Clinical trials: Aorta Dissection, open to volunteers
Acute Type A Aortic Dissection
A Prediction Model of Prolonged Mechanical Ventilation Following Acute Type A Aortic Dissection Surgery
The goal of this observational study is to develop and validate a predictive model for prolonged mechanical ventilation (PMV) following acute type A aortic dissection (ATAAD) surgery. The main questions it aims to answer are: 1.
- Trial name
- NCT06929780
- Where
- China
- Volunteers
- 1,400 people
- Sponsor
- China-Japan Friendship Hospital
Aortic Dissection, Aortic Aneurysm
NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness
Prospective, non-randomized, multi-center clinical investigation of the NEXUS™ Aortic Arch Stent Graft System (NEXUSTM) for the treatment of thoracic aortic lesions involving the aortic arch with a proximal landing zone, native…
- Conditions
- Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
- Trial name
- TRIOMPHE (NCT04471909)
- Testing
- NEXUS Aortic Stent Graft System
- Where
- 32 sites in United States, New Zealand
- Volunteers
- 110 people
- Sponsor
- Endospan Ltd.
Thoracic Aortic Aneurysm, Penetrating Aortic Ulcers (PAUs)
MBA Early Feasibility Study
The MBA 25-04 study is a prospective, multicenter, non-randomized, single-arm, early feasibility study designed to assess the initial safety of the MBA device through five years following the index endovascular procedure.
- Conditions
- Thoracic Aortic Aneurysm, Penetrating Aortic Ulcers (PAUs), Thoracic Aortic Dissection, Pseudoaneurysm
- Trial name
- NCT07564375
- Testing
- GORE® Multibranch Arch Endoprosthesis, GORE® Ascending Stent Graft
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- W.L.Gore & Associates
Aortic Dissection, Systemic Inflammatory Response Syndrome
Protective Effect of Sivelestat Against Negative Pulmonary Function and Organ Dysfunction After Cardiovascular Surgery (PANDA VI)
Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are the major causes of death in patients with cardiovascular diseases.
- Conditions
- Aortic Dissection, Systemic Inflammatory Response Syndrome, Cardiovascular Diseases (CVD)
- Trial name
- PANDA (NCT06195267)
- Testing
- Sivelestat, Blank control
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- Nanjing Medical University
Aortic Dissection
False Lumen Treatment for Prevention of Aortic Growth Using Shape Memory Polymer - First-in-Human Study
To determine the safety and feasibility of the investigational product to reduce aortic dissection false lumen perfusion.
- Trial name
- FLAGSHIP_NZL (NCT06550986)
- Testing
- False Lumen Embolization System, IMPEDE-FX RapidFill
- Where
- 2 sites in New Zealand
- Volunteers
- 30 people
- Sponsor
- Shape Memory Medical, Inc.
Thoracic Aortic Dissection
Post-market Clinical Trial of the Dominus® Stent-Graft
Real-world clinical trial evidence post-market, evaluating the safety and efficacy of the Dominus® StentGraft Endoprosthesis in treating thoracic aortic diseases, following the Instructions for Use
- Trial name
- DominusPMCF (NCT06270537)
- Testing
- Stent-Graft Dominus® Endoprosthesis
- Where
- 3 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- Braile Biomedica Ind. Com. e Repr. Ltda.
Ascending Aortic Dissection
Retrograde Ascending Dissection: Intraluminal Aortic Therapy
This study is a single-arm, open-label, multi-center clinical trial evaluating the safety and efficacy of endovascular treatment for retrograde dissection involving the ascending aorta that is not suitable for open surgery.
- Trial name
- RADIAL (NCT07405242)
- Testing
- Endovascular treatment of aortic dissection (stent implantation)
- Where
- China
- Volunteers
- 149 people
- Sponsor
- Ruijin Hospital
Aortic Aneurysm, Aortic Dissection
Cardiovascular Health Improvement Project
The goal of this project is to establish a biobank of clinical information, DNA, plasma, and aortic tissue samples from patients with cardiovascular disease as well as healthy controls.
- Conditions
- Aortic Aneurysm, Aortic Dissection, Bicuspid Aortic Valve (BAV), Heart Failure
- Trial name
- CHIP (NCT02306200)
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Vascular Disease, Dissection
Long-term Characterization of GORE® TAG® Conformable Thoracic Stent Graft With ACTIVE CONTROL System Performance
An observational, prospective multi-regional post-market registry collecting mid- and long-term data to assess outcomes through ten years of follow-up for subjects treated with GORE® TAG® Conformable Thoracic Stent Graft with…
- Conditions
- Vascular Disease, Dissection, Dissection Aortic Aneurysm, Dissection of Aorta
- Trial name
- TGR 23-02TA (NCT06658730)
- Testing
- Endovascular
- Where
- 37 sites in United States, Denmark and 8 more
- Volunteers
- 1,500 people
- Sponsor
- W.L.Gore & Associates
Coronary Artery Disease, Arrhythmias, Cardiac
Prognosis Prediction System of Patients With Cardiovascular and Cerebrovascular Diseases Based on Multi-omics
The etiology and specific pathogenesis of many cardiovascular diseases such as coronary atherosclerosis, cardiomyopathy, atrial fibrillation, and stroke are still unclear.
- Conditions
- Coronary Artery Disease, Arrhythmias, Cardiac, Heart Valve Diseases, Aortic Dissection
- Trial name
- PROSPECT (NCT06001073)
- Testing
- Observational; No Interventions were given.
