET-TAAD (NCT06676371)
- Testing
- Conventional hemiarch replacement, E-vita® Open Neo; Artivion, Thoraflex Hybrid; Terumo
- Where
- 3 sites in Austria, Hong Kong and 1 more
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Aortic Dissection, Aortic Aneurysm
NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness
Prospective, non-randomized, multi-center clinical investigation of the NEXUS™ Aortic Arch Stent Graft System (NEXUSTM) for the treatment of thoracic aortic lesions involving the aortic arch with a proximal landing zone, native…
- Conditions
- Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
- Trial name
- TRIOMPHE (NCT04471909)
- Testing
- NEXUS Aortic Stent Graft System
- Where
- 32 sites in United States, New Zealand
- Volunteers
- 110 people
- Sponsor
- Endospan Ltd.
Aortic Dissection, Aortic Arch
Repair Versus Non-repair of the Aortic Arch in Type A Aortic Dissection
Acute Stanford type A aortic dissection (TAAD) is a life-threatening clinical status requiring surgery that is usually performed as a salvage procedure.We planned a multicenter study to evaluate the balance between the patient's…
- Conditions
- Aortic Dissection, Aortic Arch, Aortic Dissection Rupture, Aortic Dilatation
- Trial name
- AoArch (NCT05912634)
- Testing
- Conservative TAAD-R, Extensive TAAD- R
- Where
- France
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Centre Cardiologique du Nord
Complex Abdominal Aortic Aneurysm, Thoracoabdominal Aortic Aneurysm
European Aortic Data Collection Project
The purpose of this study is to evaluate the safety and performance of Cook's various Custom-Made Stent-graft Devices (CMD) used for endovascular treatment of the aorta and related diseases by collecting information on the…
- Conditions
- Complex Abdominal Aortic Aneurysm, Thoracoabdominal Aortic Aneurysm, Aortic Arch Aneurysm, Chronic Aortic Dissection
- Trial name
- EADC (NCT05896397)
- Testing
- Endovascular Aortic Treatments
- Where
- 18 sites in Denmark, France and 4 more
- Volunteers
- 600 people
- Sponsor
- Cook Research Incorporated
Aortic Arch Aneurysm, Aortic Arch Dissection
Clinical Study to Evaluate the Safety and Effectiveness of Arcevo LSA
The goal of this clinical trial is to learn if the Arcevo LSA stent graft can safely and effectively treat patients that have an acute or chronic aortic dissection and/or aneurysm that involves the aortic arch and the descending…
- Conditions
- Aortic Arch Aneurysm, Aortic Arch Dissection, Chronic Aortic Dissection, Acute Aortic Dissection
- Trial name
- ARTIZEN (NCT07089576)
- Testing
- Arcevo™ LSA Hybrid Stent Graft System
- Where
- 26 sites in United States, Germany and 1 more
- Volunteers
- 132 people
- Sponsor
- Artivion Inc.
Aortic Arch; Aneurysm, Dissecting
Study of the Thoraflex™ Hybrid Device for the Treatment of Aneurysm/Dissection of the Descending Thoracic Aorta
The purpose of this national observational study is to evaluate the Thoraflex™ Hybrid vascular prosthesis in the replacement of the aortic arch and the treatment of aneurysm/dissection of the descending thoracic aorta in relation…
- Trial name
- NCT03735472
- Testing
- Thoraflex™ Hybrid
- Where
- 37 sites in France
- Volunteers
- 351 people
- Sponsor
- Vascutek Ltd.
Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Thoracic
Endovascular Treatment of TAAA and Aortic Arch Aneurysms Using Fenestrated and Branched Stent Grafts
Prospective, nonrandomized, single-center, two-arm study to assess the feasibility and safety and to evaluate clinical outcomes of endovascular repair of complex aortic aneurysms (thoracoabdominal aortic aneurysms and aortic arch…
- Conditions
- Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Thoracic, Aortic Dissection, Thoracoabdominal
- Trial name
- NCT02323581
- Testing
- Endovascular treatment of Thoracoabdominal Aortic Aneurysm, Endovascular treatment of Aortic Arch Aneurysms
- Where
- 2 sites in United States
- Volunteers
- 520 people
- Sponsor
- Darren Schneider, M.D.