- Where
- China
- Volunteers
- 25,000 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Aortic Dissection
False Lumen Treatment for Prevention of Aortic Growth Using Shape Memory Polymer - First-in-Human Study (FLAGSHIP_FRA)
To determine the safety and feasibility of investigational product to reduce aortic dissection false lumen perfusion.
- Trial name
- FLAGSHIP_FRA (NCT06740721)
- Testing
- False Lumen Embolization System, IMPEDE-FX RapidFill
- Volunteers
- 15 people
- Sponsor
- Shape Memory Medical, Inc.
Acute Coronary Syndrome, High-Risk Chest Pain
BREVOC Study: Exhaled VOCs for High-Risk Chest Pain in the ED
Study Objectives 1. Screening and identification of diagnostic biomarkers: To establish the exhaled volatile organic compound (VOC) profile of patients with acute high-risk chest pain and to differentiate high-risk chest pain…
- Conditions
- Acute Coronary Syndrome, High-Risk Chest Pain, Volatile Organic Compounds
- Trial name
- BREVOC (NCT07379567)
- Testing
- observational study
- Volunteers
- 6,000 people
- Sponsor
- Qilu Hospital of Shandong University
Aortic Aneurysm, Aortic Dissection
Diagnosis and Prognosis for Aortic Aneurysm aNd Dissection in Anzhen(DPANDA) Study
The registry study aims to determine serial biomarkers to diagnosis and prognosis of aortic aneurysm/aortic dissection.
- Trial name
- NCT03233087
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Beijing Institute of Heart, Lung and Blood Vessel Diseases
Acute Aortic Syndrome
Aortic Dissection Detection Risk Score With D-dimer to Rule-Out Acute Aortic Syndrome
The goal of this study is to evaluate the safety of integrating the Aortic Dissection Detection Risk Score (ADD-RS) and D-dimer testing for ruling out acute aortic syndrome (AAS) in the emergency department (ED).
- Trial name
- NCT07640334
- Testing
- D-dimer test
- Where
- 2 sites in Hong Kong
- Volunteers
- 746 people
- Sponsor
- Chinese University of Hong Kong
Aortic Dissection
Study on the Aortic Arch Single Branch Stent Graft System
The objective of the study is to evaluate the Safety and Efficacy of Aortic Arch Single Branch Covered Stent System for Aortic Dissection Involving the Aortic Arch
- Trial name
- NCT06915545
- Testing
- Aortic Arch Single Branch Covered Stent System
- Where
- China
- Volunteers
- 135 people
- Sponsor
- Lifetech Scientific (Shenzhen) Co., Ltd.
Type B Aortic Dissection
Safety and Efficacy of Exercise in Type-B Aortic Dissection
This is a pilot study. The goal of this clinical trial is to evaluate the safety and efficacy of exercise-based cardiac rehabilitation in patients with Type-B Aortic dissection or intramural hematoma or penetrating ulcer and…
- Trial name
- SECRET-Pilot (NCT07009067)
- Testing
- Exercise-based Cardiac Rehabilitation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Guangdong Provincial People's Hospital
Hypoxemia, Ventilator Lung
Driving Pressure-guided Lung Protective Ventilation
The study, named as "The Efficacy of Driving Pressure-guided Lung Protective Ventilation in Surgical Repair of Acute Type A Aortic Dissection: an open-label, randomized control clinical trial", aims to investigate whether driving…
- Trial name
- DPV (NCT06361420)
- Testing
- Driving pressure-guided positive end expiratory pressure, Optimal oxygenation-guided positive end expiratory pressure, Ventilation strategy
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Yong Lin, PhD
Thoracic Aortic Aneurysms, Dissecting, Aneurysm
Endovascular Treatment of Thoracic Aortic Disease
The purpose of this study is to assess the role endovascular therapy to treat aortic disease involving the ascending aorta, the aortic arch, and the visceral segment of the aorta (or thoracoabdominal aorta)
- Conditions
- Thoracic Aortic Aneurysms, Dissecting, Aneurysm, Ascending Aorta Aneurysm, Aortic Arch; Aneurysm, Dissecting
- Trial name
- EVOLVE Aorta (NCT00583817)
- Testing
- Endovascular stent-graft implantation
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- Matthew Eagleton
Aortic Dissection Aneurysm, Aortic Dissection Rupture
Effects of Precise Education on Postoperative Discomfort Symptoms in Patients With Aortic Disease Undergoing Endovascular Intervention: a Single-center Randomized Controlled Study
The incidence and severity of post-procedural discomfort were evaluated in patients undergoing endovascular repair for aortic dissection across six symptom-related dimensions: immobilization-related issues, puncture site…
- Conditions
- Aortic Dissection Aneurysm, Aortic Dissection Rupture, Aortic Dissection Involving the Descending Thoracic Aorta
- Trial name
- NCT07362901
- Testing
- postoperative precise education
- Where
- China
- Volunteers
- 132 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Type B Aortic Dissection
Conventional TEVAR Versus FABULOUS RCT
For High-risk Type B aortic dissections, a multicenter, prospective, randomized controlled study is conducted to compare the clinical outcomes of conventional proximal endovascular repair (TEVAR) alone versus the Fabulous system…
- Trial name
- NCT06740565
- Testing
- thoracic endovascular aortic repair
- Volunteers
- 392 people
- Sponsor
- Shanghai Zhongshan Hospital